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| duke molecular physiology institute: Signaling Pathways in Liver Diseases Jean-Francois Dufour, Pierre-Alain Clavien, 2015-08-31 Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist. |
| duke molecular physiology institute: Sirtuins Riekelt H. Houtkooper, 2016-11-17 The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease. |
| duke molecular physiology institute: Hurst's the Heart Valentin Fuster, R. Wayne Alexander, Robert A. O'Rourke, 2011 The trusted landmark cardiology resource thoroughly updated to reflect the latest clinical perspectives Includes DVD with image bank Through thirteen editions Hursts the Heart has always represented the cornerstone of current scholarship in the discipline. Cardiologists, cardiology fellows and internists from across the globe have relied on its unmatched authority breadth of coverage and clinical relevance to help optimize patient outcomes. The thirteenth edition of Hursts the Heart continues this standard-setting tradition with 19 new chapters and 59 new authors, each of whom are internationally recognized as experts in their respective content areas. Featuring an enhanced reader-friendly design the new edition covers need-to-know clinical advances as well as issues that are becoming increasingly vital to cardiologists worldwide. As in previous editions you will find the most complete overview of cardiology topics available plus a timely new focus on evidence-based medicine health outcomes and health quality. New Features: 1548 full-color illustrations and 578 tables. Companion DVD with image bank includes key figures and tables from the text. |
| duke molecular physiology institute: Genomic and Precision Medicine Geoffrey S. Ginsburg, Huntington F Willard, Christopher W. Woods, Ephraim L. Tsalik, 2019-08-15 Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Offers comprehensive coverage of infectious and inflammatory disease genomics Provides succinct commentary and key learning points to assist providers with the implementation of genomic and personalized medicine Presents an up-to-date overview on major opportunities for genomic and personalized medicine Includes case studies that highlight the practical use of genomics in the management of patients |
| duke molecular physiology institute: Nutrition and Growth B. Koletzko, R. Shamir, D. Turck, M. Phillip, 2017-02-07 Adequate nutrition is a crucial component for child growth. Under- or malnutrition may not only affect present and future growth, but also a child's ability to develop skills. Tremendous efforts are being made to try and understand the mechanisms leading to stunted growth, proper diet composition, and an appropriate rehabilitation diet for children suffering from under- or malnutrition in all age groups during the growth period. In this publication, specialists in nutrition and growth present some of the best studies from peer-reviewed journals published between July 2015 and June 2016. Each paper is briefly summarized and supplemented with editorial comments which evaluate the clinical importance of each article and discuss its application. This 'Yearbook' is an important tool for practicing physicians, including pediatricians, subspecialists in pediatric gastroenterology, metabolism and nutrition, and endocrinology. Nutritionists and dieticians, as well as other health professionals involved in the care of children, will also find this to be a useful resource. |
| duke molecular physiology institute: The Ageing Immune System and Health Valquiria Bueno, Janet M. Lord, Thomas A. Jackson, 2016-10-03 The present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence. The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health. |
| duke molecular physiology institute: Psychoneuroimmunology Qing Yan, |
| duke molecular physiology institute: Insights in Life-course Epidemiology and Social Inequalities: 2021 Cyrille Delpierre, Hilde Langseth, 2022-09-05 |
| duke molecular physiology institute: Nutrient-Induced Responses in Eukaryotic Cells Joris Winderickx, Peter M. Taylor, 2004-03-29 Cells of all living organisms have the ability to respond to altered nutritional conditions. They have developed mechanisms to sense nutrient availability and to produce appropriate responses, which involve changes in gene expression and the production or degradation of certain enzymes and other proteins. In recent years, the understanding of nutrient-induced signal transduction has greatly advanced and the emerging picture is that nutrient signalling mechanisms evolved early in evolution. This book provides a detailed presentation and comparison of the key nutritional regulatory mechanisms in lower as well as higher eukaryotes, written by recognised experts in this expanding field. |
