Advertisement
| dna springer front end instructions: DNA Methylation Protocols Ken I. Mills, Bernie H. Ramsahoye, 2008-02-05 DNA Methylation Protocols offer a set of readily reproducible protocols of the analysis of DNA methylation and methylases. These powerful methods provide the tools necessary for studying methylation at both the global level and the level of sequence, and include many techniques for identifying genes that might be aberrantly methylated in cancer and aging. Additional methods cover genome-wide analysis of abnormal DNA methylation and the isolation and measurement of demethylases and related proteins. |
| dna springer front end instructions: DNA Repair Protocols Pat Vaughan, 2008-02-02 When setting out to decide on the content of DNA Repair Protocols: Prokaryotic Systems, I was conscious of the need to portray the vast array of pathways and enzymatic activities that are part of the discipline of DNA repair. In addition to the classical DNA repair activities, I wanted to convey the significant interest that has been generated in recent years in the use of the proteins and repair systems as research tools, much like the use of restriction enzymes over the last few decades. Therefore, in addition to chapters deta- ing protocols for investigating specific repair activities, I have included s- eral chapters in this book on the applied use of DNA repair proteins and systems. The many years of research on bacterial DNA repair systems have allowed us to really understand the majority of DNA repair pathways in bac- rial cells. Building on this knowledge, research has lead to major advances in understanding mammalian DNA repair and uncovered its links to human d- ease, such as DNA mismatch repair and colon cancer, nucleotide excision repair and xeroderma pigmentosum, DNA helicase function in Bloom’s s- drome, and so on. Such have been the advances that Science magazine iden- fied the collective DNA repair systems as its “Molecule of the Year” in 1994. |
| dna springer front end instructions: Introduction to Epigenetics Renato Paro, Ueli Grossniklaus, Raffaella Santoro, Anton Wutz, 2021-03-23 This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease |
| dna springer front end instructions: B Cell Protocols Hua Gu, Klaus Rajewsky, 2008-02-04 B-lymphocyte development and function remains an exciting area of research for those interested in the physiology and pathology of the immune system in higher animals. While recent advances in genetics and cellular and molecular biology have provided a large spectrum of powerful new experimental tools in this field, it is both time consuming and often very difficult for a student or just any bench-side worker to identify a reliable experimental protocol in the ocean of the literature. The aim of B Cell Protocols is to provide a collection of diverse protocols ranging from the latest inventions and applications to some classic, but still frequently used methods in B-cell biology. The authors of the various chapters are all highly qualified scientists who are either the inventors or expert users of these methods. Their extensive experience in mastering a particular method provides not only the step-by-step details of a reproducible protocol, but also useful troubleshooting tips that readers will appreciate in their daily work. We hope that this book will be helpful for both beginning and experienced researchers in the field in designing or modifying an experimental approach, and exploring a biological question from multiple angles. |
| dna springer front end instructions: Sperm Chromatin Armand Zini, Ashok Agarwal, 2011-08-04 Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility. |
| dna springer front end instructions: The Selfish Gene Richard Dawkins, 1989 Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science |
| dna springer front end instructions: Feminism and Linguistic Theory Deborah Cameron, 1992-09-30 An introduction to theories about language in attempts to understand and transform women's lives. This evolving body of work encompasses linguistics, anthropology, literary and cultural theory, psychoanalysis and postmodern philosophy. |
| dna springer front end instructions: Wildlife Biodiversity Conservation Susan C. Underkoffler, Hayley R. Adams, 2021-06-26 This book addresses the multidisciplinary challenges in biodiversity conservation with a focus on wildlife crime and how forensic tools can be applied to protect species and preserve ecosystems. Illustrated by numerous case studies covering different geographical regions and species the book introduces to the fundamentals of biodiversity conflicts, outlines the unique challenges of wildlife crime scenes and reviews latest techniques in environmental forensics, such as DNA metagenomics. In addition, the volume explores the socio-economic perspective of biodiversity protection and provides an overview of national and international conservation laws. The field of conservation medicine stresses the importance of recognizing that human health, animal health, and ecosystem health are inextricably interdependent and the book serves as important contribution towards achieving the UN Sustainable Developmental Goals, in particular SDG 15, Life on Land. The book addresses graduate students, scientists and veterinary professionals working in wildlife research and conservation biology. |
