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| autism in twins studies: A Time for Metabolism and Hormones Paolo Sassone-Corsi, Yves Christen, 2016-04-04 Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies. |
| autism in twins studies: Autism Michael Rutter, Eric Schopler, 2012-12-06 This volume aims to provide the reader with an up-to-date account of knowledge, research, education, and clinical practice in the field of au tism, from an international perspective. The emphasis throughout is on the growing points of knowledge and on the new developments in prac tice. We have tried to keep a balance between the need for rigorous research and systematic evaluation and the importance of expressing new ideas and concepts so that they may influence thinking at a stage when questions are being formulated and fresh approaches to treatment are being developed. The book had its origins in the 1976 International Symposium on Autism held in St. Gallen, Switzerland but it is not in any sense a proceed ings of that meeting. Most papers have been extensively rewritten to provide a fuller coverage of the topic and also to take account of the issues raised at the meeting. Discussion dialogues have been revised and re structured to stand as self-contained chapters. Many significant contribu tions to the conference have not been induded in order to maintain the balance of a definitive review; however a few extra chapters have been added to fill crucial gaps 0 We hope the result is a vivid picture ofthe current state of the art. As editors we have been most impressed by the advances since the 1970 international conference in London. |
| autism in twins studies: Molecular Neuropathology Gareth W. Roberts, Julia M. Polak, 1995-06-08 This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology. |
| autism in twins studies: The Broad Autism Phenotype Anthony F. Rotatori, Julie A. Deisinger, 2015-03-27 This proposed volume will provide in-depth coverage about a construct known as the broad autism phenotype (BAP). |
| autism in twins studies: Autism Spectrum Disorders Andreas M. Grabrucker, 2021 Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson. |
| autism in twins studies: Autism and Talent Francesca Happé, Uta Frith, 2010-03-18 Originating from a theme issue first published in Philosophical transactions of the Royal Society. B, Biological sciences. |
| autism in twins studies: Autism and the Environment Institute of Medicine, Board on Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders, 2008-03-12 Autism spectrum disorders (ASD) constitute a major public health problem, affecting one in every 150 children and their families. Unfortunately, there is little understanding of the causes of ASD, and, despite their broad societal impact, many people believe that the overall research program for autism is incomplete, particularly as it relates to the role of environmental factors. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders, in response to a request from the U.S. Secretary of Health and Human Services, hosted a workshop called Autism and the Environment: Challenges and Opportunities for Research. The focus was on improving the understanding of the ways in which environmental factors such as chemicals, infectious agents, or physiological or psychological stress can affect the development of the brain. Autism and the Environment documents the concerted effort which brought together the key public and private stakeholders to discuss potential ways to improve the understanding of the ways that environmental factors may affect ASD. The presentations and discussions from the workshop that are described in this book identify a number of promising directions for research on the possible role of different environmental agents in the etiology of autism. |
| autism in twins studies: Methodology for Genetic Studies of Twins and Families M. Neale, L.R. Cardon, 2013-03-09 Few would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package. The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears. |
| autism in twins studies: Autism Imaging and Devices Manuel F. Casanova, Ayman El-Baz, Jasjit S. Suri, 2017-01-06 This book covers state-of-the-art medical image analysis approaches currently pursued in autism research. Chapters cover recent advances in diagnosis using structural neuroimaging. All aspects of imaging are included, such as electrophysiology (EEG, ERP, QEEG, and MEG), postmortem techniques, and advantages and difficulties of depositing/acquiring images in larger databases. The book incorporates 2D, 3D, and 4D imaging and advances scientific research within the broad field of autism imaging. |
| autism in twins studies: Autism Spectrum Disorder Michael Fitzgerald, 2015-04-02 This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism. |
| autism in twins studies: Autism Spectrum Disorders Stephen Deutsch, 2011-08-01 Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date. |
| autism in twins studies: The Neuroscience of Autism Spectrum Disorders Joseph D. Buxbaum, Patrick R. Hof, 2012-10-25 Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available |
| autism in twins studies: Homeostatic Control of Brain Function Detlev Boison, Susan Masino, 2016 Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike. |
| autism in twins studies: The Autisms Mary Coleman, Christopher Gillberg, 2012-01-05 Rev. ed. of: Biology of the autistic syndromes / Christopher Gillberg, Mary Coleman. 3rd ed. 2000. |
