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| assessment of parkinson disease: Guide to Assessment Scales in Parkinson’s Disease Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, Maria João Forjaz, Kallol Ray Chaudhuri, 2014-10-16 This Guide assesses the key clinimetric attributes in the assessment of Parkinson's Disease (PD), with the intention to offer rapid and pragmatic information on the most relevant scales used in PD. Parkinson’s disease affects approximately 4 million people globally and is most commonly seen in people over the age of 50. The disease is a progressive disorder of the nervous system, and presents a number of movement and cognitive symptoms, thereby greatly affecting a patients quality of life. The use of scales for assessment in neurological disorders such as PD arises from the need to quantify disorders and states (such constructs as disability, symptoms, quality of life). Assessment scales are often categorised into two categories: generic (i.e. those scales usable in any health condition), and specific (i.e. scales developed for exclusive use in PD). They can have a variety of components: single-item and multi-item or composite scale; unidimensional and multidimensional; and as disease-centered and patient-centered measures. The creation and validation of scales is complex, with scales undergoing numerous studies to assess criteria such as acceptability, reliability, and responsiveness. In the process of validation of a scale the following attributes should be tested to ascertain whether a scale is an effective instrument of measurement. |
| assessment of parkinson disease: Techniques for Assessment of Parkinsonism for Diagnosis and Rehabilitation Sridhar P. Arjunan, Dinesh Kant Kumar, 2021-08-02 This book describes the range of technologies that have been developed for diagnosing and assessing Parkinson’s disease patients. Also presenting the latest studies providing insights into the changes to the neural system in Parkinson’s disease, it is a valuable resource for neurologists, general practitioners and nurses. Further, the book highlights areas that require more research, and as such will appeal to researchers, biomedical engineers and clinicians. |
| assessment of parkinson disease: Research Anthology on Diagnosing and Treating Neurocognitive Disorders Management Association, Information Resources, 2020-08-30 Cognitive impairment, through Alzheimer’s disease or other related forms of dementia, is a serious concern for afflicted individuals and their caregivers. Understanding patients’ mental states and combatting social stigmas are important considerations in caring for cognitively impaired individuals. Technology is playing an increasing role in the lives of the elderly. One of the most prevalent developments for the aging population is the use of technological innovations for intervention and treatment of individuals with mental impairments. Research Anthology on Diagnosing and Treating Neurocognitive Disorders examines the treatment, diagnosis, prevention, and therapeutic and technological interventions of neurodegenerative disorders. It also describes programs and strategies that professional and family caregivers can implement to engage and improve the quality of life of persons suffering from cognitive impairment. Highlighting a range of topics such as dementia, subjective wellbeing, and cognitive decline, this publication is an ideal reference source for speech pathologists, social workers, occupational therapists, psychologists, psychiatrists, neurologists, pediatricians, researchers, clinicians, and academicians seeking coverage on neurocognitive disorder identification and strategies for clinician support and therapies. |
| assessment of parkinson disease: Diagnosis and Treatment of Parkinson's Disease Cindy Levine, 2003-01-01 |
| assessment of parkinson disease: Etiology of Parkinson's Disease Jonas H. Ellenberg, William C. Koller, James William Langston, 1995-03-01 This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism. |
| assessment of parkinson disease: An Essay on the Shaking Palsy James Parkinson, 1817 |
| assessment of parkinson disease: Rating Scales in Parkinson's Disease Cristina Sampaio, Christopher G. Goetz, Anette Schrag, 2012-06-28 For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. |
| assessment of parkinson disease: Non-Motor Symptoms of Parkinson's Disease K. Ray Chaudhuri, Eduardo Tolosa, Anthony Henry Vernon Schapira, W. Poewe, 2014 Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research. |
| assessment of parkinson disease: Sexual Dysfunction in Parkinson's Disease , 2022-04-07 Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson's disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series - Updated release includes the latest information regarding Sexual Dysfunction in Parkinson's Disease |
