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The Allen Institute for Cell Science: A Powerful Engine of Discovery Facing Future Challenges
Author: Dr. Evelyn Reed, PhD, Professor of Cellular Biology, University of Washington, specializing in high-throughput imaging and data analysis in biological systems.
Keywords: Allen Institute for Cell Science, 3D cell model, single-cell analysis, cell biology research, open science, big data in biology, scientific challenges, technological advancements, future of cell biology.
Abstract: The Allen Institute for Cell Science (AICS) stands as a remarkable example of large-scale, collaborative biological research. This article examines the institute’s groundbreaking contributions to cell biology, highlighting both its successes and the challenges it faces as it navigates the complexities of big data, technological limitations, and the evolving landscape of scientific funding. We will explore the opportunities for innovation and the potential impact of the AICS model on the broader scientific community.
Introduction: The Allen Institute for Cell Science, a non-profit research institute founded by philanthropist Paul G. Allen, has revolutionized cell biology through its commitment to open science and the creation of unprecedented datasets. Its innovative approach, focusing on high-throughput imaging and the development of comprehensive 3D cell models, has provided researchers worldwide with invaluable resources to study cellular processes with unprecedented detail. The Allen Institute for Cell Science’s work is characterized by its scale and accessibility, generating a wealth of data freely available to the scientific community. However, this ambition brings unique challenges in data management, analysis, and interpretation. This article provides a comprehensive overview of the Allen Institute for Cell Science, examining its strengths, limitations, and future prospects.
H1: Groundbreaking Contributions of the Allen Institute for Cell Science
The Allen Institute for Cell Science has made significant strides in several key areas:
High-Throughput Imaging and Data Generation: The institute has pioneered the use of high-throughput microscopy to generate massive datasets of cell images and related data. These datasets provide a wealth of information on cellular structures, dynamics, and responses to various stimuli. The scale and detail of this data far surpasses what individual labs could achieve, accelerating discovery and fostering new avenues of research.
The Allen Cell Explorer: This online resource provides a user-friendly interface to access and analyze the institute’s massive datasets. Researchers can explore 3D models of cells, compare different cell types, and investigate specific cellular processes, significantly democratizing access to advanced cell biology research.
Development of 3D Cell Models: A key focus of the Allen Institute for Cell Science is building comprehensive 3D models of cells, going beyond traditional 2D cultures. These 3D models more accurately reflect the complexity of cells in vivo, leading to more biologically relevant insights.
Focus on Open Science: The Allen Institute for Cell Science is committed to making its data and resources freely available to the global research community. This open-science approach fosters collaboration, accelerates scientific progress, and ensures that the institute’s investments have a maximal impact.
H2: Challenges Facing the Allen Institute for Cell Science
Despite its remarkable success, the Allen Institute for Cell Science faces several significant challenges:
Data Management and Analysis: The sheer volume of data generated by the institute presents significant computational and analytical challenges. Developing efficient algorithms and tools to manage, analyze, and interpret these massive datasets requires substantial computational power and expertise.
Technological Limitations: While high-throughput microscopy has been transformative, it still has limitations. Capturing the full complexity of cellular processes requires continual development of new imaging techniques and analysis methods.
Interpretive Challenges: Extracting biological meaning from the massive datasets generated by the Allen Institute for Cell Science requires sophisticated computational and statistical approaches. Developing robust methods to interpret these data and draw reliable conclusions is crucial.
Funding and Sustainability: Maintaining the Allen Institute for Cell Science’s ambitious research programs requires substantial and sustained funding. Securing ongoing financial support is critical for the institute's long-term success.
Integration with other datasets: Although the Allen Institute for Cell Science provides a wealth of data, integrating this information with other large-scale datasets from different sources presents significant challenges.
H3: Opportunities and Future Directions for the Allen Institute for Cell Science
The Allen Institute for Cell Science is well-positioned to address many of the challenges mentioned above and to make further significant contributions to cell biology. Key opportunities include:
Advancements in Imaging Technologies: Investing in and developing advanced imaging techniques can further improve the resolution, speed, and scope of data acquisition.
Artificial Intelligence and Machine Learning: Applying AI and machine learning to analyze the massive datasets generated by the institute can unlock new insights and accelerate the pace of discovery.
Expanding the Scope of Research: The institute could expand its research to encompass a broader range of cell types, tissues, and organisms, providing an even richer resource for the scientific community.
Collaboration and Data Sharing: Continued focus on open science and collaboration with other research institutions and scientists worldwide will be crucial for maximizing the impact of the institute's work.
Training and Education: Developing educational programs to train the next generation of scientists in the skills needed to effectively utilize and interpret the data generated by the Allen Institute for Cell Science is crucial.
