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| amino acid therapy for cancer: The Heterogeneity of Cancer Metabolism Anne Le, 2018-06-26 Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies. |
| amino acid therapy for cancer: Metabolism in Cancer Thorsten Cramer, Clemens A. Schmitt, 2016-08-24 This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy. |
| amino acid therapy for cancer: Antineoplastons Burzynski Research Institute, 1988 |
| amino acid therapy for cancer: Nanostructures for Cancer Therapy Alexandru Mihai Grumezescu, Anton Ficai, 2017-04-11 Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics. In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents. The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer. - Provides an examination of nanoparticle delivery systems for cancer treatment, illustrating how the use of nanotechnology can help provide more effective chemotherapeutic treatments - Examines, in detail, the different types of nanomaterials used in cancer therapy, also explaining the effect of each - Provides a cogent overview of recent developments in the use of nanostructured materials in chemotherapeutics, allowing readers to quickly familiarize themselves with this area |
| amino acid therapy for cancer: Immune Surveillance Richard T. Smith, 2012-12-02 Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology. |
| amino acid therapy for cancer: Epigenetics in Human Disease Trygve Tollefsbol, 2012-07-26 Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs |
| amino acid therapy for cancer: Amino Acids in Therapy Leon Chaitow, 1985-04 Directed primarily to the health professional, this book covers all aspects of amino acid therapy and discusses conditions that respond particularly well to this treatment. |
| amino acid therapy for cancer: The Pineal Gland and Cancer C. Bartsch, H. Bartsch, D.E. Blask, D.P. Cardinali, W.J.M. Hrushesky, Dieter Mecke, 2012-12-06 The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal - tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels. Yet unidentified low-molecular-weight pineal substances with tumor-inhibiting capacity, a possible involvement of melatonin in electromagnetic field effects on cancer, and the oncotherapeutic potential of melatonin are also addressed. The encouraging results should incite further research to elucidate the exact nature of the link between the pineal gland and cancer for the benefit of patients. |
| amino acid therapy for cancer: Amino Acid Toshiki Asao, Md Asaduzzaman, 2017-06-28 Amino Acid - New Insights and Roles in Plant and Animal provides useful information on new aspects of amino acid structure, synthesis reactions, dietary application in animals, and metabolism in plants. Section 1 includes chapters that describe the therapeutic uses, antiallergic effects, new aspects in the D-amino acid structure, historical background of desmosines, and stereoselective synthesis of ?-aminophosphonic acids. Section 2 presents the role of amino acids in plants, which includes new insights and aspects of D-amino acids, metabolism and transport in soybean, changes during energy storage compound accumulation of microalgae, and determination of amino acids from natural compounds. Section 3 describes the chapters on methodologies and requirement of dietary amino acids for Japanese quails, laying hens, and finishing pigs. The final chapter identifies potential importance of glutathione S-transferase activity for generating resistance to triclabendazole in Fasciola hepatica. |
| amino acid therapy for cancer: Cancer as a Metabolic Disease Thomas Seyfried, 2012-05-18 The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the hallmarks of cancer and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate. |
| amino acid therapy for cancer: Therapeutic Enzymes: Function and Clinical Implications Nikolaos Labrou, 2019-09-03 Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules. |
| amino acid therapy for cancer: Diet Nutrition And Cancer National Research Council, 2022-10-27 This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. |
| amino acid therapy for cancer: Amino Acids in Critical Care and Cancer Rifat Latifi, 1994 Discusses the role and function of certain amino acids as applied to the field of surgery. Topics covered include amino acid requirements of critically ill patients; glutamine in surgical nutrition and metabolism; arginine in nutrition and surgery; use of taurine in total parenteral nutrition; dipeptides in clinical nutrition; potential use of nucleosides and nucleotides in parenteral nutrition; current and potential applications of biosynthetic human growth hormone; hepatic encephalopathy; amino acids in renal failure; amino acid therapy in children and neonates; plasma amino acid profile in cancer patients; arginine and ornithine in tumor metabolism and growth; effect of alanylglutamine on tumor growth, cellular immunity and intestinal immune responses; etc. |