| duke molecular physiology institute: Women in Molecular Mechanisms of Aging Research Consuelo Borras , Aurélie Ledreux, 2024-11-07 We are delighted to present the inaugural Frontiers in Aging 'Women in Molecular Mechanisms of Aging Research' series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women to enter science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. To change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. Therefore, Frontiers in Aging is proud to offer this platform to promote the work of women scientists who are involved in research in the field of aging and related molecular mechanisms. The work presented in this Research Topic highlights the diversity of research performed and presents advances in theory, experiment, and methodology with applications to compelling problems, covering the following aspects, but not limited to: - Sex differences in molecular mechanisms of aging - Sex dimorphism in age-related diseases - Perspectives on the future of Molecular Mechanisms of Aging Research - Molecular Mechanisms of Aging Research and its impact on older women - Articles spotlighting excellent female-led contributions to the field of Aging - Perspectives on a specific field of Molecular Mechanisms of Aging Research inspired, started, or sparked by a woman - Research on gender disparities in healthcare in aging |
| duke molecular physiology institute: The immune system and inflammation in musculoskeletal health, aging, and disease Matthew William Grol, Gurpreet S Baht, 2023-06-29 |
| duke molecular physiology institute: Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism , 2014-05-23 Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as yet another general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in biomineralization science - Provides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo |
| duke molecular physiology institute: Nutrition and Diabetes Emmanuel C. Opara, Sam Dagogo-Jack, 2019-01-03 Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor, Nutrition and Diabetes: Pathophysiology and Management, Second Edition, is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches. Features Highlights the role of nutrition in the pathogenesis of obesity and diabetes Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of Diabetes Features emerging therapeutic approaches for management of obesity and diabetes Discusses experience in the management of obesity and diabetes in developing countries Presents challenges in insulin therapy and provides guidelines to overcome them The first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition, new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes. |
| duke molecular physiology institute: Genetic Analysis of Complex Disease William K. Scott, Marylyn D. Ritchie, 2021-12-06 Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology. |
| duke molecular physiology institute: Grazing in Future Multi-scapes: From Thoughtscapes to Landscapes, Creating Health from the Ground Up Pablo Gregorini, Iain James Gordon, Carol Kerven, Fred Provenza, 2022-09-27 This Research Topic is hosted in partnership with the Grazing in Future Multi-Scapes international workshop. The workshop will be held online, 30th May - 5th June 2021. Throughout different landscapes of the world, “grazing” herbivores fulfill essential roles in ecology, agriculture, economies and cultures including: families, farms, and communities. Not only do livestock provide food and wealth, they also deliver ecosystem services through the roles they play in environmental composition, structure and dynamics. Grazing, as a descriptive adjective, locates herbivores within a spatial and temporal pastoral context where they naturally graze or are grazed by farmers, ranchers, shepherds etc. In many cases, however, pastoralism with the single objective of maximizing animal production and/or profit has transformed landscapes, diminishing biodiversity, reducing water and air quality, accelerating loss of soil and plant biomass, and displacing indigenous animals and people. These degenerative landscape transformations have jeopardized present and future ecosystem and societal services, breaking the natural integration of land, water, air, health, society and culture. Land-users, policy makers and societies are calling for alternative approaches to pastoral systems; a call for diversified-adaptive and integrative agro-ecological and food-pastoral-systems designs that operate across multiple scales and ‘scapes’ (e.g. thought-, social-, land-, food-, health-, wild-scapes), simultaneously. There needs to be a paradigm shift in pastoral production systems and how grazing herbivores are managed –grazed- within them, derived initially from a change in perception of how they provide wealth. The thoughtscapes will include paradigm shifts where grazers move away from the actual archetype of pastoralism, future landscapes are re-imagined, and regenerative