| autism in twins studies: Rutter's Child and Adolescent Psychiatry Anita Thapar, Daniel S. Pine, James F. Leckman, Stephen Scott, Margaret J. Snowling, Eric A. Taylor, 2015-06-15 Rutter's Child and Adolescent Psychiatry is the leading textbook in its field. Both interdisciplinary and international, it provides a coherent appraisal of the current state of the field to help researchers, trainees and practicing clinicians in their daily work. Integrating science and clinical practice, it is a comprehensive reference for all aspects of child and adolescent psychiatry. New to this full color edition are expanded coverage on classification, including the newly revised Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and new chapters on systems neuroscience, relationship-based treatments, resilience, global psychiatry, and infant mental health. From an international team of expert editors and contributors, this sixth edition is essential reading for all professionals working and learning in the fields of child and adolescent mental health and developmental psychopathology as well as for clinicians working in primary care and pediatric settings. Michael Rutter has contributed a number of new chapters and a Foreword for this edition: I greatly welcome this new edition as providing both a continuity with the past and a substantial new look. —Professor Sir Michael Rutter, extract from Foreword. Reviews of previous editions: This book is by far the best textbook of Child & Adolescent Psychiatry written to date. —Dr Judith Rapoport, NIH The editors and the authors are to be congratulated for providing us with such a high standard for a textbook on modern child psychiatry. I strongly recommend this book to every child psychiatrist who wants a reliable, up-to-date, comprehensive, informative and very useful textbook. To my mind this is the best book of its kind available today. —Journal of Child Psychology and Psychiatry |
| autism in twins studies: Brain Connectivity in Autism Rajesh K. Kana, Lucina Q. Uddin, Tal Kenet, Diane Chugani, Ralph-Axel Müller, 2014-09-23 The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives. |
| autism in twins studies: Twin Research for Everyone Adam D. Tarnoki, David L. Tarnoki, Jennifer Harris, Nancy L. Segal, 2022-08-22 Twin Research: Biology, Health, Epigenetics, and Psychology is a comprehensive, applied resource in twinning and twin studies that is grounded in the most impactful findings from twin research in recent years. While targeted to undergraduate and graduate students, this compendium will prove a valuable resource for scholars already familiar with twin studies, as well as those coming to the field for the first time. Here, more than forty experts across an array of disciplines examine twinning and twin research methodologies from the perspectives of biology, medicine, genetic and epigenetic influences, and neuroscience. Chapters provide clear instruction in both basic and advanced research methods, family and parenting aspects of twinning, twin studies as applied across various disease areas and medical specialties, genetic and epigenetic determinants of differentiation, and academic, neurological and cognitive development. The presentation of existing studies and methods instruction empowers students and researchers to apply twin-based research and advance new studies across a range of biomedical and behavioral fields, highlighting current research trends and future directions. Offers unique insights into twinning rates, mechanisms and factors surrounding twinship Provides clear instruction on both basic and advanced twin research methods and study design Features leading international experts in twin biology, genetics, health and psychology Examines findings from recent twin studies across a broad array of health and behavioral studies |
| autism in twins studies: Environmental Epigenetics L. Joseph Su, Tung-chin Chiang, 2015-05-18 This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. |
| autism in twins studies: Philosophical Issues in Psychiatry IV Kenneth S. Kendler, Josef Parnas, 2017-04-06 The revisions of both DSM-IV and ICD-10 have again focused the interest of the field of psychiatry and clinical psychology on the issue of nosology. This interest has been further heightened by a series of controversies associated with the development of DSM-5 including the fate of proposed revisions of the personality disorders, bereavement, and the autism spectrum. Major debate arose within the DSM process about the criteria for changing criteria, leading to the creation of first the Scientific Review Committee and then a series of other oversight committees which weighed in on the final debates on the most controversial proposed additions to DSM-5, providing important influences on the final decisions. Contained within these debates were a range of conceptual and philosophical issues. Some of these - such as the definition of mental disorder or the problems of psychiatric “epidemics” - have been with the field for a long time. Others - the concept of epistemic iteration as a framework for the introduction of nosologic change - are quite new. This book reviews issues within psychiatric nosology from clinical, historical and particularly philosophical perspectives. The book brings together a range of distinguished authors - including major psychiatric researchers, clinicians, historians and especially nosologists - including several leaders of the DSM-5 effort and the DSM Steering Committee. It also includes contributions from psychologists with a special interest in psychiatric nosology and philosophers with a wide range of orientations. The book is organized into four major sections: The first explores the nature of psychiatric illness