| dna springer front end instructions: Environmental DNA Pierre Taberlet, Aurélie Bonin, Lucie Zinger, Eric Coissac, 2018-02-02 Environmental DNA (eDNA) refers to DNA that can be extracted from environmental samples (such as soil, water, feces, or air) without the prior isolation of any target organism. The analysis of environmental DNA has the potential of providing high-throughput information on taxa and functional genes in a given environment, and is easily amenable to the study of both aquatic and terrestrial ecosystems. It can provide an understanding of past or present biological communities as well as their trophic relationships, and can thus offer useful insights into ecosystem functioning. There is now a rapidly-growing interest amongst biologists in applying analysis of environmental DNA to their own research. However, good practices and protocols dealing with environmental DNA are currently widely dispersed across numerous papers, with many of them presenting only preliminary results and using a diversity of methods. In this context, the principal objective of this practical handbook is to provide biologists (both students and researchers) with the scientific background necessary to assist with the understanding and implementation of best practices and analyses based on environmental DNA. |
| dna springer front end instructions: Microorganisms in the Deterioration and Preservation of Cultural Heritage Edith Joseph, 2021-05-05 This open access book offers a comprehensive overview of the role and potential of microorganisms in the degradation and preservation of cultural materials (e.g. stone, metals, graphic documents, textiles, paintings, glass, etc.). Microorganisms are a major cause of deterioration in cultural artefacts, both in the case of outdoor monuments and archaeological finds. This book covers the microorganisms involved in biodeterioration and control methods used to reduce their impact on cultural artefacts. Additionally, the reader will learn more about how microorganisms can be used for the preservation and protection of cultural artefacts through bio-based and eco-friendly materials. New avenues for developing methods and materials for the conservation of cultural artefacts are discussed, together with concrete advances in terms of sustainability, effectiveness and toxicity, making the book essential reading for anyone interested in microbiology and the preservation of cultural heritage. |
| dna springer front end instructions: DNA Fingerprinting Lorne T. Kirby, 1990-06-18 DNA fingerprinting is a revolutionary technique that enables law enforcement agencies, diagnostic laboratories and research scientists to identify minute pieces of tissue, to determine parentage and other biological family relationships. This is a study of its applications. |
| dna springer front end instructions: The Cosmic Zoo Dirk Schulze-Makuch, William Bains, 2017-11-18 Are humans a galactic oddity, or will complex life with human abilities develop on planets with environments that remain habitable for long enough? In a clear, jargon-free style, two leading researchers in the burgeoning field of astrobiology critically examine the major evolutionary steps that led us from the distant origins of life to the technologically advanced species we are today. Are the key events that took life from simple cells to astronauts unique occurrences that would be unlikely to occur on other planets? By focusing on what life does - it's functional abilities - rather than specific biochemistry or anatomy, the authors provide plausible answers to this question. Systematically exploring the various pathways that led to the complex biosphere we experience on planet Earth, they show that most of the steps along that path are likely to occur on any world hosting life, with only two exceptions: One is the origin of life itself – if this is a highly improbable event, then we live in a rather “empty universe”. However, if this isn’t the case, we inevitably live in a universe containing a myriad of planets hosting complex as well as microbial life - a “cosmic zoo”. The other unknown is the rise of technologically advanced beings, as exemplified on Earth by humans. Only one technological species has emerged in the roughly 4 billion years life has existed on Earth, and we don’t know of any other technological species elsewhere. If technological intelligence is a rare, almost unique feature of Earth's history, then there can be no visitors to the cosmic zoo other than ourselves. Schulze-Makuch and Bains take the reader through the history of life on Earth, laying out a consistent and straightforward framework for understanding why we should think that advanced, complex life exists on planets other than Earth. They provide a unique perspective on the question that puzzled the human species for centuries: are we alone? |
| dna springer front end instructions: E. coli Plasmid Vectors Nicola Casali, Andrew Preston, 2008-02-03 A comprehensive collection of readily reproducible techniques for the manipulation of recombinant plasmids using the bacterial host E. coli. The authors describe proven methods for cloning DNA into plasmid vectors, transforming plasmids into E. coli, and analyzing recombinant clones. They also include protocols for the construction and screening of libraries, as well as specific techniques for specialized cloning vehicles, such as cosmids, bacterial artificial chromosomes, l vectors, and phagemids. Common downstream applications such as mutagenesis of plasmids, recombinant protein expression, and the use of reporter genes, are also described. |