| amino acid therapy for cancer: Chinmedomics Xijun Wang, Aihua Zhang, Hui Sun, 2015-07-15 Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. - Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method - Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications - Edited by the leading experts of research related to Chinmedomics |
| amino acid therapy for cancer: Conquering RAS Asfar Azmi, 2016-08-11 Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. - Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities - Showcases recent advancements in RAS research under one comprehensive volume - Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research |
| amino acid therapy for cancer: Mitochondria and Cancer Keshav Singh, Leslie Costello, 2009-04-05 Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy. |
| amino acid therapy for cancer: Systems Biology of Cancer Sam Thiagalingam, 2015-04-09 An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer. |
| amino acid therapy for cancer: Peptidomics of Cancer-Derived Enzyme Products , 2017-10-18 Peptidomics of Cancer-Derived Enzyme Products, Volume 42, the latest in The Enzymes series, is ideal for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, with this volume featuring high-caliber, thematic articles on the topic of peptidomics of cancer-derived enzyme products. Specific chapters cover Circulating peptidome and tumor-resident proteolysis, Colon tumor secretopeptidome, Chemoenzymatic method for glycomics, Human plasma peptidome for pancreatic cancer, Lipoproteomics and quantitative proteomics, Salivaomics: Protein markers/extracellular RNA/DNA in saliva, and Enzyme-responsive vectors for cancer therapy. |
| amino acid therapy for cancer: CURRENT Medical Diagnosis and Treatment 2011 Stephen J. McPhee, Maxine A. Papadakis, Michael W. Rabow, 2010-11-05 The 50th Anniversary Edition of the World’s Most Popular Annual General Medicine Book – Celebrated with a New Full-Color Design Includes 5 online-only chapters at no additional cost at www.AccessMedicine.com/CMDT Your first place to turn for current developments that promise better patient care Written by clinicians renowned in their respective fields, CMDT offers the most current insight into symptoms, signs, epidemiology, and treatment for more than 1,000 diseases and disorders. For each topic you’ll find concise, evidence-based answers to questions regarding both hospital and ambulatory medicine. This streamlined clinical companion is the fastest and easiest way to keep abreast of the latest medical advances, prevention strategies, cost-effective treatments, and more. MORE usable patient-care information in LESS text: A strong focus on the clinical diagnosis and patient management tools essential to daily practice Full review of all internal medicine and primary care topics, including gynecology and obstetrics, dermatology, neurology, and ophthalmology The only text with an annual review of advances in HIV treatment Hundreds of drug treatment tables, with indexed trade names and updated prices – plus helpful diagnostic and treatment algorithms Recent references with PMID numbers for fast access to abstracts or full-text articles ICD-9 codes listed on the inside covers Five online-only chapters available at no additional cost at www.AccessMedicine.com/CMDT NEW to this edition: Full-color photos and illustrations integrated with text throughout book, including much expanded dermatology and ophthalmology images Newly introduced topics: E. coli O145, floppy iris syndrome, and expanded coverage of H1N1 influenza A New information: emerging role for B-type natriuretic peptide (BNP) as marker of early left ventricular myocardial failure, new approaches to correction of aortic stenosis and to aortic regurgitation in Marfan syndrome, risks of typical and atypical antipsychotic medications, and new hypoglycemic agents Substantial update on cardiology and hypertension, including use of stents and cardiac resynchronization therapy with biventricular pacemaker insertion, recent ACC/AHA criteria for appropriateness of coronary revascularization, use of prasugrel and clopidogrel compared with aspirin in prevention of stent thrombosis, dronedarone and catheter ablation for atrial fibrillation and dabigatran versus warfarin in prevention of atrial fibrillation-related stroke, as well as guidelines for developing an antihypertensive regimen Updated information on pathogenesis and treatment of immune and drug-induced thrombocytopenia, new investigational anticoagulants such as rivaroxaban and idraparinux, risk stratification and prophylactic regimens for deep venous thrombosis and venous thromboembolism, and a prognostic model for pulmonary emboli Expanded information on methicillin-resistant Staphylococcus aureus, treatment of pharyngitis and laryngitis, approaches to the diagnosis of syphilis, diagnosis and complications with borreliosis and its coinfections, acute and chronic viral hepatitides, amyloidosis, treatment and prognosis of venous stasis ulcers, and therapy for heat stroke and burns Substantially updated treatment sections: HIV infections and AIDS and advances in therapy for breast cancer in women Updated section on immunization requirements New CMDT Online chapter on Sports Medicine and Outpatient Orthopedics |
