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| antibody sequence analysis software: Sequences of Proteins of Immunological Interest , 1991 Tabulation and analysis of amino acid and nucleic acid sequences of precursors, v-regions, c-regions, j-chain, T-cell receptors for antigen, T-cell surface antigens, l-microglobulins, major histocompatibility antigens, thy-1, complement, c-reactive protein, thymopoietin, integrins, post-gamma globulin, -macroglobulins, and other related proteins. |
| antibody sequence analysis software: Immunoinformatics Christian Schönbach, Shoba Ranganathan, Vladimir Brusic, 2007-11-21 In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines. |
| antibody sequence analysis software: Computational Genomics with R Altuna Akalin, 2020-12-16 Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015. |
| antibody sequence analysis software: Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development Jacob Glanville, Prabakaran Ponraj, Gregory C. Ippolito, 2020-08-21 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| antibody sequence analysis software: Antibody Engineering Roland E. Kontermann, Stefan Dübel, 2013-06-29 Interest in recombinant antibody technologies has rapidly increased because of its wide range of possible applications in therapy, diagnosis, and especially, cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has facilitated the development of antibody engineering technologies. This manual presents a comprehensive collection of detailed step-by-step protocols, provided by experts. The text covers all basic methods needed in antibody engineering as well as recently developed and emerging technologies. |
| antibody sequence analysis software: The Proteomics Protocols Handbook John M. Walker, 2007-10-09 Hands-on researchers describe in step-by-step detail 73 proven laboratory methods and bioinformatics tools essential for analysis of the proteome. These cutting-edge techniques address such important tasks as sample preparation, 2D-PAGE, gel staining, mass spectrometry, and post-translational modification. There are also readily reproducible methods for protein expression profiling, identifying protein-protein interactions, and protein chip technology, as well as a range of newly developed methodologies for determining the structure and function of a protein. The bioinformatics tools include those for analyzing 2D-GEL patterns, protein modeling, and protein identification. All laboratory-based protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. |
| antibody sequence analysis software: Computer-Aided Antibody Design Kouhei Tsumoto, Daisuke Kuroda, 2022-11-08 This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. |
| antibody sequence analysis software: Antibody Engineering Benny K. C. Lo, 2008-02-03 The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to a wide range of disease states, and the potential ability to direct the host’s immune s- tem for a therapeutic response. The initial excitement in finding Paul Ehrlich’s “magic bullet,” however, was met with widespread disappointment when it was demonstrated that murine antibodies frequently elicit the human anti-murine an- body (HAMA) response, thus rendering them ineffective and potentially unsafe in humans. Despite this setback, advances in recombinant DNA techniques over the last 15–20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA. The ability to p- duce bulk quantities of recombinant proteins from bacterial fermentation also fueled the design of numerous creative antibody constructs. To date, the United States Food and Drug Administration has approved more than 10 recombinant antibodies for human use, and hundreds more are in the development pipeline. The recent explosion in genomic and proteomic information appears ready to deliver many more disease targets amenable to antibody-based therapy. |
| antibody sequence analysis software: Next Generation Sequencing Jerzy Kulski, 2016-01-14 Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences. |
| antibody sequence analysis software: Therapeutic Monoclonal Antibodies Zhiqiang An, 2011-09-20 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories. |
| antibody sequence analysis software: Handbook of Therapeutic Antibodies Stefan Dübel, Janice M. Reichert, 2014-08-04 Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic. |
| antibody sequence analysis software: Bioinformatics Methods and Protocols Stephen Misener, Stephen A. Krawetz, 2008-02-02 Computers have become an essential component of modern biology. They help to manage the vast and increasing amount of biological data and continue to play an integral role in the discovery of new biological relationships. This in silico approach to biology has helped to reshape the modern biological sciences. With the biological revolution now among us, it is imperative that each scientist develop and hone today’s bioinformatics skills, if only at a rudimentary level. Bioinformatics Methods and Protocols was conceived as part of the Methods in Molecular Biology series to meet this challenge and to provide the experienced user with useful tips and an up-to-date overview of current developments. It builds upon the foundation that was provided in the two-volume set published in 1994 entitled Computer Analysis of Sequence Data. We divided Bioinformatics Methods and Protocols into five parts, including a thorough survey of the basic sequence analysis software packages that are available at most institutions, as well as the design and implemen- tion of an essential introductory Bioinformatics course. In addition, we included sections describing specialized noncommercial software, databases, and other resources available as part of the World Wide Web and a stimul- ing discussion of some of the computational challenges biologists now face and likely future solutions. |
