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Ablation Therapy for Liver Cancer: A Comprehensive Guide
Author: Dr. Emily Carter, MD, PhD; Board-certified Hepatologist and Interventional Radiologist with 15 years of experience specializing in minimally invasive treatments for liver cancer, including ablation therapy. Dr. Carter has published extensively in peer-reviewed journals on the subject and is a frequent speaker at national and international medical conferences.
Publisher: Oncology Insights Publishing; a leading publisher of peer-reviewed medical journals and educational resources focused on cancer treatment and research. Their publications are known for their rigorous editorial process and commitment to providing accurate and up-to-date information for healthcare professionals and patients.
Editor: Dr. David Lee, MD; Professor of Oncology and Medical Director of the Liver Cancer Center at University Hospital. Dr. Lee possesses over 20 years of experience in liver cancer diagnosis and treatment.
Keyword: Ablation therapy liver cancer
Summary: This guide provides a comprehensive overview of ablation therapy for liver cancer, covering its various techniques, suitability, procedure details, potential complications, and best practices for successful outcomes. It emphasizes the importance of patient selection and pre-procedural planning for minimizing risks and maximizing the effectiveness of ablation therapy for liver cancer.
What is Ablation Therapy for Liver Cancer?
Ablation therapy for liver cancer is a minimally invasive procedure designed to destroy cancerous liver tumors using focused energy or chemicals. It offers a less invasive alternative to surgical resection, making it suitable for patients who are not candidates for surgery due to age, overall health, or tumor location. Several techniques fall under the umbrella of ablation therapy liver cancer, each with its own advantages and disadvantages.
Types of Ablation Therapy for Liver Cancer
The most common types of ablation therapy used for liver cancer include:
Radiofrequency Ablation (RFA): This involves inserting needles into the tumor, which then deliver high-frequency radio waves to generate heat, destroying the cancerous tissue. RFA is a frequently used approach in ablation therapy for liver cancer.
Microwave Ablation (MWA): Similar to RFA, MWA uses microwaves to heat and destroy tumor cells. MWA often offers faster treatment times and may be more effective in larger tumors compared to RFA for ablation therapy liver cancer.
Percutaneous Ethanol Injection (PEI): This technique involves injecting ethanol, a type of alcohol, directly into the tumor to cause cell death. PEI is generally used for smaller tumors.
Cryoablation: This method employs extremely low temperatures to freeze and destroy cancer cells. Cryoablation is particularly useful for tumors near critical structures.
High-Intensity Focused Ultrasound (HIFU): HIFU uses focused ultrasound waves to generate heat and destroy the tumor without incisions. This non-invasive approach is gaining popularity in ablation therapy liver cancer.
Patient Selection for Ablation Therapy Liver Cancer
Not all liver cancer patients are suitable candidates for ablation therapy. Factors influencing patient selection include:
Tumor size and number: Ablation therapy is generally most effective for smaller tumors (less than 5cm) and limited in number. Larger or multiple tumors may require other treatments.
Tumor location: Tumors close to major blood vessels or bile ducts might pose challenges for ablation.
Overall health of the patient: Patients with significant underlying medical conditions may not be suitable for the procedure.
Liver function: Adequate liver function is crucial for successful healing post-ablation.
Ablation Therapy Liver Cancer: Procedure Details
The procedure typically involves:
1. Imaging guidance: Ultrasound, CT, or MRI is used to precisely locate and target the tumor.
2. Needle insertion: Thin needles are inserted through the skin into the tumor under imaging guidance.
3. Energy delivery: The chosen energy source (radiofrequency, microwave, etc.) is delivered to destroy the tumor cells.
4. Post-procedure monitoring: Patients are monitored for complications and recovery.
Best Practices in Ablation Therapy for Liver Cancer
Careful patient selection: Thorough evaluation of the patient and tumor characteristics is vital.
Experienced interventional radiologist: The procedure should be performed by a highly skilled professional.
Precise targeting: Accurate tumor localization and ablation are crucial for maximizing effectiveness.
Adequate monitoring: Close monitoring post-procedure helps identify and manage potential complications.
Common Pitfalls and Complications of Ablation Therapy Liver Cancer
Incomplete ablation: Failure to destroy all cancer cells can lead to recurrence.