| amino acid therapy for cancer: The Glutamate/GABA-Glutamine Cycle Arne Schousboe, Ursula Sonnewald, 2016-11-25 Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction. |
| amino acid therapy for cancer: The Emperor of All Maladies Siddhartha Mukherjee, 2011-08-09 Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer. |
| amino acid therapy for cancer: Medical Biochemistry: The Big Picture Lee W. Janson, Marc Tischler, 2012-03-25 Get the BIG PICTURE of Medical Biochemistry – and target what you really need to know to ace the course exams and the USMLE Step 1 300 FULL-COLOR ILLUSTRATIONS Medical Biochemistry: The Big Picture is a unique biochemistry review that focuses on the medically applicable concepts and techniques that form the underpinnings of the diagnosis, prognosis, and treatment of medical conditions. Those preparing for the USMLE, residents, as well as clinicians who desire a better understanding of the biochemistry behind a particular pathology will find this book to be an essential reference. Featuring succinct, to-the-point text, more than 300 full-color illustrations, and a variety of learning aids, Medical Biochemistry: The Big Picture is designed to make complex concepts understandable in the shortest amount of time possible. This full-color combination text and atlas features: Progressive chapters that allow you to build upon what you’ve learned in a logical, effective manner Chapter Overviews that orient you to the important concepts covered in that chapter Numerous tables and illustrations that clarify and encapsulate the text Sidebars covering a particular disease or treatment add clinical relevance to topic discussed Essay-type review questions at the end of each chapter allow you to assess your comprehension of the major topics USMLE-style review questions at the end of each section Three appendices, including examples of biochemically based diseases, a review of basic biochemical techniques, and a review of organic chemistry/biochemistry |
| amino acid therapy for cancer: Theranostic Bionanomaterials Wenguo Cui, Xin Zhao, 2019-05-02 Theranostic Bionanomaterials is an invaluable study of recent advances and trends in the development and application of functional bionanomaterials for theranostic applications. This book describes the design and characterization of nanomaterials which exhibit distinctive physical, chemical and biological properties and discusses how these functional nanomaterials enable the precise manipulation of architectural, physical and biochemical cell microenvironments in vitro. In addition, it covers how they can act as the carriers of diagnostic or therapeutic agents, thus providing new pathways or strategies for disease diagnosis and treatment. Specific chapters discuss protein delivery, drug delivery, tissue regeneration, bioimaging, biodetection, and much more. This book will be a critical resource for those involved in cutting-edge research in theranostics bionanomaterial. |
| amino acid therapy for cancer: Superfood and Functional Food Naofumi Shiomi, Viduranga Waisundara, 2017-02-22 Superfoods and functional foods are receiving increasing attention because of their important roles in health. This book focuses on the production of superfoods and functional foods and their role as medicine. In the early chapters, prominent researchers introduce the roles and production of microalgae and functional fruits through metabolic engineering, the use of food waste, and effective cooking procedures. In the latter chapters, other prominent researchers introduce the medical effects of polyphenols, glutamine, and unsaturated fatty acids, which are contained in superfoods and functional foods. They suggest the importance of superfoods and functional foods in the treatment and prevention of many diseases. It is also recommended for readers to take a look at a related book, Superfood and Functional Food: An Overview of Their Processing and Utilization. |
| amino acid therapy for cancer: PEGylated Protein Drugs: Basic Science and Clinical Applications Francesco M. Veronese, 2009-12-30 PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development. |
| amino acid therapy for cancer: Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach Kakoli Bose, Pradip Chaudhari, 2019-11-25 Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth. |
| amino acid therapy for cancer: The Cancer Handbook Malcolm Alison, 2002 Provides a comprehensive overview of all major areas of cancer research and oncology. Bridging the gap between the molecular biology of cancer and clinical diagnosis and treatment, this online reference work provides a resource for medical and life sciences students, as well as all scientists, clinicians and researchers working in the cancer field and related biomedical areas. |
