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| diagram of a mitochondria: Molecular Biology of the Cell , 2002 |
| diagram of a mitochondria: Mitochondrial Dysfunction Lawrence H. Lash, Dean P. Jones, 2013-10-22 Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable. |
| diagram of a mitochondria: Pharmacology of Mitochondria Harpreet Singh, Shey-Shing Sheu, 2017-08-11 This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets. |
| diagram of a mitochondria: Scanning Electron Microscopy for the Life Sciences Heide Schatten, 2013 A guide to modern scanning electron microscopy instrumentation, methodology and techniques, highlighting novel applications to cell and molecular biology. |
| diagram of a mitochondria: Mitochondria and Cancer Keshav Singh, Leslie Costello, 2009-04-05 Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy. |
| diagram of a mitochondria: Plant Mitochondria A. Moore, 1987-10-01 Eight years have elapsed since the first International Meeting on Plant Mitochondria was held in Marseilles. Since this date numerous important developments have occurred within the field and hence a further conference on this fundamental area of research was considered well overdue. This volume summarises the lecture and poster sessions of the second International Meeting on Plant Mitochondria held in Aberystwyth, July 20- 24th, 1986. The meeting was held not only to bring together plant scientists interested in the bioenergetics of plant mitochondria but also those who are interested in the regulatory role of mitochondria in plant growth and respiration. A further important aspect of this conference was to introduce plant physiologists and biochemists to the plant molecular biologists in an attempt to not only discuss problems of mutual interest but to also learn much more about the real questions which the biochemists and physiologists wish to answer. Hopefully the volume reflects much of the current excitement and advances being made in the field. Although many of the participants of the first meeting were present the expertise of Walter Bonner, Jack Hanson and Gaston Ducet, to name but a few, was sorely missed. The conference consisted of forty-five minute review lectures followed by thirty minute research lectures, the summaries of which are found in the longer articles. The meeting was divided into four seSSions, namely, organisation of the electron transport chain; mitochondrial interactions; mitochondrial biogenesis and plant growth and development. |
| diagram of a mitochondria: Encyclopedia of Genetics Eric C. R. Reeve, Isobel Black, 2001 First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa company. |
| diagram of a mitochondria: Principles of Biology Lisa Bartee, Walter Shiner, Catherine Creech, 2017 The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research. |
| diagram of a mitochondria: The Molecules of Life John Kuriyan, Boyana Konforti, David Wemmer, 2012-07-25 The field of biochemistry is entering an exciting era in which genomic information is being integrated into molecular-level descriptions of the physical processes that make life possible. The Molecules of Life is a new textbook that provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health s |
| diagram of a mitochondria: My Revision Notes: OCR A Level Biology A Frank Sochacki, 2017-01-16 Exam Board: OCR Level: A-Level Subject: Biology First Teaching: September 2015 First Exam: Summer 2016 With My Revision Notes: OCR A Level Biology A you can: - Manage your own revision with step-by-step support from experienced teacher and examiner Frank Sochacki - Apply biological terms accurately with the help of definitions and key words - Plan and pace your revision with the revision planner - Test understanding with questions throughout the book - Get exam ready with last minute quick quizzes available on the Hodder Education website |
| diagram of a mitochondria: Genetics, Biogenesis and Bioenergetics of Mitochondria W. Bandlow, R. J. Schweyen, D. Y. Thomas, K. Wolf, F. Kaudewitz, 2019-06-04 No detailed description available for Genetics, Biogenesis and Bioenergetics of Mitochondria. |
| diagram of a mitochondria: Mitochondria: Structure, Biogenesis and Transducing Functions H. Tedeschi, 2012-12-06 In the past few years, the body of experimental work on the structure, function and assembly processes of mitochondria has expanded rapidly. No one person can believe himself or herself completely in control of the burgeoning literature without possessing serious omissions or blind spots. In the present monograph I have attempted a critical evaluation of the literature. I believe that the common thread of single authorship outweighs the shortcomings of one person presenting many disparate viewpo,ints. It is my hope that the end product represents a comprehensive and coordinated review of the subject matter to the present date. Although the bulk of this monograph was completed by October 1974, I have made some attempts to update several of the sections at later times. Albany, N. Y. , November 1975 H. TEDESCHI Contents A. Structure of Mitochondria 1. General Organization . a) Conventional Thin Section Electron Microscopy b) Negative Staining Techniques . 3 c) Freeze-Cleavage . . . . . . . 4 2. Special Organization and Inclusions 10 a) Prismatic or Atypical Cristae 10 b) Filaments and Tubules . . 11 c) Amorphous Inclusions 12 d) Intramitochondrial Granules 12 e) DNA Containing Fibers 14 3. Topography of the Mitochondrial Transducing Systems 15 B. The Assembly of Mitochondria 18 1. Mitochondrial DNA and Its Genetic Role 19 2. Transcription of the Mitochondrial DNA . 28 a) mRNA . . . . . . . . . . . . . . 30 b) The Machinery for Transcription and Translation 32 c) Turnover of Mitochondrial RNA 36 3. Protein Synthesis . . . . . . . . 37 a) Mitochondrial Protein Synthesis and Its Characteristics 37 b) Role of Mitochondrial Protein Synthesis . . |