| antibody sequence analysis software: State-Of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 2. Biopharmaceutical Characterization John E. Schiel, Darryl L. Davis, Oleg V. Borisov, Oleg Borisov, 2016-06-24 Distributed in print by Oxford University Press. |
| antibody sequence analysis software: Fc-Mediated Antibody Functions and Fc-Receptor Polymorphism Volume II Guido Ferrari, R. Keith Reeves, Gabriella Scarlatti, Margaret E. Ackerman, Amy W. Chung, 2023-05-29 |
| antibody sequence analysis software: Immunoinformatics Gregory R. Bock, Jamie A. Goode, 2004-03-05 The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems. This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics. The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research. Related Novartis Foundation symposia: 247 In Silico Simulation of Biological Processes Chair: Denis Noble 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach |
| antibody sequence analysis software: Recombinant Antibodies for Cancer Therapy Martin Welschof, Jürgen Krauss, 2008-02-05 Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. Their repeated application in humans, however, is limited by the development of human antimouse antibodies (HAMA) in the recipient, leading to allergic re- tions against the foreign murine protein and rapid neutralization. To circumvent these limitations many new antibodies have recently been tailored through recombinant antibody technology. The initial clinical data show encouraging results, thus demonstrating the potential of these new therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology. It is pri- rily addressed to scientists working on recombinant antibodies as well as cli- cians involved with antibody-based therapies. As with other volumes of this series, we placed the main focus on providing detailed protocols describing procedures step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject of constant and rapid change. This volume, therefore, does not attempt to cover all possible current experimental approaches in the field. Rather, we present carefully selected protocols, written by competent authors who have successfully verified the particular method described. Given our own professional backgrounds and interest in oncology, we chose to conc- trate chiefly on therapeutic agents for cancer patients. |
| antibody sequence analysis software: Sequencing and phylogenetic analysis as a tool in molecular epidemiology of veterinary infectious diseases Iryna Goraichuk, Christina Leyson, Moh A. Alkhamis, 2023-08-02 |
| antibody sequence analysis software: Bioinformatics for Oral Cancer Mahesh KP, Raghavendra Amachawadi, Shiva Prasad Kollur, Chandan Shivamallu, 2024-05-31 Amid the rising global concern of oral cancer, this book provides a compelling exploration of the intricate oral cavity, focused on shedding light on early diagnosis and addressing outdated paradigms, it delves into the persistent challenges of oral premalignant lesions. Tailored for both beginners and researchers, its six chapters encompass the spectrum of genome sequencing, diagnostic biomarkers, gene expression, and more. Discover a fusion of basic and clinical sciences, aiming to invigorate the study of bioinformatics and oral cancer, and ultimately improve survival rates. Bioinformatics for Oral Cancer: Current Insights and Advances serves as a comprehensive guide, offering a deep dive into the multifaceted landscape of oral cancer research and bioinformatics. Within its pages, readers will uncover a wealth of knowledge, starting with foundational chapters introducing bioinformatics and establishing the backdrop of oral cancer. The book then progresses into the realm of diagnostic biomarkers, revealing cutting-edge methodologies for their identification in the context of oral cancer. The book’s keen focus extends to gene expression profiles and the intricacies of gene sequencing in the context of oral cancer progression. By systematically unravelling these critical aspects, the book bridges the gap between basic and clinical sciences, equipping readers with a holistic understanding of bioinformatics’ pivotal role in enhancing our grasp of oral cancer’s complexities. By deciphering the enigmatic landscape of oral premalignant lesions, the book equips clinicians and researchers with tools to predict malignant potentials. Its meticulous exploration of gene expression profiles and sequencing promises to reshape early detection strategies, propelling the field towards improved diagnosis and treatment outcomes. |
| antibody sequence analysis software: BioSupplyNet Source Book , 2000 |
| antibody sequence analysis software: Plant Genomes Jean-Nicolas Volff, 2008-01-01 Recent major advances in the field of comparative genomics and cytogenomics of plants, particularly associated with the completion of ambitious genome projects, have uncovered astonishing facets of the architecture and evolutionary history of plant genomes. The aim of this book was to review these recent developments as well as their implications in our understanding of the mechanisms which drive plant diversity. New insights into the evolution of gene functions, gene families and genome size are presented, with particular emphasis on the evolutionary impact of polyploidization and transposable elements. Knowledge on the structure and evolution of plant sex chromosomes, centromeres and microRNAs is reviewed and updated. Taken together, the contributions by internationally recognized experts present a panoramic overview of the structural features and evolutionary dynamics of plant genomes.This volume of Genome Dynamics will provide researchers, teachers and students in the fields of biology and agronomy with a valuable source of current knowledge on plant genomes. |