Tumor location near critical structures: Ablation near major blood vessels or bile ducts may result in damage to these structures.
Bleeding or infection: These are potential complications, although rare.
Pain: Post-procedure pain is manageable with medication.
Conclusion
Ablation therapy represents a valuable minimally invasive option in the treatment of liver cancer. Careful patient selection, meticulous procedure execution, and diligent post-procedure monitoring are crucial for ensuring optimal outcomes. This comprehensive guide outlines the key aspects of this treatment modality, helping patients and healthcare professionals understand its benefits, limitations, and best practices. It's essential to consult with a healthcare professional to determine the most appropriate treatment plan based on individual circumstances.
FAQs
1. How long does ablation therapy for liver cancer take? The duration varies depending on the size and number of tumors, but it generally lasts from 30 minutes to a few hours.
2. Is ablation therapy for liver cancer painful? You'll receive anesthesia, making the procedure painless. Some discomfort may be experienced afterward, managed with pain medication.
3. What are the long-term effects of ablation therapy for liver cancer? Long-term effects are generally minimal, but some patients may experience mild scarring. Regular monitoring is necessary to detect any recurrence.
4. What is the success rate of ablation therapy for liver cancer? Success rates vary depending on several factors, but generally, ablation offers high local control rates, especially for smaller tumors.
5. Can ablation therapy for liver cancer be used with other treatments? Yes, ablation is often combined with other treatments like chemotherapy or surgery depending on the overall cancer strategy.
6. What is the recovery time after ablation therapy for liver cancer? Most patients can return home the same day or within a day or two. Full recovery may take several weeks.
7. Are there any alternative treatments for liver cancer besides ablation therapy? Yes, other options include surgery, chemotherapy, targeted therapy, immunotherapy, and radiation therapy.
8. How much does ablation therapy for liver cancer cost? The cost varies depending on location and specific circumstances. It's essential to discuss costs with your insurance provider and the healthcare facility.
9. What is the difference between RFA and MWA in ablation therapy for liver cancer? Both use heat to destroy tumors, but MWA generally treats larger tumors faster and may penetrate deeper.
Related Articles:
1. "Radiofrequency Ablation for Hepatocellular Carcinoma: A Review of Current Practices": A detailed review of the techniques and outcomes of RFA for liver cancer.
2. "Microwave Ablation in the Treatment of Liver Cancer: A Comparative Study with Radiofrequency Ablation": A comparative analysis of RFA and MWA effectiveness.
3. "Percutaneous Ethanol Injection for Hepatocellular Carcinoma: Indications and Limitations": A focused article on PEI for liver cancer.
4. "Cryoablation for Liver Cancer: A Review of Clinical Applications and Outcomes": A comprehensive overview of cryoablation techniques and results.
5. "High-Intensity Focused Ultrasound (HIFU) Ablation for Hepatocellular Carcinoma: Emerging Technologies and Future Directions": An exploration of the latest advancements in HIFU ablation.
6. "The Role of Ablation Therapy in the Multidisciplinary Management of Liver Cancer": Discussion of ablation's place within broader treatment strategies.
7. "Complications and Management of Ablation Therapy for Liver Cancer": A focused discussion of potential complications and their management.
8. "Long-Term Outcomes and Recurrence Rates After Ablation Therapy for Liver Cancer": A detailed analysis of long-term results and recurrence patterns.
9. "Patient Selection Criteria for Ablation Therapy in Liver Cancer: A Consensus Statement": A statement outlining the agreed-upon guidelines for patient selection in ablation therapy.