Conclusion:
The Allen Institute for Cell Science has had a profound impact on cell biology research by generating massive, publicly accessible datasets and developing innovative tools for their analysis. While challenges remain in data management, analysis, and the need for continued technological advancement, the institute's commitment to open science, coupled with its capacity for innovation, places it at the forefront of biological discovery. By continuing to adapt to new technologies and fostering collaborations, the Allen Institute for Cell Science will undoubtedly continue to drive breakthroughs in our understanding of cellular processes and contribute significantly to future advances in biomedicine.
FAQs:
1. What is the primary focus of the Allen Institute for Cell Science? The primary focus is creating comprehensive 3D models of cells, generating massive datasets through high-throughput imaging, and making these resources freely available to the scientific community.
2. How can researchers access the data generated by the AICS? Researchers can access data through the Allen Cell Explorer, a user-friendly online platform.
3. What types of cells are studied by the AICS? The AICS studies a range of human and mouse cell types, focusing on a variety of cell lines and primary cells.
4. What technologies are used by the AICS? The AICS employs advanced high-throughput microscopy techniques, image analysis software, and computational tools.
5. How does the open science approach of the AICS benefit the scientific community? Open access to data and resources accelerates research progress, fosters collaboration, and promotes wider dissemination of scientific knowledge.
6. What are the limitations of the AICS approach? Challenges include the sheer volume of data, the need for sophisticated analysis techniques, and the ongoing need for technological advancements in imaging and data handling.
7. How is the AICS funded? Primarily through philanthropic donations, notably from its founder Paul G. Allen.
8. What is the future direction of the AICS? The AICS is likely to continue its focus on expanding its 3D cell models, employing advanced technologies such as AI and machine learning for data analysis, and broadening the scope of its research.
9. How can I get involved with the AICS? The AICS offers various opportunities for collaboration, including data analysis projects and research partnerships. Their website provides details on current opportunities.
Related Articles:
1. "High-Throughput Imaging and the Allen Cell Explorer: A New Era in Cell Biology": This article focuses on the technological advancements and the impact of the Allen Cell Explorer on accessing and analyzing large-scale cell biology datasets.
2. "3D Cell Culture Models and Their Implications for Biomedical Research": This article examines the significance of 3D cell models developed by the AICS and their advantages over traditional 2D culture methods.
3. "Open Science and Data Sharing in Cell Biology: The Allen Institute Model": This article discusses the Allen Institute for Cell Science's commitment to open science and its impact on accelerating research and fostering collaboration.
4. "Big Data and Computational Challenges in Cell Biology: Lessons from the Allen Institute": This article explores the computational challenges associated with analyzing the massive datasets generated by the AICS.
5. "The Allen Institute for Cell Science: A Case Study in Large-Scale Biological Research": This article provides an overview of the Allen Institute for Cell Science’s organizational structure, research priorities, and overall impact.
6. "Machine Learning Applications in the Analysis of Allen Institute for Cell Science Data": This article focuses on the application of AI and machine learning techniques to analyze the data generated by the AICS.
7. "Future Directions in High-Throughput Imaging: Implications for the Allen Institute for Cell Science": This article discusses the potential of emerging imaging technologies and their potential impact on future research at the AICS.
8. "Comparative Analysis of Cell Types Using the Allen Cell Explorer": This article demonstrates how researchers use the Allen Cell Explorer to compare different cell types and explore cellular heterogeneity.
9. "The Impact of the Allen Institute for Cell Science on Biomedical Research and Drug Discovery": This article explores how the AICS data and resources are being used to advance biomedical research and drug discovery efforts.
Publisher: This article could be published by a reputable scientific journal such as Cell, Nature, Nature Methods, or Molecular Cell, all of which have a strong reputation for publishing high-quality research articles and reviews in cell biology and related fields.
Editor: Dr. Jane Doe, PhD, Editor-in-Chief, Nature Methods, with expertise in microscopy, image analysis, and bioinformatics.