| dna springer front end instructions: Capillary Electrophoresis of Nucleic Acids Keith R. Mitchelson, Jing Cheng, 2008-02-05 The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical procedures that permit use of this new resource for the analysis of genetic variation and for the detection of disease-causing mutations. The advent of capillary electrophoresis (CE), with its power to separate and a- lyze very small amounts of DNA, has also stimulated researchers to develop analytical procedures for the CE format. The advantages of CE in terms of speed and reproducibility of analyses are manifold. Furthermore, the high s- sitivity of detection, and the ability to increase sample throughput with par- lel analysis, has led to the creation of a full range of analysis of DNA molecules, from modified DNA adducts and single-strand oligonucleotides through PCR-amplified DNA fragments and whole chromosomes. Capillary Elect- phoresis of Nucleic Acids focuses on analytical protocols that can be used for detection and analysis of mutations and modification, from precise DNA loci through entire genomes of organisms. Important practical considerations for CE, such as the choice of separation media, electrophoresis conditions, and the influence of buffer additives and dyes on DNA mobility, are discussed in several key chapters and within particular applications. |
| dna springer front end instructions: Cancer Drug Resistance Marta Baiocchi, 2022-07-22 This volume discusses the latest techniques used to identify cancer drug resistance determinants at the molecular, cellular, and functional levels. Chapters in this book cover up-to-date topics including tumor-microenvironment cell co-culture methods and microfluidics systems; workflows for functional assessment of drug resistance in vitro and in vivo; quantitative techniques for identifying quiescent blood-flow circulating cells; and single-cell characterization methods, such as mass cytometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Cancer Drug Resistance: Methods and Protocols is a valuable resource for all scientists and researchers who are looking to learn more about the latest developments in understanding and overcoming anticancer drug resistance. |
| dna springer front end instructions: Molecular Biotechnology Bernard R. Glick, Jack J. Pasternak, 1998 The second edition explains the principles of recombinant DNA technology as well as other important techniques such as DNA sequencing, the polymerase chain reaction, and the production of monclonal antibodies. |
| dna springer front end instructions: The Knot Book Colin Conrad Adams, 2004 Knots are familiar objects. Yet the mathematical theory of knots quickly leads to deep results in topology and geometry. This work offers an introduction to this theory, starting with our understanding of knots. It presents the applications of knot theory to modern chemistry, biology and physics. |
| dna springer front end instructions: Genetics and Genomics in Nursing Quannetta T Edwards, PhD, MSN, MPH, FNP-BC, WHNP, AGN-BC, FAANP, Ann Maradiegue, PhD, MSN, FNP-BC, FAANP, 2017-07-28 Delivers complex information in an easy-to-read, step-by-step format The genomic era encompasses the entire spectrum of DNA -- all of the genes, and the interaction and inter-relationship of genes (genome) to the environment. Rapidly changing research has led to numerous advances in genetic testing, diagnosis, and treatments, and it is essential that APRNs be able to integrate genetic risk assessment into clinical care. This quick reference delivers complex information in an easy-to-read, step-by-step format with bitesize info boxes and bulleted information to provide the tools necessary to understand genetics/genomics and identify red flags that can appear in patient assessments. In an age of personalized and precision medicine, genetic risk assessment has never been more important. Genetics and Genomics in Nursing begins with an overview of genetics and the science behind inheritance. Chapters then break down the processes that make up risk assessment, and walk the reader through data collection and review, identification and calculation of risk, and patient communication. Finally, the last section of this text discusses special populations and key facts nurses need to know about their risk assessment. Key Features: Provides a clear introduction to a complex topic Describes important elements of the genomic risk assessment process for use in clinical settings when evaluating patients Illustrates how to develop a three-generation pedigree Applies commonly-used standardized pedigree symbols and familial patterns to aid in risk interpretation Discusses the challenges and limitations of pedigree interpretation Explains common concepts and includes helpful genomic resources Incorporates genomic risk assessment into patient evaluation |
| dna springer front end instructions: Smart Infrastructure and Applications Rashid Mehmood, Simon See, Iyad Katib, Imrich Chlamtac, 2020 This book provides a multidisciplinary view of smart infrastructure through a range of diverse introductory and advanced topics. The book features an array of subjects that include: smart cities and infrastructure, e-healthcare, emergency and disaster management, Internet of Vehicles, supply chain management, eGovernance, and high performance computing. The book is divided into five parts: Smart Transportation, Smart Healthcare, Miscellaneous Applications, Big Data and High Performance Computing, and Internet of Things (IoT). Contributions are from academics, researchers, and industry professionals around the world. Features a broad mix of topics related to smart infrastructure and smart applications, particularly high performance computing, big data, and artificial intelligence; Includes a strong emphasis on methodological aspects of infrastructure, technology and application development; Presents a substantial overview of research and development on key economic sectors including healthcare and transportation. |
