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| diabetes and insulin signaling case study: Diabetes Associated with Single Gene Defects and Chromosomal Abnormalities Fabrizio Barbetti, Lucia Ghizzoni, Federica Guaraldi, 2017 This volume, written by renowned experts, provides complete coverage of the main genetic conditions associated with diabetes. Divided into five sections, it offers insights into genetic defects involving the pancreatic beta cell, extreme insulin resistance, ciliopathies, obesity and glucose metabolism, chromosomal defects, and other genetic conditions associated with increased susceptibility to diabetes. Other topics include the various subtypes of monogenic diabetes, such as the neonatal form and the Wolfram syndrome, as well as chromosomal defects leading to complex conditions affiliated with diabetes, like Trisomy 21 or Prader-Willi syndrome. There are also chapters dedicated to the poorly explored relationships between metabolism and neurodegenerative disorders like Friedreich's ataxia and muscular dystrophy. This book is a reference for every pediatric and adult endocrinologist and diabetologist, even experienced ones, with an interest in the intricacies and protean aspects of disorders of glucose metabolism secondary to genetic diseases. |
| diabetes and insulin signaling case study: Diabetes Mellitus Derek LeRoith, Simeon I. Taylor, Jerrold M. Olefsky, 2004 Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program. |
| diabetes and insulin signaling case study: Mechanisms of Insulin Action Alan R. Saltiel, Jeffrey E. Pessin, 2007-10-05 More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems. |
| diabetes and insulin signaling case study: Polycystic Ovary Syndrome Andrea Dunaif, R. Jeffrey Chang, Stephen Franks, Richard S. Legro, 2008-01-12 This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS. |
| diabetes and insulin signaling case study: Insulin Action Ashok K. Srivastava, Barry I. Posner, 1998-05-31 In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action. |
| diabetes and insulin signaling case study: Hypoglycemia in Diabetes Philip Cryer, 2016-07-12 Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen. |
| diabetes and insulin signaling case study: Principles of Diabetes Mellitus Leonid Poretsky, 2002 Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy. |
| diabetes and insulin signaling case study: Receptor Tyrosine Kinases: Family and Subfamilies Deric L. Wheeler, Yosef Yarden, 2015-07-31 This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail. |
| diabetes and insulin signaling case study: Diabetes Mellitus in Children Mark A. Sperling, 2005 |
| diabetes and insulin signaling case study: Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease Deric L. Wheeler, Yosef Yarden, 2014-11-26 Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks. |
| diabetes and insulin signaling case study: Atlas of Diabetes Jay Skyler, 2012-03-08 This handbook is an invaluable resource for improving the management of diabetes. Chapters cover the fundamentals, including epidemiology, history and physical examination, and functional evaluations. Diabetes in children, adolescents, adults, and geriatrics are addressed. Differential diagnosis is emphasized, and evidence-based guidelines and patient-specific considerations aid the reader with injury evaluation and care. Notably, the book highlights the importance of understanding diabetic symptoms when determining the source of illnesses. In addition, the text presents the spectrum of treatment options for diabetes. The book is complete with appendices that explain the evidence-based approach used throughout and the science behind therapeutic modalities. |
| diabetes and insulin signaling case study: Features, Transmission, Detection, and Case Studies in COVID-19 Rajkumar Rajendram, Victor R Preedy, Vinood Patel, 2024-06-15 Features, Transmission, Detection, and Case Studies in COVID-19 examines the effects of the virus on the body, as well as its transmission and clinical profile. This volume begins with an introduction to the virus and its pathogenesis, transmission, and avoidance, followed by sections on pulmonary and cardiovascular effects, obesity, diabetes, the liver, detection issues, and biomarkers. Vaccines and treatment are also discussed. Specific case studies covered include hypoxia, acute kidney injury, pneumonia, and neurological effects. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19. - Discusses COVID-19 biology, including pathogenesis and transmission - Describes systemic issues caused by COVID-19, including cardiovascular effects and loss of taste and smell - Outlines detection methods, biomarkers associated with severity, and disease outcomes - Features individual chapter introductions, summaries, and case studies to provide comprehensive descriptions of COVID-19 symptoms and effects - Contains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures |
