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| autoimmune therapy for lung cancer: Drug-Induced Liver Injury , 2019-07-13 Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series |
| autoimmune therapy for lung cancer: Cancer and Autoimmunity M.E. Gershwin, Yehuda Shoenfeld, 2000-03-27 Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying warheads to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the black box of immunology. |
| autoimmune therapy for lung cancer: Central Nervous System Metastases Manmeet Ahluwalia, Philippe Metellus, Riccardo Soffietti, 2019-11-05 This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors. |
| autoimmune therapy for lung cancer: Lung Cancer Karen L. Reckamp, 2016-08-17 This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer. |
| autoimmune therapy for lung cancer: SITC’s Guide to Managing Immunotherapy Toxicity Marc S. Ernstoff, MD, Igor Puzanov, MD, MSCI, FACP, Caroline Robert, MD, PhD, Adi M. Diab, MD, Peter M. Hersey, MD, PhD, 2019-03-15 The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer |
| autoimmune therapy for lung cancer: Hepatotoxicity Hyman J. Zimmerman, 1999 Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury. |
| autoimmune therapy for lung cancer: Immune Checkpoint Inhibitors in Cancer Fumito Ito, Marc Ernstoff, 2018-09-03 Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It's an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. - Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. - Helps you translate current research and literature into practical information for daily practice. - Presents information logically organized by disease site. - Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. - Consolidates today's available information on this timely topic into one convenient resource. |
| autoimmune therapy for lung cancer: Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Care Services, National Cancer Policy Forum, 2016-12-10 Immunotherapy is a form of cancer therapy that harnesses the body's immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop. |
| autoimmune therapy for lung cancer: Cutaneous Melanoma , |
| autoimmune therapy for lung cancer: Radiation and the Immune System: Current Knowledge and Future Perspectives Katalin Lumniczky, Serge M. Candéias, Udo S. Gaipl, Benjamin Frey, 2018-05-03 For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in the tumor microenvironment, and at systemic level. These observations paved the way for studies exploring optimal combinations of radiotherapy and immunotherapy in order to achieve a synergistic effect to eradicate tumors. However, not all interactions between radiation and the immune system are beneficial, as it was recognized that many of radiation-induced late side effects are also of immune and inflammatory nature. Currently perhaps the most studied field of research in radiation biology is focused around the biological effects of low doses, where many of the observed pathophysiological endpoints are due to mechanisms other than direct radiation-induced cell killing and are immune-related. Finally, it must not be forgotten that the interactions between the ionizing radiations and the immune system are bi-directional, and activation of the immune system also influences the outcome of radiation exposure. This Research Topic brings together 23 articles and aims to give an overview of the complex and very often contradictory nature of the interactions between ionizing radiation and the immune system. Due to its increasing penetrance in the population both through medical diagnostic or environmental sources or during cosmic travel low dose ionizing radiation exposure is becoming a major epidemiological concern world-wide. Several of the articles within the Research Topic specifically address potential long-term health consequences and the underlying mechanisms of low dose radiation exposure. A major intention of the Editors was also to draw the attention of the non-radiobiological scientific community on the fact that ionizing radiation is by far more than purely an immune suppressing agent. |
| autoimmune therapy for lung cancer: Immunotherapy of Hepatocellular Carcinoma Tim F. Greten, 2018-08-22 In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. |
| autoimmune therapy for lung cancer: Oncoimmunology Laurence Zitvogel, Guido Kroemer, 2017-12-13 In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field. |