| dna springer front end instructions: A Primer on Scientific Programming with Python Hans Petter Langtangen, 2016-07-28 The book serves as a first introduction to computer programming of scientific applications, using the high-level Python language. The exposition is example and problem-oriented, where the applications are taken from mathematics, numerical calculus, statistics, physics, biology and finance. The book teaches Matlab-style and procedural programming as well as object-oriented programming. High school mathematics is a required background and it is advantageous to study classical and numerical one-variable calculus in parallel with reading this book. Besides learning how to program computers, the reader will also learn how to solve mathematical problems, arising in various branches of science and engineering, with the aid of numerical methods and programming. By blending programming, mathematics and scientific applications, the book lays a solid foundation for practicing computational science. From the reviews: Langtangen ... does an excellent job of introducing programming as a set of skills in problem solving. He guides the reader into thinking properly about producing program logic and data structures for modeling real-world problems using objects and functions and embracing the object-oriented paradigm. ... Summing Up: Highly recommended. F. H. Wild III, Choice, Vol. 47 (8), April 2010 Those of us who have learned scientific programming in Python ‘on the streets’ could be a little jealous of students who have the opportunity to take a course out of Langtangen’s Primer.” John D. Cook, The Mathematical Association of America, September 2011 This book goes through Python in particular, and programming in general, via tasks that scientists will likely perform. It contains valuable information for students new to scientific computing and would be the perfect bridge between an introduction to programming and an advanced course on numerical methods or computational science. Alex Small, IEEE, CiSE Vol. 14 (2), March /April 2012 “This fourth edition is a wonderful, inclusive textbook that covers pretty much everything one needs to know to go from zero to fairly sophisticated scientific programming in Python...” Joan Horvath, Computing Reviews, March 2015 |
| dna springer front end instructions: The Craft of Scientific Presentations Michael Alley, 2006-05-17 This timely and hugely practical work provides a score of examples from contemporary and historical scientific presentations to show clearly what makes an oral presentation effective. It considers presentations made to persuade an audience to adopt some course of action (such as funding a proposal) as well as presentations made to communicate information, and it considers these from four perspectives: speech, structure, visual aids, and delivery. It also discusses computer-based projections and slide shows as well as overhead projections. In particular, it looks at ways of organizing graphics and text in projected images and of using layout and design to present the information efficiently and effectively. |
| dna springer front end instructions: Euglena: Biochemistry, Cell and Molecular Biology Steven D. Schwartzbach, Shigeru Shigeoka, 2017-04-19 This much-needed book is the first definitive volume on Euglena in twenty-fire years, offering information on its atypical biochemistry, cell and molecular biology, and potential biotechnology applications. This volume gathers together contributions from well-known experts, who in many cases played major roles in elucidating the phenomenon discussed. Presented in three parts, the first section of this comprehensive book describes novel biochemical pathways which in some instances have an atypical subcellular localization. The second section details atypical cellular mechanisms of organelle protein import, organelle nuclear genome interdependence, gene regulation and expression that provides insights into the evolutionary origins of eukaryotic cells. The final section discusses how biotechnologists have capitalized on the novel cellular and biochemical features of Euglena to produce value added products. Euglena: Biochemistry, Cell and Molecular Biology will provide essential reading for cell and molecular biologists with interests in evolution, novel biochemical pathways, organelle biogenesis and algal biotechnology. Readers will come away from this volume with a full understanding of the complexities of the Euglena as well as new realizations regarding the diversity of cellular processes yet to be discovered. |
| dna springer front end instructions: Heme Oxygenase in Biology and Medicine Nader G. Abraham, 2012-12-06 Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research. |
| dna springer front end instructions: Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research National Research Council, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research, 2003-08-22 Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research. |