| diabetes and insulin signaling case study: Genetic Diagnosis of Endocrine Disorders Roy E. Weiss, Samuel Refetoff, 2015-10-09 Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. - Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases - Teaches the essentials of the genetic basis of disease in each major endocrine organ system - Offers expert advice from genetic counselors on how to use genetic information in counseling patients - Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing |
| diabetes and insulin signaling case study: Stress-Activated Protein Kinases Francesc Posas, Angel R. Nebreda, 2008-01-24 In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists. |
| diabetes and insulin signaling case study: The Heterogeneity of Cancer Metabolism Anne Le, 2018-06-26 Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies. |
| diabetes and insulin signaling case study: Managing Diabetes and Hyperglycemia in the Hospital Setting Boris Draznin, 2016-05-20 As the number of patients with diabetes increases annually, it is not surprising that the number of patients with diabetes who are admitted to the hospital also increases. Once in the hospital, patients with diabetes or hyperglycemia may be admitted to the Intensive Care Unit, require urgent or elective surgery, enteral or parenteral nutrition, intravenous insulin infusion, or therapies that significantly impact glycemic control (e.g., steroids). Because many clinical outcomes are influenced by the degree of glycemic control, knowledge of the best practices in inpatient diabetes management is extremely important. The field of inpatient management of diabetes and hyperglycemia has grown substantially in the last several years. This body of knowledge is summarized in this book, so it can reach the audience of hospitalists, endocrinologists, nurses and other team members who take care of hospitalized patients with diabetes and hyperglycemia. |
| diabetes and insulin signaling case study: Neurodegenerative Diseases Shamim I. Ahmad, 2012-03-12 The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases. |
| diabetes and insulin signaling case study: Vitamin D in Clinical Medicine A. Giustina, J.P. Bilezikian, 2018-03-29 Vitamin D deficiency is prevalent today not only among the elderly but pervasively throughout all ages of life.This is due, in part, to systemic diseases that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, and to increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes. This book addresses a variety of important issues that have emerged from this fast-moving area of clinical medicine. The topics include assays of vitamin D and its binding protein, effects on aging and associated complications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates to systemic disorders such as diabetes mellitus. Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for general practitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists, and oncologists. |
| diabetes and insulin signaling case study: The Genetic Landscape of Diabetes Laura Dean, J. R. McEntyre, National Center for Biotechnology Information (U.S.), National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), 2004 |
| diabetes and insulin signaling case study: Joslin's Diabetes Mellitus Elliott Proctor Joslin, C. Ronald Kahn, 2005 The bible on diabetes mellitus is now in its Fourteenth Edition—thoroughly revised and updated by more than 80 noted experts from the Joslin Diabetes Center and other leading institutions worldwide. This edition includes a new eleven-chapter section on hormone action and the regulation of metabolism. The section on definition and pathogenesis now includes chapters on genetics, diabetes in Asia and Africa, and diabetes in U.S. minority groups. Other new chapters cover retinopathy, cardiovascular disease, wound healing, and treatment of women with diabetes. All of the Fourteenth Edition's figures have been completely updated. |
| diabetes and insulin signaling case study: Greenspan's Basic and Clinical Endocrinology, Tenth Edition David G. Gardner, Dolores M. Shoback, 2017-10-13 A full-color guide to the entire field of clinical endocrinology and its scientific underpinnings – updated with the latest breakthroughs and developments A Doody’s Core Title for 2021! Greenspan’s Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan’s is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management. Greenspan’s provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges across the lifespan. Here’s why Greenspan’s is an essential tool for learning how to manage endocrine patients: • The Tenth Edition is enhanced by updated content throughout each chapter • NEW CHAPTERS on Transgender Endocrinology and Disorders of Sexual Determination and Differentiation • Important chapter on Evidence-Based Endocrinology and Clinical Epidemiology • Concise, balanced coverage of both scientific and clinical principles that guide patient management • The best source for current concepts in endocrine pathophysiology to aid clinical decision making • The most practical, current insights into diagnostic testing • More than 270 full-color illustrations and clinical photographs If you are in need of a well-illustrated, completely up-to-date guide to the entire field of clinical endocrinology, this trusted classic belongs on your desk or computer. |
