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| european journal of medicinal chemistry impact factor: The Cystic Fibrosis Transmembrane Conductance Regulator Kevin L. Kirk, David C. Dawson, 2003-10-31 The CFTR chloride channel is one of the most well studied transport proteins in biology. Yet there remain many mysteries about the functional properties and biological roles of this ABC transporter. The Cystic Fibrosis Transmembrane Conductance Regulator addresses a select series of `hot' topics that relate to the function of CFTR, and the links between CFTR dysfunction and human disease (i.e., cystic fibrosis). The timeliness of these topics distinguishes this collection from previous volumes of this type. Given the general interest in CFTR, this collection will appeal to a broad readership with interests in CFTR, cystic fibrosis, ion channels and ABC transporters. |
| european journal of medicinal chemistry impact factor: Bioactive Heterocycles , |
| european journal of medicinal chemistry impact factor: Frontiers in Chemistry: Rising Stars Steve Suib, Huangxian Ju, Serge Cosnier, Bunsho Ohtani, John D. Wade, Gil Garnier, Nosang Vincent Myung, Luís D. Carlos, Michael Kassiou, Fan Zhang, Iwao Ojima, Pellegrino Musto, Tony D. James, Thomas S. Hofer, Sam P. De Visser, 2020-04-17 The Frontiers in Chemistry Editorial Office team are delighted to present the inaugural “Frontiers in Chemistry: Rising Stars” article collection, showcasing the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers featured within this collection were individually nominated by the Journal’s Chief Editors in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of the chemical sciences, and presents advances in theory, experiment and methodology with applications to compelling problems. This Editorial features the corresponding author(s) of each paper published within this important collection, ordered by section alphabetically, highlighting them as the great researchers of the future. The Frontiers in Chemistry Editorial Office team would like to thank each researcher who contributed their work to this collection. We would also like to personally thank our Chief Editors for their exemplary leadership of this article collection; their strong support and passion for this important, community-driven collection has ensured its success and global impact. Laurent Mathey, PhD Journal Development Manager |
| european journal of medicinal chemistry impact factor: Chemical Epigenetics Antonello Mai, 2020-03-31 This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics. |
| european journal of medicinal chemistry impact factor: The Practice of Medicinal Chemistry Camille Georges Wermuth, David Aldous, Pierre Raboisson, Didier Rognan, 2015-07-01 The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. - Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field - Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts - Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research - An image bank is available for instructors at www.textbooks.elsevier.com |
| european journal of medicinal chemistry impact factor: Fragment-Based Drug Discovery Steven Howard, Chris Abell, 2015-06-17 Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques. |
| european journal of medicinal chemistry impact factor: Deep Eutectic Solvents Diego J. Ramón, Gabriela Guillena, 2020-01-13 A useful guide to the fundamentals and applications of deep eutectic solvents Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic solvents (DESs) as an environmentally benign alternative reaction media for chemical transformations and processes. The contributors cover a range of topics including synthesis, structure, properties, toxicity and biodegradability of DESs. The book also explores myriad applications in various disciplines, such as organic synthesis and (bio)catalysis, electrochemistry, extraction, analytical chemistry, polymerizations, (nano)materials preparation, biomass processing, and gas adsorption. The book is aimed at organic chemists, catalytic chemists, pharmaceutical chemists, biochemists, electrochemists, and others involved in the design of eco-friendly reactions and processes. This important book: -Explores the promise of DESs as an environmentally benign alternative to hazardous organic solvents -Covers the synthesis, structure, properties (incl. toxicity) as well as a wide range of applications -Offers a springboard for stimulating critical discussion and encouraging further advances in the field Deep Eutectic Solvents is an interdisciplinary resource for researchers in academia and industry interested in the many uses of DESs as an environmentally benign alternative reaction media. |
| european journal of medicinal chemistry impact factor: Pain Management and the Opioid Epidemic National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse, 2017-09-28 Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring. |