| diagram of a mitochondria: Mitochondria , 2001-05-23 This title employs biochemical, cell biological, and genetic approaches to study mitochondrial structure, function, and biogenesis. Also of interest are the consequences of impaired mitochondrial function on cells, tissues, and organs. The book is full of step-by-step how to methods with sample results, interpretations, and pitfalls. There is a unique set of appendices that include gene catalogs, mtDNA maps, and reagents for probing respiratory chain function. Finally, there are applications of state-of-the art microarray and gene chip technologies. - Isolation of mitochondria from commonly used cells and tissues - Assays for mitochondrial activities, including respiration, ATP production, permeability, protein import, and interactions with the cytoskeleton - Biochemical and optical methods for studying protein-protein interactions in mitochondria - Approaches to studying mitochondrial replication, transcription, and translation - Transmitochondrial technologies - Methods in microassay data analysis |
| diagram of a mitochondria: Mitochondrial Function William S. Allison, Immo E. Scheffler, 2009 |
| diagram of a mitochondria: Handbook of Plant Science, 2 Volume Set Keith Roberts, 2007-12-10 Plant Science, like the biological sciences in general, has undergone seismic shifts in the last thirty or so years. Of course science is always changing and metamorphosing, but these shifts have meant that modern plant science has moved away from its previous more agricultural and botanical context, to become a core biological discipline in its own right. However the sheer amount of information that is accumulating about plant science, and the difficulty of grasping it all, understanding it and evaluating it intelligently, has never been harder for the new generation of plant scientists or, for that matter, established scientists. And that is precisely why this Handbook of Plant Science has been put together. Discover modern, molecular plant sciences as they link traditional disciplines! Derived from the acclaimed Encyclopedia of Life Sciences! Thorough reference of up-to-the minute, reliable, self-contained, peer-reviewed articles – cross-referenced throughout! Contains 255 articles and 48 full-colour pages, written by top scientists in each field! The Handbook of Plant Science is an authoritative source of up-to-date, practical information for all teachers, students and researchers working in the field of plant science, botany, plant biotechnology, agriculture and horticulture. |
| diagram of a mitochondria: Clinical Mitochondrial Medicine Patrick F. Chinnery, Michael J. Keogh, 2018-05-17 This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice. |
| diagram of a mitochondria: Exercise Biochemistry Vassilis Mougios, 2020 Exercise Biochemistry, Second Edition, offers a clear explanation of how exercise affects molecular-level functioning in athletes and nonathletes, both healthy and diseased. |
| diagram of a mitochondria: Understanding mitochondrial dynamics and metabolic plasticity in cancer stem cells: Recent advances in cancer treatment and potential therapeutic approaches Pramod Darvin, Varun Sasidharan Nair, 2023-06-02 |
| diagram of a mitochondria: Advanced Biology Michael Kent, 2015-06-25 For all mainstream AS and A Level specifications. No matter which specification you choose to follow, Advanced Biology provides comprehensive coverage of all the content you need to know; this revised and updated second edition will remain relevant even when specifications change. This indispensable guide takes a thorough and engaging approach to AS and A Level Biology. |
| diagram of a mitochondria: Membranes, Mitochondria, and Connective Tissues Isidore Gersh, 2012-12-02 Submicroscopic Cytochemistry, Volume II: Membranes, Mitochondria, and Connective Tissues presents laboratory findings and theoretical aspects of the cytochemistry of cellular membranes, mitochondria, and connective tissues. Emphasis is on the molecular and macromolecular organization of cellular membranes, along with the origin and distribution of the major macromolecular aggregates of connective tissue. This volume consists of 11 chapters and begins by discussing the results of cytochemical studies on lipid and protein components of membranes in acinar and hepatic cells of the murine pancreas. The following chapters focus on densitometric studies of lipid membranes in pancreatic acinar cells of the mouse; the distribution of lipids and proteins in mitochondria of hepatic and exocrine pancreatic cells of adult mice, and of nucleic acids in mitochondria of embryonic cells; and possible precursor granules in fibroblasts, chondrocytes, and osteoblasts. The distribution of DNA and of soluble and insoluble RNAs in chondrocytes of the epiphyseal plate of the rat tibia is also examined, along with vascularity in tendons of young rats. This monograph will be of interest to cytochemists, biochemists, and molecular biologists. |