and sustainable management paradigms are put in place to achieve these visions. From this will come a change in collective thinking of how communities and cultures (socialscapes) perceive their relationships with pastoral lands. The landscapes are the biotic and abiotic four-dimensional domains or environments in need of nurture. Landscapes are the tables where humans and herbivores gain their nourishment, i.e. foodscapes. Foodscapes and dietary perceptions, dictate actions and reactions that are changing as developed countries grapple with diseases related to obesity, and people starve in developing countries. Societies are demanding healthscapes and nutraceutical foodscapes, and paradoxically, some are moving away from animal products. While indigenous species of animals, including humans (wildscapes), have been displaced from many of their lands by monotonic pastoralism, multifunctional pastoral systems can be designed in view of dynamic multi-scapes of the future. The purpose of this Research Topic is to influence future mental and practical models of pastoralism in continually evolving multi-scapes. We seek a collection of papers that will cultivate such a shift in thinking towards future models of sustainable multipurpose pastoralism. The contributions will be synthesized to establish how multifunctional pastoral systems can be re-imagined and then designed in view of the integrative dynamics of sustainable future multi-scapes. |
| duke molecular physiology institute: Chronic Kidney Disease, Dialysis, and Transplantation E-Book Jonathan Himmelfarb, T. Alp Ikizler, 2018-11-06 **Selected for Doody's Core Titles® 2024 in Transplantation Surgery** From basic science to practical clinical tools, Chronic Kidney Disease, Dialysis, and Transplantation, 4th Edition provides you with the up-to-date, authoritative guidance you need to safely and effectively manage patients with chronic renal disease. Covering all relevant clinical management issues, this companion volume to Brenner and Rector's The Kidney presents the knowledge and expertise of renowned researchers and clinicians in the fields of hemodialysis, peritoneal dialysis, critical care nephrology, and transplantation – for an all-in-one, indispensable guide to every aspect of this fast-changing field. - Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. - Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. - Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. - Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. |
| duke molecular physiology institute: Orthopaedics and Trauma Pablo Slullitel, Luciano Rossi, Gastón Camino-Willhuber, 2024 Zusammenfassung: This book provides an easy-going, high-quality and updated work focused on the most common diagnoses of Traumatology and Orthopaedics. It's structured with several sub-headings, including bullet-point tips for basic concepts. Each chapter is focused on a specific pathology and includes the following sub-headings: short introduction, applied anatomy and physiology, prevalence, classification, diagnosis (including anamnesis, physical examination and complementary imaging, from plain x-ray to cross-sectional imaging), treatment (conservative-surgical options), controversies, complications, future directions and author's preference for treatment apart from references. Orthopaedics and Trauma - Current Concepts will be an inspiration to the young orthopaedic resident, fellow or even general orthopaedic surgeon and senior medical student. It will definitely help with their careers and also be a useful tool to prepare for the board certified orthopaedic examination |
| duke molecular physiology institute: The Great Plant-Based Con Jayne Buxton, 2022-06-09 WINNER OF THE INVESTIGATIVE FOOD WORK AWARD AT THE GUILD OF FOOD WRITERS AWARDS 2023 'The most incredible book' Delia Smith 'Persuasive, entertaining and well researched' Sunday Times Plant-based is best for health, go vegan to help save the planet, eat less meat... Almost every day we are bombarded with the seemingly incontrovertible message that we must reduce our consumption of meat and dairy - or eliminate them from our diets altogether. But what if the pervasive message that the plant-based diet will improve our health and save the planet is misleading - or even false? What if removing animal foods from our diet is a serious threat to human health, and a red herring in the fight against climate change. In THE GREAT PLANT-BASED CON, Jayne Buxton demonstrates that each of these 'what-ifs' is, in fact, a reality. Drawing on the work of numerous health experts and researchers, she uncovers how the separate efforts of a constellation of individuals, companies and organisations are leading us down a dietary road that will have severe repercussions for our health and wellbeing, and for the future of the planet. THE GREAT PLANT-BASED CON is neither anti-plant nor anti-vegan - it is a call for us to take an honest look at the facts about human diets and their effect on the environment. Shocking and eye-opening, this book outlines everything you need to know to make more informed decisions about the food you choose to eat. |
