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| discovering design with chemistry: Peptide Chemistry and Drug Design Ben M. Dunn, 2015-02-02 This book focuses on peptides as drugs, a growing area ofpharmaceutical research and development. It helps readers solveproblems of discovering, developing, producing, and deliveringpeptide-based drugs. • Identifies promising new areas in peptide drugdiscovery • Includes chapters on discovery from natural sources,metabolic modification, and drug delivery • Overviews separation methods and techniques foranalysis, bond formation, and purification • Offers readers both a professional reference and atext or resource for graduate-level students |
| discovering design with chemistry: Discovery and Utility of Chemical Probes in Target Discovery Paul Brennan, Saleta Vazquez Rodriguez, 2020-11-17 Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes. |
| discovering design with chemistry: Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set , 2021-04-20 Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools. |
| discovering design with chemistry: Discovery of Design Dr. Donald DeYoung, Derrik Hobbs, 2009-10-01 A world created in perfection, now unveiled... From the frontiers of scientific discovery, researchers are now taking design elements from the natural world and creating extraordinary breakthroughs that benefit our health, our quality of life, our ability to communicate, and even help us work more efficiently. An exciting look at cutting-edge scientific advances, Discover of Design highlights incredible examples that include: How things like batteries, human organ repair, microlenses, automotive engineering, paint, and even credit card security all have links to natural designs Innovations like solar panels in space unfurled using technology gleaned from beech tree leaves, and optic research rooted in the photonic properties of opal gemstones Current and future research from the fields of stealth technology, communications, cosmetics, nanotechnology, surveillance, and more! Take a fantastic journey into the intersection of science and God's blueprints for life - discovering answers to some of the most intricate challenges we face. Experience this powerful apologetics message in a multi-purpose resource as a personal enrichment tool or as an educational supplement. |
| discovering design with chemistry: Computer Applications in Drug Discovery and Development Puratchikody, A., Prabu, S. Lakshmana, Umamaheswari, A., 2018-11-23 With more restrictions upon animal experimentations, pharmaceutical industries are currently focusing on a new generation of experiments and technologies that are considerably more efficient and less controversial. The integration of computational and experimental strategies has led to the identification and development of promising compounds. Computer Applications in Drug Discovery and Development is a pivotal reference source that provides innovative research on the application of computers for discovering and designing new drugs in modern molecular biology and medicinal chemistry. While highlighting topics such as chemical structure databases and dataset utilization, this publication delves into the current panorama of drug discovery, where high drug failure rates are a major concern and properly designed virtual screening strategies can be a time-saving, cost-effective, and productive alternative. This book is ideally designed for chemical engineers, pharmacists, molecular biologists, students, researchers, and academicians seeking current research on the unexplored avenues and future perspectives of drug design. |
| discovering design with chemistry: Nuclear Receptors Mostafa Z. Badr, 2021-09-28 Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events. |
| discovering design with chemistry: Exploring Creation with Chemistry and Physics Jeannie K. Fulbright, 2013 |
| discovering design with chemistry: Artificial Intelligence in Drug Discovery Nathan Brown, 2020-11-04 Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia. |
| discovering design with chemistry: Medicinal Chemistry A.K. Ganguly, Sesha Sridevi Alluri, 2021-09-12 Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry. |
| discovering design with chemistry: Beyond the Molecular Frontier National Research Council, Division on Earth and Life Studies, Board on Chemical Sciences and Technology, Committee on Challenges for the Chemical Sciences in the 21st Century, 2003-03-19 Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future. |
| discovering design with chemistry: Handbook of Electrochemistry Cynthia G. Zoski, 2007-02-07 Electrochemistry plays a key role in a broad range of research and applied areas including the exploration of new inorganic and organic compounds, biochemical and biological systems, corrosion, energy applications involving fuel cells and solar cells, and nanoscale investigations. The Handbook of Electrochemistry serves as a source of electrochemical information, providing details of experimental considerations, representative calculations, and illustrations of the possibilities available in electrochemical experimentation. The book is divided into five parts: Fundamentals, Laboratory Practical, Techniques, Applications, and Data. The first section covers the fundamentals of electrochemistry which are