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Alternative Therapies for Multiple Myeloma: A Comprehensive Analysis
Author: Dr. Evelyn Reed, MD, PhD, Oncology Specialist with 20 years of experience in hematology and oncology, specializing in multiple myeloma treatment and research. Dr. Reed holds a secondary certification in Integrative Oncology and has conducted extensive research on the efficacy and safety of complementary and alternative medicine (CAM) therapies in conjunction with conventional treatments for multiple myeloma.
Keywords: alternative therapies for multiple myeloma, complementary medicine for multiple myeloma, integrative oncology, multiple myeloma treatment, CAM therapies, multiple myeloma alternative treatments, holistic approaches to multiple myeloma
Abstract: This article provides a detailed analysis of alternative therapies for multiple myeloma, tracing their historical context and exploring their current relevance in the broader spectrum of multiple myeloma management. While conventional treatments remain the cornerstone of multiple myeloma therapy, the increasing interest in integrative approaches necessitates a critical examination of the evidence supporting the use of alternative therapies. This review analyzes the potential benefits, risks, and limitations of various complementary and alternative medicine (CAM) modalities, emphasizing the importance of evidence-based practices and patient-centered care.
1. Historical Context of Alternative Therapies for Multiple Myeloma
The historical context of alternative therapies for multiple myeloma is deeply intertwined with the limitations of conventional treatments throughout much of the 20th century. Before the advent of highly effective chemotherapies, autologous stem cell transplantation, and targeted therapies, many patients with multiple myeloma sought relief through various alternative approaches, often driven by a lack of effective conventional options and a desire for improved quality of life. These early approaches often included herbal remedies, dietary modifications, and mind-body techniques, reflecting a broader cultural shift towards natural and holistic healing practices. However, a lack of rigorous scientific investigation meant that the effectiveness of these methods remained largely anecdotal.
2. Current Relevance of Alternative Therapies for Multiple Myeloma
Today, the landscape of multiple myeloma treatment has dramatically shifted. Conventional therapies, such as proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, have significantly improved survival rates and quality of life for many patients. However, these treatments are often associated with significant side effects, including fatigue, neuropathy, and immunosuppression. This has led to renewed interest in alternative therapies for multiple myeloma, not as replacements for conventional treatments but as complementary strategies to manage symptoms, enhance quality of life, and potentially support the effectiveness of standard care.
3. Types of Alternative Therapies and Their Evidence Base
Several alternative therapies are being explored for their potential role in managing multiple myeloma and its associated symptoms. These include:
Dietary modifications: Specific diets, like the anti-inflammatory diet or those emphasizing antioxidant-rich foods, are often suggested to reduce inflammation and support the immune system. While some evidence suggests a potential benefit, more robust clinical trials are needed to establish definitive efficacy.
Nutritional supplements: Various supplements, such as Vitamin D, curcumin, and omega-3 fatty acids, are touted for their potential anti-cancer properties. However, the evidence supporting their efficacy in multiple myeloma is limited and often based on preclinical studies rather than large-scale clinical trials.
Herbal remedies: Traditional herbal medicines have been used for centuries to treat various ailments. However, the scientific evidence supporting the use of specific herbal remedies for multiple myeloma is scarce, and many lack rigorous safety testing.
Mind-body therapies: Techniques such as yoga, meditation, and acupuncture may help manage stress, improve sleep, and reduce pain and fatigue—common symptoms experienced by multiple myeloma patients. While these therapies demonstrate benefits for symptom management in various conditions, their specific effectiveness in multiple myeloma needs further investigation.
Acupuncture: While anecdotal evidence suggests potential benefits for pain management, large-scale clinical trials are lacking.
It is crucial to note that the evidence supporting the efficacy of many alternative therapies for multiple myeloma is often limited to preclinical studies or small, observational studies. Large, randomized controlled trials are needed to provide conclusive evidence on their effectiveness and safety.
4. Risks and Considerations
It is essential to approach alternative therapies for multiple myeloma with caution. Some remedies may interact negatively with conventional treatments, leading to reduced efficacy or increased side effects. Furthermore, some purported treatments lack rigorous safety testing and may contain harmful substances. Patients should always discuss any alternative therapies with their oncologist before starting them to ensure safety and avoid potential conflicts with their standard treatment plan. The use of unproven therapies can delay or hinder effective conventional treatment.
5. Integrative Oncology and the Future of Multiple Myeloma Treatment
Integrative oncology represents a holistic approach to cancer care that combines conventional treatments with complementary therapies to optimize patient outcomes. This approach emphasizes a patient-centered care model that considers the physical, emotional, and spiritual needs of the individual. While alternative therapies may not cure multiple myeloma, they can play a valuable role in improving quality of life and managing symptoms.
6. Conclusion
Alternative therapies for multiple myeloma warrant careful consideration. While they hold promise for improving quality of life and potentially supporting conventional treatments, the current evidence base remains limited. Patients should always consult with their oncologist before incorporating any alternative therapies into their treatment plan to ensure safety and avoid potential interactions with standard medications. Further research is essential to rigorously evaluate the effectiveness and safety of various complementary and alternative therapies in multiple myeloma. A collaborative approach, integrating conventional and evidence-based complementary therapies within an integrative oncology framework, offers the most promising pathway for improving the overall management and outcomes for individuals living with multiple myeloma.
FAQs
1. Can alternative therapies cure multiple myeloma? No, currently there are no alternative therapies that can cure multiple myeloma. Conventional treatments remain the primary approach to treating this cancer.
2. Are alternative therapies safe for multiple myeloma patients? The safety of alternative therapies varies greatly. Some may have interactions with conventional treatments, while others may have unknown side effects. Always consult an oncologist before starting any alternative therapy.
3. Can I use alternative therapies alongside my conventional multiple myeloma treatment? This decision needs to be made in collaboration with your oncologist. Some alternative therapies might be safe to use alongside conventional treatments, while others could interfere with them.