| amino acid therapy for cancer: The Tumour Microenvironment Jamie A. Goode, Derek J. Chadwick, 2001-11-28 Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies. |
| amino acid therapy for cancer: Treatment of Leukemia and Lymphoma David A. Scheinberg, Joseph G. Jurcic, 2004-10-30 New Treatments of Leukemia and Lymphoma describes the most important advances in the therapy of hematopoietic cancers that have been derived from recent discoveries in cancer cell biology, kinase biochemistry, and immunology. Detailed descriptions of the large number of new and effective agents that have recently become available for the treatment of leukemias and lymphomas as well as an understanding of their mechanisms of action and their integration into current therapy are provided. A number of experimental drug reagents currently in clinical investigation are also discussed. The therapies include conventional anti-metabolites, monoclonal antibodies directed to cell surface receptors, antibodies tagged with toxins and radiopharmaceuticals, inhibitors of specific kinases, stem cell transplants, and engineered T-cells designed to selectively target hematopoietic cancers. The contents of the book will allow practitioners and investigators alike to understand what is current and state of the art as well as what to look for in the future.* Provides an up-to-date, state of the art discussion of a rapidly changing field * Great breadth covering conventional chemotherapeutic agents, biologic agents such as antibodies, novel small molecule inhibitors and genetically engineered cells * Written by international experts in each of the fields |
| amino acid therapy for cancer: Chitosan Based Biomaterials Volume 2 Jessica Amber Jennings, Joel David Bumgardner, 2016-09-28 Chitosan Based Biomaterials: Tissue Engineering and Therapeutics, Volume 2, provides the latest information on chitosan, a natural polymer derived from the marine material chitin. Chitosan displays unique properties, most notably biocompatibility and biodegradability. It can also be easily tuned to modify its structure or properties, making chitosan an excellent candidate as a biomaterial. Consequently, chitosan is being developed for many biomedical functions, ranging from tissue engineering and implant coatings to drug and gene delivery. This book provides readers with a full coverage of the applications of chitosan-based biomaterials. - Presents specific focus on tissue engineering and therapeutics - Provides comprehensive treatment of all biomaterial applications of chitosan - Contains contributions by leading researchers with extensive experience in the material |
| amino acid therapy for cancer: Keto for Cancer Miriam Kalamian, 2017 A Comprehensive Guide for Patients and Practitioners Although evidence supporting the benefits of ketogenic diet therapies continues to mount, there is little to guide those who wish to adopt this diet as a metabolic therapy for cancer. Keto for Cancer fills this need. Inspired by the work of Dr. Thomas N. Seyfried, PhD, nutritionist Miriam Kalamian has written the first book to lay out comprehensive guidelines that specifically address the many challenges associated with cancer, and particularly the deep nutritional overhaul involved with the ketogenic diet. Kalamian, a leading voice in the keto movement, is driven by passion from her own experience in using the ketogenic diet for her young son. Her book addresses the nuts and bolts of adopting the diet, from deciding whether keto is the right choice to developing a personal plan for smoothly navigating the keto lifestyle. It is invaluable for both beginners and seasoned users of the ketogenic diet, as well as for health-care professionals who need a toolkit to implement this targeted metabolic therapy. The book guides readers to a deeper understanding of the therapeutic potential of the ketogenic diet--which extends well beyond simply starving cancer--emphasizing the powerful impact the diet has on the metabolism of cancer cells. Nutritional nuances are explored in sections such as Fasting Protocols and Know What's in the Foods You Eat while meal templates and tracking tools are provided in Preparing Keto Meals. Kalamian also discusses important issues such as self-advocacy. Readers of Keto for Cancer are empowered to get off the bench and get in the game. To that end, Kalamian offers tips on how to critically examine cancer-care options then incorporate what resonates into a truly personalized treatment plan. |
| amino acid therapy for cancer: How to Starve Cancer Jane McLelland, 2018-07-08 Jane McLelland was only 30 when she was diagnosed with cancer. A few years later it was stage 4 (or terminal) and had spred to her lungs. Expected to live 12 weeks, she refused to believe there weren't any effective drugs or therapies. Her scientific training meant she was able to examine and digest hundreds of research papers she found in libraries, journals and online - and the conclusion she reached astonished her ... This is the story of how she took on her illness, changed her diet, educated herself, persuaded her oncologist and other doctors to prescribe her an unusual cocktail of commonly used drugs - some of which are already in many people's medicine cabinets - these made the difference between life and death ...--Publisher description. |