essential for everyone working in the field, presenting an overview of electrochemical conventions, terminology, fundamental equations, and electrochemical cells, experiments, literature, textbooks, and specialized books. Part 2 focuses on the different laboratory aspects of electrochemistry which is followed by a review of the various electrochemical techniques ranging from classical experiments to scanning electrochemical microscopy, electrogenerated chemiluminesence and spectroelectrochemistry. Applications of electrochemistry include electrode kinetic determinations, unique aspects of metal deposition, and electrochemistry in small places and at novel interfaces and these are detailed in Part 4. The remaining three chapters provide useful electrochemical data and information involving electrode potentials, diffusion coefficients, and methods used in measuring liquid junction potentials. * serves as a source of electrochemical information * includes useful electrochemical data and information involving electrode potentials, diffusion coefficients, and methods used in measuring liquid junction potentials * reviews electrochemical techniques (incl. scanning electrochemical microscopy, electrogenerated chemiluminesence and spectroelectrochemistry) |
| discovering design with chemistry: Discovering Chemistry With Natural Bond Orbitals Frank Weinhold, 2012-06-15 This book explores chemical bonds, their intrinsic energies, and the corresponding dissociation energies which are relevant in reactivity problems. It offers the first book on conceptual quantum chemistry, a key area for understanding chemical principles and predicting chemical properties. It presents NBO mathematical algorithms embedded in a well-tested and widely used computer program (currently, NBO 5.9). While encouraging a look under the hood (Appendix A), this book mainly enables students to gain proficiency in using the NBO program to re-express complex wavefunctions in terms of intuitive chemical concepts and orbital imagery. |
| discovering design with chemistry: Medicinal Chemistry Norma K Dunlap, Donna M Huryn, 2018-04-17 Medicinal Chemistry begins with the history of the field, starting from the serendipitous use of plant preparations to current practice of design- and target-based screening methods. Written from the perspective of practicing medicinal chemists, the text covers key drug discovery activities such as pharmacokinetics and patenting, as well as the classes and structures of drug targets (receptors, enzymes, nucleic acids, and protein-protein and lipid interactions) with numerous examples of drugs acting at each type. Selected therapeutic areas include drugs to treat cancer, infectious diseases, and central nervous system disorders. Throughout the book, historical and current examples illustrate the progress to market and case studies explore the applications of concepts discussed in the text. Each chapter features a Journal Club, as well as review and application questions to enhance and test comprehension. This textbook is ideal for upper-level undergraduates and graduate students taking a one-semester survey course on medicinal chemistry and/or drug discovery, as well as scientists entering the pharmaceutical industry. |
| discovering design with chemistry: Fragment-Based Drug Discovery and X-Ray Crystallography Thomas G. Davies, Marko Hyvönen, 2012-01-23 Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. Stamford Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter Huber Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko Hyvönen Fragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy Arnold Fragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan |
| discovering design with chemistry: Complementary Bonding Analysis Simon Grabowsky, 2021-04-06 As chemical bonds are not observable, there are various theories and models for their description. This book presents a selection of conceptually very different and historically competing views on chemical bonding analysis from quantum chemistry and quantum crystallography. It not only explains the principles and theories behind the methods, but also provides practical examples of how to derive bonding descriptors with modern software and of how to interpret them. |
| discovering design with chemistry: De novo Molecular Design Gisbert Schneider, 2013-10-10 Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more. |
| discovering design with chemistry: Information Science for Materials Discovery and Design Turab Lookman, Francis J. Alexander, Krishna Rajan, 2015-12-12 This book deals with an information-driven approach to plan materials discovery and design, iterative learning. The authors present contrasting but complementary approaches, such as those based on high throughput calculations, combinatorial experiments or data driven discovery, together with machine-learning methods. Similarly, statistical methods successfully applied in other fields, such as biosciences, are presented. The content spans from materials science to information science to reflect the cross-disciplinary nature of the field. A perspective is presented that offers a paradigm (codesign loop for materials design) to involve iteratively learning from experiments and calculations to develop materials with optimum properties. Such a loop requires the elements