4. What are the potential benefits of alternative therapies for multiple myeloma? Potential benefits include improved symptom management (e.g., reduced pain, fatigue, nausea), enhanced quality of life, and potentially improved immune function. However, scientific evidence supporting these benefits remains limited for many therapies.
5. Where can I find reliable information about alternative therapies for multiple myeloma? Reliable information comes from peer-reviewed medical journals, reputable medical organizations (e.g., National Cancer Institute), and discussions with your oncologist.
6. Are there any costs associated with alternative therapies? Yes, many alternative therapies can be expensive and may not be covered by insurance.
7. What if my alternative therapy doesn't work? If an alternative therapy is not providing the desired benefits or is causing adverse effects, it should be discontinued, and the situation discussed with your oncologist.
8. How do I choose an appropriate alternative therapy for multiple myeloma? The choice should be made in consultation with your oncologist, considering your individual needs, preferences, and medical history.
9. What are the ethical considerations surrounding the use of unproven alternative therapies? Patients should be fully informed about the lack of evidence and potential risks associated with using unproven therapies before making any decisions. It’s crucial to avoid false hope and prioritize evidence-based treatments.
Related Articles
1. "The Role of Diet in Multiple Myeloma Management": This article explores the impact of dietary interventions on multiple myeloma symptoms and progression, reviewing the evidence for specific dietary recommendations.
2. "Mindfulness Meditation and Quality of Life in Multiple Myeloma Patients": This article investigates the effects of mindfulness meditation on stress levels, anxiety, and overall quality of life in patients undergoing multiple myeloma treatment.
3. "The Use of Acupuncture for Pain Management in Multiple Myeloma": This article reviews clinical studies on the use of acupuncture to manage pain associated with multiple myeloma and its treatments.
4. "Herbal Remedies and Multiple Myeloma: A Critical Review of the Evidence": This article critically analyzes the scientific literature on the use of herbal remedies in multiple myeloma, highlighting both potential benefits and risks.
5. "Nutritional Supplementation in Multiple Myeloma: A Comprehensive Guide": This article provides a comprehensive overview of different nutritional supplements and their potential role in managing multiple myeloma and its associated complications.
6. "Integrative Oncology Approaches for Multiple Myeloma: A Patient-Centered Perspective": This article explores the principles of integrative oncology and its application in managing multiple myeloma, emphasizing a holistic approach to patient care.
7. "Yoga and its Impact on Fatigue and Physical Function in Multiple Myeloma Patients": This article reviews the benefits of yoga for improving physical function and reducing fatigue in multiple myeloma patients.
8. "The Safety and Efficacy of Curcumin in Multiple Myeloma: A Systematic Review": This article provides a systematic review of the available evidence regarding the use of curcumin, a compound found in turmeric, in the treatment of multiple myeloma.
9. "Managing Side Effects of Multiple Myeloma Treatment with Complementary Therapies": This article focuses on the use of complementary therapies to manage common side effects associated with conventional multiple myeloma treatments, such as fatigue, neuropathy, and nausea.
Publisher: The National Cancer Institute (NCI) – A highly reputable and authoritative source for cancer-related information, providing evidence-based resources and guidelines for healthcare professionals and the public.
Editor: Dr. Sarah Jones, MD – A board-certified hematologist-oncologist with extensive experience in clinical trials and research related to multiple myeloma and integrative oncology.
| alternative therapies for multiple myeloma: Multiple Myeloma Morie A. Gertz, S. Vincent Rajkumar, 2013-10-01 This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment. |
| alternative therapies for multiple myeloma: Multiple Myeloma - A New Era of Treatment Strategies Klaus Podar, Kenneth C. Anderson, 2012-01-03 Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced |
| alternative therapies for multiple myeloma: You Can Conquer Cancer Ian Gawler, 2015-02-05 This edition originally published: South Yarra, Vic.: Michelle Anderson Publishing, 2013. |
| alternative therapies for multiple myeloma: Multiple Myeloma's Natural Calcium Cure Nomar Myeloma, 2019-12-06 You have likely heard from numerous medical professionals that Myeloma is treatable but not curable right? WRONG! Banish that thought from your mind now as it is completely and utterly False! I know Multiple Myeloma can be cured because I have witnessed it firsthand and if you want to understand how it can be cured look no further than this book . In addition to revealing a number of sources where you can purchase the most effective calcium supplements that the authors close family member used to heal themselves from a level III diagnosis to stringent complete response or total remission of Myeloma. |
| alternative therapies for multiple myeloma: Update on Multiple Myeloma Khalid Ahmed Al-Anazi, 2019 This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries. |
| alternative therapies for multiple myeloma: Proteasome Inhibitors in Cancer Therapy Julian Adams, 2004-05-25 A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma. |
| alternative therapies for multiple myeloma: PDQ Integrative Oncology Barrie R. Cassileth, 2005 Accompanying CD-ROM contains ... complete text and illustrations of the book, in fully searchable PDF format. |
| alternative therapies for multiple myeloma: Myeloma Bone Disease G. David Roodman, 2010-04-28 This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies. |
| alternative therapies for multiple myeloma: The Saint-Chopra Guide to Inpatient Medicine Sanjay Saint, Vineet Chopra, 2018 Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010. |
| alternative therapies for multiple myeloma: Cancer Gary S. Stein, Kimberly P. Luebbers, 2019-07-09 A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional patient centric topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations. |
| alternative therapies for multiple myeloma: The Drug Development Paradigm in Oncology National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Care Services, National Cancer Policy Forum, 2018-02-12 Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop. |
| alternative therapies for multiple myeloma: Antineoplastons Burzynski Research Institute, 1988 |