| assessment of parkinson disease: Surgery for Parkinson's Disease Robert R. Goodman, 2019-01-16 Deep brain stimulation for the treatment of patients with Parkinson’s disease was introduced in the 1990s. Initially performed only at academic centers, over the past decade it has become a widespread surgical procedure. A variety of surgical techniques are employed and innovations are introduced frequently. This book is an ideal source of information for the many practicing neurosurgeons who did not learn this surgery during their training but would now like to add it to their practice, as well as an excellent update on exciting new developments in surgery for Parkinson’s disease. This book is designed to provide practicing neurosurgeons with current knowledge on the practical aspects of surgical treatment of patients with Parkinson’s disease. It explains how to identify surgical candidates and determine the optimal surgery, describes the various surgical techniques that are currently employed, and offers insights into how to optimize deep brain stimulation therapy after implantation. The keys to avoidance of surgical complications are carefully elucidated. In addition, an overview is provided of potential advances on the near-term horizon, including closed-loop deep brain stimulation, gene therapy, and optogenetics. All topics are covered by experienced Parkinson’s disease surgeons, in a concise and digestable format. The book will be an ideal source of information for the many practicing neurosurgeons who would like to add deep brain stimulation to their practice, as well as an excellent update on new developments in surgery for Parkinson’s disease. |
| assessment of parkinson disease: Ferri's Clinical Advisor 2020 E-Book Fred F. Ferri, 2019-06-01 Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri's Clinical Advisor 2020 features the popular 5 books in 1 format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today's medical practice. - Contains significant updates throughout, covering all aspects of current diagnosis and treatment. - Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. - Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. - Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. - Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients. |
| assessment of parkinson disease: Clinical Trials In Parkinson's Disease Santiago Perez-Lloret, 2020-08-19 This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials. |
| assessment of parkinson disease: Recent Developments in Parkinson's Disease Stanley Fahn, 1986 |
| assessment of parkinson disease: Parkinson's Disease National Institute of Neurological and Communicative Disorders and Stroke, 1976 |
| assessment of parkinson disease: Occupational Therapy for People with Parkinson's Disease Ana Aragon, Jill Kings, 2010 These practice guidelines draw upon the widest relevant knowledge and evidence available to describe and inform contemporary best practice occupational therapy for people with Parkinson's disease. They include practical examples of interventions to allow occupational therapists to apply new treatments to their practice. |
| assessment of parkinson disease: Movement Disorders Curricula Cristian Falup-Pecurariu, Joaquim Ferreira, Pablo Martinez-Martin, Kallol Ray Chaudhuri, 2017-02-27 This book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management. Reflecting the latest developments in the field, it offers a unique summary of this dynamic area by pursuing a uniform approach to movement disorders curricula. Divided into three parts, Movement Disorders Curricula provides an authoritative overview of this growing branch of neurology. The first part presents the basic elements of movement disorders, including descriptions of the anatomy and physiology of the basal ganglia. It also features sections on clinical trials for movement disorders, practical skills, and rating scales. The second and third part examine in detail hypokinetic and hyperkinetic movement disorders, respectively. Equipping readers with the practical and research skills needed in the movement disorders field, the book offers a valuable tool to help them prepare for board examinations on general neurology, as well as for fellowships in movement disorders. |
| assessment of parkinson disease: Parkinson's Disease and Parkinsonism in the Elderly Jolyon Meara, William C. Koller, 2000-05-25 This book covers the clinical features, diagnosis and management of Parkinson's disease in elderly people. |
| assessment of parkinson disease: Parkinson's Disease Jason S. Hawley, Melissa J. Armstrong, William J. Weiner, 2014-02 Parkinson's Disease: Improving Patient Care is a clinically-focused text for healthcare professionals involved in everyday management of Parkinson's disease patients. Concise chapters and abundant tables make it easy to read or use as a handy reference. |
| assessment of parkinson disease: Handbook of Parkinson's Disease, Fifth Edition Rajesh Pahwa, Kelly E. Lyons Ph.D., 2013-05-09 Highly Commended, BMA Medical Book Awards 2014 This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this volume promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies. New to this edition: • Early identification of premotor symptoms • Potential disease modification agents • Physical and occupational therapy |