of incorporating domain materials knowledge, a database of descriptors (the genes), a surrogate or statistical model developed to predict a given property with uncertainties, performing adaptive experimental design to guide the next experiment or calculation and aspects of high throughput calculations as well as experiments. The book is about manufacturing with the aim to halving the time to discover and design new materials. Accelerating discovery relies on using large databases, computation, and mathematics in the material sciences in a manner similar to the way used to in the Human Genome Initiative. Novel approaches are therefore called to explore the enormous phase space presented by complex materials and processes. To achieve the desired performance gains, a predictive capability is needed to guide experiments and computations in the most fruitful directions by reducing not successful trials. Despite advances in computation and experimental techniques, generating vast arrays of data; without a clear way of linkage to models, the full value of data driven discovery cannot be realized. Hence, along with experimental, theoretical and computational materials science, we need to add a “fourth leg’’ to our toolkit to make the “Materials Genome'' a reality, the science of Materials Informatics. |
| discovering design with chemistry: Discovering the Brain National Academy of Sciences, Institute of Medicine, Sandra Ackerman, 1992-01-01 The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the Decade of the Brain by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a field guide to the brainâ€an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€and how a gut feeling actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the Decade of the Brain, with a look at medical imaging techniquesâ€what various technologies can and cannot tell usâ€and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€and many scientists as wellâ€with a helpful guide to understanding the many discoveries that are sure to be announced throughout the Decade of the Brain. |
| discovering design with chemistry: Science in the Beginning Jay Wile, 2013-05-01 Science in the context of the seven days of creation presented in the Bible. This textbook uses activities to reinforce scientific principles presented. |
| discovering design with chemistry: Periodic Tales Hugh Aldersey-Williams, 2011-02-03 The phenomenal Sunday Times bestseller Periodic Tales by Hugh Andersey-Williams, packed with fascinating stories and unexpected information about the building blocks of our universe. Everything in the universe is made of them, including you. Like you, the elements have personalities, attitudes, talents, shortcomings, stories rich with meaning. Here you'll meet iron that rains from the heavens and noble gases that light the way to vice. You'll learn how lead can tell your future while zinc may one day line your coffin. You'll discover what connects the bones in your body with the Whitehouse in Washington, the glow of a streetlamp with the salt on your dinner table. Unlocking their astonishing secrets and colourful pasts, Periodic Tales is a voyage of wonder and discovery, showing that their stories are our stories, and their lives are inextricable from our own. 'Science writing at its best. A fascinating and beautiful literary anthology, bringing them to life as personalities. If only chemistry had been like this at school. A rich compilation of delicious tales'Matt Ridley, Prospect 'A love letter to the chemical elements. Aldersey-Williams is full of good stories and he knows how to tell them well'Sunday Telegraph 'Great fun to read and an endless fund of unlikely and improbable anecdotes'Financial Times 'The history, science, art, literature and everyday applications of all the elements from aluminium to zinc' The Times Hugh Aldersey-Williams studied natural sciences at Cambridge. He is the author of several books exploring science, design and architecture and has curated exhibitions at the Victoria and Albert Museum and the Wellcome Collection. He lives in Norfolk with his wife and son. |
| discovering design with chemistry: The Elements: A Very Short Introduction Philip Ball, 2004-04-08 This Very Short Introduction is an exciting and non-traditional approach to understanding the terminology, properties, and classification of chemical elements. It traces the history and cultural impact of the elements on humankind from ancient times through today. Packed with anecdotes, The Elements is a highly engaging and entertaining exploration of the fundamental question: what is the world made from? |
| discovering design with chemistry: Computational Drug Discovery and Design Riccardo Baron, 2011-12-21 Due to the rapid and steady growth of available low-cost computer power, the use of computers for discovering and designing new drugs is becoming a central topic in modern molecular biology and medicinal chemistry. In Computational Drug Discovery and Design: Methods and Protocols expert researchers in the field provide key techniques to investigate biomedical applications for drug developments based on computational chemistry. These include methods and techniques from binding sites prediction to the accurate inclusion of solvent and entropic effects, from high-throughput screening of large compound databases to the expanding area of protein-protein inhibition, toward quantitative free-energy approaches in ensemble-based drug design using distributed computing. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, reference to software and open source analysis tools, step-by-step, readily reproducible computational protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Computational Drug Discovery and Design: Methods and Protocols aids scientists in the continuing study of state-of-the-art concepts and computer-based methodologies. |