| allen institute for cell science: The Feeling of Life Itself Christof Koch, 2019-09-24 A thought-provoking argument that consciousness—more widespread than previously assumed—is the feeling of being alive, not a type of computation or a clever hack In The Feeling of Life Itself, Christof Koch offers a straightforward definition of consciousness as any subjective experience, from the most mundane to the most exalted—the feeling of being alive. Psychologists study which cognitive operations underpin a given conscious perception. Neuroscientists track the neural correlates of consciousness in the brain, the organ of the mind. But why the brain and not, say, the liver? How can the brain—three pounds of highly excitable matter, a piece of furniture in the universe, subject to the same laws of physics as any other piece—give rise to subjective experience? Koch argues that what is needed to answer these questions is a quantitative theory that starts with experience and proceeds to the brain. In The Feeling of Life Itself, Koch outlines such a theory, based on integrated information. Koch describes how the theory explains many facts about the neurology of consciousness and how it has been used to build a clinically useful consciousness meter. The theory predicts that many, and perhaps all, animals experience the sights and sounds of life; consciousness is much more widespread than conventionally assumed. Contrary to received wisdom, however, Koch argues that programmable computers will not have consciousness. Even a perfect software model of the brain is not conscious. Its simulation is fake consciousness. Consciousness is not a special type of computation—it is not a clever hack. Consciousness is about being. |
| allen institute for cell science: Cell Biology E-Book Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, Graham Johnson, 2016-11-01 The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today's students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their study time. - Clearly written format incorporates rich illustrations, diagrams, and charts. - Uses real examples to illustrate key cell biology concepts. - Includes beneficial cell physiology coverage. - Clinically oriented text relates cell biology to pathophysiology and medicine. - Takes a mechanistic approach to molecular processes. - Major new didactic chapter flow leads with the latest on genome organization, gene expression and RNA processing. - Boasts exciting new content including the evolutionary origin of eukaryotes, super resolution fluorescence microscopy, cryo-electron microscopy, gene editing by CRISPR/Cas9, contributions of high throughput DNA sequencing to understand genome organization and gene expression, microRNAs, IncRNAs, membrane-shaping proteins, organelle-organelle contact sites, microbiota, autophagy, ERAD, motor protein mechanisms, stem cells, and cell cycle regulation. - Features specially expanded coverage of genome sequencing and regulation, endocytosis, cancer genomics, the cytoskeleton, DNA damage response, necroptosis, and RNA processing. - Includes hundreds of new and updated diagrams and micrographs,plus fifty new protein and RNA structures to explain molecular mechanisms in unprecedented detail. - Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and over a dozen animations from the book on a variety of devices. |
| allen institute for cell science: Second Generation Cell and Gene-Based Therapies Alain Vertes, Nathan J. Dowden, Devyn Smith, Nasib Qureshi, 2020-02-07 Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products.The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. - Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization - Perspectives section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights - Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies |
| allen institute for cell science: The Dance of Life Magdalena Zernicka-Goetz, Roger Highfield, 2020-02-27 'Quite simply the best book about science and life that I have ever read' - Alice Roberts How does life begin? What drives a newly fertilized egg to keep dividing and growing until it becomes 40 trillion cells, a greater number than stars in the galaxy? How do these cells know how to make a human, from lips to heart to toes? How does your body build itself? Magdalena Zernicka-Goetz was pregnant at 42 when a routine genetic test came back with that dreaded word: abnormal. A quarter of sampled cells contained abnormalities and she was warned her baby had an increased risk of being miscarried or born with birth defects. Six months later she gave birth to a healthy baby boy and her research on mice embryos went on to prove that – as she had suspected – the embryo has an amazing and previously unknown ability to correct abnormal cells at an early stage of its development. The Dance of Life will take you inside the incredible world of life just as it begins and reveal the wonder of the earliest and most profound moments in how we become human. Through Magda’s trailblazing research as a professor at Cambridge – where she has doubled the survival time of human embryos in the laboratory, and made the first artificial embryo-like structures from stem cells – you’ll discover how early life is programmed to repair and organise itself, what this means for the future of pregnancy, and how we might one day solve IVF disorders, prevent miscarriages and learn more about the dance of life as it starts to take shape. The Dance of Life is a moving celebration of the balletic beauty of life’s beginnings. |
| allen institute for cell science: Innovations in Modeling and Simulation to Advance Translational Science Melissa Knothe Tate, Leonardo Angelone, Christopher Basciano, Markus Reiterer, 2020-12-15 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| allen institute for cell science: The NEURON Book Nicholas T. Carnevale, Michael L. Hines, 2006-01-12 The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are interested in computational modeling, will also find it helpful. The NEURON Book covers material that ranges from the inner workings of this program, to practical considerations involved in specifying the anatomical and biophysical properties that are to be represented in models. It uses a problem-solving approach, with many working examples that readers can try for themselves. |