| diagram of a mitochondria: Cell Biology by the Numbers Ron Milo, Rob Phillips, 2015-12-07 A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid |
| diagram of a mitochondria: Mitochondrial Transplantation and Transfer Gokhan Burcin Kubat, Oner Ulger, Serdar Gunaydin, 2024-08-03 Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases, among other disease types. Step-by-step instruction is provided around research protocols and methods discussed, along with careful attention to the ethical implications of mitochondrial transplantation research and application. - Provides an in-depth discussion of mitochondrial transplantation, considering fundamental biology, disease implications, research methods and applications - Discusses recent advances in the field and their meaning for future research and clinical utility - Considers ethical dimensions of mitochondrial transplantation research and use in therapeutics - Examines mitochondrial transplantation across a range of disease types, from neurological to cardiovascular disease and ischemia |
| diagram of a mitochondria: Ocular Disease: Mechanisms and Management E-Book Leonard A Levin, Daniel M. Albert, 2010-03-03 Ocular Disease—a newly introduced companion volume to the classic Adler's Physiology of the Eye—correlates basic science and clinical management to describe the how and why of eye disease processes and the related best management protocols. Editors Leonard A. Levin and Daniel M. Albert—two of the world's leading ophthalmic clinician-scientists—have recruited as contributors the most expert and experienced authorities available in each of the major areas of ophthalmic disease specific to ophthalmology: retina, cornea, cataract, glaucoma, uveitis, and more. The concise chapter structure features liberal use of color—with 330 full-color line artworks, call-out boxes, summaries, and schematics for easy navigation and understanding. This comprehensive resource provides you with a better and more practical understanding of the science behind eye disease and its relation to treatment. - Covers all areas of disease in ophthalmology including retina, cornea, cataract, glaucoma, and uveitis for the comprehensive information you need for managing clinical cases. - Presents a unique and pragmatic blend of necessary basic science and clinical application to serve as a clinical guide to understanding the cause and rational management of ocular disease. - Features 330 full-color line artworks that translate difficult concepts and discussions into concise schematics for improved understanding and comprehension. - Provides the expert advice of internationally recognized editors with over 40 years of experience together with a group of world class contributors in basic science and clinical ophthalmology. |
| diagram of a mitochondria: Using Science to Develop Thinking Skills at Key Stage 3 Pat O'Brien, 2013-01-11 This book presents a series of practical activities designed to help teachers build an effective science curriculum for more able children. It focuses on: developing higher order thinking skills using conceptual language; directed activities relating to text for developing higher order skills; and in-depth study topics that emphasize a real product outcome. |
| diagram of a mitochondria: Objective NCERT Xtract Biology for NEET 6th Edition Disha Experts, |
| diagram of a mitochondria: IIT JAM Biotechology [BT] Question Bank 3000+ Questions Based on Exam Format MCQ/NAT/Written Type DIWAKAR EDUCATION HUB, 2023-09-19 IIT JAM [Code- BT] Practice Sets 3000 + Question Answer [MCQ/NAT/writtenType] Highlights of Question Answer – Covered All 24 Chapters of Biology,Chemistry,Physics,Math Based MCQ/NAT/MSQ As Per Syllabus In Each Chapter[Unit] Given 125+ MCQ/NAT/Written Type In Each Unit You Will Get 125 + Question Answer Based on [Multiple Choice Questions (MCQs) Numerical Answer Type [NAT] & Writtern Type Questions Total 3000 + Questions Answer with Explanation Design by Professor & JRF Qualified Faculties |
| diagram of a mitochondria: Biology-vol-I Dr S Venugopal, A text book on Biology |
| diagram of a mitochondria: Plant Mitochondria Olivier Van Aken, Allan G. Rasmusson, 2021-10-15 This detailed volume presents a wide range of techniques for plant mitochondrial analysis, ranging from tried-and-tested work horse techniques to the latest innovations. Within its pages, it explores subjects such as affinity-based isolation of mitochondria with magnetic beads, mitochondrial quality assessment protocols, measurement of uptake and release of specific metabolites, mitochondrial protein identification and visualization, as well as gene splicing and editing, and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Mitochondria: Methods and Protocols provides a highly useful set of methodologies for the plant mitochondrial community to help discover more interesting aspects of plant mitochondria in the years to come. |
| diagram of a mitochondria: Molecular Biology of the Cell 6E - The Problems Book John Wilson, Tim Hunt, 2014-11-21 The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be |