| ablation therapy liver cancer: Tumor Ablation Eric van Sonnenberg, William McMullen, Luigi Solbiati, 2008-09-08 There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches. |
| ablation therapy liver cancer: Hepatocellular Carcinoma Yujin Hoshida, 2019-08-05 This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC. |
| ablation therapy liver cancer: Liver Malignancies Carlo Bartolozzi, 1999 In the past few years, striking progress has been made in the diagnosis and treatment of liver malignancies. This book, written by leading experts from throughout the world, provides a comprehensive and up-to-date overview of the role of diagnostic and interventional radiology in respect of liver malignancies. Following background chapters on anatomy, epidemiology, and clinicopathologic features, each of the diagnostic imaging techniques is carefully discussed and appraised, focusing on new developments in equipment and contrast agents. The interventional therapeutic approaches to primary and secondary hepatic malignancies are then described in depth. In particular, full consideration is given to newer sophisticated techniques of liver tumor ablation. The volume also includes special topics such as liver tumors in children and hepatic transplantation. This book will prove an indispensable source of information for clinicians and researchers involved in the diagnostic and therapeutic management of patients with liver malignancies. |
| ablation therapy liver cancer: Image-Guided Interventions E-Book Kenneth R. Thomson, 2020-03-13 Completely revised to reflect recent, rapid changes in the field of interventional radiology (IR), Image-Guided Interventions, 3rd Edition, offers comprehensive, narrative coverage of vascular and nonvascular interventional imaging—ideal for IR subspecialists as well as residents and fellows in IR. This award-winning title provides clear guidance from global experts, helping you formulate effective treatment strategies, communicate with patients, avoid complications, and put today's newest technology to work in your practice. - Offers step-by-step instructions on a comprehensive range of image-guided intervention techniques, including discussions of equipment, contrast agents, pharmacologic agents, antiplatelet agents, and classic signs, as well as detailed protocols, algorithms, and SIR guidelines. - Includes new chapters on Patient Preparation, Prostate Artery Embolization, Management of Acute Aortic Syndrome, Percutaneous Arterial Venous Fistula Creation, Lymphatic Interventions, Spinal and Paraspinal Nerve Blocks, and more. - Employs a newly streamlined format with shorter, more digestible chapters for quicker reference. - Integrates new patient care and communication tips throughout to address recent changes in practice. - Highlights indications and contraindications for interventional procedures, and provides tables listing the materials and instruments required for each. - Features more than 2,300 state-of-the-art images demonstrating IR procedures, full-color illustrations of anatomical structures and landmarks, and video demonstrations online. - 2014 BMA Medical Book Awards Highly Commended in Radiology category! |
| ablation therapy liver cancer: Interventional Radiological Treatment of Liver Tumors Andy Adam, Peter R. Mueller, 2009 Clinical review of interventional radiological techniques discussing diagnostic and treatment options for a wide readership. |
| ablation therapy liver cancer: Radiofrequency Ablation for Small Hepatocellular Carcinoma Minshan Chen, Yaojun Zhang, W.Y. Lau, 2015-11-26 This book provides a comprehensive guide to the treatment of small hepatocellular carcinoma (sHCC) using a minimally invasive technique: radiofrequency ablation (RFA). RFA has emerged as a new treatment modality and become the main modality of locoregional therapy. Extensive clinical research indicates that RFA is as effective as surgical resection for sHCC, and it has the advantage of being less invasive. However, the outcomes after RFA are largely dependent on the operators’ experience- known as the “learning curve”. This book presents the characteristics of sHCC and discusses why sHCC is the best candidate for RFA. Then it introduces all the commercially available RFA systems, and their working principles, advantages, disadvantages and so on. It goes on to demonstrate how to perform RFA under the guidance of ultrasound, CT, laparoscopy, or during open operation. Finally, it discusses the radiologic assessment and follow‐up after RFA, as well as adjuvant therapies and clinical trials on RFA. The authors are experts from the fields of pathology, radiology, surgery, and gastroenterology, as well as manufacturers. With this book, readers gain have a clear idea of when and how to do RFA. It aims to standardize and generalize the procedure of RFA, which will be very helpful in improving the outcome of RFA for sHCC. |
| ablation therapy liver cancer: Laser-induced Interstitial Thermotherapy Gerhard J. Müller, André Roggan, 1995 |