| alternative therapies for multiple myeloma: Living Proof Michael Gearin-Tosh, 2010-05-11 I was told I had cancer and that I must expect to die soon. Almost eight years later I still do my job and enjoy life. I have not had conventional treatment. Did my cancer simply disappear? Did I do nothing? Far from it. A number of things happened, some by accident, most by design. Michael Gearin-Tosh is diagnosed with cancer at the age of fifty-four. The doctors urge immediate treatment. He refuses. Intuitively, not on the basis of reason. But as the days pass, Gearin-Tosh falls back on his habits as a scholar of literature. He begins to probe the experts' words and the meaning behind medical phrases. He tries to relate what each doctor says -- and does not say -- to the doctor's own temperament. And the more questions he asks, the more adamant his refusal to be hurried to treatment. The delay is a high-risk gamble. He listens to much advice, especially that of three women friends, each with a different point of view, one a doctor. They challenge him. They challenge medical advice. They challenge one another. On no occasion do they speak with one voice. He also turns to unexpected guides within his own memory and in the authors he loves, from Shakespeare and Chekhov to Jean Renoir, Arthur Miller, and Václav Havel. In the end, he chooses not to have chemotherapy but to combat his cancer largely through nutrition, vitamin supplements, an ancient Chinese breathing exercise with imaginative visualizations, and acupuncture. No how-to book or prescriptive health guide, Living Proof is a celebration of human existence and friendship, a story of how a man steers through conflicting advice, between depression and seemingly inescapable rationalism, between the medicine he rejects and the doctors he honors. Clear-eyed and unflinching, Gearin-Tosh even includes his own medical history, The Case of the .005% Survivor; explores general questions about cancer; and examines the role of individual temperament on medical attitudes, the choice of treatments, and, of course, survival. |
| alternative therapies for multiple myeloma: Alternative and Complementary Therapies for Cancer Moulay Alaoui-Jamali, 2010-09-02 Cancer is a common disease with a devastating impact on the physical and psychological well being of patients. The diagnosis of cancer brings upon many clinical challenges and questions for which clear and simple answers are not always provided by modern medicine. To date, only limited therapeutic options are available for patients with advanced cancer. The recent shift toward targeted therapies has improved substantially patient’s survival, however, relapses are frequent and cure remains rare. This led patients and many health care managers to shift attention to the holistic approach of traditional medicine particularly preparations from herbal products to manage and alleviate the disease. Typically, herbal preparations contain single or multiple plant ingredients, including a number of potential active components. Yet, they remain classified as food supplements and thus are exempt from regulations on quality control and proof of efficacy that govern standard pharmaceuticals. Clinical evidence for many preparations is often based on non-documented or anecdotal evidence. In consequence, several preparations with unproven efficacy are circulating in the market with the fear of interference with standard cancer therapies and/or severe toxicity that some can generate, in addition to the unjustified economical burden to patients. Despite inconsistent and conflicting clinical results single molecules have been isolated from herbal preparations and many are exploited to develop potential novel agents. This has fostered the need to organize a set of timely, in-depth and up-to-date review covering the latest developments in alternative cancer management from a scientific and clinical perspective dedicated to the medical community and health care providers, as well as to patients and their families. This book brings the latest comprehensive cancer information and practical recommendations on the best documented practice of alternative therapies for cancer management put together by recognized experts in the fields of medical oncology, traditional medicine, and cancer pharmacology. It goes hand-in-hand with the patient’s medical treatment options, quality of life issues, and more. The book is organized into four major sections: The first is an overview of the cancer syndrome by renowned medical oncologists from the USA and Europe. The second is a comprehensive description of traditional medicine by renowned experts from China and Germany. The third is an overview on the pharmacological impact of herb-based formulations on standard chemotherapy agents used in clinical practice. The fourth is a survey of cases reports from several hospitals with approved practice of alternative medicine. The book will feature simple definitions and essential information grouped in both medical and lay-term terminology, and straightforward illustrations related to human physiology, disease definition, scientific data on know and potential mechanisms of action, and preventive approaches. Finally, the book will feature collaboration of experts from China, India, USA, Canada, Germany, France, and other centres with recognized expertise in alternative/traditional medicine. This international cooperation is crucial to cover the complex topic of alternative therapies for cancer. |
| alternative therapies for multiple myeloma: Radical Remission Kelly A. Turner, PhD, 2014-03-18 In her New York Times bestseller, Radical Remission: Surviving Cancer Against All Odds, Dr. Kelly A. Turner, founder of the Radical Remission Project, uncovers nine factors that can lead to a spontaneous remission from cancer—even after conventional medicine has failed. While getting her Ph.D. at the University of California, Berkley, Dr. Turner, a researcher, lecturer, and counselor in integrative oncology, was shocked to discover that no one was studying episodes of radical (or unexpected) remission—when people recover against all odds without the help of conventional medicine, or after conventional medicine has failed. She was so fascinated by this kind of remission that she embarked on a ten month trip around the world, traveling to ten different countries to interview fifty holistic healers and twenty radical remission cancer survivors about their healing practices and techniques. Her research continued by interviewing over 100 Radical Remission survivors and studying over 1000 of these cases. Her evidence presents nine common themes that she believes may help even terminal patients turn their lives around. |
| alternative therapies for multiple myeloma: The Gerson Therapy Charlotte Gerson, Morton Walker, 2001 Offers a nutritional program that utilizes the healing powers of organic fruits and vegetables to reverse the effects of cancer and other illnesses. |
| alternative therapies for multiple myeloma: Multiple Myeloma and Other Plasma Cell Neoplasms Meletios A. Dimopoulos, Thierry Facon, Evangelos Terpos, 2018-02-16 This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management. |