| amino acid therapy for cancer: Central Nervous System Metastases Manmeet Ahluwalia, Philippe Metellus, Riccardo Soffietti, 2019-11-05 This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors. |
| amino acid therapy for cancer: Protein Quality Evaluation Food and Agriculture Organization of the United Nations, 1991 |
| amino acid therapy for cancer: Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition Luc A. Cynober, 2003-11-13 The first edition of this innovative book brought a new perspective to the metabolic and therapeutic aspects of amino acids in clinical nutrition. Since its publication, a number of very important advances have been made in the field and interesting new findings have emerged. Until now, no reference has fully explored the promising new developments |
| amino acid therapy for cancer: DJ-1/PARK7 Protein Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga, 2017-11-16 This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. |
| amino acid therapy for cancer: The How Not to Die Cookbook Michael Greger, M.D., FACLM, Gene Stone, 2017-12-05 From Michael Greger, M.D., FACLM, the physician behind the trusted and wildly popular website Nutritionfacts.org, and author of the New York Times bestselling book How Not to Die, comes a beautifully-designed, comprehensive cookbook complete with more than 120 recipes for delicious, life-saving, plant-based meals, snacks, and beverages that's a perfect gift for healthy conscious eaters. Dr. Michael Greger’s bestselling book, How Not to Die, presented the scientific evidence behind the only diet that can prevent and reverse many of the causes of premature death and disability. Now, The How Not to Die Cookbook puts that science into action. From Superfood Breakfast Bites to Spaghetti Squash Puttanesca to Two-Berry Pie with Pecan-Sunflower Crust, every recipe in The How Not to Die Cookbook offers a delectable, easy-to-prepare, plant-based dish to help anyone eat their way to better health. Rooted in the latest nutrition science, these easy-to-follow, stunningly photographed recipes will appeal to anyone looking to live a longer, healthier life. Featuring Dr. Greger’s Daily Dozen—the best ingredients to add years to your life—The How Not to Die Cookbook is destined to become an essential tool in healthy kitchens everywhere. |
| amino acid therapy for cancer: The Mood Cure Julia Ross, 2003-12-30 Are you a part of the bad mood epidemic? Here are the answers you've been looking for! Julia Ross’s plan provides a natural cure for your mood. Drawing on thirty years of experience, she presents breakthrough solutions to overcoming depression, anxiety, irritability, stress, and other negative emotional states that are diminishing the quality of our lives. Her comprehensive program is based on the use of four mood-building amino acids and other surprisingly potent nutrient supplements, plus a diet rich in good-mood foods such as protein, healthy fat, and certain key vegetables. Including an individualized mood-type questionnaire, The Mood Cure has all the tools to help you get started today and feel better tomorrow. |
| amino acid therapy for cancer: Nutrient Metabolism Martin Kohlmeier, 2003-10-01 Nutrient Metabolism defines the molecular fate of nutrients and other dietary compounds in humans, as well as outlining the molecular basis of processes supporting nutrition, such as chemical sensing and appetite control. It focuses on the presentation of nutritional biochemistry; and the reader is given a clear and specific perspective on the events that control utilization of dietary compounds. Slightly over 100 self-contained chapters cover all essential and important nutrients as well as many other dietary compounds with relevance for human health. An essential read for healthcare professionals and researchers in all areas of health and nutrition who want to access the wealth of nutrition knowledge available today in one single source.Key Features* Highly illustrated with relevant chemical structures and metabolic pathways* Foreword by Steven Zeisel, Editor-in-chief of the Journal of Nutritional Biochemistry* First comprehensive work on the subject |
| amino acid therapy for cancer: Molecular Evolution Roderick D.M. Page, Edward C. Holmes, 2009-07-14 The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility. |
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Understanding cachexia as a cancer metabolism syndrome
ultimate cancer cells hijack the immune system to produce specific cytokines promoting tumor growth, survival and progression.13 Chronic inflammation is also a major driver of cachexia …
Methionine restriction promotes cGAS activation ...