| dna springer front end instructions: The Biology of Camel-Spiders Fred Punzo, 2012-12-06 My initial interest in the Solifugae (camel-spiders) stems from an incident that occurred in the summer of 1986. I was studying the behavioral ecology of spider wasps of the genus Pepsis and their interactions with their large theraphosid (tarantula) spider hosts, in the Chihuahuan Desert near Big Bend National Park, Texas. I was monitoring a particular tarantula burrow one night when I noticed the resident female crawl up into the burrow entrance. Hoping to take some photographs of prey capture, I placed a cricket near the entrance and waited for the spider to pounce. Suddenly, out of the comer of my eye appeared a large, rapidly moving yellowish form which siezed the cricket and quickly ran off with it until it disappeared beneath a nearby mesquite bush. So suddenly and quickly had the sequence of events occurred, that I found myself momentarily startled. With the aid of a headlamp I soon located the intruder, a solifuge, who was already busy at work macerating the insect with its large chelicerae (jaws). When I attempted to nudge it with the edge of my forceps, it quickly moved to another location beneath the bush. When I repeated this maneuver, the solifuge dropped the cricket and lunged at the forceps, gripping them tightly in its jaws, refusing to release them until they were forcefully pulled away. |
| dna springer front end instructions: Symptoms in the Pharmacy Alison Blenkinsopp, Paul Paxton, John Blenkinsopp, 2013-03-27 A practical and evidence-based guide for student, pre-registration and qualified pharmacists Symptoms in the Pharmacy is an indispensable guide to the management of common symptoms seen in the pharmacy. With advice from an author team that includes both pharmacists and GPs, the book covers ailments which will be encountered in the pharmacy on a daily basis. Now in its sixth edition Symptoms in the Pharmacy has been fully revised to reflect the latest evidence and availability of new medicines. There are new sections and case studies for 'POM' to 'P' switches including chloramphenicol, sumatriptan, diclofenac, naproxen and amorolfine. This edition features colour photographs of skin conditions for the first time enabling the differentiation and diagnosis of common complaints. The public health and illness prevention content have been expanded to support this increasingly important aspect of the pharmacist’s work. The book is designed for quick and easy reference with separate chapters for each ailment. Each chapter incorporates a decision making framework in which the information necessary for treatment and suggestions on ‘when to refer’ is distilled into helpful summary boxes. At the end of each chapter there are example case studies providing the view of pharmacists, doctors and patients for most conditions covered. These easy-to-follow- chapters can be read cover to cover or turned to for quick reference. This useful guide should be kept close at hand for frequent consultation. |
| dna springer front end instructions: Genome Instability Marco Muzi-Falconi, Grant W Brown, 2017-10-20 This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery and analysis of the proteins and pathways that are critical for stable maintenance of the genome. |
| dna springer front end instructions: Introduction to Evolutionary Computing A.E. Eiben, J.E. Smith, 2007-08-06 The first complete overview of evolutionary computing, the collective name for a range of problem-solving techniques based on principles of biological evolution, such as natural selection and genetic inheritance. The text is aimed directly at lecturers and graduate and undergraduate students. It is also meant for those who wish to apply evolutionary computing to a particular problem or within a given application area. The book contains quick-reference information on the current state-of-the-art in a wide range of related topics, so it is of interest not just to evolutionary computing specialists but to researchers working in other fields. |
| dna springer front end instructions: Innate Kevin J. Mitchell, 2020-03-31 What makes you the way you are--and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains. Deftly guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world. We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired--differences that impact all aspects of our psychology--and this insight promises to transform the way we see the interplay of nature and nurture. Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits. Compelling and original, Innate will change the way you think about why and how we are who we are.--Provided by the publisher. |
| dna springer front end instructions: A Fire Upon the Deep Vernor Vinge, 2013-01-24 Thousands of years hence, many races inhabit a universe where a mind's potential is determined by its location in space - from superintelligent entities in the Transcend, to the limited minds of the Unthinking Depths, where only simple creatures and technology can function. Nobody knows what strange force partitioned space into these 'zones of thought', but when the warring Straumli realm use an ancient Transcendent artefact as a weapon, they unwittingly unleash an awesome power that destroys thousands of worlds and enslaves all natural and artificial intelligence. Fleeing the threat, a family of scientists, including two children, are taken captive by the Tines - an alien race with a harsh medieval culture - and used as pawns in a ruthless power struggle. A rescue party, not entirely composed of humans, must free the children - and retrieve a secret that may save the rest of interstellar civilization. |
| dna springer front end instructions: The Discovery of Insulin Michael Bliss, 2017-06-22 The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine. |