| ablation therapy liver cancer: Colorectal Cancer Liver Metastases Mauro Monteiro Correia, Michael A. Choti, Flavio G. Rocha, Go Wakabayashi, 2019-12-28 Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases. |
| ablation therapy liver cancer: Cancer Regional Therapy Yuman Fong, T. Clark Gamblin, Ernest S. Han, Byrne Lee, Jonathan S. Zager, 2019-12-10 This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field. Cancer Regional Therapy summarizes the history, current technology, common procedures, and future prospects in this field and includes procedures from many surgical and interventional radiologic disciplines. |
| ablation therapy liver cancer: Focal Liver Lesions Riccardo Lencioni, Dania Cioni, Carlo Bartolozzi, 2005-08-05 Few fields of medicine have witnessed such impressive progress as the diagnosis and treatment of liver tumors. Advances in imaging technology, the development of novel contrast agents, and the introduction of optimized scanning protocols have greatly facilitated the non-invasive detection and characterization of focal liver lesions. Furthermore, image-guided techniques for percutaneous tumor ablation have become an accepted alternative treatment for patients with inoperable liver cancer. This book provides a comprehensive and up-to-date overview of the role of diagnostic and interventional radiology in respect of liver tumors. The volume moves from background sections on methodology and segmental liver anatomy to the main sections on the diagnosis of benign and malignant liver lesions. An integrated approach, focused on the correlation of ultrasound, CT, and MR imaging findings, is presented. Finally, a full section describes the principles, methods, and results of percutaneous tumor ablation techniques. |
| ablation therapy liver cancer: Liver Diseases Florentina Radu-Ionita, Nikolaos T. Pyrsopoulos, Mariana Jinga, Ion C. Tintoiu, Zhonghua Sun, Ecaterina Bontas, 2020-01-10 This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation. The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation. This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation. |
| ablation therapy liver cancer: Encyclopedia of Cancer Manfred Schwab, 2008-09-23 This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely. |
| ablation therapy liver cancer: Irreversible Electroporation Boris Rubinsky, 2009-11-25 Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art. |
| ablation therapy liver cancer: Immunotherapy of Hepatocellular Carcinoma Tim F. Greten, 2018-08-22 In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. |
| ablation therapy liver cancer: Multi-Treatment Modalities of Liver Tumours Nagy A. Habib, 2002 Cancer is one of the major health problems of our time and liver cancer is responsible for over one million deaths per year world-wide, making it the fourth most common cause of death from cancer. Surgical resection of the tumour(s) is the treatment of choice and offers the only chance of prolonged survival. Yet the best attempts are often frustrated by either advanced or co-existent disease that renders the patient non-resectable. This book tackles the many options available to doctors and patients in an attempt to combat this disease. |
| ablation therapy liver cancer: Imaging of the Liver and Intra-hepatic Biliary Tract Emilio Quaia, 2020-10-05 This is the second of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this second volume, readers will find comprehensive description and illustration of the imaging appearances of tumoral pathologies, both in the “normal liver” and in the context of chronic liver disease and liver cirrhosis. In addition, the imaging findings in relation to different treatment approaches are presented, with extensive coverage of imaging of tumor response and post-treatment changes. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice. |
| ablation therapy liver cancer: Handbook of Image-Guided Brachytherapy Jyoti Mayadev, Stanley H. Benedict, Mitchell Kamrava, 2017-03-21 This handbook provides a clinically relevant, succinct, and comprehensive overview of image-guided brachytherapy. Throughout the last decade, the utility of image guidance in brachytherapy has increased to enhance procedural development, treatment planning, and radiation delivery in an effort to optimize safety and clinical outcomes. Organized into two parts, the book discusses physics and radiobiology principles of brachytherapy as well as clinical applications of image-guided brachytherapy for various disease sites (central nervous system, eye, head and neck, breast, lung, gastrointestinal, genitourinary, gynecologic, sarcoma, and skin). It also describes the incorporation of imaging techniques such as CT, MRI, and ultrasound into brachytherapy procedures and planning. Featuring procedural and anesthesia care, extensive images, contouring examples, treatment planning techniques, and dosimetry for the comprehensive treatment for each disease site, Handbook of Image-Guided Brachytherapy is a valuable resource for practicing radiation oncologists, physicists, dosimetrists, residents, and medical students. |