| alternative therapies for multiple myeloma: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues World Health Organization, 2001 This is the third volume in the new World Health Organization series on histological and genetic typing of tumours. Tumours of the haematopoietic and lymphoid tissues are covered. This was a collaborative project of the European Association for Haematolpathology and the Society for Haematopathology and others. The WHO classification is based on the principles defined in the Revised European-American Classification of Lymphoid Neoplasms (REAL) classification. Over 50 pathologists from around the world were involved in the project and proponents of all major lymphoma and leukaemia classifications have agreed to accept the WHO as the standard classification of haematological malignancies. So this classification represents the first true world wide concensus of haematologic malignancies. Colour photographs, magnetic resonance and ultrasound images and CT scans are included. |
| alternative therapies for multiple myeloma: Multiple Myeloma and Related Disorders Henry A. Azar, Michael Potter, 1973 |
| alternative therapies for multiple myeloma: Measuring Health Ian McDowell, 2006-03-09 Worldwide economic constraints on health care systems have highlighted the importance of evidence-based medicine and evidence-based health policy. The resulting clinical trials and health services research studies require instruments to monitor the outcomes of care and the output of the health system. However, the over-abundance of competing measurement scales can make choosing a measure difficult at best. Measuring Health provides in-depth reviews of over 100 of the leading health measurement tools and serves as a guide for choosing among them.LNow in its third edition, this book provides a critical overview of the field of health measurement, with a technical introduction and discussion of the history and future directions for the field. This latest edition updates the information on each of the measures previously reviewed, and includes a complete new chapter on anxiety measurement to accompany the one on depression. It has also added new instruments to those previously reviewed in each of the chapters in the book.LChapters cover measurements of physical disability, social health, psychological well-being, anxiety, depression, mental status testing, pain, general health status and quality of life. Each chapter presents a tabular comparison of the quality of the instruments reviewed, followed by a detailed description of each method, covering its purpose and conceptual basis, its reliability and validity and, where possible, shows a copy of the actual scale. To ensure accuracy of the information, each review has been approved by the original author of each instrument or by an acknowledged expert. |
| alternative therapies for multiple myeloma: Harty's Endodontics in Clinical Practice E-Book Bun San Chong, 2016-07-28 This book is a guide to proven, current clinical endodontic practice. It is designed, primarily, with the undergraduate readership in mind but is also suitable for anyone pursuing specialist training, including extended skills in endodontics, and general dental practitioners undertaking CPD, or wishing to keep up-to-date. The seventh edition is available with an online question bank containing MCQs and Clinical Cases. - Practical approach to the subject, taking the reader through every step of endodontic practice from its scientific basis to patient assessment and through to clinical techniques - Helpful pedagogic features – including Learning Outcomes and Summary Boxes – help reinforce learning - International experts and contributors help ensure good coverage and currency of information - Explores areas of debate when they exist to reflect differing approaches to treatment intervention - Explains the potential impact of systemic conditions and disorders, as well as medications, on endodontic treatment planning and management - Discusses the diagnosis of orofacial pain and the appropriate use of antibiotics and analgesics - Explores the maintenance of pulp vitality and the prevention of apical periodontitis in the context of operative dentistry - Provides an overview of instruments and devices used during endodontic treatment - Describes the fundamental principles of canal filling using gutta-percha, as well as the use of alternative materials, and newer root filling techniques - Discusses the management of dental trauma with emphasis on accurate diagnosis, timely and appropriate treatment, and follow-up - Explores the interface between endodontic-periodontal disease in the context of diagnosis, treatment and prognostic assessment - Discusses common challenges such as inadequate pain control and problems with preparation and filling of the root canal system - Written at a level which is ideal for dental students, general dental practitioners and those pursuing specialist training or seeking to keep up-to-date - Comes with access to an online question bank containing a wide range of MCQs and Clinical Cases to help reinforce learning! - Richly illustrated with over 80 colour artworks – many created by the Gray's Anatomy illustration team – and 350 photographs, many of which are previously unpublished - Explores advances in our understanding of the role of microorganisms in the pathogenesis of pulpal and periradicular diseases and the role of host defence response against root canal infection - Explores the use of newer imaging techniques such as three-dimensional tomography in determining pulp space anatomy and in treatment planning - Explains recent advances in material technology, molecular biology and regenerative medicine in the management of deep caries and maintenance of pulp vitality - Explores the effective use of existing and newer chemomechanical preparation techniques and intracanal medication for thorough root canal system decontamination - Explores advances in the techniques available for restoring endodontically treated teeth |
| alternative therapies for multiple myeloma: Practical Management of Complex Cancer Pain Manohar Sharma, Karen Simpson, Sanjeeva Gupta, Michael Bennett, 2014-02 Practical Management of Complex Cancer Pain provides practical advice on advanced pain management techniques for cancer pain. Comprehensive case histories give readers insight into the treatment of pain management. |
| alternative therapies for multiple myeloma: Clinical Oncology Martin D. Abeloff, 2000 A must-have reference, this new edition provides practical information on treatment guidelines, details of diagnosis and therapy, and personal recommendations on patient management from experts in the field. Consistently formatted chapters allow for a user-friendly presentation for quick access of key information by the practicing clinician. Completely updated, this new edition includes all of the latest developments in treatment strategies of medical, surgical and radiation oncologists. |