| assessment of parkinson disease: The Rational Clinical Examination: Evidence-Based Clinical Diagnosis David L. Simel, Drummond Rennie, 2008-04-30 The ultimate guide to the evidence-based clinical encounter This book is an excellent source of supported evidence that provides useful and clinically relevant information for the busy practitioner, student, resident, or educator who wants to hone skills of physical diagnosis. It provides a tool to improve patient care by using the history and physical examination items that have the most reliability and efficiency.--Annals of Internal Medicine The evidence-based examination techniques put forth by Rational Clinical Examination is the sort that can be brought to bear on a daily basis – to save time, increase confidence in medical decisions, and help decrease unnecessary testing for conditions that do not require absolute diagnostic certainty. In the end, the whole of this book is greater than its parts and can serve as a worthy companion to a traditional manual of physical examination.--Baylor University Medical Center (BUMC)Proceedings 5 STAR DOODY'S REVIEW! Physical diagnosis has been taught to every medical student but this evidence-based approach now shows us why, presenting one of medicine's most basic tenets in a new and challenging light. The format is extraordinary, taking previously published material and updating the pertinent evidence since the initial publication, affirming or questioning or refining the conclusions drawn from the data. This is a book for everyone who has studied medicine and found themselves doubting what they have been taught over the years, not that they have been deluded, but that medical traditions have been unquestionably believed because there was no evidence to believe otherwise. The authors have uncovered the truth. This extraordinary, one-of-a-kind book is a valuable addition to every medical library.--Doody's Review Service Completely updated with new literature analyses, here is a uniquely practical, clinically relevant approach to the use of evidence in the content of physical examination. Going far beyond the scope of traditional physical examination texts, this invaluable resource compiles and presents the evidence-based meanings of signs, symptoms, and results from physical examination maneuvers and other diagnostic studies. Page after page, you'll find a focus on actual clinical questions and presentations, making it an incomparably practical resource that you'll turn to again and again. Importantly, the high-yield content of The Rational Clinical Examination is significantly expanded and updated from the original JAMA articles, much of it published here for the first time. It all adds up to a definitive, ready-to-use clinical exam sourcebook that no student or clinician should be without. FEATURES Packed with updated, new, and previously unpublished information from the original JAMA articles Standardized template for every issue covered, including: Case Presentation; Why the Issue Is Clinically Important; Research and Statistical Methods Used to Find the Evidence Presented; The Sensitivity and Specificity of Each Key Result; Resolution of the Case Presentation; and the Clinical Bottom Line Completely updated with all-new literature searches and appraisals supplementing each chapter Full-color format with dynamic clinical illustrations and images Real-world focus on a specific clinical question in each chapter, reflecting the way clinicians approach the practice of evidence-based medicine More than 50 complete chapters on common and challenging clinical questions and patient presentations Also available: JAMAevidence.com, a new interactive database for the best practice of evidence based medicine |
| assessment of parkinson disease: Parkinson's Disease National Collaborating Centre for Chronic Conditions (Great Britain), 2006 |
| assessment of parkinson disease: The ICD-10 Classification of Mental and Behavioural Disorders World Health Organization, 1993-11 The content of Diagnostic criteria for research (DCR-10) is derived from chapter V(F), Mental and behavioural disorders, of ICD-10 [International Statistical Classification of Diseases and Related Health Problems, tenth revision] |
| assessment of parkinson disease: Marsden's Book of Movement Disorders Ivan Donaldson, C. David Marsden, Susanne Schneider, Kailash Bhatia, 2012-03-29 This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders. |
| assessment of parkinson disease: Leucine-Rich Repeat Kinase 2 (LRRK2) Hardy J. Rideout, 2017-03-28 This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration. |
| assessment of parkinson disease: Dementia with Lewy Bodies John O'Brien, David Ames, Ian McKeith, Edmond Chiu, 2005-11-29 Filling a noticeable gap in the market for a new text solely focused on Dementia with Lewy Bodies, this book discusses cutting-edge topics covering the condition from diagnosis to management, as well as what is known about the neurobiological changes involved. With huge progress having been made over the last decade in terms of the disorder |