| autoimmune therapy for lung cancer: Thoracic Malignancies Steven E. Schild, MD, 2010-03-08 Thoracic Malignancies: Thoracic Malignancies is the first title in Radiation Medicine Rounds. These tumors take more lives than any others and they are among the most preventable of tumors. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Thoracic Malignancies addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and thymomas providing coverage of the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up-to-date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future. About the Series Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of Ïhot topicsÓ and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice |
| autoimmune therapy for lung cancer: Hospitalist Neurology Martin A. Samuels, 1999 Hospitalist Neurology, in the highly regarded Blue Books of Practical Neurology series, focuses on the clinical practice of in-patient neurology as well as the neurologic sequelae of non-neurologic conditions of hospitalized patients. It is meant to provide consulting hospital-based neurologists with a rational approach to evaluating neurological problems in a busy general hospital. |
| autoimmune therapy for lung cancer: Modulation of Human Immune Parameters by Anticancer Therapies Ulrich Sack, Attila Tarnok, Il-Kang Na, Frank Preijers, 2021-01-18 |
| autoimmune therapy for lung cancer: Epidemiology of Endocrine Tumors Jahangir Moini, Craig Badolato, Raheleh Ahangari, 2021-03-03 Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. - Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals - Focuses on the impact upon costs and patient deaths due to complications of these tumors - Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors - Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors - Provides review questions with an answer key and detailed glossary |
| autoimmune therapy for lung cancer: Histological Typing of Lung and Pleural Tumours W.D. Travis, T.V. Colby, B. Corrin, Y. Shimosato, E. Brambilla, 2012-12-06 with contributions by Pathologists from 14 Countries |
| autoimmune therapy for lung cancer: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? Kulmira Nurgali, R. Thomas Jagoe, Raquel Abalo, 2018-06-12 Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them. |
| autoimmune therapy for lung cancer: Immunological Surveillance Macfarlane Burnet, 2014-05-17 Immunological Surveillance |
| autoimmune therapy for lung cancer: Immune-Related Adverse Events for Patients with Lung Cancer Xuelei Ma, Hubing Shi, Benjamin Frey, Udo S. Gaipl, 2022-01-25 |
| autoimmune therapy for lung cancer: Dermatologic Principles and Practice in Oncology Mario E. Lacouture, 2013-11-26 The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions. |
| autoimmune therapy for lung cancer: Guide to Immunotherapy Suzanne L. Walker, Elizabeth Prechtel Dunphy, 2018-10 |
| autoimmune therapy for lung cancer: Current Trends in Cancer Management Liliana Streba, Dan Ionut Gheonea, Michael Schenker, 2019-09-25 The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques. |
| autoimmune therapy for lung cancer: Lung Cancer and Autoimmune Disorders Mieczyslaw Pokorski, 2014-11-22 Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips. |
| autoimmune therapy for lung cancer: Cancer Immunotherapy Principles and Practice Lisa H. Butterfield, Howard L. Kaufman, Francesco M. Marincola, 2017 Part 1: Intratumoral Signatures Associated With Immune Responsiveness |
| autoimmune therapy for lung cancer: Oral, Head and Neck Oncology and Reconstructive Surgery - E-Book R. Bryan Bell, Peter A. Andersen, Rui P. Fernandes, 2017-08-25 Oral, Head and Neck Oncology and Reconstructive Surgery is the first multidisciplinary text to provide readers with a system for managing adult head and neck cancers based upon stage. Using an evidence-based approach to the management and treatment of a wide variety of clinical conditions, the extensive experience of the author and contributors in head and neck surgery and oncology are highlighted throughout the text. This includes computer aided surgical simulation, intraoperative navigation, robotic surgery, endoscopic surgery, microvascular reconstructive surgery, molecular science, and tumor immunology. In addition, high quality photos and illustrations are included, which are easily accessible on mobile devices. - Management protocols and outcomes assessment provide clear guidelines for managing problems