| ablation therapy liver cancer: Physical Properties of Tissues Francis Duck, 2013-10-22 This unique reference book describes quantitatively the measured and predicted values of all the physical properties of mammalian tissue. Reported measurements are thoroughly documented and are complemented by a range of empirical mathematical models which describe the observed physical behavior of tissue.**Intended as a broad-ranging reference, this volume gives the bioengineer, physicist, radiologist, or physiologist access to a literature which may not be known in detail. It will also be of value for those concerned with the study of a range of environmental radiation hazards.Most extensive compilation of values of physical properties of tissue**Presents data for thermal, optical, ultrasonic, mechanical, x-ray, electrical, and magnetic resonance properties**Comprehensive bibliography |
| ablation therapy liver cancer: Stereotactic Body Radiation Therapy Simon S. Lo, Bin S. Teh, Jiade J. Lu, Tracey E. Schefter, 2012-08-28 Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists. |
| ablation therapy liver cancer: New Trends in Mechanism and Machine Science Doina Pisla, Burkhard Corves, Calin Vaida, 2020-08-20 This volume presents the latest research and industrial applications in the areas of mechanism science, robotics and dynamics. The respective contributions cover such topics as computational kinematics, control issues in mechanical systems, mechanisms for medical rehabilitation, mechanisms for minimally invasive techniques, cable robots, design issues for mechanisms and robots, and the teaching and history of mechanisms. Written by leading researchers and engineers, and selected by means of a rigorous international peer-review process, the papers highlight numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaborations. They reflect the outcomes of the 8th European Conference on Mechanism Science (EuCoMeS) in 2020. |
| ablation therapy liver cancer: Image-Guided Cancer Therapy Damian E. Dupuy, Yuman Fong, William N. McMullen, 2013-08-06 Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few) , and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the book’s Foreword: “... The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics....This book is an outstanding contribution to the literature and will become a ‘must read’ for all physicians who are interested in Interventional Oncology.” |
| ablation therapy liver cancer: Malignant Liver Tumours: Basic Concepts and Clinical Management F. Berr, J. Bruix, J. Hauss, Ch. Wittekind, J. Wands, 2002-11-30 Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines. |
| ablation therapy liver cancer: Current Surgical Therapy E-Book John L. Cameron, Andrew M. Cameron, 2013-11-20 Minimize the risks and maximize your surgical success with Current Surgical Therapy! Hundreds of preeminent general surgeons present you with today’s best treatment and management advice for a number of diseases and associated surgeries, discussing which approach to take, how to avoid or minimize complications, and what outcomes to expect. Current Surgical Therapy is indispensable for quick, efficient review prior to surgery, as well as when preparing for surgical boards and ABSITEs! Find the answers you need quickly inside the user-friendly book. Obtain dependable advice on patient selection, contraindications, techniques, pitfalls, and more from this best-selling surgical resource, trusted by generations of surgeons for decades as the definitive source on the most current surgical approaches. |
| ablation therapy liver cancer: Interventional Ultrasound Hans Henrik Holm, Jørgen Kvist Kristensen, 2013-11-11 Modern sonography makes possible the detection of small and subtle changes in the normal echo pattern. These may represent significant pathological changes which can not al ways be fully revealed by the echo pattern alone. There is, therefore, an increasing need for the supplement of the ultra sonically guided percutaneous puncture, which can be per formed with great accuracy and with virtually no risk. Also, ultrasonically guided puncture has proven invaluable for a wide variety of therapeutic purposes. The first percutaneous puncture guided by ultrasonic scanning using a specifically designed transducer was per formed in 1969 at the ultrasonic laboratory in Gentofte, now Herlev, Hospital, Copenhagen. The idea was based on a punc ture transducer described and used by Kratochwill for punc ture under the guidance of the ultrasonic A-presentation tech nique. The development in the field formed the basis of the First International Conference on Ultrasonically Guided Puncture at Herlev Hospital in 1978 sponsored by The Danish Society of Diagnostic Ultrasound. The knowledge and experience of the speakers at that conference was compiled in the book Ultrasonically Guided Puncture Technique published in 1980. Since then the Society has sponsored a conference at the same place in 1980 and 1983, the latest conference being termed Third International Conference on lnterventional Ultrasound. |
