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| duration of maintenance therapy in multiple myeloma: Handbook of Multiple Myeloma Mohamad Mohty, Jean-Luc Harousseau, 2015-07-14 This handbook is an in-depth and comprehensive guide to the pathophysiology, diagnosis, staging, treatment and management of patients with multiple myeloma. The Handbook was commissioned to address an unmet need for a book of this kind in the myeloma field and to provide busy healthcare professionals with an informative and educational review of the current and emerging treatment recommendations for multiple myeloma. Myeloma is a type of bone marrow cancer arising from plasma cells and is the second most common form of bone marrow cancer, but represents just 1% of all cancers. The causes of myeloma are not fully understood but it is thought to be caused by an interaction of both genetic and environmental factors. This Handbook discusses these issues as well the latest developments in the field and will be an invaluable source of topical information for all healthcare professionals with an interest in multiple myeloma. |
| duration of maintenance therapy in multiple myeloma: Multiple Myeloma Morie A. Gertz, S. Vincent Rajkumar, 2013-10-01 This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment. |
| duration of maintenance therapy in multiple myeloma: Update on Multiple Myeloma Khalid Ahmed Al-Anazi, 2019 This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries. |
| duration of maintenance therapy in multiple myeloma: Cutaneous T-Cell Lymphoma Herschel S. Zackheim, 2004-10-28 Cutaneous T-cell lymphoma (CTCL) is a general term for many lymphomas of the skin including mycosis Fungoides and Sezary syndrome. This book presents the state of the art in CTCL epidemiology, clinical features, pathology, immunochemistry, diagnostic molecular techniques, staging and prognosis, and treatment. Edited by one of the leading experts in |
| duration of maintenance therapy in multiple myeloma: Essentials of Cardiac Anesthesia for Noncardiac Surgery E-Book Joel A. Kaplan, 2018-07-21 Patients with cardiac conditions routinely present for noncardiac surgeries, requiring special protocols for perioperative assessment and management by the anesthesiologist. Essentials of Cardiac Anesthesia for Noncardiac Surgery: A Companion to Kaplan's Cardiac Anesthesia provides current, easily accessible information in this complex area, ideal for general anesthesiologists and non-cardiac subspecialists. From preoperative assessment through postoperative care, this practical reference covers all perioperative approaches to today's patients with cardiac conditions. - Provides guidance on the anesthetic diagnosis and management of the full range of cardiac lesions, helping minimize adverse outcomes and reduce complications for patients with common, complex, or uncommon cardiac conditions. - Includes complete coverage of echocardiography and current monitoring techniques needed for thorough perioperative assessment – all from the anesthesiologist's perspective. - Discusses safe and effective perioperative anesthetic management of patients presenting with advanced levels of cardiac care such as drug-eluting stents, multiple antiplatelet drugs, ventricular assist devices, multiple drugs for end-stage heart failure, and implanted electrical devices that produce cardiac resynchronization therapy, as well as patients with complicated obstetric problems or other significant cardiovascular issues. - Features a concise, easy-to-navigate format and Key Points boxes in each chapter that help you find answers quickly. |
| duration of maintenance therapy in multiple myeloma: Measuring Health Ian McDowell, 2006-03-09 Worldwide economic constraints on health care systems have highlighted the importance of evidence-based medicine and evidence-based health policy. The resulting clinical trials and health services research studies require instruments to monitor the outcomes of care and the output of the health system. However, the over-abundance of competing measurement scales can make choosing a measure difficult at best. Measuring Health provides in-depth reviews of over 100 of the leading health measurement tools and serves as a guide for choosing among them.LNow in its third edition, this book provides a critical overview of the field of health measurement, with a technical introduction and discussion of the history and future directions for the field. This latest edition updates the information on each of the measures previously reviewed, and includes a complete new chapter on anxiety measurement to accompany the one on depression. It has also added new instruments to those previously reviewed in each of the chapters in the book.LChapters cover measurements of physical disability, social health, psychological well-being, anxiety, depression, mental status testing, pain, general health status and quality of life. Each chapter presents a tabular comparison of the quality of the instruments reviewed, followed by a detailed description of each method, covering its purpose and conceptual basis, its reliability and validity and, where possible, shows a copy of the actual scale. To ensure accuracy of the information, each review has been approved by the original author of each instrument or by an acknowledged expert. |