and the way in which it is defined, including clinical and psychometric perspectives. The second section examines problems in the reification of psychiatric diagnostic criteria, the problem of psychiatric epidemics, and the nature and definition of individual symptoms. The third section explores the concept of epistemic iteration as a possible governing conceptual framework for the revision efforts for official psychiatric nosologies such as DSM and ICD and the problems of validation of psychiatric diagnoses. The book ends by exploring how we might move from the descriptive to the etiologic in psychiatric diagnoses, the nature of progress in psychiatric research, and the possible benefits of moving to a living document (or continuous improvement) model for psychiatric nosologic systems. The result is a book that captures the dynamic cross-disciplinary interactions that characterize the best work in the philosophy of psychiatry. |
| autism in twins studies: Genetic Approaches to Mental Disorders Elliot S. Gershon, 1994 Since the 1940s, the American Psychopathological Association has been a driving force in psychiatric genetic research. Having studied the Kallmann and Kety Hoch Award papers, many researchers have attempted to advance psychiatric genetic knowledge from epidemiological findings to biological findings. Genetic Approaches to Mental Disorders provides the latest information on the relationship between genetics and mental disorders. Divided into four sections, this book presents analysis of the genetic data, linkage mapping and association, debate over genetic Kraepelinian dichotomy, and mapping and association results in psychiatry. |
| autism in twins studies: Twin Allen Shawn, 2010-12-30 A heartbreaking yet deeply hopeful memoir about life as a twin in the face of autism. When Allen Shawn and his twin sister, Mary, were two, Mary began exhibiting signs of what would be diagnosed many years later as autism. Understanding Mary and making her life a happy one appeared to be impossible for the Shawns. At the age of eight, with almost no warning, her parents sent Mary to a residential treatment center. She never lived at home again. Fifty years later, as he probed the sources of his anxieties in Wish I Could Be There, Shawn realized that his fate was inextricably linked to his sister's, and that their natures were far from being different. Twin highlights the difficulties American families coping with autism faced in the 1950s. Shawn also examines the secrets and family dramas as his father, William, became editor of The New Yorker. Twin reconstructs a parallel narrative for the two siblings, who experienced such divergent fates yet shared talents and proclivities. Wrenching, honest, understated, and poetic, Twin is at heart about the mystery of being inextricably bonded to someone who can never be truly understood. |
| autism in twins studies: Handbook of Autism and Pervasive Developmental Disorders, Diagnosis, Development, Neurobiology, and Behavior Fred R. Volkmar, Rhea Paul, Ami Klin, Donald J. Cohen, 2005-04-29 Now expanded to two volumes, this invaluable reference work provides a comprehensive review of all information presently available about these disorders, drawing on findings and clinical experience from a number of related disciplines such as psychiatry, psychology, neurobiology, pediatrics, etc. The Handbook covers descriptive and diagnostic characteristics, biological contributions, intervention techniques, legal and social issues. The Third Edition is updated to include the newest work in animal models, genetics, neuropsychological processes, screening and assessment methods. |
| autism in twins studies: The Puzzle of Autism , 2006 |
| autism in twins studies: The Oxford Handbook of Quantitative Methods, Vol. 2: Statistical Analysis Todd D. Little, 2013-02-01 Research today demands the application of sophisticated and powerful research tools. Fulfilling this need, The Oxford Handbook of Quantitative Methods is the complete tool box to deliver the most valid and generalizable answers to todays complex research questions. It is a one-stop source for learning and reviewing current best-practices in quantitative methods as practiced in the social, behavioral, and educational sciences. Comprising two volumes, this handbook covers a wealth of topics related to quantitative research methods. It begins with essential philosophical and ethical issues related to science and quantitative research. It then addresses core measurement topics before delving into the design of studies. Principal issues related to modern estimation and mathematical modeling are also detailed. Topics in the handbook then segway into the realm of statistical inference and modeling with chapters dedicated to classical approaches as well as modern latent variable approaches. Numerous chapters associated with longitudinal data and more specialized techniques round out this broad selection of topics. Comprehensive, authoritative, and user-friendly, this two-volume set will be an indispensable resource for serious researchers across the social, behavioral, and educational sciences. |