| european journal of medicinal chemistry impact factor: Anion-Binding Catalysis Olga Garcia-Mancheno, 2022-03-21 Explores the potential of new types of anion-binding catalysts to solve challenging synthetic problems Anion-Binding Catalysis introduces readers to the use of anion-binding processes in catalytic chemical activation, exploring how this approach can contribute to the future design of novel synthetic transformations. Featuring contributions by world-renowned scientists in the field, this authoritative volume describes the structure, properties, and catalytic applications of anions as well as synthetic applications and practical analytical methods. In-depth chapters are organized by type of catalyst rather than reaction type, providing readers with an accessible overview of the existing classes of effective catalysts. The authors discuss the use of halogens as counteranions, the combination of (thio)urea and squaramide-based anion-binding with other types of organocatalysis, anion-binding catalysis by pnictogen and tetrel bonding, nucleophilic co-catalysis, anion-binding catalysis by pnictogen and tetrel bonding, and more. Helping readers appreciate and evaluate the potential of anion-binding catalysis, this timely book: Illustrates the historical development, activation mode, and importance of anion-binding in chemical catalysis Explains the analytic methods used to determine the anion-binding affinity of the catalysts Describes catalytic and synthetic applications of common NH- and OH-based hydrogen-donor catalysts as well as C-H triazole/triazolium catalysts Covers amino-catalysis involving enamine, dienamine, or iminium activation approaches Discusses new trends in the field of anion-binding catalysis, such as the combination of anion-binding with other types of catalysis Presenting the current state of the field as well as the synthetic potential of anion-binding catalysis in future, Anion-Binding Catalysis is essential reading for researchers in both academia and industry involved in organic synthesis, homogeneous catalysis, and pharmaceutical chemistry. |
| european journal of medicinal chemistry impact factor: How Tobacco Smoke Causes Disease United States. Public Health Service. Office of the Surgeon General, 2010 This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products. |
| european journal of medicinal chemistry impact factor: Leafy Medicinal Herbs Dawn C P Ambrose, Annamalai Manickavasagan, Ravindra Naik, 2016-07-25 Medicinal herbs are rich in vitamins, minerals and antioxidants, and are able to synthesize secondary metabolites with disease preventive properties. It is due to these qualities that herbs have been used throughout history for flavouring and in food, medicine and perfumery preparations. They are also often considered to be safe alternatives to modern medicines because of their healing properties. Though interest in medicinal and aromatic crops is growing worldwide, there is still little focus on the area of leafy medicinal herbs. This book compiles the literature for 23 globally relevant leafy medicinal herbs. Beginning with a general overview and discussion of the importance of these plants, it then handles each herb by chapter. Chapters discuss the botany of the crop, including its history and origin, geographical distribution and morphology, before focusing on the chemical composition and phytochemical attributes. They then review postharvest technology aspects such as processing and value addition, before concluding with the general and pharmacological uses for each crop. A complete compilation of the subject, this book forms a vital resource for researchers, students, farmers and industrialists in the area of leafy medicinal herbs. |
| european journal of medicinal chemistry impact factor: Merck's Index , 1907 |
| european journal of medicinal chemistry impact factor: The Practice of Medicinal Chemistry Camille Georges Wermuth, 2016 |
| european journal of medicinal chemistry impact factor: Quinazolinone and Quinazoline Derivatives Ali Gamal Al-kaf, 2020 |
| european journal of medicinal chemistry impact factor: Making Medicines Affordable National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Care Services, Committee on Ensuring Patient Access to Affordable Drug Therapies, 2018-03-01 Thanks to remarkable advances in modern health care attributable to science, engineering, and medicine, it is now possible to cure or manage illnesses that were long deemed untreatable. At the same time, however, the United States is facing the vexing challenge of a seemingly uncontrolled rise in the cost of health care. Total medical expenditures are rapidly approaching 20 percent of the gross domestic product and are crowding out other priorities of national importance. The use of increasingly expensive prescription drugs is a significant part of this problem, making the cost of biopharmaceuticals a serious national concern with broad political implications. Especially with the highly visible and very large price increases for prescription drugs that have occurred in recent years, finding a way to make prescription medicinesâ€and health care at largeâ€more affordable for everyone has become a socioeconomic imperative. Affordability is a complex function of factors, including not just the prices of the drugs themselves, but also the details of an individual's insurance coverage and the number of medical conditions that an individual or family confronts. Therefore, any solution to the affordability issue will require considering all of these factors together. The current high and increasing costs of prescription drugsâ€coupled with the broader trends in overall health care costsâ€is unsustainable to society as a whole. Making Medicines Affordable examines patient access to affordable and effective therapies, with emphasis on drug pricing, inflation in the cost of drugs, and insurance design. This report explores structural and policy factors influencing drug pricing, drug access programs, the emerging role of comparative effectiveness assessments in payment policies, changing finances of medical practice with regard to drug costs and reimbursement, and measures to prevent drug shortages and foster continued innovation in drug development. It makes recommendations for policy actions that could address drug price trends, improve patient access to affordable and effective treatments, and encourage innovations that address significant needs in health care. |