| discovering design with chemistry: Recent Highlights in the Discovery and Optimization of Crop Protection Products Peter Maienfisch, Ir. Sven Mangelinckx, 2021-03-24 Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete. Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field. - Based on science presented at the 2019 International Union of Pure and Applied Chemistry Conference on Crop Protection - Provides real-world perspectives on pesticide and disease control progress - Presents scientific developments from an international array of contributing authors |
| discovering design with chemistry: Computational Drug Design D. C. Young, 2009-01-28 Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. Computational Drug Design is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file. |
| discovering design with chemistry: Silent Spring Rachel Carson, 2020-03-26 Now recognized as one of the most influential books of the twentieth century, Silent Spring exposed the destruction of wildlife through the widespread use of pesticides Rachel Carson's Silent Spring alerted a large audience to the environmental and human dangers of pesticides, spurring revolutionary changes in the laws affecting our air, land, and water. Despite condemnation in the press and heavy-handed attempts by the chemical industry to ban the book, Carson succeeded in creating a new public awareness of the environment which led to changes in government and inspired the ecological movement. It is thanks to this book, and the help of many environmentalists, that harmful pesticides such as DDT were banned from use in the US and countries around the world. This Penguin Modern Classics edition includes an introduction by Lord Shackleton, a preface by World Wildlife Fund founder Julian Huxley, and an afterword by Carson's biographer Linda Lear. |
| discovering design with chemistry: Super Simple Chemistry DK, 2020-05-14 From acids to alloys and equations to evaporation, this guide makes complex topics easy to grasp at a glance. Perfect support for coursework, homework, and exam revision. Each topic is fully illustrated, to support the information, make the facts crystal clear, bring the science to life and make studying a breeze. A large central image explains the idea visually and each topic is summed up on a single page, helping children to quickly get up to speed and really understand how chemistry works. For key ideas, How it Works and Look Closer boxes explain the theory with the help of simple graphics. And for revision, a handy Key Facts box provides a simple summary you can check back on later. With clear, concise coverage of all the core topics, Super Simple Chemistry is the perfect accessible guide to chemistry for children, supporting classwork, and making studying for exams the easiest it's ever been. |
| discovering design with chemistry: The Ten Most Beautiful Experiments George Johnson, 2009-11-10 George Johnson tells the stories of ten beautiful experiments which changed the world. From Galileo singing to mark time as he measured the pull of gravity and Newton carefully inserting a needle behind his own eye, to Joule packing a thermometer on his honeymoon to take the temperature of waterfalls and Michelson recovering from a dark depression to discover that light moves at the same speed in every direction - these ten dedicated men employed diamonds, dogs, frogs and even their own bodies as they worked to discover the laws of nature and of the universe. |
| discovering design with chemistry: Essentials of Physical Chemistry Arun Bahl, Essentials of Physical Chemistry is a classic textbook on the subject explaining fundamentals concepts with discussions, illustrations and exercises. With clear explanation, systematic presentation, and scientific accuracy, the book not only helps the students clear misconceptions about the basic concepts but also enhances students' ability to analyse and systematically solve problems. This bestseller is primarily designed for B.Sc. students and would equally be useful for the aspirants of medical and engineering entrance examinations. |
