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| design and analysis software quantstudio: Hemostasis and Thrombosis Emmanuel J. Favaloro, Robert C. Gosselin, 2023-05-19 This second edition volume expands on the previous edition with updates about the latest state-of-the-art techniques used in leading hemostasis and thrombosis laboratories for diagnosis and exclusion of hemorrhagic and thrombotic diseases. The chapters in this book are organized into seven parts. Part One provides a general overview on hemostasis and thrombosis, preanalytical issues in testing, and routine hemostasis assays. Part Two covers laboratory testing for thrombophilia, including reviews for activated protein C resistance, protein C, lupus anticoagulant testing, and antiphospholipid antibodies. Part Three addresses monitoring continuous anticoagulant infusions and measuring the effects of oral anti-thrombotic therapy. Part Four talks about heparin induced thrombocytopenia and vaccine induced immune thrombotic thrombocytopenia. Part Five and Six cover ADAMTS13 activity testing and new information on bleeding disorders such as chromogenic factor VIII assays, measurement of emicizumab, and treatment of hemophilia A and B. Finally, Part Seven discusses global assays, research applications, and postanalytical considerations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Hemostasis and Thrombosis: Methods and Protocols, Second Edition is a valuable resource for scientists and researchers struggling to identify the appropriate methods for hemostasis and thrombosis testing, or who seek additional expert guidance on such testing. |
| design and analysis software quantstudio: PCR Lucília Domingues, 2023-09-23 This second volume focuses on PCR methods and PCR application specificities to the biotechnology and bioengineering field. New and updated chapters detail real-time PCR protocols, synthetic biology applications, pathogen detection, microfluidics, digital, multiplex detection recent advances. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, PCR: Methods and Protocols, Second Edition aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. |
| design and analysis software quantstudio: Innovations in Development, Translational Research and Manufacturing of CAR T cells Michael Hudecek, Qasim Rafiq, Stephen Goldrick, Ulrike Koehl, Helene Negre, Carmen Sanges, 2024-10-03 Immunotherapy with genetically engineered immune cell products is a transformative treatment modality with potential applications in various fields of medicine. A prime example is chimeric antigen receptor (CAR)-modified T cells in hematology and oncology, and the advent of CAR T cell therapies to treat infectious diseases, autoimmune disorders, and cardiovascular diseases. The medical need and demand from patients and caregivers require radical innovations to accelerate and improve pre-clinical development and clinical translation, provision of gene-transfer vectors, and immune cell product manufacturing as well as a critical reflection and discussion on ethical and socioeconomic aspects. The goal of this special issue of Frontiers in Immunology is to provide a comprehensive and multi-faceted view on the current state-of-the-art, imminent and future directions the field is taking in order to accelerate the pre-clinical development, clinical translation, and manufacturing of CAR T cells, increase access and sustainability of CAR T cell therapy for health care systems (in developed and in developing countries). This special issue will focus on the medical and scientific dimension incl. approved and emerging indications, new areas in medicine, advanced gene-transfer and gene-editing technologies, innovations in pre-clinical assessment (efficacy, toxicology, genomic safety), innovations in scalable automated manufacturing (bioprocessing), the implementation of high content data acquisition, machine learning and artificial intelligence, innovations in clinical trial design; and consider the ethical, socioeconomic and societal dimension of CAR T cells in particular and gene-engineered immune cell therapy in general. |
| design and analysis software quantstudio: Understanding the Immuno-Oncological Mechanism of Cancer Using Systems Immunology Approaches Rifat Hamoudi, Daniel Olive, Lucia Conti, Alexander John MacRobert, 2024-01-02 |
| design and analysis software quantstudio: Optimized Gene-Engineering and Combination Therapies to Boost γδT Cell Immunotherapeutic Performance Jonathan Fisher, Daniel Abate-Daga, Marta Barisa, 2024-04-25 |
| design and analysis software quantstudio: Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis Ralf Weiskirchen, 2020-12-29 Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics. |
| design and analysis software quantstudio: Metabolic Adjustments and Gene Expression Reprogramming for Symbiotic Nitrogen Fixation in Legume Nodules Brett James Ferguson, Kiwamu Minamisawa, Nacira Belen Muñoz, Hon-Ming Lam, 2020-01-15 |