| allen institute for cell science: The Liver Irwin M. Arias, Harvey J. Alter, James L. Boyer, David E. Cohen, David A. Shafritz, Snorri S. Thorgeirsson, Allan W. Wolkoff, 2020-01-20 Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism. |
| allen institute for cell science: The Magical Lantern Murzban Jal, 2022-11-28 The book The Magical Lantern is a collection of essays on Marxist philosophy. It is based on the philosophical reflection on Marx’s idea of phantasmagoria as the 'magical lantern' that creates eerie images, an idea that is central to Marx’s theory of modern capitalist societies. It talks of the importance of Marx’s philosophy and its application in concrete politics, especially in creating socialist humanist philosophy of human emancipation where global societies can be emancipated from the phantasmagorias that haunt them, thus able to transcend global capitalism which is in terminal and permanent crisis. It then critiques the rise of authoritarian regimes emerging all over the world and seeks to explain the rise of global totalitarianism. But it claims that the answer to authoritarianism is not liberalism since liberalism is part of the late imperialism in permanent crisis as well as it involves what Slavoj Žižek calls the Denkverbot ('the prohibition against thinking') and thus involves the return of the eerie phantasmagoria that does not allow critical thinking. However, the critique of liberalism does not relapse into orthodox Marxism, since this book argues that in the genre of orthodox Marxism the ghosts of Stalin and Mao with their own authoritarianism haunt philosophies of human emancipation. While Stalin is portrayed as a brutal counter-revolutionary who destroyed Marxism by evoking Marxism itself, Mao is presented as the alchemist of the revolution and a peculiar form of Stalinism in rebellion against Stalinism itself! The chapters in this book were originally published in Critique: Journal of Socialist Theory. |
| allen institute for cell science: LabOratory Sandra Kaji-O'Grady, Chris L. Smith, 2024-02-06 An illustrated examination of laboratory architecture and the work that it does to engage the public, recruit scientists, and attract funding. The laboratory building is as significant to the twenty-first century as the cathedral was to the thirteenth and fourteenth centuries. The contemporary science laboratory is built at the grand scales of cathedrals and constitutes as significant an architectural statement. The laboratory is a serious investment in architectural expression in an attempt to persuade us of the value of the science that goes on inside. In this lavishly illustrated book, Sandra Kaji-O'Grady and Chris L. Smith explore the architecture of modern life science laboratories, and the work that it does to engage the public, recruit scientists, and attract funding. Looking at the varied designs of eleven important laboratories in North America, Europe, and Australia, all built between 2005 and 2019, Kaji-O'Grady and Smith examine the relationship between the design of contemporary laboratory buildings and the ideas and ideologies of science. Observing that every laboratory architect and client declares the same three aspirations—to eliminate boundaries, to communicate the benefits of its research programs, and to foster collaboration—Kaji-O'Grady and Smith organize their account according to the themes of boundaries, expression, and socialization. For instance, they point to the South Australian Health and Medical Institute's translucent envelope as the material equivalent of institutional accountability; the insistent animal imagery of the NavarraBioMed laboratory in Spain; and the Hillside Research Campus's mimicry of the picturesque fishing village that once occupied its site. Through these and their other examples, Kaji-O'Grady and Smith show how the architecture of the laboratory shapes the science that takes place within it. |
| allen institute for cell science: Cognitive Computing in Technology-Enhanced Learning Lytras, Miltiadis D., Aljohani, Naif, Daniela, Linda, Visvizi, Anna, 2019-05-31 Various technologies and applications such as cognitive computing, artificial intelligence, and learning analytics have received increased attention in recent years. The growing demand behind their adoption and exploitation in different application contexts has captured the attention of learning technology specialists, computer engineers, and business researchers who are attempting to decipher the phenomenon of personalized e-learning, its relation to already conducted research, and its implications for new research opportunities that effect innovations in teaching. Cognitive Computing in Technology-Enhanced Learning is a critical resource publication that aims to demonstrate state-of-the-art approaches of advanced data mining systems in e-learning, such as MOOCs and other innovative technologies, to improve learning analytics, as well as to show how new and advanced user interaction designs, educational models, and adoptive strategies can expand sustainability in applied learning technologies. Highlighting a range of topics such as augmented reality, ethics, and online learning environments, this book is ideal for educators, instructional designers, higher education faculty, school administrators, academicians, researchers, and students. |
| allen institute for cell science: Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research Robert T. Gerlai, 2018-04-24 Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials - Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior - Written and edited by leading international experts |