| european journal of medicinal chemistry impact factor: Disease Control Priorities in Developing Countries Dean T. Jamison, Joel G. Breman, Anthony R. Measham, George Alleyne, Mariam Claeson, David B. Evans, Prabhat Jha, Anne Mills, Philip Musgrove, 2006-04-02 Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries. |
| european journal of medicinal chemistry impact factor: Vector-Borne Diseases David Claborn, Sujit Bhattacharya, Syamal Roy, 2020-06-03 Vector-Borne Diseases - Recent Developments in Epidemiology and Control utilizes the unique capabilities of open-access publishing to share exciting developments in the biology, diagnosis, and treatment of diseases spread by arthropods. From malaria to dengue to leishmaniasis, the diseases addressed in this book continue to present threats to the life and well-being of millions around the world. The international cast of writers published here provide specific insight into a full spectrum of diseases spread by insects and their close relatives. |
| european journal of medicinal chemistry impact factor: Network Pharmacology Shao Li, 2021-09-29 This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of network target for the first time, which has become the core theory of network pharmacology. The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases. |
| european journal of medicinal chemistry impact factor: A Trunk for Henrietta Dorothy Walker, 2004 The story of two unlikely friends, a bird and a snake, who long for a life different from their own. |
| european journal of medicinal chemistry impact factor: Growth Hormone Deficiency in Adults Jens O. L. Jørgensen, Jens Sandahl Christiansen, 2005-01-01 It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH. |
| european journal of medicinal chemistry impact factor: The ADME Encyclopedia Alan Talevi, 2022-06-14 The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties |
| european journal of medicinal chemistry impact factor: Modern Methods of Clinical Investigation Institute of Medicine, Committee on Technological Innovation in Medicine, 1990-02-01 The very rapid pace of advances in biomedical research promises us a wide range of new drugs, medical devices, and clinical procedures. The extent to which these discoveries will benefit the public, however, depends in large part on the methods we choose for developing and testing them. Modern Methods of Clinical Investigation focuses on strategies for clinical evaluation and their role in uncovering the actual benefits and risks of medical innovation. Essays explore differences in our current systems for evaluating drugs, medical devices, and clinical procedures; health insurance databases as a tool for assessing treatment outcomes; the role of the medical profession, the Food and Drug Administration, and industry in stimulating the use of evaluative methods; and more. This book will be of special interest to policymakers, regulators, executives in the medical industry, clinical researchers, and physicians. |
| european journal of medicinal chemistry impact factor: Heterocyclic Chemistry in Drug Discovery Jie Jack Li, 2013-04-26 Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery. |
| european journal of medicinal chemistry impact factor: Drug-like Properties: Concepts, Structure Design and Methods Li Di, Edward H Kerns, 2010-07-26 Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint |
| european journal of medicinal chemistry impact factor: Toxoplasmosis of Animals and Humans J. P. Dubey, 2016-04-19 Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publi |
| european journal of medicinal chemistry impact factor: Advanced Healthcare Materials Ashutosh Tiwari, 2014-05-09 Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers |
| european journal of medicinal chemistry impact factor: Fundamentals of Pharmaceutical Inorganic Chemistry Rati Kailash Prasad Tripathi, 2021-03-15 Fundamentals of Pharmaceutical Inorganic Chemistry serves as an invaluable source to meet the long-term demand of students of Bachelor of Pharmacy for a standard book on Pharmaceutical Inorganic Chemistry. This book can serve as a stand-alone textbook for an advanced undergraduate or first-year graduate course in pharmaceutical inorganic chemistry. The book is presented with an aim to enable the students to easily apprehend unfamiliar, unacquainted and apparently complicated concepts of Pharmaceutical Inorganic Chemistry so that it assists them to tackle with their confusion especially during the examinations and at the same time aids to elicit their interest in the subject. |
| european journal of medicinal chemistry impact factor: Carbohydrate Bioengineering Tuula T. Teeri, 2002 Carbohydrate bioengineering is a rapidly expanding field with many applications in medicine and industry. Presenting state-of-the-art research, Carbohydrate Bioengineering: Interdisciplinary Approaches brings together international experts on many different aspects of this burgeoning topic. Coverage includes: the engineering of glycosidases for constructive purposes; structure-function studies and protein engineering of carbohydrate-active enzymes; chemo-enzymatic carbohydrate synthesis; and trends emerging from comprehensive work on genomes and glycomes. This timely publication will be welcomed by all those needing access to the latest research in the field, including practitioners in the medicinal, chemical, food and pharmaceutical areas. |
| european journal of medicinal chemistry impact factor: Thiazole and Its Derivatives, Part 1 Jacques V. Metzger, 1979-03-01 The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists. |