| discovering design with chemistry: Exploring Creation with Physical Science Jay L. Wile, 2007 This should be the last course a student takes before high school biology. Typically, we recommend that the student take this course during the same year that he or she is taking prealgebra. Exploring Creation With Physical Science provides a detailed introduction to the physical environment and some of the basic laws that make it work. The fairly broad scope of the book provides the student with a good understanding of the earth's atmosphere, hydrosphere, and lithosphere. It also covers details on weather, motion, Newton's Laws, gravity, the solar system, atomic structure, radiation, nuclear reactions, stars, and galaxies. The second edition of our physical science course has several features that enhance the value of the course: * There is more color in this edition as compared to the previous edition, and many of the drawings that are in the first edition have been replaced by higher-quality drawings. * There are more experiments in this edition than there were in the previous one. In addition, some of the experiments that were in the previous edition have been changed to make them even more interesting and easy to perform. * Advanced students who have the time and the ability for additional learning are directed to online resources that give them access to advanced subject matter. * To aid the student in reviewing the course as a whole, there is an appendix that contains questions which cover the entire course. The solutions and tests manual has the answers to those questions. Because of the differences between the first and second editions, students in a group setting cannot use both. They must all have the same edition. A further description of the changes made to our second edition courses can be found in the sidebar on page 32. |
| discovering design with chemistry: Structure-Based Drug Discovery Roderick E Hubbard, 2007-10-31 Structure-based drug discovery is a collection of methods that exploits the ability to determine and analyse the three dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of discovery of new drug candidates. After an introductory overview of the principles and application of structure-based methods in drug discovery, this book then describes the essential features of the various methods. Chapters on X-ray crystallography, NMR spectroscopy, and computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories to demonstrate the major impact that structure-based methods have had on discovering drug molecules. Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides the scientific background for the non-expert reader. The book provides a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences. |
| discovering design with chemistry: Science in the Ancient World Jay Wile, 2015-02-10 |
| discovering design with chemistry: Molecular Modeling Hans-Dieter Höltje, Gerd Folkers, 2008-07-11 Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling calculations. Its main objective is the description of the various pitfalls to be avoided. Without unnecessary overhead it leads the reader from simple calculations on small molecules to the modeling of proteins and other relevant biomolecules. A textbook for beginners as well as an invaluable reference for all those dealing with molecular modeling in their daily work! |
| discovering design with chemistry: The Discovery of Oxygen Joseph Priestley, 1894 |
| discovering design with chemistry: Discovering Cosmetic Science Stephen Barton, Allan Eastham, Amanda Isom, Denise Mclaverty, Yi Ling Soong, 2020-09-23 Welcome to this ‘novice’s guide’. At last a book that explains the real science behind the cosmetics we use. Taking a gentle approach and a guided journey through the different product types, we discover that they are not as superficial as often thought and learn that there is some amazing science behind them. We shall uncover some of the truths behind the myths and point out some interesting facts on our way. Did you know? Vitamin E is the world’s most used cosmetic active ingredient. At just 1mm thick, your amazing skin keeps out just about everything it’s exposed to – including your products! A ‘chemical soup’ of amino acids, urea, mineral salts and organic acids act as ‘water magnets’ in the skin keeping it naturally moisturised. Discovered centuries ago, iron oxides (yes, the same chemicals as rust) are still commonly used inorganic pigments in foundations. A lipstick is a fine balance of waxes, oils and colourants to keep the stick stable and leave an even gloss on your lips. |
| discovering design with chemistry: Fragment-based Drug Discovery Daniel A. Erlanson, Wolfgang Jahnke, 2016-02-23 From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets. |
| discovering design with chemistry: Superheavy Kit Chapman, 2019-06-13 SHORTLISTED FOR THE 2020 AAAS/SUBARU SB&F PRIZE FOR EXCELLENCE IN SCIENCE BOOKS How new elements are discovered, why they matter and where they will take us. Creating an element is no easy feat. It's the equivalent of firing six trillion bullets a second at a needle in a haystack, hoping the bullet and needle somehow fuse together, then catching it in less than a thousandth of a second – after which it's gone forever. Welcome to the world of the superheavy elements: a realm where scientists use giant machines and spend years trying to make a single atom of mysterious artefacts that have never existed on Earth. From the first elements past uranium, and their role in the atomic bomb, to the latest discoveries stretching the bounds of our chemical world, Superheavy reveals the hidden stories lurking at the edges of the periodic table. Why did US Air Force fly planes into mushroom clouds? Who won the transfermium wars? How did an earthquake help give Japan its first element? And what happened when Superman almost spilled nuclear secrets? In a globe-trotting adventure that stretches from the United States to Russia, Sweden to Australia, Superheavy is your guide to the amazing science filling in the missing pieces of the periodic table. You'll not only marvel at how nuclear science has changed our lives – you'll wonder where it's going to take us in the future. |