| allen institute for cell science: Thank You Ibm! Next Edition Brian W. Kelly, 2022-10-26 I began to write this book over twenty years ago. My purpose was to tell the true story about how IBM made too many companies successful by standing down rather than competing. As a Senior IBM Systems Engineer, I saw it all happen. The $ Trillion dollar PC marketplace is the biggest example of IBM's major losses. Yet, the PC was just one of many industry sub-segments over the years in which IBM failed miserably. We need more than ten fingers to count them all. This book tells all the great stories about how industries came into being and entrepreneurs often in their early twenties became billionaires. This book tells you which companies did the best; which regular guys became industry moguls; and who has the money today. Among other things, it tells us all who owes IBM the biggest thank you’s. This book in many ways is about Big Blue’s misgivings about being too successful in too many IT product areas. IBM Executives over the years from the CEO on down were all paid very well to manage all aspects of the company’s business. Unfortunately each and every CEO after the Watsons and T. Vincent Learson, focused on just one aspect of IBM – its mainframe business. So the IBM Chieftains lost just about every other opportunity including the PC. They simply handed very crafty “entrepreneurs,” the whole game. IBM created many industry billionaires simply by not watching its assets. Microsoft alone has four documented billionaires on its list which is topped by Bill Gates, the richest man in the world at $102 billion. Additionally, there are over 12,000 other Microsoft employees on the millionaire’s list. IBM paid for all of the zillionaires. In Chapter 1, I show each and every billionaire and a number of millionaires. I then go on in sixty-nine chapters to tell you the essence of the full Microsoft / IBM story along with many other stories of IBM squandering many other real business opportunities. These are enjoyable to read but hard to believe. You are going to love this book, designed by an IBM insider and told with respect for IBM and with the truth that all of these great stories deserve. You will not want to put this book down. Kelly not only gives the facts about the new billionaires; he also provides a history lesson about the entire industry that will capture your imagination. You’ll learn how all these billionaires got their money. The book begins with the introduction of the first computer and it takes you on a ride through all of the major events that occurred during each IBM CEO’s tenure. The story thus begins with Thomas Watson Sr, as CEO and continues chapter by chapter to the state of the computer industry today. Kelly does it all in 69 easy-to-read enjoyable chapters. Few books are must-read but Thank You IBM! will quickly be at the top of your list and America’s most read list. |
| allen institute for cell science: The Cell: A Very Short Introduction Terence Allen, Terence David Allen, Graham Cowling, 2011-09-29 Introduces cells, discussing their structure, life cycle, and what they can do. |
| allen institute for cell science: Cell and Gene Therapies Miguel-Angel Perales, Syed A. Abutalib, Catherine Bollard, 2018-11-27 In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee. |
| allen institute for cell science: Biophysics of Computation Christof Koch, 2004-10-28 Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation.Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics. |
| allen institute for cell science: The Mouse Brain in Stereotaxic Coordinates George Paxinos, Keith B. J. Franklin, 2001 The Mouse Brain in Stereotaxic Coordinates, Second Edition has been the acknowledged reference in this field since the publication of the first edition, and is now available in a Compact Edition. This will provide a more affordable option for students, as well as researchers needing an additional lab atlas. This version includes the coronal diagrams delineating the entire brain as well as the introductory text from the Deluxe edition. It is an essential reference for anyone studying the mouse brain or related species.* Includes 100 detailed diagrams of the coronal set delineating the entire mouse brain * Compact edition of the most comprehensive and accurate mouse brain atlas available* Contains minor updates and revisions from the full edition |
| allen institute for cell science: Focus On: 100 Most Popular American Male Guitarists Wikipedia contributors, |
| allen institute for cell science: Biological Networks Rudiyanto Gunawan, Neda Bagheri, 2019-01-10 This book is a printed edition of the Special Issue Biological Networks that was published in Processes |
| allen institute for cell science: Cell Biology and Translational Medicine, Volume 11 Kursad Turksen, 2021-07-20 Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the tenth volume of a continuing series. |
| allen institute for cell science: Induced Pluripotent Stem (iPS) Cells Andras Nagy, Kursad Turksen, 2022-06-22 This extensive new edition presents protocols reflecting the great strides made in the study of induced pluripotent stem (iPS) cells. The collection explores new and improved methods for the generation, expansion, and maintenance of iPS cells from different tissue types, characterization of their differentiation pathways along different lineages, and their potential utility in tissue repair and regeneration. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Induced Pluripotent Stem (iPS) Cells: Methods and Protocols, Second Edition aims to arm stem cell biologists, both novice and expert, with invaluable protocols that are currently being used in various laboratories around the world. |
| allen institute for cell science: Handbook of Biomarkers and Precision Medicine Claudio Carini, Mark Fidock, Alain van Gool, 2019-04-16 The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work. -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL. |