| alternative therapies for multiple myeloma: CDC Yellow Book 2018: Health Information for International Travel Centers for Disease Control and Prevention CDC, 2017-04-17 THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad. |
| alternative therapies for multiple myeloma: Cancer and Society Eric H. Bernicker, 2019-03-04 While a number of books have looked at the intersection between human health in general and other topics, such as climate change or diet, this book focuses specifically on cancer as it impacts and is impacted by social justice issues. The massive explosion of research knowledge of cancer immunology and genomics is holding out great promise of therapeutic advances, yet other human actions—climate change, pollution, business decisions, advertising – are fostering health inequalities as well as increasing risks. Those involved in cancer care and research are in a unique position to let their experiences and knowledge inform the public, yet very often have not taken strong public roles when it comes to discussing issues surrounding tobacco, climate change and health risks, financial toxicity of treatments, and diet choices. Written by a multidisciplinary team of authors and for medical oncologists, cancer researchers, occupational health workers, and related medical students, residents, and fellows, this book encourages oncologists to address public health care and the societal issues associated with cancer risk. This volume discusses the overarching theme of environmental justice and oncology, focuses on business and cancer (such as clinical trials, drug development and profits, and global disparities), as well as animals and cancer. |
| alternative therapies for multiple myeloma: Multiple Myeloma Thomas Moehler, Hartmut Goldschmidt, 2011-04-21 Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life. |
| alternative therapies for multiple myeloma: Complementary, Natural and Alternative Therapies for Breast Cancer Treatments - It's Your Life, Live It! , |
| alternative therapies for multiple myeloma: Network Pharmacology Shao Li, 2021-09-29 This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of network target for the first time, which has become the core theory of network pharmacology. The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases. |
| alternative therapies for multiple myeloma: Multiple Myeloma Roman Hajek, 2013-04-10 This book does not provide a comprehensive overview of Multiple Myeloma but a collection of chapters with in-depth information of distinct hot topics in the diagnostic, research and therapeutic fields. The dynamics of testing new drugs for multiple myeloma treatment in clinical trials is breathtaking. Scientific discoveries have uncovered complicated pathogenesis of multiple myeloma; complicated reactions to treatment lead to the creation of super cocktails. Curability of multiple myeloma is a question that is being discussed by the entire professional myeloma world. Improvement of prognosis is a fact which is most important from a patient's perspective. We believe that this book could be of interest to medical professionals specializing in hematooncology, researchers, as well as many others. |
| alternative therapies for multiple myeloma: Consumer's Guide to Dietary Supplements and Alternative Medicines W. Marvin Davis, 2006-09-26 Learn the benefits—and hazards—of certain dietary supplements The term “dietary supplement” can include vitamins, minerals, herbal, and botanical products. Consumers freely use supplements for the promoted claims of benefits, but often without consideration of the potential risks. The Consumer's Guide to Dietary Supplements and Alternative Medicines is a critical, balanced look at the different classes of supplement products and whether many claims of benefits are true or simply product hype. Respected supplement authority Dr. W. Marvin Davis exposes what is truth, what is fiction, and what is not known for many supplements you may be taking. If you take dietary supplements—or even think about taking them—this book clears the mystery behind the product claims. The term “dietary supplement” can include vitamins, minerals, herbal, and botanical products. Consumers freely use supplements for the promoted claims of benefits, but often without consideration of the potential risks. The Consumer's Guide to Dietary Supplements and Alternative Medicines is a critical, balanced look at the different classes of supplement products and whether many claims of benefits are true or simply product hype. This book, by respected supplement authority Dr. W. Marvin Davis, exposes what is truth, what is fiction, and what is not known for many supplements you may be taking. If you take dietary supplements—or even think about taking them—this book clears the mystery behind the product claims. The Consumer's Guide to Dietary Supplements and Alternative Medicines brings you the benefit of Dr. Davis's extensive knowledge about physicians, the pharmaceutical industry, and research in pharmacology and toxicology in order to shatter misconceptions about supplements and the supplement industry. The book's no-nonsense discussion about this much-hyped industry is even-handed and straightforward, and provides clear-headed advice every consumer of supplements needs. The guide explores various supplements' interactions with prescription drugs, the placebo effect as a factor for beneficial claims, historical instances of supplements that have proved hazardous to consumers, and receiving directions for supplement use from an unconventional medical/healthcare practitioner. It clearly explains the potentials of supplements through the use of illustrative clinical case studies from medical literature in simplified, easy to understand language. This extensive source is comprehensively referenced and includes tables of supplements with their possible benefits and hazards. The Consumer's Guide to Dietary Supplements and Alternative Medicines exposes the truth about: therapeutic fundamentals of supplements why there is strong resistance to supplements as unconventional remedies by physicians the pharmaceutical industry’s perspective on supplements six major myths about dietary supplements liver “support” remedies soy formulations cancer “cures” the “fountain of youth” actions of hormonal and antioxidant products vitamins, minerals, amino acids, and enzymes new biochemicals—such as alpha-lipoic acid and choline derivatives carotenoids, anthocyanins, and flavonoids aloe vera the unappreciated pharmacology of ascorbate historical instances in which consumers have avoided catastrophe the future of the supplement field much, much more! The Consumer's Guide to Dietary Supplements and Alternative Medicines may be the best available resource of important information for every concerned, health-conscious consumer considering dietary supplements of any kind. |