| autism in twins studies: Immunization Safety Review Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, 2004-09-30 This eighth and final report of the Immunization Safety Review Committee examines the hypothesis that vaccines, specifically the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally associated with autism. The committee reviewed the extant published and unpublished epidemiological studies regarding causality and studies of potential biologic mechanisms by which these immunizations might cause autism. Immunization Safety Review: Vaccines and Autism finds that the body of epidemiological evidence favors rejection of a causal relationship between thimerosal-containing vaccines and autism. The book further finds that potential biological mechanisms for vaccine-induced autism that have been generated to date are only theoretical. It recommends a public health response that fully supports an array of vaccine safety activities and recommends that available funding for autism research be channeled to the most promising areas. The book makes additional recommendations regarding surveillance and epidemiological research, clinical studies, and communication related to these vaccine safety concerns. |
| autism in twins studies: Identically Different Tim Spector, 2014-07-30 In this book, a geneticist who studies identical twins “treats the view that genes are destiny with skepticism” (The New York Times). How much are the things you choose to do every day determined by your genes and how much is your own free will? Drawing on his own cutting-edge research of identical twins, leading geneticist Tim Spector shows us how the same upbringing, the same environment, and even the same exact genes can lead to very different outcomes. Thought-provoking, entertaining, and enlightening, Identically Different helps us understand the science behind what makes each of us unique and so quintessentially human. |
| autism in twins studies: Cultural Hegemony in a Scientific World , 2020-12-07 A comprehensive survey of how scientific disciplines have always been informed by politics and ideology on the basis of the Gramscian views in historical materialism, hegemony and civil society. |
| autism in twins studies: Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability Carlo Sala, Chiara Verpelli, 2016-04-30 Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. - Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities - Describes the genes implicated in autistic spectrum disorders and their function - Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies - Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture |
| autism in twins studies: Born Together—Reared Apart Nancy L. Segal, 2012-06-18 The Minnesota Study of Twins Reared Apart startled scientists by demonstrating that twins reared apart are as alike, across a number of personality traits and other measures, as those raised together, suggesting that genetic influence is pervasive. Segal offers an overview of the study’s scientific contributions and effect on public consciousness. |
| autism in twins studies: Unstrange Minds Roy Richard Grinker, 2008-07-31 A father's inspiring portrait of his daughter informs this classic reassessment of the epidemic of autism. When Isabel Grinker was diagnosed with autism in 1994, it occurred in only about 3 of every 10,000 children. Within ten years, rates had skyrocketed. Some scientists reported rates as high as 1 in 150. The media had declared autism an epidemic. Unstrange Minds documents the global quest of Isabel's father, renowned anthropologist Roy Richard Grinker, to discover the surprising truth about why autism is so much more common today. In fact, there is no autism epidemic. Rather, we are experiencing an increase in autism diagnoses, and Grinker shows that the identification and treatment of autism depends on culture just as much as it does on science. Filled with moving stories and informed by the latest science, Unstrange Minds is a powerful testament to a father's search for the truth. |
| autism in twins studies: Genomic Disorders James R. Lupski, Pawel T. Stankiewicz, 2007-11-10 A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection. |
| autism in twins studies: The Trouble with Twin Studies Jay Joseph, 2014-11-20 The Trouble with Twin Studies questions popular genetic explanations of human behavioral differences based upon the existing body of twin research. Psychologist Jay Joseph outlines the fallacies of twin studies in the context of the ongoing decades-long failure to discover genes for human behavioral differences, including IQ, personality, and the major psychiatric disorders. This volume critically examines twin research, with a special emphasis on reared-apart twin studies, and incorporates new and updated perspectives, analyses, arguments, and evidence. |
| autism in twins studies: Transforming the Workforce for Children Birth Through Age 8 National Research Council, Institute of Medicine, Board on Children, Youth, and Families, Committee on the Science of Children Birth to Age 8: Deepening and Broadening the Foundation for Success, 2015-07-23 Children are already learning at birth, and they develop and learn at a rapid pace in their early years. This provides a critical foundation for lifelong progress, and the adults who provide for the care and the education of young children bear a great responsibility for their health, development, and learning. Despite the fact that they share the same objective - to nurture young children and secure their future success - the various practitioners who contribute to the care and the education of children from birth through age 8 are not acknowledged as a workforce unified by the common knowledge and competencies needed to do their jobs well. Transforming the Workforce for Children Birth Through Age 8 explores the science of child development, particularly looking at implications for the professionals who work with children. This report examines the current capacities and practices of the workforce, the settings in which they work, the policies and