| duration of maintenance therapy in multiple myeloma: Multiple Myeloma and Related Disorders Henry A. Azar, Michael Potter, 1973 |
| duration of maintenance therapy in multiple myeloma: Multiple Myeloma Thomas Moehler, Hartmut Goldschmidt, 2011-04-21 Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life. |
| duration of maintenance therapy in multiple myeloma: Multiple Myeloma and Other Plasma Cell Neoplasms Meletios A. Dimopoulos, Thierry Facon, Evangelos Terpos, 2018-02-16 This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management. |
| duration of maintenance therapy in multiple myeloma: Allogeneic Stem Cell Transplantation Hillard M. Lazarus, Mary J. Laughlin, 2010-03-02 Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation. |
| duration of maintenance therapy in multiple myeloma: Proteasome Inhibitors in Cancer Therapy Julian Adams, 2004-05-25 A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma. |
| duration of maintenance therapy in multiple myeloma: Myeloma Bone Disease G. David Roodman, 2010-04-28 This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies. |
| duration of maintenance therapy in multiple myeloma: The European Blood and Marrow Transplantation Textbook for Nurses Michelle Kenyon, Aleksandra Babic, 2018-03-14 This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge. |
| duration of maintenance therapy in multiple myeloma: Outcomes Assessment in Cancer Joseph Lipscomb, Carolyn C. Gotay, Claire Snyder, 2011-08-18 The U.S. National Cancer Institute established the Cancer Outcomes Measurement Working Group in 2001 to evaluate measurements of the important and diverse impacts of cancer on individuals and populations. The findings and recommendations of the working group's 35 internationally recognized members provide alternative approaches for comprehensively measuring the burden of cancer and the effectiveness of preventive and therapeutic interventions. |
| duration of maintenance therapy in multiple myeloma: Angiogenesis, Lymphangiogenesis and Clinical Implications G. Marone, F. Granata, 2013-10-21 Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders. |
| duration of maintenance therapy in multiple myeloma: Stem Cells Ariff Bongso, Eng Hin Lee, 2011 Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications. |
| duration of maintenance therapy in multiple myeloma: Oncologic Critical Care Joseph L. Nates, Kristen J. Price, 2019-10-30 This major reference work is the most comprehensive resource on oncologic critical care. The text reviews all significant aspects of oncologic ICU practices, with a particular focus on challenges encountered in the diagnosis and management of the critically ill cancer patient population. Comprised of over 140 chapters, the text explores such topics as the organization and management of an oncologic ICU, diseases and complications encountered in the oncologic ICU, multidisciplinary care, surgical care, transfusion medicine, special patient populations, critical care procedures, ethics, pain management, and palliative care. Written by worldwide experts in the field, Oncologic Critical Care is a valuable resource for intensivists, advance practice providers, nurses, and other healthcare providers, that will help close significant knowledge and educational gaps within the realm of medical care for critically ill cancer patients. |
| duration of maintenance therapy in multiple myeloma: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues World Health Organization, 2001 This is the third volume in the new World Health Organization series on histological and genetic typing of tumours. Tumours of the haematopoietic and lymphoid tissues are covered. This was a collaborative project of the European Association for Haematolpathology and the Society for Haematopathology and others. The WHO classification is based on the principles defined in the Revised European-American Classification of Lymphoid Neoplasms (REAL) classification. Over 50 pathologists from around the world were involved in the project and proponents of all major lymphoma and leukaemia classifications have agreed to accept the WHO as the standard classification of haematological malignancies. So this classification represents the first true world wide concensus of haematologic malignancies. Colour photographs, magnetic resonance and ultrasound images and CT scans are included. |