and has promise for cancer treatment.27,28 Cancer cells have a high metabolic demand and compete with immune cells for amino acid resources.29 Tumor intrinsic mechanisms and meta …
Reprogramming of glucose, fatty acid and amino acid
acid and amino acid metabolism, their crosstalk, and rel-evant cancer therapy strategy. Keywords Metabolism Glucose Fatty acid Amino acid Cancer Introduction Energy metabolism …
Branched-chain amino acid transaminase 1 confers EGFR-TKI …
ARTICLE OPEN Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation Tao Zhang 1, Zilu Pan1,2, Jing Gao 1, Qingqing Wu3, …
YOUR GUIDE TO LUTATHERA TREATMENT - Carcinoid Cancer …
LUTATHERA® is a medicine that uses radiation to kill cancer cells, which means it works differently than most other cancer medicines. It is given as an infusion in a hospital setting and …
Resetting amino acid metabolism of cancer cells by ATB0,
Resetting amino acid metabolism of cancer cells by ATB0,+-targeted nanoparticles for enhanced anticancer therapy Longfa Kou a, 1, Xinyu Jiang a, b, 1 ... cancer therapy [3]. Lapatinib, an ...
Meeting the Amino Acid Requirements for Protein Anabolism …
Until such time as the amino acid requirements of cancer patients are empirically determined, a suit-able starting point might be the recommended pro- ... ia therapy. 10.7 Meeting the Amino …
The regulation of amino acid metabolism in tumor cell death …
The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions ... target for cancer therapy. The dynamic balance of cell survival and death is …
Mechanism and application of nonessential amino acid …
As research progresses, the application of amino acid deprivation in tumor therapy is beginning to take shape. Serine and glycine have been shown to be ... neutral amino acid exchangers in …
Dual Ribosome Profiling reveals metabolic limitations of …
tantly, immune checkpoint blockade therapy imposes amino acid restrictions specifically in T cells, demonstrating that therapies create distinct metabolic …
Beggars banquet: Metabolism in the tumor immune …
Tumors can also alter amino acid metabolic pathways in T cells in the TME. Amino acids and their metabolites can serve ... metabolic pathways in cancer is considered a logical approach …
The significant role of amino acid metabolic reprogramming in
light on its implications for cancer biology and therapy. The role of amino acids in tumor cells Metabolic reprogramming of amino acids in tumor cells is a pivotal aspect of cancer biology. …
Inhibition of cancer-type amino acid transporter LAT1
Metastasis is the leading cause of mortality in cancer patients. L‑type amino acid transporter 1 (LAT1, ... therapy. Cancer cells require high nutrients, including sugars and amino acids, to ...
Amino acid metabolism in immune cells: essential regulators …
an emphasis on amino acid competition between the immune cells and tumor cells. From a clinical perspec-tive, we also discuss potential therapeutic strategies tar-geting amino acids …
Targeting TLK2 inhibits the progression of gastric cancer by ...
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ ASNS axis Mingliang Wang 1,3, ... Cancer Gene Therapy …
Metabolic reprogramming in prostate cancer - Nature
cryosurgery and hormone therapy, metastatic prostate cancer remains incurable. ... results in the upregulation of glucose and amino acid transporters, which helps cancer cells to compete for ...