| duke molecular physiology institute: Highlights in Pediatric Nephrology: 2021 Michael L. Moritz, 2021-08-19 |
| duke molecular physiology institute: Livestock Production and the Functioning of Agricultural Ecosystems: Volume I Gary S. Kleppel, Fred Provenza, Juan Jose Villalba, 2021-08-24 |
| duke molecular physiology institute: Frontiers In Autism Research: New Horizons For Diagnosis And Treatment Valerie W Hu, 2014-05-09 This book focuses on the emerging and expanding areas of research on ASD and their potential to lead to better diagnosis and more effective therapies. These areas include innovative and integrative approaches to genetic/genomic analyses and investigations of epigenetic contributions, including the role of noncoding RNAs, DNA methylation, alternative splicing, RNA editing, and faulty translation in gene regulation and expression, metabolic and immune dysfunction, co-morbidities, as well as hormonal and gene-environment interactions that may increase risk for ASD.Within each chapter, experts review cutting-edge research as well as provide their perspective on the future of research in their respective areas, including the challenges involved and the types of studies or advances that are necessary to move the field forward to achieve predicted translational goals.Contributors: Argel Aguilar-Valles, Evdokia Anagnostou, Emma Ashwin, Bonnie Auyeung, Kelly M Bakulski, Simon Baron-Cohen, Margaret L Bauman, Donna Betts, Chad A Bousman, Daniel B Campbell, Manuel F Casanova, Bhismadev Chakrabarti, Gursharan Chana, Abha Chauhan, Ved Chauhan, Jessica DeWitt, Keith W Dunaway, Alal Eran, Ian P Everall, M Daniele Fallin, Richard E Frye, Piers Gillett, Matthew Ginsberg, Christos G Gkogkas, Rhonda J Greenhaw, Simon G Gregory, Elena L Grigorenko, Feng Gu, Rebecca Harmer, Martha Herbert, Valerie W Hu, Karen L Jones, Petra Kern, Arkady Khoutorsky, Rebecca Knickmeyer, Isaac S Kohane, Louis M Kunkel, Janine M LaSalle, Michael V Lombardo, Deepali Mankad, Marvin Natowicz, Laura Nicholls, Christos Pantelis, Natalia Rakhlin, Radhika Ramadas, Daniel A Rossignol, Tewarit Sarachana, Stephen W Scherer, Gabriela Schmulevich, Ayten Shah, Frank R Sharp, Alison B Singer, Efstratios Skafidas, Estate M Sokhadze, Nahum Sonenberg, Boryana Stamova, Zohreh Talebizadeh, Renee Testa, Judy Van de Water, Irina Voineagu, Daniel Williams, Ryan K C Yuen, Daniela Zantomio. |
| duke molecular physiology institute: Rheumatology E-Book Marc C. Hochberg, Alan J. Silman, Josef S. Smolen, Michael E. Weinblatt, Michael H. Weisman, Ellen M Gravallese, 2018-01-08 Thoroughly revised and updated, the 7th Edition of Rheumatology remains a leading text in this fast-changing field, keeping you abreast of recent advances in medications, therapies, clinical trials, and much more. Dr. Mark Hochberg and his team of expert authors and editors cover everything you need to know -- from basic scientific principles to practical clinical management strategies, all in a user-friendly, accessible manner. Provides access to quick, concise videos depicting musculoskeletal ultrasound including anisotropy, comet tail needle artifact, rheumatoid arthritis synovitis, acute gout, and more. Uses a consistent, logical, reader-friendly format with templated content and large-scale images for efficient visual reference. Features 14 completely new chapters covering biomedical and translational science, disease and outcome assessment, including new imaging modalities and early emerging disease, clinical therapeutics, and patient management and rehabilitation. Includes updated content on the latest diagnostic perspectives and approaches to therapy including tapering down of treatment, pulmonary hypertension and scleroderma, psoriatic arthritis, and the latest oral anticoagulants. Covers hot topics such as pathogenesis and pathophysiology of axial spondyloarthritis, DXA and measurement of bone, infectious arthritis, and more. Shares the knowledge and expertise of internationally recognized rheumatoid arthritis expert and new editor, Dr. Ellen Gravallese. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. |
| duke molecular physiology institute: Insights in Cardiovascular Epidemiology and Prevention: 2021 Lydia Bazzano, 2022-09-15 |