| duration of maintenance therapy in multiple myeloma: Post-Authorization Safety Studies of Medicinal Products Ayad K. Ali, Abraham G. Hartzema, 2018-06-27 Post-Authorization Safety Studies of Medicinal Products: The PASS Book bridges the gap in the literature by providing a complete look at post-authorization safety studies and important pharmacoepidemiology and pharmacovigilance aspects. It covers various types and limitations of active surveillance programs, including the use of large databases and disparate data sources for rapid signal detection, as well as novel and advanced design and analysis approaches for causal interference from observational data. This book serves as an important reference for pharmacovigilance scientists and pharmacoepidemiologists who are searching for the appropriate study design to answer safety research questions. Readers will be able to effectively and efficiently design and interpret findings from post-authorization safety studies with the goal of improving the benefit-risk balance of a drug in order to optimize patient safety. - Discusses all types of observational studies in post-marketing drug safety assessment, from spontaneous reporting systems, to pragmatic trials, with examples from real-world settings - Presents various types of post-authorization safety studies - Offers solutions to the common challenges in the design and conduct of these studies - Highlights active surveillance programs, including common data models for rapid signal detection of drug safety issues |
| duration of maintenance therapy in multiple myeloma: Non-Myeloablative Allogeneic Transplantation Asad Bashey, Edward D. Ball, 2002-02-28 Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use. |
| duration of maintenance therapy in multiple myeloma: Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation , 1994 |
| duration of maintenance therapy in multiple myeloma: Life Gets in The Way: Powering Through Adversity with Grit and Grace Sally Kalksma, 2021-05-21 A young widow suddenly must raise three children alone—all while living with a rare blood cancer and working full-time. This situation might make any woman despair, but Sally Kalksma is not just any woman. With her passion for life and her infectious energy, she found the motivation to power through adversity with tenacity and grit while never giving up hope, even when life looked its bleakest. Although Sally is now in remission, she still takes chemo as a maintenance therapy for multiple myeloma, but she knows how to turn pain into positivity. In Life Gets in the Way, this superstar, world-renowned athlete shares her memoirs on climbing toward a world without cancer. |
| duration of maintenance therapy in multiple myeloma: Treatment of Multiple Myeloma and Related Disorders S. Vincent Rajkumar, Robert A. Kyle, 2008-10-27 Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome. |
| duration of maintenance therapy in multiple myeloma: Liquid Biopsies in Solid Tumors Massimo Cristofanilli, 2018-05-08 This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity. |
| duration of maintenance therapy in multiple myeloma: Neoplastic Diseases of the Blood Peter H. Wiernik, 1985 |
| duration of maintenance therapy in multiple myeloma: NDI PLUS , 1999 |
| duration of maintenance therapy in multiple myeloma: The Flexitarian Diet: The Mostly Vegetarian Way to Lose Weight, Be Healthier, Prevent Disease, and Add Years to Your Life Dawn Jackson Blatner, 2008-10-05 Lose weight, increase energy, and boost your immunity—without giving up meat! With her flexible mix-and-match plans, Dawn Jackson Blatner gives us a smart new approach to cooking and eating. --Joy Bauer, M.S., RD, CDN, Today show dietitian and bestselling author of Joy Bauer's Food Cures The Flexitarian Diet is a fresh approach to eating that's balanced, smart, and completely do-able. --Ellie Krieger, host of Food Network's Healthy Appetite and author of The Food You Crave Offers a comprehensive, simple-to-follow approach to flexitarian eating--the most modern, adaptable, delicious way to eat out there. --Frances Largeman-Roth, RD, senior food and nutrition editor of Health magazine It's about time someone told consumers interested in taking control of their weight and health how to get the benefits of a vegetarian lifestyle without having to cut meat completely out of their life. --Byrd Schas, senior health producer, New Media, Lifetime Entertainment Services Introducing the flexible way to eat healthy, slim down, and feel great! Flexitarianism is the hot new term for healthy dieting that minimizes meat without excluding it altogether. This ingenious plan from a high-profile nutritionist shows you how to use flexfoods to get the necessary protein and nutrients--with just a little meat for those who crave it. As the name implies, it’s all about flexibility, giving you a range of options: flexible meal plans, meat-substitute recipes, and weight loss tips. Plus: it’s a great way to introduce the benefits of vegetarianism into your family's lifestyle. Enjoy these Five Flex Food Groups: Flex Food Group One: Meat Alternatives (Beans, peas, lentils, nuts, and seeds; Vegetarian versions of meats; Tofu; Eggs) Flex Food Group Two: Vegetables and Fruits Flex Food Group Three: Grains (Barley, corn, millet, oat, quinoa, rice, wheat, pasta) Flex Food Group Four: Dairy Flex Food Group Five: Natural flavor-enhancers(Spices, buttermilk ranch, chili powder, cinnamon, Italian seasoning, herbs; Fats, oils, butter spreads; Sweeteners, granulated sugars, honey, chocolate; Ketchup, mustard, salad dressing, vinegars, low-fat sour cream) |