| diabetes and insulin signaling case study: Lewis's Medical-Surgical Nursing, Fourth South Asia Edition - E-Book Chintamani, Dr. L. Gopichandran, Mrinalini Mani, 2021-12-21 - Content mapped and aligned to the revised BSc Nursing syllabus - Nearly 60 nursing care plans incorporated within the textbook, focusing on nursing assessment, diagnoses, intervention, and outcome, applying them to nursing practice - Several new pathophysiology maps added to the chapters - National programs added - National Blindness Control Program - National Deafness Control Program - Indian Transplantation programs - Other topics incorporated in the text - Eye banking - Post heart transplant follow-up management with checklist - Nursing management of patients in emergency and disaster situations - Highlights of newly introduced courses, e.g. Nurse Practitioner Midwifery - Hospice care in India - National Pressure Ulcer Advisory Panel (NPUAP) guidelines for assessment of pressure ulcers - Screening for breast cancer and cervical cancer - Content on occupational and industrial disorders added Ancillary Content on MedEnact Website - Educator Resources - TEACH for Nurses lesson plans - PowerPoint presentations - Image Collection - Nursing Care Plans - Student Resources - Key Points - Review Questions - Case Studies - Answer Keys for Case Studies and Rationales for Bridge to NCLEX Examination questions Nursing Care Plans |
| diabetes and insulin signaling case study: Hyperandrogenism in Women R. Pasquali, D. Pignatelli, 2019-09-09 Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions. |
| diabetes and insulin signaling case study: Islets of Langerhans, 2. Ed Shahidul Islam, |
| diabetes and insulin signaling case study: Atypical Diabetes Boris Draznin, 2018-05-01 Although the vast majority of diabetes cases (type 1 and type 2) are polygenic diseases, research, funded by the American Diabetes Association, has found that some forms of diabetes, distinct from type 1 or type 2 diabetes, are caused by single gene mutations. It has been estimated that these monogenic forms of diabetes account for up to five percent of all diabetes cases. In addition to monogenic diabetes, there are other atypical causes of diabetes, including: genetic defects in insulin action; diseases of the exocrine pancreas; and endocrinopathies. Given recent advances in our understanding of sub-types of diabetes, the time has come for a book on how to correctly diagnose and treat patients with atypical forms of this disorder. The book will be divided into three parts, each exploring distinct categories of atypical diabetes. Part I: Monogenic Diabetes: Genetic Defects of β-cell development and function; Part II: Insulin resistance, genetic defects in insulin action, and diseases of exocrine pancreas; Part III: Endocrinopathies, Immune-mediated diabetes, Diabetes of Unknown cause, and Other genetic syndromes sometimes associated with diabetes. |
| diabetes and insulin signaling case study: Insulin and IGFs , 2009-03-10 First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. - Longest running series published by Academic Press - Contributions by leading international authorities |
| diabetes and insulin signaling case study: The Discovery of Insulin Michael Bliss, 2017-06-22 The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine. |
| diabetes and insulin signaling case study: Textbook of Biochemistry for Medical Students D M Vasudevan, Sreekumari S, Kannan Vaidyanathan, 2016-06-02 Fully revised, new edition presenting students with latest advances in field of biochemistry. Features clinical case studies, MCQs, short questions, essays and viva voce questions for revision. |
| diabetes and insulin signaling case study: Signaling by Receptor Tyrosine Kinases Joseph Schlessinger, Mark A. Lemmon, 2014 Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epidermal growth factor, and nerve growth factor. They activate highly conserved intracellular signaling pathways that regulate cell proliferation, differentiation, and metabolism, playing essential roles in developing and adult animals. This book examines the nature of these receptors and their ligands, the molecular mechanisms that they regulate within cells, and the roles of the receptors in normal physiology and control of embryogenesis. It also discusses how dysfunction of these mechanisms can contribute to cancer and other diseases. |