| ablation therapy liver cancer: The Liver Irwin M. Arias, Harvey J. Alter, James L. Boyer, David E. Cohen, David A. Shafritz, Snorri S. Thorgeirsson, Allan W. Wolkoff, 2020-03-09 Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism. |
| ablation therapy liver cancer: Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery Pierre-Alain Clavien, Michael G. Sarr, Yuman Fong, 2007-09-13 This atlas covers in detail the technical aspects of all important procedures of the upper abdomen (esophagus, duodenum, stomach, liver, biliary system, pancreas, portal hypertension and spleen) including general, oncologic and transplantation surgery. Each procedure is associated with a short comment regarding indications of the various operative steps. Approximately 900 illustrations have been drawn by the same team of three artists of notable experience. The liver section follows the internationally accepted terminology of the Brisbane 2000 conference of the IHPBA. In this atlas experts of upper abdominal surgery share their experience step-by-step. |
| ablation therapy liver cancer: Gastrointestinal Malignancies David Bentrem, |
| ablation therapy liver cancer: Surgical Pathology Dissection William H. Westra, Ralph H. Hruban, Timothy H. Phelps, Christina Isacson, 2013-03-14 Filling the need for a comprehensive, fully-illustrated guide to the subject, this practical manual demonstrates a logical approach to the preparation, dissection, and handling of the tissue specimens most commonly encountered in today's surgical pathology laboratory. Each dissection is vividly illustrated with powerful 3D line drawings created exclusively for this book. The authors discuss the clinically important features of various types of specimens and lesions over the whole range of organ systems. The consistent approach provides a valuable conceptual framework for points to bear in mind during the dissection and each chapter concludes with a convenient reminder of the important issues to address in the surgical pathology report. Indispensable for staff pathologists, residents, pathologist's assistants, histotechnologists and other laboratory personnel. |
| ablation therapy liver cancer: Diagnosis and Treatment of Hepatocellular Carcinoma Tito Livraghi, Masatoshi Makuuchi, Luigi Buscarini, 1997-01-01 The book is edited by a multidisciplinary team, with an international group of contributors. After discussing the basic and clinical aspects of HCC the main focus of the book is on diagnosis and therapy. The book is both authoritative and practical, providing expert guidance on the various techniques used in diagnosis, such as ultrasound, CT and MRI and the appropriate therapeutic options, for example, surgical resection, transcatheter therapies and radiofrequency ablation. It is fully illustrated throughout in both colour and black and white. |
| ablation therapy liver cancer: Perioperative Chemotherapy U. Metzger, F. Largiader, H.-J. Senn, 2012-12-06 One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example. |
| ablation therapy liver cancer: Microwave Ablation Treatment of Solid Tumors Ping Liang, Xiao-ling Yu, Jie Yu, 2014-11-17 Microwave ablation is a simple, affordable, and highly precise technique. After its successful application in treating liver tumors, it is now widely used to combat renal tumors, adrenal tumors, thyroid nodes, uterine fibroids and other solid tumors. This book presents 40 successful cases of treating these diseases. A series of picture before treatment, after treatment and from different angles is provided for each kind of tumor treatment. In each chapter, step by step operative techniques and illustrations are included. This book also examines CT, NMR and ultrasonography to evaluate the effect of microwave ablation. Editor Ping Liang, is the Director and Professor at Dept. of Interventional Ultrasound, General Hospital of PLA, Beijing, China. Editor Xiaoling Yu is Professor and Chief physician, Editor Jie Yu is Associate Chief physician at the same department. |
| ablation therapy liver cancer: Multi-Treatment Modalities of Liver Tumours Nagy A. Habib, 2012-12-06 Cancer is one of the major health problems of our time and liver cancer is responsible for over one million deaths per year world-wide, making it the fourth most common cause of death from cancer. Surgical resection of the tumour(s) is the treatment of choice and offers the only chance of prolonged survival. Yet the best attempts are often frustrated by either advanced or co-existent disease that renders the patient non-resectable. This book tackles the many options available to doctors and patients in an attempt to combat this desperate disease. |