| duke molecular physiology institute: Nutritional Strategies to Promote Muscle Mass and Function Across Health Span Daniel Moore, Andrew Philp, 2020-12-10 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| duke molecular physiology institute: The Chiari Malformations R. Shane Tubbs, Mehmet Turgut, W. Jerry Oakes, 2020-06-09 This unique, contemporary book is the successor edition of a ground-breaking, authoritative title devoted to the pathology and treatment of chiari malformations. Since an abundance of research and development has occurred after the publication of the Chiari Malformations this updated title meets the market need for a reference that reflects such advances in the field. Chiari Malformations, 2nd Edition is divided into nine sections. Opening sections feature chapters on general aspects, diagnostic features and clinical presentation. These are followed by sections on differential diagnosis, treatment and prognosis. Finally, the book closes with an extensive discussion on research, related pathologies and patient resources. Expertly written chapters are supplemented with numerous high-quality illustrations and images to aid in visual learning. An impressive, nuanced successor, Chiari Malformations, 2nd Edition, is an invaluable resource for neuroscientists and clinicians at all levels, as well as graduate students to specific research scientists studying this region. |
| duke molecular physiology institute: Nutrition and Growth D. Turck, R. Shamir, B. Koletzko, M. Philip, 2020-01-28 Children’s growth is a common concern to all health care providers treating neonates, infants, toddlers, children, and adolescents. Defining the best nutrition for healthy and active children as well as for those who suffer from acute or chronic disease is relevant to the children, their care givers, and to health care providers. For this publication, an international group of experts in nutrition, metabolism, gastroenterology, endocrinology, and auxology have selected some of the most important manuscripts published between July 2018 and June 2019. Each paper is supplemented with editorial comments aiming to highlight the lessons that can be learnt. This book provides a significant contribution to the knowledge base and will help all subspecialties of health care providers dealing with the pediatric age group to get updated on some of the key issues in the interaction between nutrition and growth. |
| duke molecular physiology institute: The Science of Effective Mentorship in STEMM National Academies of Sciences, Engineering, and Medicine, Policy and Global Affairs, Board on Higher Education and Workforce, Committee on Effective Mentoring in STEMM, 2019-12-24 Mentorship is a catalyst capable of unleashing one's potential for discovery, curiosity, and participation in STEMM and subsequently improving the training environment in which that STEMM potential is fostered. Mentoring relationships provide developmental spaces in which students' STEMM skills are honed and pathways into STEMM fields can be discovered. Because mentorship can be so influential in shaping the future STEMM workforce, its occurrence should not be left to chance or idiosyncratic implementation. There is a gap between what we know about effective mentoring and how it is practiced in higher education. The Science of Effective Mentorship in STEMM studies mentoring programs and practices at the undergraduate and graduate levels. It explores the importance of mentorship, the science of mentoring relationships, mentorship of underrepresented students in STEMM, mentorship structures and behaviors, and institutional cultures that support mentorship. This report and its complementary interactive guide present insights on effective programs and practices that can be adopted and adapted by institutions, departments, and individual faculty members. |
| duke molecular physiology institute: Pediatric Obesity Michael S. Freemark, 2018-01-05 This second edition of Freemark’s text embodies all of the strengths of the original work but is deeper and broader in scope, with new chapters on emerging themes including metabolomics, genomics, and the roles of gastrointestinal hormones, the microbiome, brown adipose tissue, and endocrine disruptors in the pathogenesis of childhood obesity. Reviews of the effects of weight excess on cognitive performance and immune function complement detailed analyses of the biochemical and molecular pathways controlling the development of childhood adiposity and metabolic disease. Critical assessments of nutritional interventions (including new chapters on infant feeding practices and vegetarian diets) and superb reviews of behavioral counseling, pharmacotherapy, and bariatric surgery provide practical guidance for the management of overweight children. Penetrating analyses of the obesity epidemic in its social, cultural, economic, and political contexts highlight challenges and opportunities for obesity prevention and community action. The perspective is international in scope and reflects the expertise and experience of many of the leading figures in the field. Comprehensive and up-to-date, this new edition of Pediatric Obesity: Etiology, Pathogenesis and Treatment will be an invaluable guide for all healthcare providers and policy makers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic. |