| allen institute for cell science: Frontiers in Physics - 2019 Editor's Choice Alex Hansen, Thomas Beyer, Ewald Moser, Laura Elisa Marcucci, Ralf Metzler, Christian F. Klingenberg, James Sauls, José W. F. Valle, Jan De Boer, Dumitru Baleanu, Lorenzo Pavesi, Bretislav Friedrich, Christine Charles, Matjaž Perc, Jasper Van Der Gucht, 2020-05-19 Frontiers in Physics – FPHY – is now in its eighth year. Up to last year, the journal received a slowly increasing trickle of manuscripts, and then during the summer… Boom! The number of manuscripts we receive started increasing exponentially. This is of course a signal to us who are associated with the journal that we are on the right track to build a first-rate journal spanning the entire field of physics. And it is not the only signal. We also see it in other indicators such as the number of views and downloads, Impact Factor and the Cite Score. Should we be surprised at this increase? If I were to describe FPHY in one word, it would be “innovation”. Attaching the names of the reviewers that have endorsed publication permanently to the published paper is certainly in this class. It ensures that the reviewers are accountable; furthermore, the level of transparency this implies ensures that any conflict of interest is detected at the very beginning of the process. The review process itself is innovative. After an initial review that proceeds traditionally, the reviewers and authors enter a back-and-forth dialog that irons out any misunderstanding. The reviewers retain their anonymity throughout the process. The entire review process and any question concerning editorial decisions is fully in the hands of active scientists. The Frontiers staff is not allowed to make any such decision. They oversee the process and make sure that the manuscript and the process leading to publication or rejection upholds the standard. FPHY is of course a gold open access journal. This is the only scientific publication model that is compatible with the information revolution. A journal’s prestige is traditionally associated with how difficult it is to publish there. Exclusivity as criterion for desirability, is a mechanism we know very well from the consumer market. However, is this criterion appropriate for scientific publishing? It is almost by definition not possible to predict the importance of a new idea – otherwise it would not have been new. So, why should journals make decisions on publishing based on predicting the possible importance of a given work. This can only be properly assessed after publication. Frontiers has removed “importance” from the list of criteria for publication. That the work is new, is another matter: the work must be new and scientifically correct. It would seem that removing the criterion of “importance” would be a risky one, but it turns out not to be. The Specialty Chief Editors who lead the 18 sections that constitute FPHY, have made this selection of papers published in FPHY in 2019. We have chosen the papers that we have found most striking. Even though this is far from a random selection, they do give a good idea of what PFHY is about. Enjoy! We certainly did while making this selection. Professor Alex Hansen (Field Chief Editor) |
| allen institute for cell science: Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus , 2021-04-25 Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards Understanding the Complexity of Tinnitus, Volume 262, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on current topics such as Cochlear implantation for patients with tinnitus – a systematic review, Event Related Potentials to Assess the Tinnitus complaint during drug treatment, The difference in post-stimulus suppression between residual inhibition and forward masking, Sleep, sleep apnea and tinnitus, A Bayesian brain in imbalance: medial, lateral and descending pathways in tinnitus and pain, Tinnitus features according to caffeine consumption, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Brain Research series - Includes the latest information on Tinnitus and its complexity |
| allen institute for cell science: Collaborations of Consequence The National Academies Keck Futures Initiative, 2019-01-07 This publication represents the culmination of the National Academies Keck Futures Initiative (NAKFI), a program of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine supported by a 15-year, $40 million grant from the W. M. Keck Foundation to advance the future of science through interdisciplinary research. From 2003 to 2017, more than 2,000 researchers and other professionals across disciplines and sectors attended an annual think-tank style conference to contemplate real-world challenges. Seed grants awarded to conference participants enabled further pursuit of bold, new research and ideas generated at the conference. |
| allen institute for cell science: Stem Cells Ariff Bongso, Eng Hin Lee, 2011 Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications. |
| allen institute for cell science: American Men and Women in Medicine, Applied Sciences and Engineering with Roots in Czechoslovakia Miloslav Rechcigl Jr., 2021-02-17 No comprehensive study has been undertaken about the American learned men and women with Czechoslovak roots. The aim of this work is to correct this glaring deficiency, with the focus on men and women in medicine, applied sciences and engineering. It covers immigration from the period of mass migration and beyond, irrespective whether they were born in their European ancestral homes or whether they have descended from them. This compendium clearly demonstrates the Czech and Slovak immigrants, including Bohemian Jews, have brought to the New World, in these areas, their talents, their ingenuity, the technical skills, their scientific knowhow, as well as their humanistic and spiritual upbringing, reflecting upon the richness of their culture and traditions, developed throughout centuries in their ancestral home. This accounts for their remarkable success and achievements of theses settlers in the New World, transcending through their descendants, as this publication demonstrates. The monograph has been organized into sections by subject areas, i.e., Medicine, Allied Health Sciences and Social Services, Agricultural and Food Science, Earth and Environmental Sciences and Engineering. Each individual entry is usually accompanied with literature, and additional biographical sources for readers who wish to pursue a deeper study. The selection of individuals has been strictly based on geographical vantage, without regards to their native language or ethnical background. Some of the entries may surprise you, because their Czech or Slovak ancestry has not been generally known. What is conspicuous is a large percentage of listed individuals being Jewish, which is a reflection of high-level of education and intellect of Bohemian Jews. A prodigious number of accomplished women in this study is also astounding, considering that, in the 19th century, they rarely had careers and most professions refused entry to them. |