| diagram of a mitochondria: Exercise Physiology for Health, Fitness, and Performance Sharon Plowman, Denise Smith, 2007-06-01 This textbook integrates basic exercise physiology with research studies to stimulate learning, allowing readers to apply principles in the widest variety of exercise and sport science careers. It combines basic exercise physiology with special applications and contains flexible organisation of independent units. |
| diagram of a mitochondria: Discovering Cell Mechanisms William Bechtel, 2006 Bechtel emphasises how mechanisms were discovered by cell biologists and the instruments that made these inquiries possible. |
| diagram of a mitochondria: Magnetic Resonance in Dementia Frederik Barkhof, Jaap Valk, Nick C. Fox, Philip Scheltens, 2013-12-21 This is the first work to take a comprehensive look at the application of Magnetic Resonance (MR) techniques in the diagnosis, follow-up and therapy monitoring of dementing illnesses. The authors present an overview of MR findings in neurodegenerative and vascular disorders leading to dementia. In doing so, they also discuss other diseases that lead to cognitive and/or behavioural deterioration, such as infectious inflammatory disorders, toxic encephalopathies, inborn errors of metabolism of adult onset and post-traumatic, post-radiotherapy and post-chemotherapy conditions. This authoritative, well-written and richly illustrated reference work is indispensable for anybody working in the field. |
| diagram of a mitochondria: Fungi Ramesh Maheshwari, 2005-06-23 Today’s accelerated pace of research, aided by new instruments and techniques that combine the approaches of genetics, biochemistry, and cell biology, has changed the character of mycology. A new approach is necessary for the organization and study of fungi. Fungi: Experimental Methods in Biology presents the latest information in fungal biology generated through the application of genetics, molecular biology, and biochemistry. This book analyzes information derived through real experiments, and focuses on unresolved questions in the field. Divided into six sections comprising 14 chapters, the text describes the special features of fungi, interactions of fungi with other organisms, model fungi in research, gene manipulation, adaptations, and natural populations. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research, benefiting both beginning research workers and experienced professionals. A comprehensive appendix covers the principles in naming fungi and discusses their broad classification. |
| diagram of a mitochondria: Physical Biology of the Cell Rob Phillips, Jane Kondev, Julie Theriot, Hernan Garcia, 2012-10-29 Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that |
| diagram of a mitochondria: Encyclopedia of Fish Physiology , 2011-06-01 Fish form an extremely diverse group of vertebrates. At a conservative estimate at least 40% of the world's vertebrates are fish. On the one hand they are united by their adaptations to an aquatic environment and on the other they show a variety of adaptations to differing environmental conditions - often to extremes of temperature, salinity, oxygen level and water chemistry. They exhibit an array of behavioural and reproductive systems. Interesting in their own right, this suite of adaptive physiologies provides many model systems for both comparative vertebrate and human physiologists. This four volume encyclopedia covers the diversity of fish physiology in over 300 articles and provides entry level information for students and summary overviews for researchers alike. Broadly organised into four themes, articles cover Functional, Thematic, and Phylogenetic Physiology, and Fish Genomics. Functional articles address the traditional aspects of fish physiology that are common to all areas of vertebrate physiology including: Reproduction, Respiration, Neural (Sensory, Central, Effector), Endocrinology, Renal, Cardiovascular, Acid-base Balance, Osmoregulation, Ionoregulation, Digestion, Metabolism, Locomotion, and so on. Thematic Physiology articles are carefully selected and fewer in number. They provide a level of integration that goes beyond the coverage in the Functional Physiology topics and include discussions of Toxicology, Air-breathing, Migrations, Temperature, Endothermy, etc. Phylogenetic Physiology articles bring together information that bridges the physiology of certain groupings of fishes where the knowledge base has a sufficient depth and breadth and include articles on Ancient Fishes, Tunas, Sharks, etc. Genomics articles describe the underlying genetic component of fish physiology and high light their suitability and use as model organisms for the study of disease, stress and physiological adaptations and reactions to external conditions. Winner of a 2011 PROSE Award Honorable Mention for Multivolume Science Reference from the Association of American Publishers The definitive encyclopedia for the field of fish physiology Three volumes which comprehensively cover the entire field in over 300 entries written by experts Detailed coverage of basic functional physiology of fishes, physiological themes in fish biology and comparative physiology amongst taxonomic Groups Describes the genomic bases of fish physiology and biology and the use of fish as model organisms in human physiological research Includes a glossary of terms |