| duration of maintenance therapy in multiple myeloma: Multiple Myeloma - A New Era of Treatment Strategies Klaus Podar, Kenneth C. Anderson, 2012-01-03 Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced |
| duration of maintenance therapy in multiple myeloma: Total Marrow Irradiation Jeffrey Y. C. Wong, Susanta K. Hui, 2021-03-01 This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation. Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic. |
| duration of maintenance therapy in multiple myeloma: Principles of Molecular Oncology Miguel H. Bronchud, 2014-01-15 |
| duration of maintenance therapy in multiple myeloma: Multiple Myeloma, An Issue of Hematology/Oncology Clinics Kenneth C. Anderson, 2014-11-22 This issue of Hematology/Oncology Clinics of North America, devoted to Multiple Myeloma, is edited by Dr. Kenneth C. Anderson. Articles in this issue include: Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma; Diagnosis and Risk Stratification in Myeloma; Treatment of Newly Diagnosed Transplant Eligible Patients; Treatment of Newly Diagnosed Transplant Ineligible Patients; Treatment of Relapsed/Refractory Myeloma; Maintenance Therapy; Novel Targeted Therapies; Novel Immune-based Therapies; Allotransplantation in Myeloma; and Waldenstrom’s Macroglobulinemia. |
| duration of maintenance therapy in multiple myeloma: A Pilgrimage Without End Cherie Rineker, 2016-06-21 ~A Pilgrimage Without End is a heartfelt and engaging story about a woman who was diagnosed with an incurable cancer. When life seemed at its best, it was derailed by a serious cancer diagnosis. After Cherie found herself in the Emergency Room with a terminal and incurable cancer, she went through the absolute darkest period of her life. By bringing together all the lessons life had taught her, she found Inner Peace, something most of us long for yet few are lucky enough to possess. ~A Pilgrimage Without End goes deep into the psyche of the author, who overcame a difficult childhood by staying open to the goodness that exists in the world and by taking ownership of her own mistakes. Through her willingness to forgive, and learn from her mistakes, she was able to take a very difficult life, and subsequent cancer diagnosis, and turn it into a powerful Pilgrimage that taught her that Happiness can be found in the unlikeliest of places, as long as we are open to everything life hands us. This book will leave you astonished and empowered, and you will likely walk away with a renewed appreciation for your own life. A Pilgrimage Without End comes with powerful pictures and quotes created by the author herself, making it an all-around fun reading experience. As one reader put it:I hope you will find Cherie to be as engaging an author as I have. Her tale is intimately personal. Cherie shares the deepest part of herself, her struggles and the lessons she has learned along the way. Her story is not just another autobiographical journal of her battle with cancer. A Pilgrimage Without End is much more than that! It is a well-crafted self-examination from which we all can learn. In it she reveals her deepest, and often darkest emotional, physical and spiritual struggles she has faced throughout her life. Much of what she has to say is relevant to all of us, and not just those facing a battle with cancer. More than this, Cherie's self-examination and search for truth provides the reader with practical and spiritual guidance and insight when facing our own struggles. Thus, her story is one from which we all can benefit, whether we are confronting cancer, emotional struggles, or life changing events. Read it and be blessed. |
| duration of maintenance therapy in multiple myeloma: Bortezomib in the Treatment of Multiple Myeloma Irene M. Ghobrial, Paul G. Richardson, Kenneth C. Anderson, 2010-10-20 Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry. |
| duration of maintenance therapy in multiple myeloma: Understanding Multiple Myeloma Cristina Gasparetto, Dharshan Sivaraj, 2017-12-15 The only text to provide both the doctor’s and patient’s views, Understanding Multiple Myeloma gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. |
| duration of maintenance therapy in multiple myeloma: Contemporary Management of Multiple Myeloma Ravi Vij, 2012-12-15 This book Contemporary Management of Multiple Myeloma discusses in detail about the management of multiple myeloma. Multiple Myeloma is the second most common hematological malignancy in the United States. This book highlights the interplay between the malignant plasma cell and the microenvironment, and the role of genetic alterations, adhesion molecules and critical cytokines in this complex milieu. The first chapter of this book discusses epidemiology, etiology and pathogenesis of multiple myeloma. The clinical presentation of the common plasma cell dyscrasias and discuss the diagnostic and prognostic work-up with a highlighting on recent advances in