| discovering design with chemistry: The Elements Philip Ball, 2021-08-27 This book offers a largely chronological illustrated guide to how the chemical elements were discovered over the past three millennia. It provides a view not just of how we came to understand what everything is made of but also of how chemistry developed from a trial-and-error craft of making and transforming substances into a rational modern science that provides us with new materials, drugs, and much else. While other books have described the properties of the chemical elements and often delved into their histories, none has done so in this highly visual manner. The closest comparison is Theodore Gray's illustrated book The Elements - but this does not take a historical approach as this does here. The pictorial material for this subject is very rich, including some gorgeous alchemical documents as well as portraits, colour charts, woodcuts of mining, artefacts such as John Dalton's wooden balls, advertisements (for example, for radium 'cures') and postage stamps. The book contains separate short sections for each element or groups of related elements, which are gathered into several sections to order the sequence into several chronological eras of element discovery. Included are short 'interludes' (or 'feature spreads') presenting important intellectual milestones in how we think about elements. With 192 illustrations |
| discovering design with chemistry: Exploring Creation with Biology Jay L. Wile, Marilyn F. Durnell, 2005-01-01 |
| discovering design with chemistry: The Vital Question Nick Lane, 2015-04-23 Why is life the way it is? Bacteria evolved into complex life just once in four billion years of life on earth-and all complex life shares many strange properties, from sex to ageing and death. If life evolved on other planets, would it be the same or completely different? In The Vital Question, Nick Lane radically reframes evolutionary history, putting forward a cogent solution to conundrums that have troubled scientists for decades. The answer, he argues, lies in energy: how all life on Earth lives off a voltage with the strength of a bolt of lightning. In unravelling these scientific enigmas, making sense of life's quirks, Lane's explanation provides a solution to life's vital questions: why are we as we are, and why are we here at all? This is ground-breaking science in an accessible form, in the tradition of Charles Darwin's The Origin of Species, Richard Dawkins' The Selfish Gene, and Jared Diamond's Guns, Germs and Steel. |
| discovering design with chemistry: The Great Mental Models, Volume 1 Shane Parrish, Rhiannon Beaubien, 2024-10-15 Discover the essential thinking tools you’ve been missing with The Great Mental Models series by Shane Parrish, New York Times bestselling author and the mind behind the acclaimed Farnam Street blog and “The Knowledge Project” podcast. This first book in the series is your guide to learning the crucial thinking tools nobody ever taught you. Time and time again, great thinkers such as Charlie Munger and Warren Buffett have credited their success to mental models–representations of how something works that can scale onto other fields. Mastering a small number of mental models enables you to rapidly grasp new information, identify patterns others miss, and avoid the common mistakes that hold people back. The Great Mental Models: Volume 1, General Thinking Concepts shows you how making a few tiny changes in the way you think can deliver big results. Drawing on examples from history, business, art, and science, this book details nine of the most versatile, all-purpose mental models you can use right away to improve your decision making and productivity. This book will teach you how to: Avoid blind spots when looking at problems. Find non-obvious solutions. Anticipate and achieve desired outcomes. Play to your strengths, avoid your weaknesses, … and more. The Great Mental Models series demystifies once elusive concepts and illuminates rich knowledge that traditional education overlooks. This series is the most comprehensive and accessible guide on using mental models to better understand our world, solve problems, and gain an advantage. |
Discovering Design with Chemistry Set - Memoria Press: …
Discovering Design with Chemistry is a high school chemistry course designed for students who have completed Algebra I. It covers all the fundamental aspects of chemistry such as the …
Discovering Design with Chemistry - MODG
Discovering Design with Chemistry is a high school chemistry course designed for students who have completed Algebra 1. This course covers fundamental aspects of chemistry such as the …
Discovering Design with Chemistry (audiobook on Awesound)
Jun 22, 2021 · This independent-study, college-preparatory course covers fundamental aspects of chemistry such as the classification of matter, atomic structure, spectroscopy, chemical …
DISCOVERING DESIGN WITH CHEMISTRY BY JAY WILES
This course is designed to be a first-year high school chemistry course and gives the student a rigorous foundation in chemistry, in order to prepare him or her for a college-level course.