Targeting the Proline Glutamine Asparagine Arginine …
Metabolic Axis in Amino Acid Starvation Cancer Therapy Macus Tien Kuo 1,*, Helen H. W. Chen 2, Lynn G. Feun 3 and Niramol Savaraj 4 Citation: Kuo, M.T.; Chen, H.H.W.; ... Amino acid …
L-type amino acid transporter 1 is associated with ... - Nature
Therefore, we explored the amino acid metabolism, including L‑type amino acid transporter‑ (LAT), in breast cancer tissues and claried the role of LAT in therapeutic resistance and clinical ...
Metabolic control of cancer metastasis: role of amino acids at ...
Fig. 1 Amino acid metabolic pathways critical in metastasis and key Inhibitors. A simplified diagram of major pathways of selected amino acid metabolism relevant to metastasis to the …
Clickable Shiga Toxin B Subunit for Drug Delivery in Cancer …
tumor cells, with prospects for improved cancer therapy in terms of straightforward drug attachment and effectivecancer cell elimination. T he improvement of strategies for targeted …
PATIENT & CAREGIVER EDUCATION N-Acetylcysteine
It has not been proven to be an effective treatment for cancer. N-acetylcysteine (NAC) is a dietary supplement derived from the amino acid L-cysteine. It is used as an antidote for …
Branched-chain amino acid aminotransferase 2 regulates
Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells ... been implicated as a tumor-suppressor function for cancer therapy. Recent advance revealed …
Proline dehydrogenase in cancer: apoptosis, autophagy, …
secondary amino acid that endows several functions not pos-sible with other amino acids (Liu et al. 2020). Hence, proline ... autophagy, nutrient dependency and cancer therapy 1893 1 3 may …
Amino acid transporters as emerging therapeutic targets in …
AMINO ACID IN CANCER Diversity in amino acid metabolism among tumors has been ob-served at the same time in various cancers. Recent studies have shown that some amino acids are …
Chemical Engineering Journal - NSF Public Access
cancer [18], the catalytic therapy based on generation of ROS was also powerful companion for chemotherapy. Spherical nanostructures are readily obtained by Fe ion-coordinated …
The Evaluation of an Amino Acid- Oral Re-hydration Solution …
Amino Acid- Oral Rehydration Solution to Reduce Chemotherapy Related Diarrhea and Improve Quality of Life in Solid Tumor Cancer Patients . Introduction . Chemotherapy related diarrhea …
A metabolic vulnerability of pancreatic cancer - Nature
biosynthesis an attractive target for cancer therapy. However, the most successful poly- ... metabolism in pancreatic cancer cells. The amino acid ornithine can be the substrate for
In-silico study of aminobenzoic acid Schiff base copper …
especially in the development of cancer drugs [21, 22]. The aim of this work is to synthesize and investigate in-silico Schiff base copper complexes of aminobenzoic acid moiety as CDK 7 …
USP24 promotes drug resistance during cancer therapy
2620-amino acid protein that contains one ubiquitin-associated domain (UBA), which binds to the ubiquitin ... resistance during cancer therapy by stabilizing several ABC
Branched-Chain Amino Acid Metabolic Reprogramming …
proliferation, invasion, and resistance to drug therapy (Vander Heiden and DeBerardinis, 2017). Recently, aberrant branched-chain amino acid (BCAA) metabolism has been implicated in …
The Second Department of Surgery , Tohoku University …
KOIKE, N., TOYODA, T. and MORI, S. Anti-Cancer Therapy with Valine-Depleted Amino Acid Imbalance Solution. Tohoku J. exp. Med. , 1988, 156 (3), 259-270 For the purpose of …
Amino Acid Transporters: Emerging Roles in Drug Delivery …
Amino Acid Transporters: Emerging Roles in Drug Delivery for Tumor -targeting Therapy Ling Zhang a, Chengguang Sui a, Wenhan Yang b,c, Qiuhua Luo b,c,* a Department of Biotherapy, …
Amino Acid Metabolism in Cancer Drug Resistance
sure leads to metabolic reprogramming, driving drug resistance in cancer cells [3,4]. Amino acid metabolism has been recognized as the key determinant of drug resistance in tumors, …