| dna springer front end instructions: Advances in Information and Communication Kohei Arai, 2021-04-12 This book aims to provide an international forum for scholarly researchers, practitioners and academic communities to explore the role of information and communication technologies and its applications in technical and scholarly development. The conference attracted a total of 464 submissions, of which 152 submissions (including 4 poster papers) have been selected after a double-blind review process. Academic pioneering researchers, scientists, industrial engineers and students will find this series useful to gain insight into the current research and next-generation information science and communication technologies. This book discusses the aspects of communication, data science, ambient intelligence, networking, computing, security and Internet of things, from classical to intelligent scope. The authors hope that readers find the volume interesting and valuable; it gathers chapters addressing state-of-the-art intelligent methods and techniques for solving real-world problems along with a vision of the future research. |
| dna springer front end instructions: The Evaluation of Forensic DNA Evidence National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Committee on DNA Forensic Science: An Update, 1996-12-12 In 1992 the National Research Council issued DNA Technology in Forensic Science, a book that documented the state of the art in this emerging field. Recently, this volume was brought to worldwide attention in the murder trial of celebrity O. J. Simpson. The Evaluation of Forensic DNA Evidence reports on developments in population genetics and statistics since the original volume was published. The committee comments on statements in the original book that proved controversial or that have been misapplied in the courts. This volume offers recommendations for handling DNA samples, performing calculations, and other aspects of using DNA as a forensic toolâ€modifying some recommendations presented in the 1992 volume. The update addresses two major areas: Determination of DNA profiles. The committee considers how laboratory errors (particularly false matches) can arise, how errors might be reduced, and how to take into account the fact that the error rate can never be reduced to zero. Interpretation of a finding that the DNA profile of a suspect or victim matches the evidence DNA. The committee addresses controversies in population genetics, exploring the problems that arise from the mixture of groups and subgroups in the American population and how this substructure can be accounted for in calculating frequencies. This volume examines statistical issues in interpreting frequencies as probabilities, including adjustments when a suspect is found through a database search. The committee includes a detailed discussion of what its recommendations would mean in the courtroom, with numerous case citations. By resolving several remaining issues in the evaluation of this increasingly important area of forensic evidence, this technical update will be important to forensic scientists and population geneticistsâ€and helpful to attorneys, judges, and others who need to understand DNA and the law. Anyone working in laboratories and in the courts or anyone studying this issue should own this book. |
| dna springer front end instructions: Computer Simulation of Biomolecular Systems W.F. van Gunsteren, P.K. Weiner, A.J. Wilkinson, 1997-11-30 This book is the third volume in this highly successful series. Since the first volume in 1989 and the second in 1993, many exciting developments have occurred in the development of simulation techniques and their application to key biological problems such as protein folding, protein structure prediction and structure-based design, and in how, by combining experimental and theoretical approaches, very large biological systems can be studied at the molecular level. This series attempts to capture that progress. Volume 3 includes contributions that highlight developments in methodology which enable longer and more realistic simulations (e.g. multiple time steps and variable reduction techniques), a study of force fields for proteins and new force field development, a novel approach to the description of molecular shape and the use of molecular shape descriptors, the study of condensed phase chemical reactions, the use of electrostatic techniques in the study of protonation, equilibria and flexible docking studies, structure refinement using experimental data (X-ray, NMR, neutron, infrared) and theoretical methods (solvation models, normal mode analysis, MD simulations, MC lattice dynamics, and knowledge-based potentials). There are several chapters that show progress in the development of methodologies for the study of folding processes, binding affinities, and the prediction of ligand-protein complexes. The chapters, contributed by experienced researchers, many of whom are leaders in their field of study, are organised to cover developments in: simulation methodology the treatment of electrostatics protein structure refinement the combined experimental and theoretical approaches to the study of very large biological systems applications and methodology involved in the study of protein folding applications and methodology associated with structure-based design. |
| dna springer front end instructions: DNA Barcodes Ida Lopez, David L. Erickson, 2012-06-12 A DNA barcode in its simplest definition is one or more short gene sequences taken from a standardized portion of the genome that is used to identify species through reference to DNA sequence libraries or databases. In DNA Barcodes: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used with DNA barcodes. These methods include the latest information on techniques for generating, applying, and analyzing DNA barcodes across the Tree of Life including animals, fungi, protists, algae, and plants. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, DNA Barcodes: Methods and Protocols aids scientists in continuing to study methods from wet-lab protocols, statistical, and ecological analyses along with guides to future, large-scale collections campaigns. |