| diabetes and insulin signaling case study: A Case Oriented Approach Towards Biochemistry Namrata Chhabra, 2012-12-30 Presented as case studies, this book provides students with up to date, logical coverage of basic biochemistry with normal and abnormal aspects of physiological chemistry. Each section features case studies discussing different disorders and conditions in topics including chemistry and metabolism of carbohydrates, lipids, amino acids, proteins and nucleotides, as well as vitamins, minerals, hormones, diet and detoxification. Each case is presented in a problem-solving approach, describing the history, clinical manifestations and laboratory findings of the disease, assisted by detailed illustrations. The final sections offer normal laboratory reference values and case studies and answers for self assessment. Key points Case studies presented in problem solving approach covering history, clinical manifestations and laboratory findings of biochemistry of different diseases and conditions Separate sections dedicated to AIDS, cancer, molecular biology, organ function tests and water and electrolyte imbalance Includes normal laboratory reference values and case studies for self assessment |
| diabetes and insulin signaling case study: Gestational Diabetes During and After Pregnancy Catherine Kim, Assiamira Ferrara, 2014-01-02 Gestational Diabetes Mellitus is becoming an increasingly prevalent disease as obesity and other chronic diseases are on the rise. It requires careful and informed clinical management as the care received during pregnancy affects not only perinatal health but the risk of developing type 2 diabetes even decades into the future, in both the mother and the child.From epidemiology and pathophysiology to diagnosis and management, covering recent breakthroughs in research and up-to-date developments in clinical practice, Gestational Diabetes During and After Pregnancy offers the reader a comprehensive and current look at Gestational Diabetes. Anyone involved in the research, public health or clinical aspects of Gestational Diabetes will find this volume a valuable aid in consolidating all recent developments regarding this disease. |
| diabetes and insulin signaling case study: Nutritional Pathophysiology of Obesity and its Comorbidities Susan Ettinger, 2016-09-01 Nutritional Pathophysiology of Obesity and Its Comorbidities: A Case-Study Approach challenges students and practitioners to understand the role of nutrients within the pathophysiology and development of disease, specifically those diseases which develop as a result of obesity. Through a case-based approach, the author presents complex clinical scenarios that require multiple treatment strategies, including targeted diet modification as an adjuvant to medical therapy. The book is divided into 9 modules and 5 appendices each of which covers aspects of obesity and its comorbidities. Within each module, a case is detailed with relevant history, laboratory and physical data, and follow-up information. Each case is followed by a resource section which delineates current understanding of the pathophysiology of the condition, as well as the actions of nutrients and food components shown to modify these processes. A further readings section cites current supporting clinical and basic literature as well as published guidelines. - Explores how obesity is a key player in the pathophysiology of many diseases, including diabetes mellitus, chronic renal failure, hypertension, and atherosclerosis - Integrates current understandings of the molecular mechanisms of nutrient action on the processes of disease development and treatment - Presents students and early practitioners with complex clinical scenarios through a practical case-based approach |
| diabetes and insulin signaling case study: Case Studies in Bayesian Statistical Modelling and Analysis Clair L. Alston, Kerrie L. Mengersen, Anthony N. Pettitt, 2012-10-10 Provides an accessible foundation to Bayesian analysis using real world models This book aims to present an introduction to Bayesian modelling and computation, by considering real case studies drawn from diverse fields spanning ecology, health, genetics and finance. Each chapter comprises a description of the problem, the corresponding model, the computational method, results and inferences as well as the issues that arise in the implementation of these approaches. Case Studies in Bayesian Statistical Modelling and Analysis: Illustrates how to do Bayesian analysis in a clear and concise manner using real-world problems. Each chapter focuses on a real-world problem and describes the way in which the problem may be analysed using Bayesian methods. Features approaches that can be used in a wide area of application, such as, health, the environment, genetics, information science, medicine, biology, industry and remote sensing. Case Studies in Bayesian Statistical Modelling and Analysis is aimed at statisticians, researchers and practitioners who have some expertise in statistical modelling and analysis, and some understanding of the basics of Bayesian statistics, but little experience in its application. Graduate students of statistics and biostatistics will also find this book beneficial. |