infrastructure that set qualifications and provide professional learning, and the government agencies and other funders who support and oversee these systems. This book then makes recommendations to improve the quality of professional practice and the practice environment for care and education professionals. These detailed recommendations create a blueprint for action that builds on a unifying foundation of child development and early learning, shared knowledge and competencies for care and education professionals, and principles for effective professional learning. Young children thrive and learn best when they have secure, positive relationships with adults who are knowledgeable about how to support their development and learning and are responsive to their individual progress. Transforming the Workforce for Children Birth Through Age 8 offers guidance on system changes to improve the quality of professional practice, specific actions to improve professional learning systems and workforce development, and research to continue to build the knowledge base in ways that will directly advance and inform future actions. The recommendations of this book provide an opportunity to improve the quality of the care and the education that children receive, and ultimately improve outcomes for children. |
| autism in twins studies: Diagnosis and Treatment of Autism C. Gillberg, 2014-01-15 |
| autism in twins studies: G is for Genes Kathryn Asbury, Robert Plomin, 2013-09-04 G is for Genes shows how a dialogue between geneticists and educationalists can have beneficial results for the education of all children—and can also benefit schools, teachers, and society at large. Draws on behavioral genetic research from around the world, including the UK-based Twins’ Early Development Study (TEDS), one of the largest twin studies in the world Offers a unique viewpoint by bringing together genetics and education, disciplines with a historically difficult relationship Shows that genetic influence is not the same as genetic determinism and that the environment matters at least as much as genes Designed to spark a public debate about what naturally-occurring individual differences mean for education and equality |
| autism in twins studies: Autism Breakthrough Raun K. Kaufman, 2014-04-01 As a boy, Raun Kaufman was diagnosed by multiple experts as severely autistic, with an IQ below 30, and destined to spend his life in an institution. Years later, Raun graduated with a degree in Biomedical Ethics from Brown University and has become a passionate and articulate autism expert and educator with no trace of his former condition. So what happened? Thanks to The Son-Rise Program, a revolutionary method created by his parents, Raun experienced a full recovery from autism. (His story was recounted in the best-selling book Son-Rise: The Miracle Continues and in the award-winning NBC television movie Son-Rise: A Miracle of Love.) In Autism Breakthrough, Raun presents the ground-breaking principles behind the program that helped him and thousands of other families with special children. Autism, he explains, is frequently misunderstood as a behavioral disorder when, in fact, it is a social relational disorder. Raun explains what it feels like to be autistic and shows how and why The Son-Rise Program works. A step-by-step guide with clear, practical strategies that readers can apply immediately—in some cases, parents see changes in their children in as little as one day—Autism Breakthrough makes it possible for these special children to defy their original often-very-limited prognoses. Parents and educators learn how to enable their children to create meaningful, caring relationships, vastly expand their communications, and to participate successfully in the world. An important work of hope, science, and progress, Autism Breakthrough presents the powerful ideas and practical applications that have already changed the lives of families all over the world. |
| autism in twins studies: The Autism Revolution Dr. Martha Herbert, Karen Weintraub, 2013-03-12 “An in-depth, scientific—yet hopeful and positive—look at how the brain and body work together . . . [Dr. Martha Herbert] has developed a new way of seeing autism.”—Library Journal After years of treating patients and analyzing scientific data, Harvard Medical School researcher and clinician Dr. Martha Herbert offers a revolutionary new view of autism and a transformative strategy for dealing with it. Autism, she concludes, is not a hardwired impairment programmed into a child’s genes and destined to remain fixed forever. Instead, it is the result of a cascade of events, many seemingly minor. And while other doctors may dismiss your child’s physical symptoms—the anxiety, sensory overload, sleeplessness, frequent illnesses or seizures—as coincidental or irrelevant, Dr. Herbert sees them as vital clues to what the underlying problems are, and how to help. Drawing from the newest research, technologies, and insights, as well as inspiring case studies of both children and adults, Dr. Herbert guides you toward restoring health and resiliency in your loved one with autism. Her specific recommendations aim to provide optimal nutrition, reduce toxic exposures, limit stress, and open the door to learning and creativity. As thousands of families who have cobbled together these solutions themselves already know, this program can have dramatic benefits—for your child with autism, and for you, your whole family, and perhaps your next baby as well. “Invaluable . . . a must-read . . . Dr. Martha Herbert gets it. She not only gets it, but she puts it out there in an awesome book so the rest of us can get it, too.”—Autism Watch “[Herbert] goes further than most autism specialists. Her impressive science background merges with common sense and even intuitive sense [making] complex scientific and medical materials seamlessly blend with a holistic viewpoint.”—Relieve Autism “Hope and practical guidance . . . With this easy-to-read book, parents can gain wisdom on how to guide your child to achieve a healthy and thriving life.”—Mom Central |