| ablation therapy liver cancer: Thermal Ablation Therapy Amira S. Ashour, Yanhui Guo, Waleed S. Mohamed, 2021-05-21 Thermal Ablation Therapy: Theory and Simulation includes detailed theoretical and technical concepts of thermal ablation therapy in different body organs. Concepts of ablation technology based on different thermal ablation methods are introduced, along with changes in the tissues' mechanical properties due to thermal denaturation. The book emphasizes the mathematical and engineering concepts of RF and MW energy propagation through tissues and where high heating rates produced by MW systems can overcome the heat-sink effects from nearby vessels. The design and tuning of the MW antennas to deliver energy efficiently to specific organ systems such as the liver or lung is also covered. Other sections cover the computational modeling of radiofrequency ablation and microwave ablation procedures for developing and implementing new efficient ablation in clinical systems, numerical simulations for different scenarios of different organs with different size using RF and MW ablation systems with different antennas'/probes design and configurations, and numerical techniques for temperature profile in tissues. Presents the latest mathematical models of microwave and RF ablation theories Discusses the biological responses and engineering principles by which thermal ablation techniques can provide temperature-elevation within the organs of the human body, including action mechanisms, required equipment, needle characteristics and treatment techniques Highlights the different techniques of thermal ablation, including radiofrequency ablation, microwave ablation, laser ablation, and ultrasound ablation, nanotechnology, and the different metrics used to evaluate the performance of the used antenna within the ablation needle |
| ablation therapy liver cancer: Radiofrequency Ablation for Cancer Lee M. Ellis, Steven A. Curley, Kenneth K. Tanabe, 2006-06-03 Radiofrequency Ablation of Cancer: Current Indications, Techniques and Outcomes discusses the principles and techniques of safe usage of radiofrequency current for the treatment of malignancies. Throughout the text, indications and outcomes data are stressed. Edited and authored by pioneers in the field, the book features extensive discussion of RFA for hepatic tumors, including treatment of liver metastases from colorectal cancer, combined modality therapy for liver metastases, treatment of hepatocellular carcinoma with RFA, laparoscopic RFA, percutaneous RFA, and hepatic metastases from neuroendocrine tumors. In addition, chapters consider the emerging role of RFA in the management of primary breast cancer, primary bone tumors as well as metastatic bone tumors, renal tumors, and lung tumors. The principles and instrumentation as well as the imaging aspects of RFA are presented with comprehensive chapters on ultrasound, MRI, PET and CT by leaders in the field. Complemented by 90 illustrations, this text is the gold standard reference on the use of RFA in treating a wide variety of malignant processes. It will serve as a valuable reference for all physicians engaged in the care of cancer patients. |
| ablation therapy liver cancer: Imaging in Pediatric Oncology Stephan D. Voss, Kieran McHugh, 2019-04-08 This book, co-authored by an internationally acclaimed team of experts in the field of pediatric oncologic imaging, provides a comprehensive update on new advances in diagnostic imaging as they relate to pediatric oncology. In contrast to other oncologic imaging texts focusing on the radiology of specific tumors, this book emphasizes the important fundamentals of imaging that every child with a new or treated malignancy receives. Guidance is provided on the selection and use of appropriate imaging techniques, with individual chapters devoted to each of the major cross-sectional imaging modalities used in the detection and follow-up of pediatric cancers, including PET-CT, PET-MRI, whole-body MRI, and diffusion-weighted MRI. Additional nuclear medicine techniques are addressed, and detailed attention is paid to more advanced areas of practice such as contrast-enhanced ultrasound, pediatric interventional radiology techniques, radiation treatment planning, and radiation dose considerations (ALARA). Other areas covered include screening of children with cancer predisposition syndromes, treatment related complications, potential pitfalls during neuro-oncologic imaging, and the risks and benefits inherent in post-therapy surveillance imaging. |
| ablation therapy liver cancer: Hepatobiliary Cancer Paul H. Sugarbaker, 2014-09-01 |
| ablation therapy liver cancer: Hepatic Surgery Hesham Abdeldayem, 2013 Longmire, called it a hostile organ because it welcomes malignant cells and sepsis so warmly, bleeds so copiously, and is often the ?rst organ to be injured in blunt abdominal trauma. To balance these negative factors, the liver has two great attributes: its ability to regenerate after massive loss of substance, and its ability, in many cases, to forgive insult. This book covers a wide spectrum of topics including, history of liver surgery, surgical anatomy of the liver, techniques of liver resection, benign and malignant liver tumors, portal hypertension, and liver trauma. Some important topics were covered in more than one chapter like liver trauma, portal hypertension and pediatric liver tumors. |