| diabetes and insulin signaling case study: The Underlying Mechanisms and Novel Approaches for Diabetes and its Related Complications Qi Pan, Lixin Guo, Chen Chen , Solomon Tesfaye, 2024-08-30 Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels, which severely affects the quality of life and survival of patients. The latest data from the International Diabetes Federation showed that there are approximately 537 million diabetic patients globally in 2021, and it is expected to reach 783 million by 2045. The treatment regime of diabetic patients mainly refers to the management of blood glucose and its complications. At present, typical hypoglycemic medications include insulin and non-insulin hypoglycemic drugs, which can be subdivided into a-glucosidase inhibitors, metformin, thiazolidinediones, sulfonylureas, glinides, DPP-4i, GLP-1RA, and SGLT-2i. Diabetic patients with poor islet function usually require insulin replacement, but the majority of patients fail to meet ideal therapeutic targets with multiple hypoglycemic drug combinations (including insulin). Furthermore, poor glycemic control is closely associated with an increased risk of diabetes complications, consequently an increased rate of mortality. More recently, promising new drugs and therapies emerged, which have many other important benefits beyond glucose-lowering. In addition, some traditional Chinese medicine have gradually revealed their therapeutic advantages. All of them provide more choices for the treatment of diabetes patients. |
| diabetes and insulin signaling case study: Herbal Medicine Iris F. F. Benzie, Sissi Wachtel-Galor, 2011-03-28 The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef |
| diabetes and insulin signaling case study: Diabetes and You Naheed Ali, 2011-02-16 Today, there are more than 23 million diabetics in the United States and with that number expected to rise drastically over the next decade the nation is faced with a health crisis of epidemic proportions. For those personally afflicted by this debilitating disease the everyday challenges can often seem overwhelming. In Diabetes and You, Dr. Naheed Ali offers both hope and empowerment to these sufferers and their families. Using the latest findings in clinical and physician studies, this book helps diabetics to successfully combat this disease and its symptoms on a number of fronts. Ali offers not only a hopeful perspective but also new and practical ways to confront and live with this condition. The full scope of diabetes-from its causes to its prevention and from the newest methods of treatment to the effects of diet and mental heath-is introduced in simple, non-technical language accessible to all readers. Diabetes and You is both state-of-the-art and user friendly, and emphasizes a whole body approach to this increasingly common, high-profile disease. As a physician and medical lecturer with a long association within the health care industry, Ali presents detailed advice to make coping with diabetes much simpler and easier than ever before. The reader is introduced to groundbreaking information on the risk factors associated with diabetes, the signs and symptoms, the different types of the disease, and how it can crop up in juvenile health. Diabetes and You will motivate diabetics to fight their condition in new and effective ways. |
| diabetes and insulin signaling case study: The Role of the Liver in Maintaining Glucose Homeostasis Michael J. Pagliassotti, Stephen N. Davis, Alan Cherrington, 1994 |
| diabetes and insulin signaling case study: Exercise and Diabetes Sheri R. Colberg, 2013-05-30 Physical movement has a positive effect on physical fitness, morbidity, and mortality in individuals with diabetes. Although exercise has long been considered a cornerstone of diabetes management, many health care providers fail to prescribe it. In addition, many fitness professionals may be unaware of the complexities of including physical activity in the management of diabetes. Giving patients or clients a full exercise prescription that take other chronic conditions commonly accompanying diabetes into account may be too time-consuming for or beyond the expertise of many health care and fitness professionals. The purpose of this book is to cover the recommended types and quantities of physical activities that can and should be undertaken by all individuals with any type of diabetes, along with precautions related to medication use and diabetes-related health complications. Medications used to control diabetes should augment lifestyle improvements like increased daily physical activity rather than replace them. Up until now, professional books with exercise information and prescriptions were not timely or interactive enough to easily provide busy professionals with access to the latest recommendations for each unique patient. However, simply instructing patients to “exercise more” is frequently not motivating or informative enough to get them regularly or safely active. This book is changing all that with its up-to-date and easy-to-prescribe exercise and physical activity recommendations and relevant case studies. Read and learn to quickly prescribe effective and appropriate exercise to everyone. |