| design and analysis software quantstudio: Host-parasite interactions at the cellular, tissue, and organism level Xuexian Yang, William Harold Witola, Hua Cong, Huongzhi Chen, 2024-05-31 Protozoan and helminth parasites infect animals and humans and cause debilitating pathologies that cause a variety of morbidities and deaths worldwide. The ability of parasites to establish infection and cause disease in mammalian hosts is a result of a series of intricate mechanisms evolved by parasitic species to confront and evade the host's defensive responses, along with the ability to use the host’s metabolic and catabolic processes and host cellular organelles to their benefit. For instance, parasites may have predilection sites in the host that are not accessible to immune effector molecules and mechanisms, may acquire host-derived masking molecules, can vary their surface molecules, and can produce molecules that block or misguide the host immune responses. The host's interactions with the parasite, on the other hand, are critical for the initiation and induction of host signaling events that are critical in mounting formidable defensive immune responses against the invading parasite. Therefore, the ability of a parasite to successfully establish infection and cause disease largely depends on its interaction with the host and the ability of the host to mount successful and effective resistance. Thus, studying host-parasite interactions and cross-talks is critical for understanding parasite infection and adaptation mechanisms within the host, as well as for developing strategies for effective prevention and control of parasitic infections in humans and animals. The topic will cover a wide spectrum of parasitic protozoa and helminths and provide an opportunity to share new molecular and translational advances in parasitic infections and diseases. |
| design and analysis software quantstudio: Advances and Challenges of RNAi Based Technologies for Plants - Volume 2 Bruno Mezzetti, Jeremy Bruton Sweet, Guy Smagghe, Elena Baraldi, Salvatore Arpaia, Antje Dietz-Pfeilstetter, Vera Ventura, 2022-08-04 |
| design and analysis software quantstudio: Exploring the Bee Microbiome: Distributions, Interactions, and Functions Hao Zheng, Erick Motta, Quinn McFrederick, 2023-09-12 |
| design and analysis software quantstudio: Rhizosphere Microbiology: Toward a Clean and Healthy Soil Environment Wanting Ling, Bin Ma, Wei Zhang, 2022-09-13 |
| design and analysis software quantstudio: 2021 WHO Classification of Pediatric Brain Tumors: A Final Wedding Between Morphology and Molecular Biology? Angela Mastronuzzi, Andrea Carai, Lucia Quaglietta, Elisabetta Schiavello, 2024-05-22 Tumors of the central nervous system (CNS) are a dramatic health problem due to their high morbidity and mortality in all ages. In the pediatric population, brain tumors constitute the second most common cancer diagnosed worldwide each year, accounting for approximately 25% of childhood cancers. Although there has been a moderate increase in survival rates for children with CNS tumors over the past decades, CNS tumors remain the second leading cause of cancer death in children less than 20 years of age. The fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5) was recently released. This builds on the 2016 WHO CNS tumor update, which for the first time incorporated molecular data with histology in classifying CNS tumors. The changes in the WHO CNS5 group tumors into more biologically and molecularly defined entities with better characterized natural histories, as well as introducing new tumor types and subtypes, especially in the pediatric population. Most importantly, these updated classifications will enable clinicians to have a better understanding of the prognosis and optimal therapy for patients with specific CNS tumors. Therefore, optimizing the treatment of childhood CNS tumors remains a tremendously challenging task, requiring a multidisciplinary approach involving many pediatric specialists as well as the support of molecular biologists and pharmacologists. |
| design and analysis software quantstudio: Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics Boris M. Velichkovsky, Pavel M. Balaban, Vadim L. Ushakov, 2021-04-17 This book reports on theoretical and experimental research answering key questions in neuroscience, philosophy of mind, and cognitive research. It gives a special emphasis on findings achieved within the territory of the former U.S.S.R, which has remained largely unknown to an international readership. The volume gathers authoritative studies on cognitive development, consciousness, attention and perception. It covers research on eye movements, language, speech and semantics, emotion, as well as brain functional states, and a variety of decision-making processes. It also highlights important advances in cognitive robotics and artificial intelligence, discussing brain-computer interfaces and other practically-relevant technologies. It includes studies on human subjects, in both healthy and disease conditions, and investigations on the molecular mechanisms of cognition in animal models. Chapters are based on invited lectures and peer-reviewed contributions to the 9th International Conference on Cognitive Sciences, Intercognsci–2020, held on October 10-16, 2020, in Moscow. The conference was organized by the Interregional Association of Cognitive Studies, with the participation of the Pavlov Society for Neurophysiology and Higher Nervous Activity, and supported by the Russian Academy of Sciences, the Russian Foundation for Basic Research and a number of the north eastern European research institutions. All in all, this book provides cognitive scientists around the world with a timely snapshot of interdisciplinary research and cutting-edge models, and a major source of inspiration for future collaborations in the areas of artificial intelligence and cognitive neuroscience. |