related to adult head and neck oncology and reconstructive surgery. - State-of-the art guidance by recognized experts details current techniques as well as technological advances in head and neck/cranio-maxillofacial surgery and oncology. - Evidence-based content details the latest diagnostic and therapeutic options for treating a wide-variety of clinical problems with an emphasis on surgical technique and outcomes. - Multidisciplinary approach reflects best practices in managing head and neck oncology and cranio-maxillofacial surgery. - 900 highly detailed images clearly demonstrate pathologies and procedures. - Designed for the modern classroom which lets you access important information anywhere through mobile tablets and smart phones. |
| autoimmune therapy for lung cancer: Advancing Healthcare Through Personalized Medicine Priya Hays, 2021-09-27 This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients. |
| autoimmune therapy for lung cancer: Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book Daniel W. Lee, Nirali N. Shah, 2019-11-30 From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy. |
| autoimmune therapy for lung cancer: Selective Immunosuppression Luciano Adorini, 1995 |
| autoimmune therapy for lung cancer: The Dysautonomia Project Msm Kelly Freeman, MD Phd Goldstein, MD Charles R. Thmpson, 2015-10-05 The Dysautonomia Project is a much needed tool for physicians, patients, or caregivers looking to arm themselves with the power of knowledge. It combines current publications from leaders in the field of autonomic disorders with explanations for doctors and patients about the signs and symptoms, which will aid in reducing the six-year lead time to diagnosis. |
| autoimmune therapy for lung cancer: Aocnp Exam Secrets Study Guide: Aocnp Test Review for the Oncc Advanced Oncology Certified Nurse Practitioner Exam Aocnp Exam Secrets Test Prep, 2018-04-12 ***Includes Practice Test Questions*** AOCNP Exam Secrets helps you ace the ONCC Advanced Oncology Certified Nurse Practitioner Exam without weeks and months of endless studying. Our comprehensive AOCNP Exam Secrets study guide is written by our exam experts, who painstakingly researched every topic and concept that you need to know to ace your test. Our original research reveals specific weaknesses that you can exploit to increase your exam score more than you've ever imagined. AOCNP Exam Secrets includes: The 5 Secret Keys to AOCNP Exam Success: Time is Your Greatest Enemy, Guessing is Not Guesswork, Practice Smarter, Not Harder, Prepare, Don't Procrastinate, Test Yourself; A comprehensive General Strategy review including: Make Predictions, Answer the Question, Benchmark, Valid Information, Avoid Fact Traps, Milk the Question, The Trap of Familiarity, Eliminate Answers, Tough Questions, Brainstorm, Read Carefully, Face Value, Prefixes, Hedge Phrases, Switchback Words, New Information, Time Management, Contextual Clues, Don't Panic, Pace Yourself, Answer Selection, Check Your Work, Beware of Directly Quoted Answers, Slang, Extreme Statements, Answer Choice Families; A comprehensive Content review including: Intracellular Signaling, Tyrosine Phosphorylation, Nuclear Factor-Kb Protein Complex, Cell Adhesion Molecules, Metastases, Cell Cycle, Apoptosis, Tumorigenesis, Retroviral Vectors, Immunotherapeutic, Hematopoietic Stem Cells, Angiogenesis, Carcinogens, Chemoprevention, Nucleotide Excision Repair, Epstein-Barr Virus, Human Papilloma Viruses, Cancer Genetic Counseling, Fine Needle Aspiration, Flow Cytometry, Lymphoproliferative Disorders, Cytogenetic Analysis, Hematolymphoid-Derived Malignancies, Tumor Marker Assays, Oncology, DNA, Ultraviolet Radiation Exposure, Nicotine Replacement Therapy, Neoadjuvant Chemotherapy, Antimetabolites, Nitrosoureas, Anti-Hormones, Cellular Microenvironment, Pharmacodynamics, and much more... |