| european journal of medicinal chemistry impact factor: Successful Drug Discovery, Volume 5 Janos Fischer, Christian Klein, Wayne E. Childers, 2021-02-12 Filled with unique insights into current drugs that have made it to the marketplace In the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drugs discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the books nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume: - Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references - Contains information and insight that is new and often not even available from the primary literature - Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market - Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process. |
| european journal of medicinal chemistry impact factor: The Health Effects of Cannabis and Cannabinoids National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Population Health and Public Health Practice, Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda, 2017-03-31 Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€that summarizes and prioritizes pressing research needs. |
| european journal of medicinal chemistry impact factor: Essentials of Materials Management Peter N. T. Pang, 2003-12 Essentials of Materials Management is an invaluable resource for personnel working in the materials department, and for those who need some knowledge of materials management and organization. Principles and practices of inventory control management, materials planning and schedule, production requirements planning, material requirements planning, capacity requirements planning, distribution requirements planning, supply chain management, transportation and assignment models are outlined and illustrated. In addition, the book provides a comprehensive and easy-to-read outline of the principles and pragmatic approaches in integrating and managing the materials functions. Examples are clearly provided to illustrate the principles of the text. |
| european journal of medicinal chemistry impact factor: Na-ion Batteries , 2021-05-11 This book covers both the fundamental and applied aspects of advanced Na-ion batteries (NIB) which have proven to be a potential challenger to Li-ion batteries. Both the chemistry and design of positive and negative electrode materials are examined. In NIB, the electrolyte is also a crucial part of the batteries and the recent research, showing a possible alternative to classical electrolytes – with the development of ionic liquid-based electrolytes – is also explored. Cycling performance in NIB is also strongly associated with the quality of the electrode-electrolyte interface, where electrolyte degradation takes place; thus, Na-ion Batteries details the recent achievements in furthering knowledge of this interface. Finally, as the ultimate goal is commercialization of this new electrical storage technology, the last chapters are dedicated to the industrial point of view, given by two startup companies, who developed two different NIB chemistries for complementary applications and markets. |
| european journal of medicinal chemistry impact factor: Herbal Medicine Iris F. F. Benzie, Sissi Wachtel-Galor, 2011-03-28 The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef |
| european journal of medicinal chemistry impact factor: List of Journals Indexed in Index Medicus National Library of Medicine (U.S.), 1996 Issues for 1977-1979 include also Special List journals being indexed in cooperation with other institutions. Citations from these journals appear in other MEDLARS bibliographies and in MEDLING, but not in Index medicus. |
| european journal of medicinal chemistry impact factor: Therapeutic Uses of Cannabis British Medical Association, 2020-08-17 At the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma. |
| european journal of medicinal chemistry impact factor: Practical Medicinal Chemistry with Macrocycles Eric Marsault, Mark L. Peterson, 2017-09-12 Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations |
| european journal of medicinal chemistry impact factor: Marijuana and Medicine Institute of Medicine, 1999-07-10 The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers. |
| european journal of medicinal chemistry impact factor: N-Heterocycles Keshav Lalit Ameta, Ravi Kant, Andrea Penoni, Angelo Maspero, Luca Scapinello, 2022-04-23 This book presents an overview of the recent advancements for the synthesis of small- and medium-sized azaheterocycles, including pyrroles, indoles, pyrimidines, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, and 1,2,3-triazoles, which are significant scaffolds for compounds with pharmaceutical uses. The book also discusses various properties and performance attributes of azaheterocycles including their bioactivity and synthetic strategies. Given the contents, the book will be a valuable reference for students, researchers, and professionals interested in organic synthesis and medicinal chemistry. |
| european journal of medicinal chemistry impact factor: Forensic Science Advances and Their Application in the Judiciary System Danielle Sapse, Lawrence Kobilinsky, 2011-08-01 This volume examines how new cutting edge forensic techniques are currently being applied or have the potential to be applied in judicial proceedings. Examples include new applications of Raman spectroscopy, quantum chemistry, lithium in DNA analysis, and the burgeoning area of toxicogenetics. In each case legal issues are addressed, including the |
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Your gateway to the EU, News, Highlights | European Union
Jun 6, 2025 · Teaching material, games and much more about the European Union and its activities, for children, teenagers, teachers and parents.