| antibody sequence analysis software: Clinical Bioinformatics Ronald Trent, 2016-08-23 In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics. |
| antibody sequence analysis software: DNA Kresten Ovesen, Ulrich Matthiesen, 2009 DNA (deoxyribonucleic acid) is the hereditary material in humans and almost all other organisms. DNA sequencing is a common and requisite practice for molecular biologists today working in all areas of biology, including microbiology. This book aims to provide clues for DNA sequencing projects directed to unsequenced organisms in which many transcripts wait to be discovered, either coding small RNAs or genes homologue to known genes coding for protein products. This book also looks at the adoption of the polymerase chain reaction (PCR) to generate DNA profiles from minute biological samples, and the use of mitochondrial DNA to obtain information from old bones and the applications of Y chromosomal polymorphisms in sexual assault cases. Present research focuses on genetic markers for external visible traits and on improving the utility of poor quality samples with degraded DNA. The other direction of forensic DNA research addresses the difficulty of obtaining a DNA profile in a degraded crime stain. The third topic covered in this book is DNA chips- a microchip that holds DNA probes that form half of the DNA double helix. This book examines the development of DNA chips, as the prototype for global technology genetics.--Publisher's description. |
| antibody sequence analysis software: Protein Therapeutics Tristan Vaughan, Jane Osbourn, Bahija Jallal, 2017-08-02 In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed. |
| antibody sequence analysis software: Protein-Protein Interactions Weibo Cai, Hao Hong, 2012-03-30 Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others. |
| antibody sequence analysis software: The Immunoglobulin FactsBook Marie-Paule Lefranc, Gerard Lefranc, 2001-05-23 The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee. |
| antibody sequence analysis software: Processing Metabolomics and Proteomics Data with Open Software Robert Winkler, 2020-03-16 Metabolomics and proteomics allow deep insights into the chemistry and physiology of biological systems. This book expounds open-source programs, platforms and programming tools for analysing metabolomics and proteomics mass spectrometry data. In contrast to commercial software, open-source software is created by the academic community, which facilitates the direct interaction between users and developers and accelerates the implementation of new concepts and ideas. The first section of the book covers the basics of mass spectrometry, experimental strategies, data operations, the open-source philosophy, metabolomics, proteomics and statistics/ data mining. In the second section, active programmers and users describe available software packages. Included tutorials, datasets and code examples can be used for training and for building custom workflows. Finally, every reader is invited to participate in the open science movement. |
| antibody sequence analysis software: Genomics and computational science for virus research Hironori Sato, Masaru Yokoyama, Hiroyuki Toh, A biologically striking and clinically important feature of viruses is their rapid evolutionary dynamics in nature. The continual interactions between viruses and host organisms promote quick changes in virus populations, eventually leading to co-evolution of viruses and hosts for their survival. The structural and functional information on the interactions between viruses and hosts should provide a molecular and biological basis to understand infection, replication, cell/host-tropism, immune escape, pathogenesis, and direction of evolution of viruses. The information is also essential to develop methods to control transmission and replication of pathogenic viruses. However, the integrated information on the structure, function, and evolution of viruses and hosts has remained poorly accumulated, partly due to the limitation of analytical methods. Recent progress in genome science and computational approach may open up a new avenue of research of the interactions between viruses and hosts by integrating information on the structures, functions, and evolution. In this Research Topic, we welcome papers concerning the computer-assisted structural and functional studies based on genomic information, with theoretical or in combination with experimental approaches, for understanding molecules, infection, replication, cell/host-tropism, immune escape, pathogenesis, and evolution of viruses in nature. |
| antibody sequence analysis software: Bioinformatics for Beginners Supratim Choudhuri, 2014-05-09 Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. - Avoids non-essential coverage, yet fully describes the field for beginners - Explains the molecular basis of evolution to place bioinformatic analysis in biological context - Provides useful links to the vast resource of publicly available bioinformatic databases and analysis tools - Contains over 100 figures that aid in concept discovery and illustration |
| antibody sequence analysis software: Monoclonal Antibodies Maher Albitar, 2008-02-02 This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy. |