| autoimmune therapy for lung cancer: Diagnosing and Treating Adult Cancers and Associated Impairments National Academies Of Sciences Engineeri, National Academies of Sciences Engineering and Medicine, Health And Medicine Division, Board On Health Care Services, Committee on Diagnosing and Treating Adult Cancers, 2021-11-10 Cancer is the second leading cause of death among adults in the United States after heart disease. However, improvements in cancer treatment and earlier detection are leading to growing numbers of cancer survivors. As the number of cancer survivors grows, there is increased interest in how cancer and its treatments may affect a person's ability to work, whether the person has maintained employment throughout the treatment or is returning to work at a previous, current, or new place of employment. Cancer-related impairments and resulting functional limitations may or may not lead to disability as defined by the U.S. Social Security Administration (SSA), however, adults surviving cancer who are unable to work because of cancer-related impairments and functional limitations may apply for disability benefits from SSA. At the request of SSA, Diagnosing and Treating Adult Cancers and Associated Impairments provides background information on breast cancer, lung cancer, and selected other cancers to assist SSA in its review of the listing of impairments for disability assessments. This report addresses several specific topics, including determining the latest standards of care as well as new technologies for understanding disease processes, treatment modalities, and the effect of cancer on a person's health and functioning, in order to inform SSA's evaluation of disability claims for adults with cancer. |
| autoimmune therapy for lung cancer: Regulation of Cancer Immune Checkpoints , 2020 This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies. |
| autoimmune therapy for lung cancer: Immunotherapy and multimodality therapy for lung cancer Qun Xue, Jie Mei, Zichao Luo, Wenjun Mao, Yuan Wan, Yifei Liu, 2024-02-07 |
| autoimmune therapy for lung cancer: Autoimmune Aspects of Lung Disease D.A. Isenberg, S. Spiro, 2012-12-06 The lung forms an integral part of the body's immune system and is subject to a range of diseases which are either autoimmune in nature or have clear-cut immunological abnormalities. Autoimmune Aspects of Lung Disease provides a concise review of the lung's role in the immune system and a detailed account of both primary and secondary lung diseases which are characterised by immunological perturbation or frank autoimmunity. The volume presents a detailed, up-to-date account of disorders ranging from infection to neoplasia and is written in both an informative and stimulating style by a prestigious group of authors. The chapters are extensively referenced and provide numerous insights into the aetiopathogenesis and clinical features and treatment of immunologically-linked pulmonary disease. The book is intended as both an overview for physicians and scientists with an established interest in diseases of the lung, immunologists seeking to learn more about relevant disorders in the lung and general physicians, whether specialists or in training, seeking to enrich their knowledge of the links between the pulmonary and immune systems. |
| autoimmune therapy for lung cancer: Facing Immunotherapy Justine Cohen, Leyre Zubiri, Kerry Reynolds, 2019-12-18 Facing Immunotherapy is for anyone whose life is affected by cancer and who is considering (or is receiving) immunotherapy. Written by leading physicians in their fields, Facing Immunotherapy combines top-tier medical information and compassionate counsel on the use and tolerability of immunotherapies, with a caring and sensible approach to the emotional aspects of living with cancer treatment and its complications. This book provides easily readable and trustworthy information, which is divided amongst twenty-six chapters that ask and answer pertinent questions about immunotherapy and its medical, surgical, and psychiatric/psychological components. A glossary of terms provides important background information to readers (e.g., about the disease, nutrition, diet, exercise, and risk-reduction); online resources and references are also offered. Each chapter is accompanied by selected reference and internet resources as well as illustrations and photographs. |
| autoimmune therapy for lung cancer: Immunotherapy Against Lung Cancer Shvetank Bhatt, |
| autoimmune therapy for lung cancer: Immunotherapy in specific patients with lung cancer Yi Zhao, Tao Jiang, Alessandro Russo, Dawei Chen, 2023-04-12 |
| autoimmune therapy for lung cancer: Comparative Oncology Alecsandru Ioan Baba, Cornel Cătoi, 2007 |
| autoimmune therapy for lung cancer: Immunotherapy with checkpoint inhibitors for non-small cell lung cancer, colon cancer and esophageal cancer Xuelei Ma, Hubing Shi, Udo S. Gaipl, Benjamin Frey, 2022-12-16 |
autoimmune Effects of Lung Cancer Immunotherapy …