| design and analysis software quantstudio: Identifying Novel Biomarkers in Bladder Cancer, 2nd edition Thornsten Ecke, Thierry Massfelder, 2023-07-18 Bladder cancer is one of the most common urological diseases with a high mortality rate and poor prognosis. It is currently ranked as the 10th most common malignancy worldwide. The majority of bladder cancer patients have been found to be diagnosed with non-muscle invasive bladder cancer (NMIBC) and the remaining, are diagnosed with muscle-invasive bladder cancer (MIBC). Although there have been advances in the treatment and therapies provided for bladder cancer patients, the survival rate remains low, primarily due to recurrence and metastasis of the disease following treatment. Surgical treatment is currently the most common form including radical cystectomy which is the standard form of treatment combined with neoadjuvant chemotherapy. However, the 5-year overall survival rate is 50%. Therefore, further studies are required to understand the molecular mechanisms involved in the progression of bladder cancer and identify novel biomarkers to act as a diagnostic tool for patients. There have been many studies involving the detection of biomarkers in bladder cancer in addition to monitoring disease recurrence to understand the impact and predict potential outcomes. A variety of urine biomarkers have been developed to detect bladder cancer and prognostic risk stratification including mutational DNA and the levels of RNA expression. Circulating tumor cells have also been identified as a potential biomarker for bladder cancer patients. However, there are significant challenges as bladder cancer has demonstrated high levels of cellular and molecular heterogeneity and some markers do not have sufficient sensitivity for accurate detection. Therefore, further studies are required to continue to identify new novel biomarkers for bladder cancer. The aim of this Research Topic is to discuss novel biomarkers in bladder cancer and how it impacts the disease progression and the survival rate for bladder cancer patients. |
| design and analysis software quantstudio: Omics-Driven Crop Improvement for Stress Tolerance Weicong Qi, Jian Chen, Yi Han, Zhen Li, 2023-08-07 |
| design and analysis software quantstudio: The Role of Toll-like Receptors and their Related Signaling Pathways in Viral Infection and Inflammation Ralf Kircheis, Oliver Planz, 2024-02-01 Toll-like receptors (TLRs) represent a powerful system for recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. TLRs are mainly expressed on immune cells, but can also be present on other cell populations. Typical PAMPs include bacterial cell wall components, viral pathogens, or pathogenic nucleic acids, including viral RNA and DNA. Activation of TLRs leads to the production of proinflammatory cytokines and type I interferons which are important for induction of the host immune response against bacterial and viral infections. However, dysregulation and overstimulation can be detrimental leading to hyper-inflammation, sepsis, and loss of tissue integrity. Furthermore, TLRs are involved in the pathogenesis of acute viral infections, including COVID-19. Consequently, TLRs are promising targets for pharmacological intervention and treatment. |
| design and analysis software quantstudio: Novel Developments for Promoting Health Through Microbiota Modulation Carlos Gómez-Gallego, Hani El-Nezami, 2023-11-29 |
| design and analysis software quantstudio: Identifying novel biomarkers in bladder cancer Thorsten Ecke, Thierry Massfelder, 2023-04-27 |
| design and analysis software quantstudio: Wireless Intercellular Communications in Cardiac Pathology: The Role of Exosomes Mahmood Khan, Nazish Sayed, Prasanna Krishnamurthy, Yaoliang Tang, 2020-12-18 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| design and analysis software quantstudio: Insights in Hematologic Malignancies: 2021 Alessandro Isidori, 2022-08-09 |
| design and analysis software quantstudio: COVID-19: Integrating Artificial Intelligence, Data Science, Mathematics, Medicine and Public Health, Epidemiology, Neuroscience, Neurorobotics, and Biomedical Science in Pandemic Management, volume II Atefeh Abedini, Reza Lashgari, 2024-02-29 |
| design and analysis software quantstudio: Fish as Model Organism for Skeletal Diseases Erika Kague, Christoph Winkler, Ronald Kwon, 2023-11-30 |
| design and analysis software quantstudio: Inducing Plant Resistance Against Insects Using Exogenous Bioactive Chemicals: Key Advances and Future Perspectives Islam S. Sobhy, Yonggen Lou, Toby J. A. Bruce, 2022-05-05 |
| design and analysis software quantstudio: Intestinal Dysbiosis in Inflammatory Diseases Gislane Lelis Vilela de Oliveira, Alessio Fasano, Veena Taneja, Cristina Ribeiro De Barros Cardoso, 2021-09-29 Dr. Fasano holds stocks in Alba Therapeutics and receives financial support from Takeda Pharmaceuticals. Dr. Taneja receives financial support from Elysium Health and Evelo Biosciences. The other Topic Editors declare no competing interests with regards to the Research Topic subject. |
| design and analysis software quantstudio: Epizootic Hemorrhagic Disease Virus Carrie Batten, |
| design and analysis software quantstudio: Women in Cytokines and Soluble Mediators in Immunity Diana Boraschi, Giselle Penton-Rol, Marita Troye Blomberg, Olukemi Amodu, 2024-02-13 We are delighted to present the inaugural Frontiers in Immunology “Women in Cytokines and Soluble Mediators in Immunity” series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and Science, Technology, Engineering and Mathematics (STEM) research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. |