| duke molecular physiology institute: A Life Everlasting Sarah Gray, 2016-09-27 A donor mother’s powerful memoir of grief and rebirth that is also a fascinating medical science whodunit, taking us inside the world of organ, eye, tissue, and blood donation and cutting-edge scientific research. When Sarah Gray received the devastating news that her unborn son Thomas was diagnosed with anencephaly, a terminal condition, she decided she wanted his death—and life—to have meaning. In the weeks before she gave birth to her twin sons in 2010, she arranged to donate Thomas’s organs. Due to his low birth weight, they would go to research rather than transplant. As transplant donors have the opportunity to meet recipients, Sarah wanted to know how Thomas's donation would be used. That curiosity fueled a scientific odyssey that leads Sarah to some of the most prestigious scientific facilities in the country, including Harvard, Duke, and the University of Pennsylvania. Pulling back the curtain of protocol and confidentiality, she introduces the researchers who received Thomas’s donations, held his liver in their hands, studied his cells under the microscope. Sarah’s journey to find solace and understanding takes her beyond her son’s donations—offering a breathtaking overview of the world of medical research and the valiant scientists on the horizon of discovery. She goes behind the scenes at organ procurement organizations, introducing skilled technicians for whom death means saving lives, empathetic counselors, and the brilliant minds who are finding surprising and inventive ways to treat and cure disease through these donations. She also shares the moving stories of other donor families. A Life Everlasting is an unforgettable testament to hope, a tribute to life and discovery, and a portrait of unsung heroes pushing the boundaries of medical science for the benefit of all humanity. |
| duke molecular physiology institute: Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Care Services, 2021-01-15 As part of the overall disability determination process, the Social Security Administration uses a step-by-step approach to understand how severe an individual's condition is and whether it meets program criteria for disability. The use of various types of biomarkers has been suggested as a way to strengthen the amount and quality of objective evidence available to the review process. At the request of the Social Security Administration, the National Academies of Sciences, Engineering, and Medicine's Board on Health Care Services organized a virtual workshop on July 21, 2020, titled The State of the Science of the Use of Biomarkers to Establish the Presence and Severity of Impairments. Workshop discussions focused on the current and potential uses for biomarkers; explored legal and ethical implications associated with biomarker use in clinical decision making; and considered the possible uses of nongenetic biomarkers as tools for the diagnosis or prognosis of the severity of specific physical and mental impairments. This publication summarizes the presentations and discussion of the workshop. |
| duke molecular physiology institute: Physiology and Pathology of Chloride Transporters and Channels in the Nervous System F. Javier Alvarez-Leefmans, Eric Delpire, 2009-08-22 The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field |
| duke molecular physiology institute: Principles of Molecular Regulation P. Michael Conn, Anthony R. Means, 2000-07-28 With the dramatic growth in our knowledge of hormone action and the mechanisms of cell regulation, the need for an up-to-date broad-ranging survey of these processes has become pressing. In Principles of Molecular Regulation, P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear receptor-initiated gene regulation. Chosen for the excellence of their research as well as their demonstrated writing skills, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. They also discuss the molecular regulation of cell proliferation and death, as well as the impact of new technologies on rational drug discovery. Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today. |