In this study, we utilized the real-world data from a nation-wide health insurance data set to identify the risk of developing autoimmune diseases in lung cancer patients who have …
Immunotherapy for Lung Cancer
Immunotherapy uses the body’s natural defenses (immune system) to treat cancer. Starting in 2015, a number of immuno-therapy drugs have been approved to treat both non-small cell …
Improved lung cancer clinical outcomes in patients with …
Purpose Concomitant autoimmune rheumatic diseases (ARD) can add morbidity and complicate treatment decisions for patients with lung cancer. We evaluated the tumour characteristics at …
Autoimmune diseases and immune-checkpoint inhibitors for …
Patients with cancer and with preexisting active autoimmune diseases (ADs) have been excluded from immunotherapy clinical trials because of concerns for high susceptibility to the …
Unlocking the power of the immune system to fight cancer …
IMP761 is LAG-3 agonist antibody to treat autoimmune disorders. Phase III in collaboration with MSD evaluating efti + KEYTRUDA + chemo with potential to establish new standard-of-care in …
Safety and efficacy of immune checkpoint inhibitors in cancer …
We conducted a systematic review and meta-analysis of existing data to compare the safety and eficacy of ICI treatment in cancer patients with and without autoimmune disease [5]. We found …
Risk and survival of patients with non-small cell lung cancer …
Mar 30, 2024 · Background: The risk and survival of patients with non-small cell lung cancer (NSCLC) with pre-existing auto-immune disorders (AIDs) receiving immune checkpoint …
Marked, Lasting Disease Regression and Concomitantly …
Here, we report a rare case of concomitant autoimmune hemolytic anemia and hemophagocytic lym-phohistiocytosis caused by atezolizumab plus chemotherapy in a patient with lung …
The Link between Autoimmune Diseases and Lung Health
Understanding the link between autoimmune diseases and lung health is essential for clinicians and researchers alike, as it can inform diagnostic approaches, treatment strategies and patient …
Predictors of Response, Progression-Free Survival, and …
Apr 9, 2021 · Studies have revealed improved objective response rates, progression-free sur-vival, and overall survival with immune checkpoint in-hibitors when used in both first and …
Effect of corticosteroids on the outcome of patients with …
Exogenous corticosteroid administration has been the cornerstone of treatment for autoimmune disorders for more than half a century. Steroids exert their immunosuppressive properties in a …
Safety of Programmed Death–1 Pathway Inhibitors Among …
advanced non–small-cell lung cancer (NSCLC), the large number of patients with NSCLC and concurrent autoimmune disease (AID) have been universally excluded from immunotherapy …
How does autoimmune disease impact treatment and …
Lung cancer Autoimmune disease Immune therapy SEER-medicare ABSTRACT Background: The advent of cancer immunotherapy has made autoimmune disease in oncology populations …
Neurologic Autoimmunity in the Era of Checkpoint Inhibitor …
Small cell lung cancer and thymoma are commonly associated with neurologic autoimmunity, but in the context of checkpoint inhibitor therapy, other malignancy associations are increasingly …
Advances in Small Molecule Inhibitors for Cancer …
Kinase inhibitors such as imatinib (targeting BCR-ABL in chronic myeloid leukemia) and erlotinib (targeting EGFR in lung cancer) have revolutionized cancer therapy by selectively blocking …
Autoimmune Effects of Lung Cancer Immunotherapy …
To identify lung cancer patients from the dataset, we first flagged each member based on four criteria: Diagnosis Criterion, Procedure Criterion, Pharmacy NDC Criterion, and Pharmacy …
Autoimmune encephalitis The Author(s) 2024 following …
Apr 29, 2024 · Autoimmune encephalitis is a rare and potentially fatal neurological adverse event. This current case report describes a male patient in his late 50s with ES-SCLC who developed …
Cytokine Release Syndrome Induced by Immune-checkpoint …
Immune-related adverse events, including autoimmune toxicity, may develop as a consequence of immune-checkpoint inhibitor (ICI) cancer therapy. Cytokine release syndrome (CRS) is a …
P1.13A SMALL CELL LUNG CANCER AND P1.13A.02 …
Tarlatamab is a bispecic T-cell engager fi (BiTE®) immunotherapy that binds delta-like ligand 3 on the surface of SCLC cells and CD3 on T cells, facilitating T-cell-mediated cancer cell lysis.