chapters 3 and 4. Chapters from 5 to 9 focus on the therapeutic evolution that has occurred, and accumulate the landmark clinical trials that have changed clinical practice for up-front treatment of both transplant eligible and ineligible patients and for those with relapsed and refractory disease. These chapters also highlights on the important role of clinical research with stem cell transplantation, proteasome-inhibition and immunomodulatory drugs that form the backbone of our present day therapeutic armamentarium. Recommendations for response assessment and current understanding of the value of maximizing the depth of response in personalized therapy and patient segmentation are briefly explained in chapters 10 and 11. Chapter 12 and 13 discussed about adjunctive treatment modalities and novel therapeutic compounds in clinical trial and targets for future drug development. This book provides complete information about current landscape for multiple myeloma which is helpful in future aspects. |
| duration of maintenance therapy in multiple myeloma: Wintrobe's Clinical Hematology John P. Greer, Daniel A. Arber, Bertil Glader, Alan F. List, Robert T. Means, Frixos Paraskevas, George M. Rodgers, 2013-08-29 With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors. |
| duration of maintenance therapy in multiple myeloma: Cancer Vincent T. DeVita, Theodore S. Lawrence, Steven A. Rosenberg, 2010 Introducing the first volume of a new series, Cancer: Principles & Practice of Oncology—Annual Advances in Oncology. This series of annual volumes will focus on the most significant changes in oncologic research and practice that have taken place during the preceding year. Each volume identifies scientific and clinical areas in oncology that are rapidly changing and show a high potential for affecting the management of cancer patients in the future. These areas may reflect current controversies in oncology and every effort is made to provide clear direction for the practicing oncologist. |
| duration of maintenance therapy in multiple myeloma: Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition , 2013-07-22 Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| duration of maintenance therapy in multiple myeloma: Cambridge Medical Reviews: Haematological Oncology: Volume 3 Alan Burnett, James Armitage, Adrian Newland, Armand Keating, 1994-08-11 Haematological Oncology serves as a regular forum for the evaluation and dissemination of new information in this field and the topics selected for review range from basic science to clinical applications. The papers in Volume 3 cover the epidemiology of lymphoma; viral etiology of Hodgkin disease; cytogenetics of ALL; fungal infection; peripheral blood stem cell transplantation; conventional and aggressive treatment of myloma; and the laboratory aspects of myclodysplasia and differentiation therapy. This up-to-date review of the current state of research in hematological oncology will be an important source of information and knowledge. |
| duration of maintenance therapy in multiple myeloma: Hematology Board Review Francis P. Worden, MD, Rami N. Khoriaty, MD, Kathleen A. Cooney, MD, Michael W. Deininger, MD, PhD, 2018-05-28 Hematology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering all topics that appear on the Hematology Certification Exam. The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the exam and highlights topic areas that are often found on the test. For hematology and oncology fellows as well as practicing clinicians needing a refresher before taking MOC, this handy study guide provides succinct overviews of all blood disorders, syndromes and diseases with practice questions on the go. Each disorder or disease-based chapter provides the same structure for ease of use beginning with the epidemiology, and followed by the etiology and risk factors, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. The authors provide the most accurate and up-to-date information, including well-established treatment regimens for a variety of blood disorders, including iron disorders, bone marrow failure syndromes, platelet and megakaryocytic disorders, hemostasis, thrombosis, and hematologic malignancies. Later chapters review other major subspecialty areas found on the exam including transfusion medicine and hematopoietic cell transplantation. With 200 board-style questions and answers with detailed rationales, Hematology Board Review is the go-to, quick review for any trainee preparing for initial certification and for hematologists or oncologists preparing for recertification. Key Features: Includes 200 board-style questions and answers with rationales Provides key point summaries of each topic area for quick study and easy recall Thorough coverage of hematologic malignancies, blood disorders, transfusion medicine, hematopoietic cell transplantation, and standard treatment regimens Tables providing key data and information related to staging, treatment options, and disease classifications |
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