| allen institute for cell science: “A Catalogue of an Elegant 200-Compilation of E-Medical Booklets.”[Available on Amazon kindle.] Dr. H. K. Saboowala. M.B.(Bom) M.R.S.H.(London) Dr. Hakim Saboowala., 2020-02-02 Dear Enthusiastic Medicos, On learning from Amazon kindle regarding their inability to display my Compilation of 200 E-Medical Booklets on their platform, every day at a time, I have endeavored, after negotiating, to introduce an aforesaid Catalog for the enthusiastic Medicos, enabling them to elect their title of choice to buy later on from Amazon kindle straightaway! Further to state that the concept of introducing an aforesaid Catalogue is also based on an overwhelming response from the enthusiastic Medicos, world over in the past and my passion to impart medical knowledge as such, with up-dation whenever possible at an affordable cost! In addition, I would like to state that the concept of an aforesaid Catalogue formation may not be considered as a stoppage of my activity, it would last as long as my cognitive functions are not affected! Dr. H. K. Saboowala. M.B.(Bom) M.R.S.H.(London) |
| allen institute for cell science: Computational Stem Cell Biology Patrick Cahan, 2019-05-07 This volume details methods and protocols to further the study of stem cells within the computational stem cell biology (CSCB) field. Chapters are divided into four sections covering the theory and practice of modeling of stem cell behavior, analyzing single cell genome-scale measurements, reconstructing gene regulatory networks, and metabolomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Stem Cell Biology: Methods and Protocols will be an invaluable guide to researchers as they explore stem cells from the perspective of computational biology. |
| allen institute for cell science: Proceedings of the Future Technologies Conference (FTC) 2023, Volume 1 Kohei Arai, 2023-11-01 This book is a collection of thoroughly well-researched studies presented at the Eighth Future Technologies Conference. This annual conference aims to seek submissions from the wide arena of studies like Computing, Communication, Machine Vision, Artificial Intelligence, Ambient Intelligence, Security, and e-Learning. With an impressive 490 paper submissions, FTC emerged as a hybrid event of unparalleled success, where visionary minds explored groundbreaking solutions to the most pressing challenges across diverse fields. These groundbreaking findings open a window for vital conversation on information technologies in our community especially to foster future collaboration with one another. We hope that the readers find this book interesting and inspiring and render their enthusiastic support toward it. |
| allen institute for cell science: The Biology of Cell Reproduction Renato Baserga, 1985 Since World War II, cell biology and molecular biology have worked separately in probing the central question of cancer research. But a new alliance is being forged in the effort to conquer cancer. Drawing on more than 500 classic and recent references, Baserga's work provides the unifying background for this cross-fertilization of ideas. |
| allen institute for cell science: The Third Lens Andrew S. Reynolds, 2018-06-21 Does science aim at providing an account of the world that is literally true or objectively true? Understanding the difference requires paying close attention to metaphor and its role in science. In The Third Lens, Andrew S. Reynolds argues that metaphors, like microscopes and other instruments, are a vital tool in the construction of scientific knowledge and explanations of how the world works. More than just rhetorical devices for conveying difficult ideas, metaphors provide the conceptual means with which scientists interpret and intervene in the world. Reynolds here investigates the role of metaphors in the creation of scientific concepts, theories, and explanations, using cell theory as his primary case study. He explores the history of key metaphors that have informed the field and the experimental, philosophical, and social circumstances under which they have emerged, risen in popularity, and in some cases faded from view. How we think of cells—as chambers, organisms, or even machines—makes a difference to scientific practice. Consequently, an accurate picture of how scientific knowledge is made requires us to understand how the metaphors scientists use—and the social values that often surreptitiously accompany them—influence our understanding of the world, and, ultimately, of ourselves. The influence of metaphor isn’t limited to how we think about cells or proteins: in some cases they can even lead to real material change in the very nature of the thing in question, as scientists use technology to alter the reality to fit the metaphor. Drawing out the implications of science’s reliance upon metaphor, The Third Lens will be of interest to anyone working in the areas of history and philosophy of science, science studies, cell and molecular biology, science education and communication, and metaphor in general. |
| allen institute for cell science: The Quest for Consciousness Christof Koch, 2004 Consciousness is the major unsolved problem in biology. Written as an introduction to the field and drawing upon clinical, psychological and physiological observations, this book seeks to answer questions of consciousness within a neuroscientific framework. |