Understanding Immunotherapy - Cancer Council
Immunotherapy is a treatment that uses the body’s own immune system to fight cancer. There are several different types of immunotherapy. Checkpoint inhibitors help the immune system to …
Cancer Facts & Figures 2018 - American Cancer Society
by comparing cancer occurrence in people with a certain exposure or trait to cancer occurrence in people without this characteristic. For example, men and women who smoke are about 25 …
Paraneoplastic autoimmunity and small-cell lung cancer: …
Paraneoplastic autoimmunity and small-cell lung cancer: Neurological and serological accompaniments ... and autoimmune neurological manifestations did not differ significantly …
BC Cancer Protocol Summary for First-Line Treatment of …
Postive Non-Small Cell Lung Cancer. N Engl J Med.2016. 2. Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the Treatment of Non-Small Cell Lung Cancer. N Engl J …
OPEN Hyperbaric oxygen suppressed tumor progression lung …
cancer therapy as an adjuvant treatment for solid tumors, such as lung cancer. Tumor hypoxia has been a concern for cancer therapy 1,2 . Hypoxia can increase tumor resistance to …
Autoimmune Diseases and Lung Cancer: A Mendelian …
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Immuno-Oncology (I-O) Therapy Basics Fact Sheet - ReachMD
1. ELIMINATION (cancer immunosurveillance) - Cancer cells are detected by the immune system and/or eliminated.6,7 Tumor cells not destroyed may enter the equilibrium phase.6,7 2. …
NRG-LU005 SCHEMA PATIENT POPULATION: Limited stage
Mar 18, 2019 · overlap of radiation therapy fields; prior tangent fields for breast cancer with minimal overlap with target volumes are allowed per approval of study PIs. 3.3.6 Patients with …
First-Line Atezolizumab plus Chemotherapy in Extensive …
small-cell lung cancer. Patients with treated asymp - ... in the Supplementary Appendix). Key exclusion criteria were a history of autoimmune disease ... but thoracic radiation therapy was not.
BC Cancer Protocol Summary for First-Line Treatment of …
BC Cancer Protocol Summary LUAVPPIPNI Page 1 of 6 Activate: 1 May 2022 Revised: 1 Mar 2025 (Tests and dose modifications updated) Warning: The information contained in these …
BC Cancer Protocol Summary for First-Line Treatment of …
BC Cancer Protocol Summary LUAVPCIPNI Page 5 of 6 Activate: 1 May 2022 Revised: 1 Aug 2023 (Eligibility and exclusions updated) Warning: The information contained in these …
BC Cancer Protocol Summary for Treatment of Advanced Non …
2. Brahmer J, Reckcamp KL, Baas P, et al. Nivolumab vs docetaxel in advanced squamous cell non-small cell lung cancer. N Engl J Med 2015;373(2):123-5. 3. Borghaei H, Paz-Ares L, Horn …
Autoimmune Encephalitis: Distinguishing Features and …
Autoimmune encephalitis is a rapidly progressive neurologic condition with significant ... perts in immune therapy is essential to efficient diagnosis and treatment of autoimmune encephalitis. …
Current status and future perspectives of bispecific antibodies …
Clinical Statuses of bsAbs in Lung Cancer Targeted therapy guided by tumor-driving genes or immune-checkpoint blockade has become important arsenals in the treatment of advanced …
Varicella Zoster Virus Encephalitis Mimicking Nivolumab …
Sundquist K. Effect of autoimmune diseases on risk and survival in histology-specific lung cancer. Eur Respir J. 2012;40:1489–1495. 2. Khan SA, Pruitt SL, Xuan L, Gerber DE. …
ADVANCED LUNG CANCER PATIENTS GET ACCESS TO …
August PBS listing of OPDIVO® is for patients with locally advanced or metastatic NSCLC (advanced lung cancer) who have progressed on or after prior platinum based chemotherapy …
Pembrolizumab-induced autoimmune encephalitis in a …
with only four cases of autoimmune encephalitis in patients with lung cancer treated with ICPi reported in the literature to date (2-4). We herein report the case of a patient undergoing …