| assessment of parkinson disease: Whittle's Gait Analysis Jim Richards, David Levine, Michael W. Whittle, 2012-07-13 Whittle’s Gait Analysis – formerly known as Gait Analysis: an introduction – is now in its fifth edition with a new team of authors led by David Levine and Jim Richards. Working closely with Michael Whittle, the team maintains a clear and accessible approach to basic gait analysis. It will assist both students and clinicians in the diagnosis of and treatment plans for patients suffering from medical conditions that affect the way they walk. Highly readable, the book builds upon the basics of anatomy, physiology and biomechanics Describes both normal and pathological gait Covers the range of methods available to perform gait analysis, from the very simple to the very complex. Emphasizes the clinical applications of gait analysis Chapters on gait assessment of neurological diseases and musculoskeletal conditions and prosthetics and orthotics Methods of gait analysis Design features including key points A team of specialist contributors led by two internationally-renowned expert editors 60 illustrations, taking the total number to over 180 Evolve Resources containing video clips and animated skeletons of normal gait supported by MCQs, an image bank, online glossary and sources of further information. Log on to http://evolve.elsevier.com/Whittle/gait to register and start using these resources today! |
| assessment of parkinson disease: A Guide to the Extrapyramidal Side Effects of Antipsychotic Drugs D. G. Cunningham Owens, 1999-03-11 A very readable and well illustrated 1999 clinical guide to the common side effects of antipsychotic medication. |
| assessment of parkinson disease: International Neurology Robert P. Lisak, Daniel D. Truong, William M. Carroll, Roongroj Bhidayasiri, 2016-04-13 This unique textbook deals with the variations in the causes, presentations and treatment of neurological disease throughout human populations. International Neurology is an indispensable guide to the full range of neurological conditions you will see in your ever-changing patient population. Comprehensive coverage of neurological diseases and disorders with a clinical approach to diagnosis, treatment and management Truly international authorship distils expert knowledge from around the world Succinct, bite-sized, templated chapters allow for rapid clinical referral Further reading recommendations for each chapter guide readers requiring more depth of information Endorsed by the World Federation of Neurology |
| assessment of parkinson disease: Oxford Textbook of Movement Disorders David Burn, 2013-10 Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the basic science and clinical concepts underlying the movement disorders, as well as the diagnosis and treatment of individual hypokinetic and hyperkinetic movement disorders. |
| assessment of parkinson disease: Principles and Practice of Movement Disorders E-Book Joseph Jankovic, Mark Hallett, Stanley Fahn, 2011-08-09 Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com. |
| assessment of parkinson disease: Parkinson's Disease: A Multidisciplinary Guide to Management Fiona Lindop, Rob Skelly, 2021-10 This new book is a practical guide to integrated, multidisciplinary care for people with Parkinson's. Written by experts in Parkinson's care, the book explains the common symptoms at each stage of Parkinson's and describes pharmacological and non-pharmacological interventions. The role of each discipline within the multidisciplinary team (MDT) is outlined and the perspectives of individuals with Parkinson's and their caregivers are explored. Parkinson's Disease: A Multidisciplinary Guide to Management is ideal for all health care professionals who want to deliver the best care for people with Parkinson's. It explains the concepts of multidisciplinary working in Parkinson's and offers evidence-based, practical guidance to support health care professionals in delivering the best patient outcomes. Evidence-based advice to ensure best practice Top tips in every chapter for practical guidance Person-centred approach that orders information according to Parkinson's stage rather than by discipline Contributions from many members of the MDT including neurologists, geriatricians, nurses, physiotherapists, occupational therapists, speech and language therapists and psychologists Insights from people with Parkinson's Latest challenges affecting Parkinson's care, including remote management, bone health and exercise Developing a multidisciplinary Parkinson's service Atypical Parkinsonian syndromes including progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy |
| assessment of parkinson disease: Run in the Light John Mitrofanis, 2019-08-05 Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful dynamic duo, offering a most effective neuroprotective treatment option to patients. |
| assessment of parkinson disease: Levodopa pharmacokinetics -from stomach to brain Maria Nord, 2019-01-07 Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation. |
| assessment of parkinson disease: MANUAL OF DISEASES OF THE NERVOUS SYSTEM, WILLIAM RICHARD. GOWERS, 2018 |