| design and analysis software quantstudio: Disease Modifying Therapies in Multiple Sclerosis Mahsa Ghajarzadeh, Simona Bonavita, Luigi Lavorgna, 2022-09-30 |
| design and analysis software quantstudio: Biology of Myxobacteria Honghui Zhu, Li Zhoukun, David Edward Whitworth , David Cole Stevens, Jingjing Wang, 2024-07-22 Myxobacteria are ubiquitous Gram-negative soil bacteria with a complex multicellular population behavior. They are highly social microbes that move, hunt and develop to build fruiting bodies, which are associated with feeding on a diverse range of bacteria and fungi for nutrition. Therefore, myxobacteria are classified as keystone taxa in the microbial food web and are key players in determining community organization, with potential applications in the biocontrol of plant diseases, wastewater treatment, and bioconversion. In addition, myxobacteria are regarded as natural pharmaceutical and functional enzyme factories due to their diversity and the unique properties of their secondary metabolites and enzymes, making them highly attractive for resource discovery. However, the difficulty in purifying and cultivating many types of myxobacteria limits the in-depth study of myxobacteria. Otherwise, key factors involved in the biological interaction and bioconversion of myxobacteria taxa remain largely unexplored, hindering their practical applications. |
| design and analysis software quantstudio: Nutrition, Disease, Environmental Stress, and Microorganisms in Crustacean Aquaculture Yangfang Ye, Xiangli Tian, Chris Hauton, Ying Liu, 2022-11-02 |
| design and analysis software quantstudio: Insights In Biosafety & Biosecurity 2022/2023: Novel Developments, Current Challenges, and Future Perspectives Segaran P. Pillai, Stephen Allen Morse, 2024-03-20 We are now entering the third decade of the 21st century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the rapidly growing fields of bioengineering and biotechnology. This annual collection, which highlights article submissions from our Editorial Board members, looks to explore new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Biosafety & Biosecurity. |
| design and analysis software quantstudio: Novel Small-Molecule Agents in Overcoming Multidrug Resistance in Cancers Qingbin Cui, Yingfang Fan, Qianxiong Zhou, Cong Wang, Leli Zeng, 2022-05-30 |
| design and analysis software quantstudio: Nutrition and Metabolic Aging Zachary Clayton, Devin Wahl, 2023-05-02 |
| design and analysis software quantstudio: Proceedings of FSTP3 Congress - A Sustainable Durum Wheat Chain for Food Security and Healthy Lives Brian L. Beres, Aldo Ceriotti, Agata Gadaleta, Curtis J. Pozniak, Roberto Tuberosa, Luigi Cattivelli, 2021-06-04 |
| design and analysis software quantstudio: Biomarkers and early warning scores: The time for highprecision emergency medicine Francisco Martín-Rodríguez, Ancor Sanz-Garcia, Raúl López-Izquierdo, 2024-01-19 |
| design and analysis software quantstudio: Women in Pediatric Oncology: 2021 Sarah K. Tasian, Yong-mi Kim, Paraskevi Panagopoulou, 2023-01-06 |
| design and analysis software quantstudio: Novel modalities in cancer diagnostics and therapeutics Dong-Hua Yang, Haichang Li, 2023-01-02 |
| design and analysis software quantstudio: Antibiotic resistance and its continuity in the environmental niche Marina Spinu, Magdalena Rzewuska, 2023-01-30 |
| design and analysis software quantstudio: Omics and Fish Nutrition Kang-le Lu, Samad Rahimnejad, Songlin Li, 2022-10-26 |
| design and analysis software quantstudio: Examination of the in vitro Regenerative and Neuroprotective Potential of Short Chain Fatty Acid Butyrate Clarissa Annabella Lohmann, |
| design and analysis software quantstudio: Gene Quantification Francois Ferre, 2012-12-06 Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population. |
Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the …
Angel Oaks | Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the …
Rock House | Strang - strang.design
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the …
Kiaora Residence | Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the …
INSIDE NATURE - strang.design
102 FLORIDA DESIGN’S MIAMI EDITION 21-1 above: In the primary bathroom, the spa shower is made of Italian limestone while the floor is a mosaic …
Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
Angel Oaks | Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
Rock House | Strang - strang.design
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
Kiaora Residence | Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
INSIDE NATURE - strang.design
102 FLORIDA DESIGN’S MIAMI EDITION 21-1 above: In the primary bathroom, the spa shower is made of Italian limestone while the floor is a mosaic of pebble tiles. As with all the Florida …
Elbow Cay Residence | Strang - strang.design
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
Beyond Vernacularity: Lessons of Elemental Modernism | Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
Irvine Residence | Strang - strang.design
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
Team | Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
Hill Residence | Strang
STRANG is a Miami-based design firm renowned for advancing the principles of Environmental Modernism in extraordinary locations around the world. This concept, dubbed by the firm, …