| duke molecular physiology institute: Exercise Immunology James Turner, Guillaume Spielmann, John Campbell, 2024-10-24 Exercise immunology is a discipline at the nexus of exercise physiology and immunology that aims to characterise the effects of exercise on the immune system in health and disease. This new edition of Exercise Immunology begins by providing an evidence‐based introduction to the effects that individual bouts of exercise and exercise training have on the characteristics and functioning of the immune system. In addition to introducing the immune system and summarising how different forms of exercise affect the characteristics and functioning of the immune system, this new and fully revised edition will explore exercise immunology in the context of immune ageing, cancer, autoimmune diseases and cardiometabolic disease. In addition, the authors discuss other factors that impact immune health, such as nutrition and environmental stressors, and explain the physiological basis of how exercise changes immune function across the healthspan and lifespan. This book is written by leading exercise immunologists and is structured to provide a suggested curriculum of an exercise immunology degree component. Every chapter includes summaries of current and up‐to‐date research and offers practical guidelines to translate laboratory‐based information into clinical settings. This textbook is essential for any exercise immunology degree component or advanced exercise physiology degree and will be vital reading for students in exercise and biological sciences and clinicians and researchers interested in the therapeutic applications of exercise. |
| duke molecular physiology institute: Molecular Mechanisms of Proteinuria, Volume II Ilse Sofia Daehn, 2022-11-16 |
| duke molecular physiology institute: Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes Jonathan Peter Little, Kristian Karstoft, Adeel Safdar, 2018-06-26 This eBook contains a collection of peer-reviewed original and review articles published in either Frontiers in Endocrinology or Frontiers in Physiology focused on the research topic Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes. |
| duke molecular physiology institute: Epigenetics Methods Trygve O Tollefsbol, 2020-07-08 In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. - Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application - Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods - Written at verbal and technical levels that can be understood by scientists and students alike - Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics |
| duke molecular physiology institute: The Olfactory System Bradley J. Goldstein, Hiroaki Matsunami, 2023 This volume discusses the latest approaches used to investigate molecular biology and physiology in the peripheral and central olfactory system. Understanding both normal function and pathobiology provides readers with insight into understanding human olfactory disorders. The chapters in this book cover topics such as techniques for manipulating and measuring olfactory cilia function; approaches for investigating spatial RNA expression in olfactory mucosa; the use of chromatin immunoprecipitation with olfactory neurons; in vivo methods to label and identify activated olfactory neurons; defining organization in the olfactory bulbs and cortex; and the use of optical recording in the mouse olfactory bulb for acute or chronic experiments. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, The Olfactory System: Methods and Protocols is a valuable resource for all researchers who are interested in learning more about this important and developing field. |
| duke molecular physiology institute: Werner & Ingbar's The Thyroid Lewis E. Braverman, 2020-04-21 Through ten outstanding editions, Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text has been the go-to reference for the most comprehensive coverage of the thyroid, including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Now in full color throughout, the 11th Edition of this award-winning text remains the clinician’s preferred source of authoritative information on the thyroid—an essential resource for all endocrinologists and thyroid surgeons. |
| duke molecular physiology institute: Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions Lluis Fajas, Albert Giralt, 2018-04-27 Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer. |
| duke molecular physiology institute: Molecular Mechanisms of Neural Development and Insights into Disease , 2021-03-09 Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series |
常春藤、25所新常春藤、公立常春藤都是哪些学校？ - 知乎
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭 …
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Apr 17, 2025 · 知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌 …
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北卡罗莱纳州（North Carolina）在美国是怎样的存在…
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常春藤、25所新常春藤、公立常春藤都是哪些学校？ - 知乎
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和 …
能否介绍一下数学界的期刊？ - 知乎
T1: Duke Math, Annales Sci l'ENS, JEMS, CPAM, GAFA T2: JMPA, Proc London, AMJ, TAMS, Math Ann, Crelle Journal, …
英伟达 RTX 5060 Ti 正式开售，国行售价 3199 元起，这代 60Ti 值 …
Apr 17, 2025 · 知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享 …
如何合理的检索外文参考文献的出版地和出版商？ - 知乎
我的毕业论文参考文献中有大量的[sl]和[sn]标志,前者是表示出版地未知，后者是表示出版商未知，我需要高…
北卡罗莱纳州（North Carolina）在美国是怎样的存在…
北卡大学质量在美国名列前茅，杜克大学排名第8，Wake第27，UNC-CH第30，Davidson在Liberal Arts College …