| assessment of parkinson disease: Frontiers In Pattern Recognition And Artificial Intelligence Marleah Blom, Nicola Nobile, Ching Yee Suen, 2019-06-17 The fifth volume in this book series consists of a collection of new papers written by a diverse group of international scholars. Papers and presentations were carefully selected from 160 papers submitted to the International Conference on Pattern Recognition and Artificial Intelligence held in Montreal, Quebec (May 2018) and an associated free public lecture entitled 'Artificial Intelligence and Pattern Recognition: Trendy Technologies in Our Modern Digital World'. Chapters address topics such as the evolution of AI, natural language processing, off and on-line handwriting analysis, tracking and detection systems, neural networks, rating video games, computer-aided diagnosis, and digital learning.Within an increasingly digital world, 'artificial intelligence' is becoming a household term and a topic of great interest to many people worldwide. Pattern recognition, in using key features to classify data, has a strong relationship with artificial intelligence. This book not only complements other monographs in the series, it also provides the latest information. It is geared to promote interest and understanding about pattern recognition and artificial intelligence to the general public. It may also be of interest to graduate students and researchers in the field. Rather than focusing on one specific area, the book introduces readers to various basic concepts and to various potential areas where pattern recognition and artificial intelligence can be applied to make valuable contributions to other fields such as medicine, teaching and learning, forensic science, surveillance, online reviews, computer vision and object tracking. |
| assessment of parkinson disease: Returning Individual Research Results to Participants National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Committee on the Return of Individual-Specific Research Results Generated in Research Laboratories, 2018-08-23 When is it appropriate to return individual research results to participants? The immense interest in this question has been fostered by the growing movement toward greater transparency and participant engagement in the research enterprise. Yet, the risks of returning individual research resultsâ€such as results with unknown validityâ€and the associated burdens on the research enterprise are competing considerations. Returning Individual Research Results to Participants reviews the current evidence on the benefits, harms, and costs of returning individual research results, while also considering the ethical, social, operational, and regulatory aspects of the practice. This report includes 12 recommendations directed to various stakeholdersâ€investigators, sponsors, research institutions, institutional review boards (IRBs), regulators, and participantsâ€and are designed to help (1) support decision making regarding the return of results on a study-by-study basis, (2) promote high-quality individual research results, (3) foster participant understanding of individual research results, and (4) revise and harmonize current regulations. |
| assessment of parkinson disease: Engineering Applications of Neural Networks Giacomo Boracchi, Lazaros Iliadis, Chrisina Jayne, Aristidis Likas, 2017-07-30 This book constitutes the refereed proceedings of the 18th International Conference on Engineering Applications of Neural Networks, EANN 2017, held in Athens, Greece, in August 2017. The 40 revised full papers and 5 revised short papers presented were carefully reviewed and selected from 83 submissions. The papers cover the topics of deep learning, convolutional neural networks, image processing, pattern recognition, recommendation systems, machine learning, and applications of Artificial Neural Networks (ANN) applications in engineering, 5G telecommunication networks, and audio signal processing. The volume also includes papers presented at the 6th Mining Humanistic Data Workshop (MHDW 2017) and the 2nd Workshop on 5G-Putting Intelligence to the Network Edge (5G-PINE). |
| assessment of parkinson disease: Cognition in Parkinson's Disease , 2022-03-02 Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson's disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson's disease, Animal models of cognition in Parkinson's disease, Functional neuroanatomy of cognition in Parkinson's disease, Neuroimaging approaches to cognition in Parkinson's disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson's disease, Neuropsychology of Parkinson's disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Progress in Brain Research series - Updated release includes the latest information on Cognition in Parkinson's Disease |