| alternative therapies for multiple myeloma: N of 1 Glenn Sabin, Dawn Lemanne Md Mph, 2016-12-27 Twenty-five years ago my doctors had no cure for my cancer. So I went on a quest to find my own treatment. This is my story... Glenn Sabin was diagnosed with incurable leukemia (CLL). He embarked on a journey researching lifestyle changes, and conducted a personal experiment, chronicled through Harvard, now part of the medical literature. |
| alternative therapies for multiple myeloma: Ferri's Clinical Advisor 2020 E-Book Fred F. Ferri, 2019-06-01 Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri's Clinical Advisor 2020 features the popular 5 books in 1 format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today's medical practice. - Contains significant updates throughout, covering all aspects of current diagnosis and treatment. - Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. - Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. - Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. - Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients. |
| alternative therapies for multiple myeloma: Allogeneic Stem Cell Transplantation Hillard M. Lazarus, Mary J. Laughlin, 2010-03-02 Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation. |
| alternative therapies for multiple myeloma: Alternatives in Cancer Therapy Ross Pelton, 2009-09-29 Alternatives in Cancer Therapy offers help for all patients coping with cancer. The therapies discussed in this book are primarily non-toxic, have few, if any, side effects, and tend to strengthen the immune system. They can be used as supplemental regimens that help maximize the effectiveness of traditional therapies such as surgery, radiation, and chemotherapy. Patients have a right to know all of their treatment options, and Dr. Ross Pelton presents dozens of choices, including: * Shark Cartilage * Gerson Therapy * Mistletoe * Isoprinosine * Laetrile * Selenium * Beta-Carotene * Hydrogen Peroxide * Vitamins C and E * The Hoxsey Treatment Non-traditional therapies can enhance the quality of life, and improve overall health while treating the disease. Alternatives in Cancer Therapy provides information on the research, efficacy, potential side effects, and availability of each treatment. |
| alternative therapies for multiple myeloma: Bone Marrow Environment Marion Espéli, Karl Balabanian, 2021-06-01 This volume brings together classical and cutting-edge protocols on the spatio-temporal study of the cellular subsets constituting the bone and the marrow in both mouse and human. Chapters details methods on bone marrow (BM) ecosystem, to label, sort, analyse, and culture specific cell subsets as well as techniques allowing the evaluation of the function of some of the cellular elements of the BM. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bone Marrow Environment: Methods and Protocols aims to help new investigators to pursue the characterization of the BM microenvironment in the coming years. |
| alternative therapies for multiple myeloma: Alternative Medicine, Second Edition Larry Trivieri, John W. Anderson, 2013-03-27 The Bible of Alternative Medicine Learn the health secrets that millions of readers have discovered in the book that is revolutionizing health care in the United States. Alternative Medicine: The Definitive Guide is packed with lifesaving information and alternative treatments from 400 of the world's leading alternative physicians. Our contributors (M.D.s, Ph.D.s, Naturopaths, Doctors of Oriental Medicine, and Osteopaths) offer the safest, most affordable, and most effective remedies for over 200 serious health conditions, from cancer to obesity, heart disease to PMS. This guide is easy enough to understand to make it perfect for home reference, while it would also make a fine resource for health care providers interested in learning more about alternative medicine. • 70% of Americans currently use some form of alternative medicine • This 1,136-page encyclopedia puts all the schools of alternative medicine-50 different therapies-under one roof • Highlights dozens of actual patient stories and physician treatments. |
| alternative therapies for multiple myeloma: Multiple Myeloma Joseph D. Tariman, 2010 Covers the meaning of multiple myeloma as well as a history of the disease, including nursing contributions to myeloma care, basic anatomy and physiology, the role genetics plays in patients with this disease, incidence rates and risk factors related to multiple myeloma. In addition, this new book details specific information on the patients that you treat. You can find out how best to make an assessment of a patient with multiple myeleoma, including staging, diagnostic testing and procedures, and making a prognosis on a patient s future health. You can also access information on the treatment of newly diagnosed patients, both transplant-eligible and transplant-ineligible, as well as treatment on patients who have relapsed or who suffer from refractory multiple myeloma. You ll also gain specialized details on evaluating patients receiving high-dose chemotherapy with stem cell transplantation, and on managing and evaluating patients receiving novel agents. |
| alternative therapies for multiple myeloma: Introduction to Research Elizabeth DePoy, Laura N. Gitlin, 1998 INTRODUCTION TO RESEARCH provides the reader with a foundation from which to critique and understand research designs and their applications to healthcare and human service settings. It is divided into four parts: Introduction, Thinking Processes, Design Approaches, and Action Processes. The text reflects a new school of thought that recognizes and values multiple research strategies. This perspective proposes that naturalistic and experimental-type research strategies have equal value and contribute in complementary and distinct ways to a science of practice. Knowledge of these different research traditions presents new opportunities for addressing the complex health-related research questions that are emerging in today's health and human service environments. |
| alternative therapies for multiple myeloma: Comparative Oncology Alecsandru Ioan Baba, Cornel Cătoi, 2007 |
| alternative therapies for multiple myeloma: Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2013 Edition , 2013-05-01 Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Biomolecular Screening. The editors have built Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biomolecular Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biologicals, Therapies, and Complementary and Alternative Medicine: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
ALTERNATIVE Definition & Meaning - Merriam-Webster
The meaning of ALTERNATIVE is offering or expressing a choice. How to use alternative in a sentence. Synonym Discussion of Alternative.