Amino acid metabolism reprogramming: shedding new light …
Zheng et al. J Exp Clin Cancer Res Page 3 of 23 Fig. 1 Schematic diagram summarizing the bridge between amino acid metabolism and T cell. A In the TME, T cells compete with tumor …
Clickable amino acid tuned self-assembly of a nucleus …
Clickable amino acid tuned self-assembly of a nucleus-selective multi-component nanoplatform for synergistic cancer therapy† Lan Yang,a Xiao He,a Zhiying Zeng,a Jiakun Tang,a Dongmei …
The amino acid transporter SLC6A14 in cancer and its
Accepted Manuscript The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy Yangzom D. Bhutia , Ellappan Babu , Puttur D. Prasad , Vadivel Ganapathy , …
アミノ酸トランスポーターを標的とした診断と治療のための …
cers. We have developed several lines of compounds for cancer diagnosis and therapy. To diagnose cancer by using positron emission tomography (PET)probes, we have created amino …
Amino acid metabolism, redox balance and epigenetic …
May 2, 2023 · Amino acid metabolism might support cancer cells survival and further induce therapeutic resistance by maintaining redox homeostasis, sustaining energy generation and …
Amino Acid Therapy (PDF) - api.spsnyc.org
Amino Acid Therapy: Amino Acids in Therapy Leon Chaitow,1985-04 Directed primarily to the health professional this book covers all ... Addiction Habit Billie Jay Sahley,Katherine M. …
Amino Acid Therapy (Download Only) - api.spsnyc.org
Amino Acid Therapy Gordon Press Publishers,1996-06 Weight Control, Stress and Amino Acid Therapy Gordon Press ... dietary supplements aimed at enhancing performance Amino Acids …
Amino Acid Therapy (book) - api.spsnyc.org
Amino Acid Therapy: ... Hyperactivity with Amino Acids and Nutrient Therapy Billie Jay Sahley,1988 Amino Acids in Critical Care and Cancer Rifat Latifi,1994 Discusses the role and …
Induction of CTH expression in response to amino acid …
L type amino acid transporter 1 (LAT1) is an attractive molecular target for cancer therapy because of its overexpression in many cancer cells. JPH203, a selective LAT1 inhibitor, …
Branched-chain amino acid and cancer: metabolism, immune ...
Valine is an essential amino acid for the occurrence and development of gastric cancer (GC) [14]. An 13, imbalanced content of amino acids in the body can enhance the sensitivity of cells to …
Poly(vinyl alcohol) boosting therapeutic potential of p ...
In the current clinical boron neutron capture therapy (BNCT), -boronophenylalanine (BPA) has been the most p powerful drug owing to its ability to accumulate selectively within cancers …
Fueling the fight against cancer: Exploring the impact of …
May 22, 2024 · amino acid catalyzation on cancer and cancer immune microenvironment Qianquan Ma a,1, Haoyu Li b,c,h,1, Zhihao Song b,c,h, Zhili Deng d,e,f, Wei Huang b,c,g,h,*, …
Promising Application of D-Amino Acids toward Clinical …
Int. J. Mol. Sci. 2022, 23, 10794 3 of 18 is an endogenous and potent co-agonist of NMDAR, which distributes in the hypothalamic structure and especially in the forebrain structure [23–26].
Immune control by amino acid catabolism during …
of the essential amino acid tryptophan (Trp), a common ... Hence, effective cancer therapy must disrupt immune checkpoints to allow antitumour RT TG GOGT VQNGT RT VJGT ECWUG …
Is the intravenous supplementation of amino acid to cancer …
Intravenous amino acid in cancer patients Parenteral amino acid in cancer patients Amino acid requirement of cancer patients Protein requirement of cancer patients summary Background & …
Selective enhanced cytotoxicity of amino acid deprivation for …
of essential nutrients, such as amino acids (AAs) and glucose, is a rapid way to directly disrupt and inhibit the dierentiation and proliferation of cancer cells. Currently, E. coli-derived L …
DRUG NAME: Polatuzumab vedotin - BC Cancer
Metabolism expected to undergo catabolism to small peptides, amino acids, unconjugated MMAE, and unconjugated MMAE-related catabolites active metabolite(s) no information found ... see …