| autism in twins studies: The Complete Autism Handbook Benison O'Reilly, Kathryn Wicks, 2016-02 The third edition of The Complete Autism Handbook is a practical and comprehensive guide to every aspect of raising a child with Autism Spectrum Disorder (ASD) in Australia or New Zealand. The book has been updated with the latest information on early intervention, the NDIS and HCWA funding. |
| autism in twins studies: Adult Asperger's Syndrome Kenneth E. Roberson, 2016-03-31 Do you have Asperger's Syndrome or know someone who does? Are you looking for a reference guide about Asperger's in adults? Do you have questions you'd like to ask an expert in adult Asperger's? If your answer is Yes to any of these questions, this book is for you. Clinical psychologist and Asperger's authority, Dr. Kenneth Roberson, examines the often neglected area of Asperger's in adults, covering topics such as: What causes Asperger's Syndrome? Is it different in adults than it is in children? How can you find out if you have Asperger's? What are the advantages and disadvantages of a diagnosis? What therapy is best for adults who have Asperger's? Can adults with Asperger's change? Are there benefits to having Asperger's? Can adults with Asperger's have intimate relationships? Can they be successful parents? These and many other questions are covered in this important addition to the field of Asperger's as it occurs in adults. Resources and reference material about adult Asperger's are included, along with a feature allowing readers to ask questions of Dr. Roberson. |
| autism in twins studies: The Research Basis for Autism Intervention Eric Schopler, Nurit Yirmiya, Cory Shulman, Lee M. Marcus, 2007-05-08 As the pastPresident ofthe Israel Society forAutism, it gives me great pleasure to c- gratulate Professor Schopler and his colleagues on the publication of their new book concerning the relationship between scientific research and treatment. When we in Israel began our specifically structured education program for young children with autism, our work was based on slim to scarceknow-how andinformation, and with no experience whatsoever. Whatever information we could gather was mostly from psychological educational centers in the U.S. One of the most important and significant connections was established between the TEACCH program of North Carolina, led and conducted by the two important scholars, Professor Eric Schopler and Professor Lee Marcus, and our Israel Society for Autism. During our many encounters, seminars, and conferences, we profited enormously from all their accumulated expertise and scientific research, while perhaps it was also an important experience for them to see how a young society with very limited means was eventually shaping its educational program and arriving at some excellent results. We, ofcourse, have the highest esteem for Governor Hunt who has been following this program with so much attention and support, and we still remember his visit to Israel with distinguished representatives of the TEACCH Program. I wish the new book every success. I know it will be an enormous contribution to all those who must cope with a difficult and painful issue—autism—for whom there is no end to the need for research and continuously improving methods of care and education. |
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May 22, 2025 · Autism spectrum disorder is a condition related to brain development that affects how people see others and socialize with them. This causes problems in communication and …
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Autism spectrum disorder - Symptoms and causes - Mayo Clinic
May 22, 2025 · Autism spectrum disorder is a condition related to brain development that affects how people see others and socialize with them. This causes problems in communication and …
Autism spectrum disorder - Diagnosis and treatment - Mayo Clinic
May 22, 2025 · Your child's healthcare professional looks for signs of developmental delays at regular well-child checkups. If your child shows any symptoms of autism, you'll likely be referred …
Trastorno del espectro autista - Síntomas y causas - Mayo Clinic
Apr 19, 2025 · Autism spectrum disorder (ASD) (Trastorno del espectro autista). Centros para el Control y la Prevención de Enfermedades (Centers for Disease Control and Prevention). …
Mayo Clinic Minute: What is autism?
Apr 13, 2017 · Autism spectrum disorder is a serious neurodevelopmental disorder that impairs a child's ability to communicate and interact with others. It also includes restricted repetitive …
Early signs of autism - Mayo Clinic Press
Dec 22, 2021 · Most children show clear signs of autism before 2 or 3 years of age. However, some kids on the mild end of the spectrum might not be identified as having autism until later in …
Understanding autism: The path to diagnosis, awareness and support
Apr 28, 2024 · Autism affects children and adults in three areas: communication, social interaction and behaviors. Children with autism spectrum disorder may struggle with recognizing their …
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