| diabetes and insulin signaling case study: Clinical Diabetes Research Michael Roden, 2007-08-20 A practical how to guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006 Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced – and are being developed further – that facilitate monitoring of metabolism and even diagnosis of certain defects in human metabolism. While some of these methods are restricted to research facilities, others are already used in clinical practice. The correct beneficial use of these methods requires knowledge of the nature of the techniques and their clinical relevance. Clinical Diabetes Research: Methods and Techniques provides summaries of established state-of-the art-techniques and introduces the new technologies, evaluating their potential in clinical diabetes research. One section compares the efficacy of all metabolic tests that measure insulin action. Another section describes methods that allow quantification of whole body and intracellular metabolic fluxes relevant to diabetes research. The final section focuses on the planning and pitfalls of clinical studies in the field of metabolism. Each chapter throughout the book combines the theoretical basis of the approach with practical recommendations. There are further chapters on the design of clinical trials and ethical considerations. The publication is timely in view of the impressive development of the methods and techniques with their application to understanding the pathophysiology of diabetes, insulin resistance syndromes, obesity, and the metabolic effects of treatment. Clinical Diabetes Research: Methods and Techniques is of great relevance for researchers (from students and post-docs to principal investigators) in the field of human metabolism, clinical endocrinologists and diabetologists who are involved in clinical studies. |
| diabetes and insulin signaling case study: International Textbook of Diabetes Mellitus R. A. DeFronzo, E. Ferrannini, Paul Zimmet, George Alberti, 2015-03-11 The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available. |
Diabetes: Symptoms, Causes, Treatment, Prevention, and More
Jan 7, 2025 · Diabetes mellitus is a metabolic disease that causes high blood sugar. Your body either doesn’t make enough insulin or can’t effectively use the insulin it makes. The hormone …
Diabetes: What It Is, Causes, Symptoms, Treatment & Types
Feb 17, 2023 · Diabetes is a common condition that affects people of all ages. There are several forms of diabetes. Type 2 is the most common. A combination of treatment strategies can help …
Diabetes - Wikipedia
Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [10] [11] Diabetes is due to either the …
¿Qué es la diabetes? - NIDDK
La diabetes ocurre cuando el nivel de glucosa en la sangre es demasiado alto, lo que puede provocar problemas de salud. Los principales tipos de diabetes son la tipo 1, la tipo 2 y la …
What Is Diabetes? - NIDDK - National Institute of Diabetes ...
This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. NIDDK translates and …
Diabetes Research, Education, Advocacy | ADA
Leading the fight against the deadly consequences of diabetes for those affected by it through research funding, community services, education and advocacy.
What is Diabetes? Types, Symptoms, and Causes - Harvard Health
Apr 18, 2022 · What is prediabetes? Just as the name implies, prediabetes is a condition that's often (though not always) a precursor to full-blown diabetes. If you're diagnosed with …
About Diabetes | ADA
Diagnosed with prediabetes, type 1 or type 2? learn warning signs, understand diabetes, access tools, health tips and food ideas.
Diabetes: Symptoms, Causes, Treatment, Prevention, and More
Jan 7, 2025 · Diabetes mellitus is a metabolic disease that causes high blood sugar. Your body either doesn’t make enough insulin or can’t effectively use the insulin it makes. The hormone …
Diabetes: What It Is, Causes, Symptoms, Treatment & Types
Feb 17, 2023 · Diabetes is a common condition that affects people of all ages. There are several forms of diabetes. Type 2 is the most common. A combination of treatment strategies can help …
Diabetes - Wikipedia
Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [10] [11] Diabetes is due to either the …
¿Qué es la diabetes? - NIDDK
La diabetes ocurre cuando el nivel de glucosa en la sangre es demasiado alto, lo que puede provocar problemas de salud. Los principales tipos de diabetes son la tipo 1, la tipo 2 y la …
What Is Diabetes? - NIDDK - National Institute of Diabetes ...
This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. NIDDK translates and …
Diabetes Research, Education, Advocacy | ADA
Leading the fight against the deadly consequences of diabetes for those affected by it through research funding, community services, education and advocacy.
What is Diabetes? Types, Symptoms, and Causes - Harvard Health
Apr 18, 2022 · What is prediabetes? Just as the name implies, prediabetes is a condition that's often (though not always) a precursor to full-blown diabetes. If you're diagnosed with …
About Diabetes | ADA
Diagnosed with prediabetes, type 1 or type 2? learn warning signs, understand diabetes, access tools, health tips and food ideas.