Safety and efficacy of immune checkpoint inhibitors in …
CONTACT Peng Chen chenpengdoc@sina.com Department of Thoracic Oncology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, …
The role of the gut microbiome in immune modulation: …
the anti-PD-1 immunotherapy response in non-small cell lung cancer patients. Additionally, we will go over new treatment techniques that aim to change the microbiome to enhance …
Increased rates of immunosuppressive treatment and …
into cancer diagnosis groups based on the International Classification of Diseases (ICD)9/10 codes and included patients with malignant melanoma and lung cancer. In this analysis, we …
`BC Cancer Protocol Summary for First-Line Treatment of …
lung cancer. N Engl J Med. 2018;379(21):2040-51. 5. Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care …
A phase II study of pembrolizumab and paclitaxel in refractory …
therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment. 3) Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior …
Chemotherapy Protocol LUNG CANCER Atezolizumab …
LUNG CANCER Atezolizumab (1680mg 28 days) Regimen • Lung – Atezolizumab ... Atezolizumab belongs to the immunotherapy class of cancer treatments. Autoimmune toxicities …
Immune Checkpoint Inhibition and the Prevalence of …
ties are listed in Table 2. Patients with cancer with autoimmune disease were more likely to be women, older, and had higher prevalence of comorbidities than patients with cancer without …
BC Cancer Protocol Summary for Treatment of Extensive …
Patients previously treated with combined modality therapy for limited stage disease ... known or suspected autoimmune disease Patients with long term immunosuppressive therapy or …
Real-world data analyses unveiled the immune-related …
ARTICLE OPEN Real-world data analyses unveiled the immune-related adverse effects of immune checkpoint inhibitors across cancer types Feicheng Wang 1, Shihao Yang1,2,3, …
AUTOIMMUNE GASTROINTESTINAL DYSMOTILITY - Mayo
• Paraneoplastic neurologic autoimmune disorders: a group of disorders in which unusual neurological signs and symptoms are the initial manifestations of cancer. • Autoimmune GI …
Chinese expert consensus recommendations for the …
non-small-cell lung cancer (NSCLC), small-cell lung cancer, melanoma, classic Hodgkin’s lym-phoma (cHL), hepatocellular carcinoma, esopha-geal cancer, gastric cancer, urothelial cancer, …
Plasma metabolomics of immune-related adverse events for …
lung cancer received ICIs treatment. INTRODUCTION Lung cancer remains to have the highest inci-dence among cancers in men and leading cause of cancer-related deaths worldwide.1 2 …
The Emerging Link Between Autoimmune Disorders and …
AUTOIMMUNE SYNAPTIC ENCEPHALITIS Limbic encephalitides, which until recently were invari-ably thought to be viral or paraneoplastic in origin, commonly result from idiopathic …
Phase I Trial of Pembrolizumab and Radiation Therapy after …
ORIGINAL ARTICLE Phase I Trial of Pembrolizumab and Radiation Therapy after Induction Chemotherapy for Extensive-Stage Small Cell Lung Cancer James W. Welsh, MD,a,* John V. …
Thiopurines in current medical practice: molecular …
Therapy-related cancer will remain a potential consequence of prolonged treatment for these generally non-life-threatening conditions. Understanding how thiopurines
Follow-up and Management of Checkpoint Inhibitor Related …
atezolizumab (Tecentriq) PD-L1 mAb Non-small cell lung cancer, hepatocellular carcinoma . Special access: ... It is widely acknowledged that cancer patients with pre-existing autoimmune …
Characterization of nivolumab-associated skin reactions in …
ter to predict a better therapy response.13,14 The aim of this study is to (i) characterize skin irAEs in patients with advanced lung cancer treated with nivolumab and (ii) to specify the pattern of T …