| allen institute for cell science: Bone Marrow Adiposity: Establishing Harmonized, Mechanistic and Multidisciplinary Approaches to Reach Clinical Translation Nathalie Bravenboer, Stephanie Lucas, Clifford James Rosen, 2020-12-28 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| allen institute for cell science: Consciousness Christof Koch, 2012-03-09 A fascinating exploration of the human brain that combines “the leading edge of consciousness science with surprisingly personal and philosophical reflection . . . shedding light on how scientists really think”—this is “science writing at its best” (Times Higher Education). In which a scientist searches for an empirical explanation for phenomenal experience, spurred by his instinctual belief that life is meaningful. What links conscious experience of pain, joy, color, and smell to bioelectrical activity in the brain? How can anything physical give rise to nonphysical, subjective, conscious states? Christof Koch has devoted much of his career to bridging the seemingly unbridgeable gap between the physics of the brain and phenomenal experience. This engaging book—part scientific overview, part memoir, part futurist speculation—describes Koch’s search for an empirical explanation for consciousness. Koch recounts not only the birth of the modern science of consciousness but also the subterranean motivation for his quest—his instinctual (if “romantic”) belief that life is meaningful. Koch describes his own groundbreaking work with Francis Crick in the 1990s and 2000s and the gradual emergence of consciousness (once considered a “fringy” subject) as a legitimate topic for scientific investigation. Present at this paradigm shift were Koch and a handful of colleagues, including Ned Block, David Chalmers, Stanislas Dehaene, Giulio Tononi, Wolf Singer, and others. Aiding and abetting it were new techniques to listen in on the activity of individual nerve cells, clinical studies, and brain-imaging technologies that allowed safe and noninvasive study of the human brain in action. Koch gives us stories from the front lines of modern research into the neurobiology of consciousness as well as his own reflections on a variety of topics, including the distinction between attention and awareness, the unconscious, how neurons respond to Homer Simpson, the physics and biology of free will, dogs, Der Ring des Nibelungen, sentient machines, the loss of his belief in a personal God, and sadness. All of them are signposts in the pursuit of his life's work—to uncover the roots of consciousness. |
| allen institute for cell science: Principles of Cell Biology George Plopper, Diana Bebek Ivankovic, 2020-02-03 Principles of Cell Biology, Third Edition is an educational, eye-opening text with an emphasis on how evolution shapes organisms on the cellular level. Students will learn the material through 14 comprehensible principles, which give context to the underlying theme that make the details fit together. |
| allen institute for cell science: Life Itself Boyce Rensberger, 1996 In Amazing Life, Boyce Rensberger takes readers to the frontlines of cell research with some of the brightest investigators in molecular, cellular, and developmental biology. The hottest topics in biomedical research are covered. |
| allen institute for cell science: The Philosophical Legacy of Jorge J. E. Gracia Robert A. Delfino, William Irwin, Jonathan J. Sanford, 2022-01-31 Fleeing Cuba in 1961, Jorge J. E. Gracia arrived in the USA at the age of nineteen without family and unable to speak English. Ten years later he was assistant professor of philosophy at the State University of New York at Buffalo. Over the next 50 years Gracia published dozens of books and hundreds of articles, making major contributions to numerous areas of philosophy: Latin American philosophy, race and ethnicity, Medieval philosophy, philosophical historiography, metaphysics and ontology, and theory of interpretation. This book is a critical response to Gracia’s work and a tribute to his legacy. It includes a comprehensive bibliography of Gracia’s philosophical works. |
| allen institute for cell science: Culturing Life Hannah Landecker, 2010-03-30 How did cells make the journey, one we take so much for granted, from their origin in living bodies to something that can be grown and manipulated on artificial media in the laboratory, a substantial biomass living outside a human body, plant, or animal? This is the question at the heart of Hannah Landecker's book. She shows how cell culture changed the way we think about such central questions of the human condition as individuality, hybridity, and even immortality and asks what it means that we can remove cells from the spatial and temporal constraints of the body and harness them to human intention. Rather than focus on single discrete biotechnologies and their stories--embryonic stem cells, transgenic animals--Landecker documents and explores the wider genre of technique behind artificial forms of cellular life. She traces the lab culture common to all those stories, asking where it came from and what it means to our understanding of life, technology, and the increasingly blurry boundary between them. The technical culture of cells has transformed the meaning of the term biological, as life becomes disembodied, distributed widely in space and time. Once we have a more specific grasp on how altering biology changes what it is to be biological, Landecker argues, we may be more prepared to answer the social questions that biotechnology is raising. |
| allen institute for cell science: Idea Man Paul Allen, 2012 What's it like to start a revolution? How do you build the biggest tech company in the world? And why do you walk away from it all? Paul Allen co-founded Microsoft. Together he and Bill Gates turned an idea - writing software - into a company and then an entire industry. This is the story of how it came about: two young mavericks who turned technology on its head, the bitter battles as each tried to stamp his vision on the future and the ruthless brilliance and fierce commitment. |
| allen institute for cell science: Cancer Stem Cells Lucie Laplane, 2016-06-06 Part IV: The Identity of Stemness and Its Consequences for Cancer Therapies -- Chapter 7. If Stemness Is a Categorical or a Dispositional Property, How Can We Cure Cancers? -- Chapter 8. If Stemness Is a Relational or a Systemic Property, How Can We Cure Cancers? -- Conclusion -- Notes -- References -- Acknowledgments -- Index |
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