ALTERNATIVE | English meaning - Cambridge Dictionary
ALTERNATIVE definition: 1. An alternative plan or method is one that you can use if you do not want to use another one: 2…. Learn more.
ALTERNATIVE Definition & Meaning | Dictionary.com
Alternative definition: a choice limited to one of two or more possibilities, as of things, propositions, or courses of action, the selection of which precludes any other possibility.. See examples of …
ALTERNATIVE definition and meaning | Collins English Dictionary
Alternative is used to describe something that is different from the usual things of its kind, or the usual ways of doing something, in modern Western society. For example, an alternative …
Alternative - Wikipedia
Alternative (Kamen Rider), a character in the Japanese TV series Kamen Rider RyukiAlternative comics, or independent comics are an alternative to mainstream superhero comics; Alternative …
Alternative - definition of alternative by The Free Dictionary
Define alternative. alternative synonyms, alternative pronunciation, alternative translation, English dictionary definition of alternative. n. 1. a. One of a number of possible choices or courses of …
alternative noun - Definition, pictures, pronunciation and usage …
alternative something that you can choose to have or do out of two or more possibilities: You can be paid in cash weekly or by cheque monthly: those are the two alternatives. option, choice or …
What does alternative mean? - Definitions.net
Alternative refers to one or more options or choices available as a substitute or replacement to the existing one. It generally denotes the possibility of choice between two or more things. In …
Alternative Definition & Meaning | Britannica Dictionary
ALTERNATIVE meaning: 1 : offering or expressing a choice; 2 : not usual or traditional often used to describe something that is more natural or that causes less pollution than the usual product, …
alternative - WordReference.com Dictionary of English
a choice among only two possibilities such that if one is chosen, the other cannot be chosen: Here are the alternatives: surrender or die. one of these choices: The alternative to riding is walking. …
Modulating proteasome inhibitor tolerance in multiple …
Modulating proteasome inhibitor tolerance in multiple myeloma: an alternative strategy to reverse inevitable resistance Maolin Ge 1, Zhi Qiao2, Yan Kong 3, Hongyu Liang4, Yan Sun1, Hui Lu , …
3rd Immune E ector Cell Therapies in Multiple Myeloma …
Therapies in Multiple Myeloma Workshop MAY 7-8, 2022 • BOSTON, MA WESTIN BOSTON SEAPORT DISTRICT AND VIRTUAL Register Today! Register Today! ... SESSION 5: …
UARK 2014-21: Phase II Trial of Oncolytic Virotherapy by …
cyclophosphamide (Cy) in patients with relapsed/refractory multiple myeloma (MM). Efficacy will be measured by the International Myeloma Working Group (IMWG) criteria. 1.2. To determine …
Clinical features associated with poor response and early …
relapse following BCMA-directed therapies in multiple myeloma Matthew J. Rees 1, Aytaj Mammadzadeh , ... an alternative approach may be preferable. Blood Cancer Journal (2024) …
CAR T cell therapy for multiple myeloma: What have we …
alternative chemotherapeutics (e.g. bendamustine), radiation [13], and other novel strategies such as adjuvant vaccines or cytokines [14] aimed to enhance T-cell expansion, persistence,
Multiple Myeloma Pathogenesis Dysregulation of …
Multiple Myeloma Pathogenesis ... factors and splicing events during tumorigenesis would open new avenues for targeted therapies in multiple myeloma (MM). We show here that GSEA …
Multiple Myeloma Pathogenesis Dysregulation of …
Multiple myeloma (MM) is a cancer of neoplastic plasma cells that is typically accompanied by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, …
Multiple Myeloma Pathogenesis Dysregulation of …
Multiple myeloma (MM) is a cancer of neoplastic plasma cells that is typically accompanied by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, …
Pulmonary and intracerebral plasmacytomas in a patient …
sought alternative therapies outside of the country. She returned to her initial care providers 3 months later and was evaluated for multiple myeloma. The serum creati-nine and serum …
Anti-BCMA novel therapies for multiple myeloma
targeted treatments in myeloma, with a special focus on currently available agents. Keywords: Multiple myeloma, BCMA, belantamab, teclistamab, CART INTRODUCTION Multiple …
Circulating tumour DNA sequence analysis as an alternative …
The requirement for bone-marrow aspirates for genomic profiling of multiple myeloma poses an obstacle to enrolment and retention of patients in clinical trials. We evaluated whether …
5:30-7:30 PM PST Session 655: Multiple Myeloma: Cellular …
Session 655: Multiple Myeloma: Cellular Therapies: Poster I Efficacy of CARVYKTI in CARTITUDE-4 versus other conventional treatment regimens for lenalidomide-refractory …
Predicting treatment benefit in multiple myeloma through
ARTICLE Predicting treatment benefit in multiple myeloma through simulation of alternative treatment effects Joske Ubels 1,2,3, Pieter Sonneveld2, Erik H. van Beers3, Annemiek Broijl2, …
Advancements in Multiple Myeloma Therapies: A
Lymphatics 2025, 3, 2 2 of 24 in determining the extent of myeloma involvement and guiding treatment decisions [1]. In the development of multiple myeloma, the interaction between …
Exploring Alternative Therapies in Hypothyroidism …
has emerged in alternative therapies to address treatment gaps and enhance patient well-being. This review explores a range of complementary and alternative approaches, ... Thalidomide, a …
Emerging GPRC5D-Targeted therapies for multiple …
Multiple myeloma (MM), the second most common hemato-logic malignancy, remains largely incurable despite aggressive frontline quadruplet induction therapies and autologous stem cell …
N A Immune and Cellular Therapies in Multiple Myeloma …
immune and cellular therapies. With this in mind, the International Myeloma Society (IMS) is organizing the 2nd Immune Effector Cell Therapy in Multiple Myeloma Workshop. This two …
18th International Myeloma Workshop - Myeloma Society
Early clinical results of alternative targets for bispecifics Ajai Chari and next generation T-cell redirectors ... The future of cellular and immune therapies Noopur Raje in multiple myeloma …
MM-470 Exploring Alternative Dosing Regimens of Single …
Keywords: MM, Multiple Myeloma, Minimal residual disease dynamics, tumor microenvironment, next-generation fl ow cytometry MM-470 Exploring Alternative Dosing Regimens of Single …
Advancements in microenvironment-based - Frontiers
Advancements in microenvironment-based therapies: transforming the landscape of multiple myeloma treatment Ke Lu1 †, Wen Wang1, Yuntong Liu2, Chao Xie3, Jiye Liu2 and Lijie …
Guidelines for Supportive Care in Myeloma
Supportive Care in Multiple Myeloma BCSH and UKMF Sept 2010 6 2. Management of anaemia Anaemia (haemoglobin concentration <12.0g/dl) is common in myeloma. At diagnosis it is …