Europe | History, Countries, Map, & Facts | Britannica
2 days ago · The creation of the European Economic Community in 1957 and the EU in 1993 greatly enhanced economic cooperation between many of the continent’s countries. Europe’s …
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Reveal your most beautiful skin with bikini waxing, Brazilian waxing, eyebrow waxing, facial waxing, body waxing and skin care products at European Wax Center.
European Union (EU): What It Is, Countries, History, Purpose - Investopedia
Dec 14, 2023 · The EU is a powerful alliance of 27 European countries that promotes democratic values among its members. It serves to faciliate political and economic integration throughout …
EUROPEAN Definition & Meaning - Merriam-Webster
The meaning of EUROPEAN is of, relating to, or characteristic of Europe or its people.
Europe Map / Map of Europe - Facts, Geography, History of ... - WorldAtlas
The European continent, bordered by numerous bodies of water, is separated from Asia by Russia's Ural Mountains and by the Caspian and Black Seas. It is separated from Africa by the …
Europe - World History Encyclopedia
Jun 9, 2023 · The Age of Exploration established European culture in the so-called New World between 1492-1620 with greater numbers of colonists arriving up through 1720 and even more …
List of countries in Europe - Countries of the world
Armenia and Cyprus politically are considered European countries, though geographically they are located in the West Asia territory. Europe's largest country is Russia (37% of total …
European Union - Wikipedia
The European Union (EU) is a supranational political and economic union of 27 member states that are located primarily in Europe. [8] [9] The union has a total area of 4,233,255 km 2 …
Find A Wax Center Near You | European Wax Center
European Wax Center locations offer the best waxing services so that you can keep your brows fierce and your skin glowing. Our wax services include: bikini waxing, Brazilian waxing, leg …
Your gateway to the EU, News, Highlights | European Union
Jun 6, 2025 · Teaching material, games and much more about the European Union and its activities, for children, teenagers, teachers and parents.
Europe | History, Countries, Map, & Facts | Britannica
2 days ago · The creation of the European Economic Community in 1957 and the EU in 1993 greatly enhanced economic cooperation between many of the continent’s countries. Europe’s …
Reveal and Maintain Beautiful Skin | European Wax Center
Reveal your most beautiful skin with bikini waxing, Brazilian waxing, eyebrow waxing, facial waxing, body waxing and skin care products at European Wax Center.
European Union (EU): What It Is, Countries, History, Purpose - Investopedia
Dec 14, 2023 · The EU is a powerful alliance of 27 European countries that promotes democratic values among its members. It serves to faciliate political and economic integration throughout …
EUROPEAN Definition & Meaning - Merriam-Webster
The meaning of EUROPEAN is of, relating to, or characteristic of Europe or its people.
Europe Map / Map of Europe - Facts, Geography, History of ... - WorldAtlas
The European continent, bordered by numerous bodies of water, is separated from Asia by Russia's Ural Mountains and by the Caspian and Black Seas. It is separated from Africa by the …
Europe - World History Encyclopedia
Jun 9, 2023 · The Age of Exploration established European culture in the so-called New World between 1492-1620 with greater numbers of colonists arriving up through 1720 and even more …
List of countries in Europe - Countries of the world
Armenia and Cyprus politically are considered European countries, though geographically they are located in the West Asia territory. Europe's largest country is Russia (37% of total …