Discovering Design with Chemistry Set - R.O.C.K. Solid Home …
The Discovering Design with Chemistry Student Notebook provides daily assignments, comprehension check questions, chapter review questions, guidance on how to document …
Discovering Design with Chemistry - Simply Charlotte Mason
This independent-study, college-preparatory course covers fundamental aspects of chemistry such as the classification of matter, atomic structure, spectroscopy, chemical bonding, …
Discovering Design with Chemistry - Textbook - Nature's …
Discovering Design with Chemistry is a high school chemistry course designed for students who have completed Algebra 1. This independent-study, college-preparatory course covers …
Discovering Design with Chemistry - Christianbook.com
Discovering Design with Chemistry is a high-school college-prep chemistry course by Dr. Jay Wile. Designed for homeschooled students to use independently, this course features at-home …
Discovering Design with Chemistry Textbook - Memoria Press: …
Discovering Design with Chemistry is a high school chemistry course designed for homeschool students who have completed Algebra I.
Discovering Design with Chemistry, 2 Volumes - Christianbook.com
Discovering Design with Chemistry is a high-school, college-prep chemistry course by Dr. Jay Wile. Designed for homeschooled students to use independently, this course features at-home …
Discovering Design with Chemistry Set - Memoria Press: …
Discovering Design with Chemistry is a high school chemistry course designed for students who have completed Algebra I. It covers all the fundamental aspects of chemistry such as the …
Discovering Design with Chemistry - MODG
Discovering Design with Chemistry is a high school chemistry course designed for students who have completed Algebra 1. This course covers fundamental aspects of chemistry such as the …
Discovering Design with Chemistry (audiobook on Awesound)
Jun 22, 2021 · This independent-study, college-preparatory course covers fundamental aspects of chemistry such as the classification of matter, atomic structure, spectroscopy, chemical …
DISCOVERING DESIGN WITH CHEMISTRY BY JAY WILES
This course is designed to be a first-year high school chemistry course and gives the student a rigorous foundation in chemistry, in order to prepare him or her for a college-level course.
Discovering Design with Chemistry Set - R.O.C.K. Solid Home …
The Discovering Design with Chemistry Student Notebook provides daily assignments, comprehension check questions, chapter review questions, guidance on how to document …
Discovering Design with Chemistry - Simply Charlotte Mason
This independent-study, college-preparatory course covers fundamental aspects of chemistry such as the classification of matter, atomic structure, spectroscopy, chemical bonding, …
Discovering Design with Chemistry - Textbook - Nature's …
Discovering Design with Chemistry is a high school chemistry course designed for students who have completed Algebra 1. This independent-study, college-preparatory course covers …
Discovering Design with Chemistry - Christianbook.com
Discovering Design with Chemistry is a high-school college-prep chemistry course by Dr. Jay Wile. Designed for homeschooled students to use independently, this course features at-home …
Discovering Design with Chemistry Textbook - Memoria Press: …
Discovering Design with Chemistry is a high school chemistry course designed for homeschool students who have completed Algebra I.
Discovering Design with Chemistry, 2 Volumes - Christianbook.com
Discovering Design with Chemistry is a high-school, college-prep chemistry course by Dr. Jay Wile. Designed for homeschooled students to use independently, this course features at-home …