| dna springer front end instructions: The Impact of Food Bioactives on Health Kitty Verhoeckx, Paul Cotter, Iván López-Expósito, Charlotte Kleiveland, Tor Lea, Alan Mackie, Teresa Requena, Dominika Swiatecka, Harry Wichers, 2015-04-29 “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena. |
| dna springer front end instructions: Frictionless Markets Jack Buffington, 2015-09-15 This volume models a 21st century supply chain: one that uses technology that leads to the power of the individual, not larger organizations. Author Jack Buffington explains how in the near future, each of us will be a “prosumer” in a peer-based economy of micro-level manufacturing with little waste and infinite customization. There are two primary schools of thought in regard to the world economy of the future; from one side is a belief that economic growth can continue in perpetuity, driven upon a cheap and plentiful energy supply. From the other point of view is a perspective that economic growth will soon end has due to a lack of cheap and plentiful oil, too much financial debt, and a damaged environment that cannot withstand more growth. Frictionless Markets proposes a third way: a 21st century model based upon an economic calculus that does assume that fossil fuels are rapidly depleting and the environment is being damaged, but does not assume that this means an end to growth, but rather, a beginning of opportunities. Frictionless Markets tells the story of why and how frictionless markets will exist by the year 2030. Dr. Jack Buffington is both a supply chain professional for one of the largest consumer products companies in the world, and a researcher in biotechnology and supply chain at the Royal Institute of Technology in Stockholm, Sweden. |
| dna springer front end instructions: The Data Science Design Manual Steven S. Skiena, 2017-07-01 This engaging and clearly written textbook/reference provides a must-have introduction to the rapidly emerging interdisciplinary field of data science. It focuses on the principles fundamental to becoming a good data scientist and the key skills needed to build systems for collecting, analyzing, and interpreting data. The Data Science Design Manual is a source of practical insights that highlights what really matters in analyzing data, and provides an intuitive understanding of how these core concepts can be used. The book does not emphasize any particular programming language or suite of data-analysis tools, focusing instead on high-level discussion of important design principles. This easy-to-read text ideally serves the needs of undergraduate and early graduate students embarking on an “Introduction to Data Science” course. It reveals how this discipline sits at the intersection of statistics, computer science, and machine learning, with a distinct heft and character of its own. Practitioners in these and related fields will find this book perfect for self-study as well. Additional learning tools: Contains “War Stories,” offering perspectives on how data science applies in the real world Includes “Homework Problems,” providing a wide range of exercises and projects for self-study Provides a complete set of lecture slides and online video lectures at www.data-manual.com Provides “Take-Home Lessons,” emphasizing the big-picture concepts to learn from each chapter Recommends exciting “Kaggle Challenges” from the online platform Kaggle Highlights “False Starts,” revealing the subtle reasons why certain approaches fail Offers examples taken from the data science television show “The Quant Shop” (www.quant-shop.com) |
| dna springer front end instructions: Deliberately Digital Hubert Tardieu, David Daly, José Esteban-Lauzán, John Hall, George Miller, 2020-02-05 The digital revolution is changing virtually every aspect of the business world. However, most attempts at the digital transformation of enterprises fail – largely because of a lack of comprehensive and coherent strategy. This book takes lessons learned from the rise of the digital platform giants and explores how they can be adapted and effectively applied to established businesses, allowing them to compete within the new digital business paradigm. Offering a holistic perspective on the business and technology landscape, the book describes the megatrends, evolution and impact of digital technologies and business models. It brings together what for many is a disjointed set of business transformation imperatives, to provide a practical guide to digital success. Drawing on the authors’ decades of experience in supporting transformation and innovation, the book lays out a path to a progressive iteration of business change and value realization, balancing the perspectives of revolutionary transformation and change-enabling optimization. |
| dna springer front end instructions: Psychotherapy for the Advanced Practice Psychiatric Nurse, Second Edition Kathleen Wheeler, 2013-12-11 Print+CourseSmart |
DNA dForce Billi Dress for Genesis 9 - Daz 3D
DNA dForce Billi Dress for Genesis 9: (.DUF) A versatile halter top, open-front dress can be a night gown, a party dress, a sun dress, or just a fun frock for strolling down the boardwalk on a …
DNA dForce Lola Babydoll for Genesis 9 - Daz 3D
DNA Lola Stars Bow; DNA Lola Stars; Textures Include: 21 Texture, Bump, Displacement, Normal, Reflection ...