| antibody sequence analysis software: Computational Structural Biology Torsten Schwede, 2008 This is a comprehensive introduction to Landau-Lifshitz equations and Landau-Lifshitz-Maxwell equations, beginning with the work by Yulin Zhou and Boling Guo in the early 1980s and including most of the work done by this Chinese group led by Zhou and Guo since. The book focuses on aspects such as the existence of weak solutions in multi dimensions, existence and uniqueness of smooth solutions in one dimension, relations with harmonic map heat flows, partial regularity and long time behaviors. The book is a valuable reference book for those who are interested in partial differential equations, geometric analysis and mathematical physics. It may also be used as an advanced textbook by graduate students in these fields. |
| antibody sequence analysis software: Biological Sequence Analysis Richard Durbin, Sean R. Eddy, Anders Krogh, Graeme Mitchison, 1998-04-23 Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field. |
| antibody sequence analysis software: Immunogenetics: A Molecular and Clinical Overview Muneeb U Rehman, Azher Arafah, Md. Niamat Ali, Shafat Ali, 2021-11-30 A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. - Contains exclusive information about research on immunogenetics from around the globe - Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications - Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner |
| antibody sequence analysis software: Methods for studying the genetics, molecular biology, physiology, and pathogenesis of the streptococci Paula M. Fives-Taylor, Donald J. LeBlanc, 2013-06-29 This book is devoted entirely to methods developed in and for studies of members of the bacterial family Streptococcaceae. Many of the studies that have been conducted on the Streptococcaceae were initiated because of the diseases they cause, or to enhance their utility from an industrial perspective. However, the results of many of these investigations have demonstrated a complexity among some members of the family that warrants an interest in them in their own right, apart from or in addition to any biomedical or industrial considerations. It is therefore hoped and expected that the advanced methods contained in this book will be of interest to those who work with the streptococci and other Gram-positive organisms, to researchers interested in industrial and medical microbiology and to any researcher who seeks to obtain a better understanding of how microorganisms interact with each other, their environment and their hosts. |
| antibody sequence analysis software: Immunology for Engineers , 2024-05-17 Immunology for Engineers, Volume 140 consists of chapters from stalwarts of the field, covering topics such as antibody engineering, adjuvant requirement and its methodology for assessment, and the need to develop immunotherapy, etc. Chapters covered in this volume discuss Current Status and Future Prospective of Breast Cancer Immunotherapy, Engineering high affinity antigen binders- beyond antibodies, Platelets and Inter-Cellular Communication in Immune Responses: Dialogue with both Professional and Non-Professional Immune Cells, Chimeric Antigen Receptor (CAR) T cell-based cancer immunotherapy: A boon for cancer-free life, and Molecular insights and promise of Oncolytic Virus based Immunotherapy. - Presents the latest in immunological engineering - Delves into timely topics such as antibody engineering - Covers vaccine engineering amongst many other important topics |
| antibody sequence analysis software: Antibody Engineering Volume 1 Roland E. Kontermann, Stefan Dübel, 2010-03-10 Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. Antibody Engineering provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest hands on knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development. |
| antibody sequence analysis software: Therapeutic Antibody Engineering William R Strohl, Lila M Strohl, 2012-10-16 The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. - Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships - Integration of knowledge across all areas of antibody engineering, development, and marketing - Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity |
| antibody sequence analysis software: Applications of Cloud Computing Prerna Sharma, Moolchand Sharma, Mohamed Elhoseny, 2020-11-12 In the era of the Internet of Things and with the explosive worldwide growth of electronic data volume, and associated need of processing, analysis, and storage of such a humongous amount of data, it has now become mandatory to exploit the power of massively parallel architecture for fast computation. Cloud computing provides a cheap source of such a computing framework for a large volume of data for real-time applications. It is, therefore, not surprising to see that cloud computing has become a buzzword in the computing fraternity over the last decade. Applications of Cloud Computing: Approaches and Practices lays a good foundation for the core concepts and principles of cloud computing applications, walking the reader through the fundamental ideas with expert ease. The book progresses on the topics in a step-by-step manner. It reinforces theory with a full-fledged pedagogy designed to enhance students' understanding and offer them a practical insight into the applications of it. It is a valuable source of knowledge for researchers, engineers, practitioners, and graduate and doctoral students working in the field of cloud computing. It will also be useful for faculty members of graduate schools and universities. |