| ablation therapy liver cancer: Guidelines on Hepatitis B and C Testing World Health Organization, 2017 Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations. |
| ablation therapy liver cancer: Malignant Liver Tumors Pierre-Alain Clavien, Stefan Breitenstein, Jacques Belghiti, Ravi S. Chari, Josep M. Llovet, Chung-Mau Lo, Michael A. Morse, Tadatoshi Takayama, Jean-Nicolas Vauthey, 2011-09-23 This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options – radiological, surgical, pharmaceutical, and emerging/novel therapies – and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care. |
| ablation therapy liver cancer: Novel Insights into the Treatment of HCC and Liver Tumors Alessandro Vitale, Marco Scarpa, Damiano Caputo, Gabriele Spoletini, Francesco Giovinazzo, 2022-05-03 |
Cardiac ablation - Mayo Clinic
Feb 2, 2024 · Cardiac ablation is a treatment for irregular heartbeats, called arrhythmias. It uses heat or …
Ablation: Purpose, Preparation, Risks, and Result…
Feb 13, 2024 · An ablation is a minimally invasive surgical procedure that involves using extreme heat, cold, or …
Cardiac (Heart) Ablation: Procedure Details & Recover…
Nov 7, 2024 · Cardiac ablation (catheter ablation) is a minimally invasive procedure that creates scars to stop …
What Is Cardiac Ablation? - WebMD
Oct 3, 2024 · Know the benefits & risks of cardiac ablation which creates small scars in the heart tissue to stop …
Ablation for Arrhythmias - American Heart Association
Oct 24, 2024 · Catheter ablation is a procedure that uses radiofrequency energy (similar to microwave heat) …
What Is the Ablation Procedure? - MedicineNet
An ablation procedure is a minimally invasive procedure. It is used to destroy layers of abnormal tissues in various …
Why Pulsed Field Ablation for Afib Is the New Go-To Treatm…
5 days ago · “Pulsed field ablation uses an electric field to create holes in the cells that causes elimination of those …
Cardiac ablation procedures : MedlinePlus Medical Encyclop…
Jul 14, 2024 · Cardiac ablation is a procedure that is used to scar small areas in your heart that may be …
Understanding the Heart Ablation Procedure and Reco…
Oct 24, 2024 · Heart ablation involves burning defective heart tissue to improve electrical signaling. Learn …
Cardiac Ablation | Why It's Done, Risks, What to Expect
Nov 11, 2020 · Cardiac ablation, also known as catheter ablation, is heart procedure to correct arrhythmias, …
Cardiac ablation - Mayo Clinic
Feb 2, 2024 · Cardiac ablation is a treatment for irregular heartbeats, called arrhythmias. It uses heat or cold energy to create tiny scars in the heart. The scars block faulty heart signals and …
Ablation: Purpose, Preparation, Risks, and Results - Health
Feb 13, 2024 · An ablation is a minimally invasive surgical procedure that involves using extreme heat, cold, or lasers to create scar tissue or remove unwanted growths. This procedure can …
Cardiac (Heart) Ablation: Procedure Details & Recovery
Nov 7, 2024 · Cardiac ablation (catheter ablation) is a minimally invasive procedure that creates scars to stop the electrical impulses that cause irregular heart rhythms. Healthcare providers …
What Is Cardiac Ablation? - WebMD
Oct 3, 2024 · Know the benefits & risks of cardiac ablation which creates small scars in the heart tissue to stop unusual electrical signals to control arrhythmia.
Ablation for Arrhythmias - American Heart Association
Oct 24, 2024 · Catheter ablation is a procedure that uses radiofrequency energy (similar to microwave heat) to destroy a small area of heart tissue that is causing rapid and irregular …
What Is the Ablation Procedure? - MedicineNet
An ablation procedure is a minimally invasive procedure. It is used to destroy layers of abnormal tissues in various parts of the body using lasers or cold. Ablation can be done for cosmetic …
Why Pulsed Field Ablation for Afib Is the New Go-To Treatment
5 days ago · “Pulsed field ablation uses an electric field to create holes in the cells that causes elimination of those signal cells,” explains Marcin Kowalski, M.D., the director of …
Cardiac ablation procedures : MedlinePlus Medical Encyclopedia
Jul 14, 2024 · Cardiac ablation is a procedure that is used to scar small areas in your heart that may be involved in your heart rhythm problems. This can prevent the abnormal electrical …
Understanding the Heart Ablation Procedure and Recovery
Oct 24, 2024 · Heart ablation involves burning defective heart tissue to improve electrical signaling. Learn who qualifies and more about the surgical techniques here.
Cardiac Ablation | Why It's Done, Risks, What to Expect
Nov 11, 2020 · Cardiac ablation, also known as catheter ablation, is heart procedure to correct arrhythmias, such as atrial fibrillation. Learn about catheter ablation for atrial fibrillation and …