| diagram of a mitochondria: Translation in Mitochondria and Other Organelles Anne-Marie Duchêne, 2013-09-13 The present book gives an overview on the similarities and differences of the various translation systems. Moreover, it highlights the mechanisms and control of translation in mitochondria and other organelles such as chloroplasts, plastids and apicoplasts in different organisms. Lastly, it offers an outlook on future developments and applications that might be made possible by a better understanding of translation in mitochondria and other organelles. |
| diagram of a mitochondria: The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments Manoj Kumar Jaiswal, 2017-04-17 Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The suffering of the ALS patients, and their families is enormous and the economic burden is colossal. There is therefore a pressing need for new therapies. Different molecular pathways and pathological mechanisms have been implicated in ALS. According to past studies, altered calcium homeostasis, abnormal mitochondrial function, protein misfolding, axonal transport defects, excessive production of extracellular superoxide radicals, glutamate-mediated excitotoxicity, inflammatory events, and activation of oxidative stress pathways within the mitochondria and endoplasmic reticulum can act as major contributor that eventually leads to loss of connection between muscle and nerve ultimately resulting to ALS. However, the detailed molecular and cellular pathophysiological mechanisms and origin and temporal progression of the disease still remained elusive. Ongoing research and future advances will likely advance our improve understanding about various involved pathological mechanism ultimately leading to discoveries of new therapeutic cures. Importantly, clinical biomarkers of disease onset and progression are thus also urgently needed to support the development of the new therapeutic agents and novel preventive and curative strategies. Effective translation from pre-clinical to clinical studies will further require extensive knowledge regarding drug activity, bioavailability and efficacy in both the pre-clinical and clinical setting, and proof of biological activity in the target tissue. During the last decades, the development of new therapeutic molecules, advance neuroimaging tools, patient derived induced stem cells and new precision medicine approaches to study ALS has significantly improved our understanding of disease. In particular, new genetic tools, neuroimaging methods, cellular probes, biomarker study and molecular techniques that achieve high spatiotemporal resolution have revealed new details about the disease onset and its progression. In our effort to provide the interested reader, clinician and researchers a comprehensive summaries and new findings in this field of ALS research, hereby we have created this electronic book which comprises of twenty seven chapters having various reviews, perspective and original research articles. All these chapters and articles in this book not only summarize the cutting-edge techniques, approaches, cell and animal models to study ALS but also provide unprecedented coverage of the current developments and new hypothesis emerging in ALS research. Some examples are novel genetic and cell culture based models, mitochondria-mediated therapy, oxidative stress and ROS mechanism, development of stem cells and mechanism-based therapies as well as novel biomarkers for designing and testing effective therapeutic strategies that can benefit ALS patients who are at the earlier stages in the disease. I am extremely grateful to all the contributors to this book and want to thank them for their phenomenal efforts. Manoj Kumar Jaiswal, Ph.D. February 5, 2017 New York, NY |
| diagram of a mitochondria: Repurposed Drugs Targeting Cancer Signaling Pathways: Dissecting New Mechanisms of Action Through in vitro and in vivo Analyses Alma D. Campos-Parra, Carlos Pérez-Plasencia, Teresita Padilla-Benavides, Eduardo López-Urrutia, 2021-11-29 |
| diagram of a mitochondria: Microcompartmentation D.P. Jones, 2018-01-18 Microcompartmentation refers to nonhomogeneous distribution of solutes in compartments of cells or associated structures without intervening membranal barriers. Such variations in concentration of ions, metabolites, intracellular messengers, and nutrients can introduce significant heterogeneity in subcellular function and regulation. The current focus on biological examples of microcompartmentation provides ample evidence for its importance and the role of physical structure in determining local chemical environments. The examples present in the different chapters include microcompartmentation of Ca2+,H+,ATP. ADP, O2, glycolytic intermediates, fatty acids, amino acids, and nucleic acid precursors. In reviewing these systems, the authors provide a useful resource for experimental approaches to study microcompartmentation and provide the basis for future studies of its role in regulation of cell functions. |
| diagram of a mitochondria: Mitochondria in Renal Health and Disease Egor Plotnikov, Giuliano Ciarimboli, 2021-09-29 |
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