| assessment of parkinson disease: Balance, Gait, and Falls , 2018-11-24 Balance, Gait, and Falls, Volume 159 presents the latest information on sensorimotor anatomy, sensory integration, gravity and verticality, standing balance, balance perturbations, voluntary stepping and gait initiation, gait and gait adaptability, disorders of balance and gait that result from aging and neurological diseases. The book provides a brief overview of age-related changes in the structure and function of sensorimotor and central processes, with sections specifically devoted to Parkinson's disease, parkinsonism, cerebellar ataxia, stroke, corticobasal degeneration, multiple sclerosis, Huntington's disease, dystonia, tremor, Alzheimer's disease, frontotemporal dementia, cerebral palsy, polio, motor neuron disease, brainstem lesions, spinal lesions, peripheral nerve disease, and psychogenic conditions. Diseases covered have a common structure comprising background and epidemiology, pathology, balance disorders, gait disorders, falls, therapies (including fall prevention), and future directions. - Covers all aspects of basic and clinical research on disorders of balance and gait in neurological disease - Presents a multidisciplinary review of balance and gait physiology, the epidemiology and natural history of balance and gait impairments in aging, and a broad range of neurological diseases - Addresses impairments of balance and gait for basic and clinical researchers in neuroscience, human movement science, physiotherapy and exercise physiology |
| assessment of parkinson disease: Psychogenic Movement Disorders Mark Hallett, C. Robert Cloninger, 2006 This groundbreaking volume is the first text devoted to psychogenic movement disorders. Co-published by Lippincott Williams & Wilkins and the American Academy of Neurology, the book contains the highlights of an international, multidisciplinary conference on these disorders and features contributions from leading neurologists, psychiatrists, psychologists, physiatrists, and basic scientists. Major sections discuss the phenomenology of psychogenic movement disorders from both the neurologist's and the psychiatrist's viewpoint. Subsequent sections examine recent findings on pathophysiology and describe current diagnostic techniques and therapies. Also included are abstracts of 16 seminal free communications presented at the conference. |
Understanding psychological testing and assessment
Nov 10, 2013 · A psychological assessment can include numerous components such as norm-referenced psychological tests, informal tests and surveys, interview information, school or …
Testing, assessment, and measurement
Testing, assessment, and measurement Psychological tests, also known as psychometric tests, are standardized instruments that are used to measure behavior or mental attributes. These …
APA Guidelines for Psychological Assessment and Evaluation
sure. These PAE guidelines apply to all assessment procedures whether or not the tests are referenced by psychological terminol-ogy (e.g., psychological testing) and apply to any …
Pre-K to 12 Teaching Principle: Assessment
Assessment includes three key principles that highlight the importance and distinctiveness of formative and summative assessments; the effectiveness of assessment processes rooted in …
Testing and Assessment - American Psychological Association (APA)
Statement on Third Party Observers in Psychological Testing and Assessment: An Updated Framework for Decision Making (PDF, 80 KB) Statement on the Use of Secure Psychological …
PATIENT HEALTH QUESTIONNAIRE-9 (PHQ-9)
PATIENT HEALTH QUESTIONNAIRE-9 (PHQ-9) Over the last 2 weeks, how often have you been bothered by any of the following problems?
PTSD Assessment Instruments - American Psychological …
Initial assessments can help determine possible treatment options, and periodic assessment throughout care can guide treatment and gauge progress. The following instruments (or earlier …
BASC-3 Brochure - American Psychological Association (APA)
Comprehensive Assessment Help children thrive in their school and home environments with effective behavior assessment. The BASC™ holds an exceptional track record for providing a …
Standardized Assessment and Testing in PreK-12 Education
If assessment is to be used in high-stakes decisions such . as which students will advance and what subjects will be taught, it is vital that we understand how to measure student learning and …
Patient Health Questionnaire (PHQ-9 & PHQ-2)
Description of Measure: The PHQ-9 and PHQ-2, components of the longer Patient Health Questionnaire, offer psychologists concise, self-administered tools for assessing depression.
Understanding psychological testing and assessment
Nov 10, 2013 · A psychological assessment can include numerous components such as norm-referenced psychological tests, informal tests and surveys, interview information, …
Testing, assessment, and measurement
Testing, assessment, and measurement Psychological tests, also known as psychometric tests, are standardized instruments that are used to measure behavior or mental attributes. These …
APA Guidelines for Psychological Assessment a…
sure. These PAE guidelines apply to all assessment procedures whether or not the tests are referenced by psychological terminol-ogy (e.g., psychological testing) and apply to …
Pre-K to 12 Teaching Principle: Assessment
Assessment includes three key principles that highlight the importance and distinctiveness of formative and summative assessments; the effectiveness of assessment …
Testing and Assessment - American Psychological Assoc…
Statement on Third Party Observers in Psychological Testing and Assessment: An Updated Framework for Decision Making (PDF, 80 KB) Statement on the Use of Secure Psychological Tests in …