P3.02c-039 Endocrinological Side-Effects of Nivolumab in …
Lung Cancer Topic: IT Giovanni Rossi,1 Manuela Albertelli,2 Elena Nazzari,2 Erka Rijavec,1 Carlo Genova,1 Giulia Barletta,1 Federica Biello,1 Claudia Maggioni,1 Maria Giovanna Dal Bello,1 …
BC Cancer Protocol Summary for Treatment of Advanced Non …
second- or subsequent-line therapy . Note: ... Active, known or suspected autoimmune disease ... non-small cell lung cancer (OAK): a phase 3, open-label, multicenter randomized controlled …
BC Cancer Protocol Summary for Treatment of Advanced Non …
second- or subsequent-line therapy, and ... Active, known or suspected autoimmune disease ... advanced non-small cell lung cancer (KEYNOTE -010): a randomised controlled trial. The …
Endocrine toxicities of immune checkpoint inhibitors - Nature
Apr 19, 2021 · therapy, as a fundamental pillar of cancer treatment. ... non-small-cell lung cancer, thus expanding their use to ... Toxicities induced by ICIs are autoimmune in nature and are …
Targeted Therapies: A New Generation of Cancer Treatments
cluster of differentiation 20 (CD20), CD33, immune cell; in targeted cancer therapy, they are directed against molecules and CD52, which are present on lymphoma and leukemia cells.
221 Dose-escalation/confirmation results of ENCORE 601, a …
Nov 10, 2016 · Oncology Group performance status 0 or 1; no autoimmune disease; no immunodeficiency; no steroid or immunosuppressive therapy within 7 days prior to the first …
Non-Small Cell Lung Cancer: Epidemiology, Screening
NoneSmall Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment ... epidermal growth factor receptor inhibitors as first- and second-line therapy ... metastasis and …
TITLE: Phase I/II trial of anti-PD-1 checkpoint inhibitor …
Small cell lung cancer (SCLC), which accounts up to 15% of all new cases of lung cancer, is a lethal cancer with a poor prognosis. About 60% of patients present with extensive-stage …
Immune Checkpoint Inhibitor Rechallenge Safety ... - Clinical …
Lung cancer is the leading cause of cancer death worldwide, with an estimated 1.8 million people dying of lung cancer in 2020. 1 According to the American Cancer Society, an estimated 236, …
Distinct immune-effector and metabolic profile of CD8 T Cells …
Mar 12, 2022 · T cell activation are a milestone in cancer management. Their initial success in patients with advanced melanoma and non-small-cell lung cancer (NSCLC) has encouraged …
Research Area: Small Cell Lung Cancer - Amgen
therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study treatment • History of solid organ transplantation • Active autoimmune disease that has …
Supplementary Appendix Perioperative Nivolumab in …
Assessment Questionnaire (NSCLC-SAQ), Functional Assessment of Cancer Therapy - Lung (FACT-L) Scale, the 3-level version of the EQ-5D, the PROMIS ® Item Bank v2.0 – Physical
CD19 CAR-T cell therapy in a pediatric patient with MDA5 ...
Case repor t CD19 CAR-T cell therapy in a pediatric patient with MDA5+ dermatomyositis and rapidly progressive interstitial lung disease Andre´ s Parı´s-Mun˜ oz,1,20 Rosa M. Alcobendas …
Durvalumab with chemoradiotherapy for limited-stage small …
Original Research Durvalumab with chemoradiotherapy for limited-stage small-cell lung cancer Sehhoon Park a,1, Jae Myoung Noh b,1, Yoon-La Choi c, Sang Ah Chi d, Kyunga Kim e, Hyun …
COMMON TOXICITY CRITERIA (CTC) - Cancer
Cancer Therapy Evaluation Program 1 Revised March 23, 1998 Common Toxicity Criteria, Version 2.0 DCTD, NCI, NIH, DHHS March 1998 COMMON TOXICITY CRITERIA (CTC) ...
Lambert-Eaton Myasthenic Syndrome is Underrecognized in …
• Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by proximal muscle weakness, loss of tendon reflexes, and autonomic dysfunction that can occur …