| antibody sequence analysis software: Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology, 2007-12-19 The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€an effort requiring funding, interagency coordination, and data management strategies. |
| antibody sequence analysis software: TRP Channels Michael X. Zhu, 2016-04-19 The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles |
| antibody sequence analysis software: Genotype Phenotype Coupling Stefan Zielonka, Simon Krah, 2023-07-05 This detailed new edition broadens the scope of the first edition by moving beyond classical display technologies. This book explores methodologies for the generation of natively paired antibody libraries, single cell technologies, alternative scaffolds, and in silico antibody sequence assessments are described. The application of these methods may allow for a generation of improved therapeutics and diagnostic reagents in a shorter time frame. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Genotype Phenotype Coupling: Methods and Protocols, Second Edition serves as an ideal guide for researchers seeking to expand their knowledge of antibody-based therapeutics. |
Antibody - Wikipedia
Each antibody binds to a specific antigen in a highly specific interaction analogous to a lock and key. An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the …
Antibodies: Definition, Types & Function - Cleveland Clinic
May 6, 2022 · An antibody is a protein produced by your immune system to attack and fight off these antigens. How do antibodies fight off antigens? The molecules on the surfaces of …
Antibody | Definition, Structure, Function, & Types | Britannica
May 30, 2025 · Antibody, a protective protein produced by the immune system in response to the presence of a foreign substance, called an antigen. Antibodies recognize and latch onto …
Antibody: Definition, Structure, Types, Forms, Functions
Aug 3, 2023 · Antibody (Immunoglobulin) diversity. The immune system has the ability to generate a high level of diversity in order to recognize a very vast range of unique molecules estimated …
What is an antibody? - Medical News Today
Aug 11, 2021 · Antibodies develop in response to an infection or enter the body passively through vaccination. An antibody is sometimes called an immunoglobulin. But not all antibodies are …
Physiology, Antibody - StatPearls - NCBI Bookshelf
May 1, 2023 · The five antibody classes produced by the body include IgG, IgM, IgA, IgD, and IgE. IgM is the first antibody produced and acts as a B-cell surface immunoglobulin(Ig). …
Antibodies: Definition, Types, and Function - Health
Sep 8, 2024 · IgG: The most abundant antibody found in the body. It can help to block infections caused by bacteria, viruses, parasites , or other disease-causing organisms.
Antibody - National Human Genome Research Institute
6 days ago · An antibody is a protein component of the immune system that circulates in the blood, recognizes foreign substances like bacteria and viruses, and neutralizes them.
Antibody basics - Abcam
The basic principle of any immunoassay is that a specific antibody binds with its specific antigen, forming an exclusive antibody-antigen complex. This chapter defines what an antigen is and …
Antibody- Structure, Classes and Functions
Jan 23, 2024 · Antibody (Ab) also know as Immunoglobulin (Ig) is the large Y shaped protein produced by the body’s immune system when it detects harmful substances, called antigens …
Antibody - Wikipedia
Each antibody binds to a specific antigen in a highly specific interaction analogous to a lock and key. An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the …
Antibodies: Definition, Types & Function - Cleveland Clinic
May 6, 2022 · An antibody is a protein produced by your immune system to attack and fight off these antigens. How do antibodies fight off antigens? The molecules on the surfaces of …
Antibody | Definition, Structure, Function, & Types | Britannica
May 30, 2025 · Antibody, a protective protein produced by the immune system in response to the presence of a foreign substance, called an antigen. Antibodies recognize and latch onto …
Antibody: Definition, Structure, Types, Forms, Functions
Aug 3, 2023 · Antibody (Immunoglobulin) diversity. The immune system has the ability to generate a high level of diversity in order to recognize a very vast range of unique molecules estimated …
What is an antibody? - Medical News Today
Aug 11, 2021 · Antibodies develop in response to an infection or enter the body passively through vaccination. An antibody is sometimes called an immunoglobulin. But not all antibodies are …
Physiology, Antibody - StatPearls - NCBI Bookshelf
May 1, 2023 · The five antibody classes produced by the body include IgG, IgM, IgA, IgD, and IgE. IgM is the first antibody produced and acts as a B-cell surface immunoglobulin(Ig). …
Antibodies: Definition, Types, and Function - Health
Sep 8, 2024 · IgG: The most abundant antibody found in the body. It can help to block infections caused by bacteria, viruses, parasites , or other disease-causing organisms.
Antibody - National Human Genome Research Institute
6 days ago · An antibody is a protein component of the immune system that circulates in the blood, recognizes foreign substances like bacteria and viruses, and neutralizes them.
Antibody basics - Abcam
The basic principle of any immunoassay is that a specific antibody binds with its specific antigen, forming an exclusive antibody-antigen complex. This chapter defines what an antigen is and …
Antibody- Structure, Classes and Functions
Jan 23, 2024 · Antibody (Ab) also know as Immunoglobulin (Ig) is the large Y shaped protein produced by the body’s immune system when it detects harmful substances, called antigens …