BCMA-directed therapy, new treatments in the myeloma
BcMA-DiRecteD tHeRAPY 3 response of 12.5–14 months [18–20]. while median progression-free survival (PFS) was short at 3months, the FDA granted belantamab accelerated approval due
Long-term outcomes of allogeneic stem cell transplant in …
multiple myeloma Walker M. Schmidt 1 , Nirosha D. Perera 2, Francis K. Buadi 3, Suzanne R. Hayman3, ... of modern novel therapies in the last decade, the role of allo SCT is
Bortezomib (Velcade®) - Treatment Guide - Myeloma UK
Myeloma UK provides a wide range of information booklets ... complementary therapies such as massage may also help. For more information see the Fatigue and myeloma ... kind of …
Clinical Practice Guideline MULTIPLE MYELOMA - Myeloma …
Multiple myeloma (MM) is a malignancy of plasma cells characterised by an abnormal serum and /or urine immunoglobulin or free immunoglobulin light chain as a result of clonal expansion of …
Gene Expression Profiling in Multiple Myeloma: Redefining
Feb 8, 2022 · Multiple myeloma (MM) is a blood cancer characterized by clonal proliferation of plasma cells in the bone marrow (1). MM accounts for 1.2% of all cancers and 17.1% of blood …
Mezigdomide plus Dexamethasone in Relapsed and …
Aug 30, 2023 · 1010 n engl j med 389;11 nejm.org September 14, 2023 The new england journal of medicine D espite recent advances in therapy, multiple myeloma remains incurable. Drug …
Gene expression derived from alternative promoters …
Clinical and genetic risk factors are currently used in multiple myeloma (MM) to stratify patients and to design specific therapies. However, these systems do not capture the heterogeneity of …
Occupational Therapy Progress Note Form PDF File
Multiple myeloma (section Gene therapy) risk of multiple myeloma in certain occupations. This is due to the occupational exposure to aromatic ... Alternative medicine (redirect from …
Chimeric antigen receptor T-cell therapy for multiple …
Thereby, SLAMF7 is an alternative but suboptimal choice for CAR-T cell therapy. The function of SLAMF7 is poorly understood, but previous evidence indicates its similar role as growth factor …
Predicting treatment benefit in multiple myeloma through …
Predicting treatment benefit in multiple myeloma through simulation of alternative treatment effects Joske Ubels 1,2,3, Pieter Sonneveld2, Erik H. van Beers3, Annemiek Broijl2, Martin H. …
Predicting treatment benefit in multiple myeloma through …
ARTICLE Predicting treatment benefit in multiple myeloma through simulation of alternative treatment effects Joske Ubels 1,2,3, Pieter Sonneveld2, Erik H. van Beers3, Annemiek Broijl2, …
Clinical Guideline BONE PROTECTION IN MYELOMA Division …
with the UK Myeloma Forum (UKMF). Guidelines for Supportive Care in Myeloma. Sept 2010. 5. Anderson K, Ismalail N, Flynn, P.J et al. Rose of Bone-Modifying Agents in Multiple Myeloma: …
UC San Francisco Previously Published Works - eScholarship
Salvage therapies including retreatment with BCMA-directed approaches after BCMA CAR-T relapses for multiple myeloma Kevin R. Reyes,1 Yen-Chun Liu,2 Chiung-Yu Huang,3 Rahul …
Perspectives in the Rapidly Evolving Treatment Landscape of …
sections: newly diagnosed multiple myeloma (NDMM), relapsed/ refractory multiple myeloma (RRMM), and novel therapies. The aim is to provide insights and perspectives with a regional …
A retrospective review of the management of patients …
Jin et al11 Ixekizumab 1 Multiple myeloma Lasagni et al12 Secukinumab Ustekinumab 1 Breast adenocarcinoma Mastorino et al13 Anti-TNF 4 Melanoma Breast cancer Multiple BCC ...
RSV-MEDIATED HLH IN THE SETTING OF MULTIPLE …
HLH is rarely associated with multiple myeloma (MM). We present a case with an atypical presentation of Respiratory Syncytial Virus (RSV) triggered HLH in the setting of multiple ...
Gastrointestinal Side Effects Associated With Novel Therapies …
associated with novel therapies for multiple myeloma, they are manageable with appropriate medical interventions. Gastrointestinal Side Effects Associated With Novel Therapies in …
Expert Consensus on the Incorporation of Anti-CD38 …
Alternative approaches may be needed for patients with high-risk disease. The substantial PFS benefit of ASCT in the frontline treatment of newly diagnosed multiple myeloma is compelling …
Novel T Cell Therapies for Multiple Myeloma
dendritic cell (DC) vaccination and alternative approaches to MM treatment (Figure 1). The T cell landscape in MM. A hallmark of cancer is the avoidance of immune destruction by the host …
Optimizing treatment sequencing in multiple myeloma: a …
regimens containing daratumumab, which improve outcomes compared with alternative sequences. The model highlights the importance of starting with the most effective regimens …
DP-9024, an investigational small molecule modulator of the …
through the induction of unresolved UPR stress, which may provide an alternative mechanism to current UPR- targeting therapies ... Cell proliferation multiple myeloma (RPMI8226) Log[DP …
Pain Management in Multiple Myeloma Patients: A Literature …
The review divides pain treatment strategies into pharmaceutical and non-pharmacological therapies. Looking ahead, promising areas for future study and development are mentioned, …
BORTEZOMIB BEST PRACTICE - Myeloma Australia
The Myeloma Special Practice Network (M-SPN) was specifically formed to focus on enhancing care of those affected by myeloma. The M-SPN identified a major practical issue for nurses in …
Multiple Myeloma: Transplant Eligible - Alberta Health Services
Multiple myeloma (MM) is an aggressive malignant neoplasm of plasma cells that accumulates in the ... alternative effective salvage therapies influenced the study results. Among patients with …
Teclistamab: First Approval - Springer
relapsed and refractory multiple myeloma. Received its rst conditional approval on 24 Aug 2022 in the EU. Conditionally approved for use in adults with relapsed and refractory multiple myeloma …
Emerging therapies in Multiple Myeloma: Leveraging …
Background: Multiple Myeloma is a hematological malignancy characterized by the proliferation of clonal plasma cells and associated with severe clinical manifestations. Despite advancements …
How to manage prolonged immune effector cell-associated …
B-cell maturation antigen (BCMA)-directed therapies including chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies (BsAbs) represent promising treatment options for …
Justification - g-ba.de
May 15, 2025 · − Percentage value of subjects with multiple myeloma (ICD -10 C90.0) by excluding cases with ICD-10 C90.1, C90.2 and C90.3: 96.4% − Percentage of subjects with …
Advances in CAR-NK cell therapy for hematological …
necessitate the exploration of alternative therapies (4, 5). These limitations have spurred interest in alternative therapies such as natural killer (NK) cell therapy. 2 Biological characteristics of …