DNA Citrus Suit for Genesis 9 - Daz 3D
Donnena presents the Citrus! This is a conforming 2-piece swimsuit designed to show off our Dear Girl's curves. Nine fun in the sun textures are provided to cover any occasion. The first is …
Fashion DNA dForce Lola Babydoll for Genesis 9 Add-On
Fashion DNA dForce Lola Babydoll for Genesis 9 Add On is a *Texture Expansion* for the beautiful DNA dForce Lola Babydoll for Genesis 9 by Donnena. It provides 08 high-quality new …
DNA Irean - a dForce Dress for Genesis 9 - Daz 3D
Donnena is excited to offer Irean, a color-block mini dress with slit sleeves and skirts. Irean comes with a dozen eclectic textures. Irean can go from the office to the dance floor with ease. …
DNA Jan dForce Dress for Genesis 9 - Daz 3D
Donnena is happy to offer the Jan for your consideration. Jan is a tea-length dress with puffed elbow-length sleeves and a ruffled hem. Jan is a joyous spring frock, dedicated to casual …
DNA Berry - a dForce Mini for Genesis 9 - Daz 3D
Donnena is Happy to offer the sweet Berry Fun-in-the-Sun Dress. Berry features a short skirt with a halter top and a wide midriff. You may find that you don't need to sim the outfit, but the …
DNA Pepper - dForce Loungewear for Genesis 9 - Daz 3D
DNA Pepper Sheer; Textures Include: 16 Textures for Bump, Displacement, and Transparency Maps (4096 x 4096
DNA dForce Maya Dress for Genesis 9 - Daz 3D
DNA dForce Maya features numerous sexy cutouts in this unabashed party dress for Genesis 9. Our dear girl insisted on a far more risque dress than we usually offer. This dress is suited to …
DNA Aza dForce Dress for Genesis 9 - Daz 3D
Donnena is thrilled to introduce the Aza Dress. This is unabashedly a cocktail dress. Just for parties, with its split asymmetrical hem and single sleeve. As they say in New Orleans, Let the …
DNA dForce Billi Dress for Genesis 9 - Daz 3D
DNA dForce Billi Dress for Genesis 9: (.DUF) A versatile halter top, open-front dress can be a night gown, a party dress, a sun dress, or just a fun frock for strolling down the boardwalk on a …
DNA dForce Lola Babydoll for Genesis 9 - Daz 3D
DNA Lola Stars Bow; DNA Lola Stars; Textures Include: 21 Texture, Bump, Displacement, Normal, Reflection ...
DNA Citrus Suit for Genesis 9 - Daz 3D
Donnena presents the Citrus! This is a conforming 2-piece swimsuit designed to show off our Dear Girl's curves. Nine fun in the sun textures are provided to cover any occasion. The first is …
Fashion DNA dForce Lola Babydoll for Genesis 9 Add-On
Fashion DNA dForce Lola Babydoll for Genesis 9 Add On is a *Texture Expansion* for the beautiful DNA dForce Lola Babydoll for Genesis 9 by Donnena. It provides 08 high-quality new …
DNA Irean - a dForce Dress for Genesis 9 - Daz 3D
Donnena is excited to offer Irean, a color-block mini dress with slit sleeves and skirts. Irean comes with a dozen eclectic textures. Irean can go from the office to the dance floor with ease. …
DNA Jan dForce Dress for Genesis 9 - Daz 3D
Donnena is happy to offer the Jan for your consideration. Jan is a tea-length dress with puffed elbow-length sleeves and a ruffled hem. Jan is a joyous spring frock, dedicated to casual …
DNA Berry - a dForce Mini for Genesis 9 - Daz 3D
Donnena is Happy to offer the sweet Berry Fun-in-the-Sun Dress. Berry features a short skirt with a halter top and a wide midriff. You may find that you don't need to sim the outfit, but the …
DNA Pepper - dForce Loungewear for Genesis 9 - Daz 3D
DNA Pepper Sheer; Textures Include: 16 Textures for Bump, Displacement, and Transparency Maps (4096 x 4096
DNA dForce Maya Dress for Genesis 9 - Daz 3D
DNA dForce Maya features numerous sexy cutouts in this unabashed party dress for Genesis 9. Our dear girl insisted on a far more risque dress than we usually offer. This dress is suited to …
DNA Aza dForce Dress for Genesis 9 - Daz 3D
Donnena is thrilled to introduce the Aza Dress. This is unabashedly a cocktail dress. Just for parties, with its split asymmetrical hem and single sleeve. As they say in New Orleans, Let the …
