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| azide alkyne click chemistry: Click Reactions in Organic Synthesis Srinivasan Chandrasekaran, 2016-09-13 Endlich ein Buch zu Click-Reaktionen mit Schwerpunkt auf der organischen Synthese. Beschrieben werden das Click-Konzept, die zugrunde liegenden Mechanismen und Hauptanwendungsgebiete. NÜTZLICH: Die Click-Chemie ist ein wirkungsvoller Ansatz, um auf einfache Weise komplexe organische Moleküle aus verfügbaren Ausgangsmaterialien zu erzeugen ? der Traum jedes Organikers. EINZIGARTIGER SCHWERPUNKT: Aufgrund des besonderen Schwerpunkts auf der organischen Synthese ist dieses Buch für jeden Synthesechemiker von hohem Interesse. HILFREICH: Click-Reaktionen sind stereospezifisch, einfach durchzuführen, hoch ergiebig und lassen sich in einfach zu entfernenden oder nicht schädlichen Lösungsmitteln durchführen. INTERDISZIPLINÄR: Das Click-Konzept ist bei der Herstellung natürlicher Produkte, bioaktiver Verbindungen, von Kohlenhydraten, Arzneimitteln, Polymeren, supramolekularer Strukturen und Materialien weit verbreitet. |
| azide alkyne click chemistry: Copper Catalysis in Organic Synthesis Gopinathan Anilkumar, Salim Saranya, 2020-12-07 The most current information on growing field of copper catalysis Copper Catalysis in Organic Synthesis contains an up-to-date overview of the most important reactions in the presence of copper catalysts. The contributors—noted experts on the topic—provide an introduction to the field of copper catalysis, reviewing its development, scope, and limitations, as well as providing descriptions of various homo- and cross-coupling reactions. In addition, information is presented on copper-catalyzed C–H activation, amination, carbonylation, trifluoromethylation, cyanation, and click reactions. Comprehensive in scope, the book also describes microwave-assisted and multi-component transformations as well as copper-catalyzed reactions in green solvents and continuous flow reactors. The authors highlight the application of copper catalysis in asymmetric synthesis and total synthesis of natural products and heterocycles as well as nanocatalysis. This important book: Examines copper and its use in organic synthesis as a more cost-effective and sustainable for researchers in academia and industry Offers the first up-to-date book to explore copper as a first line catalyst for many organic reactions Presents the most significant developments in the area, including cross-coupling reactions, C–H activation, asymmetric synthesis, and total synthesis of natural products and heterocycles Contains over 20 contributions from leaders in the field Written for catalytic chemists, organic chemists, natural products chemists, pharmaceutical chemists, and chemists in industry, Copper Catalysis in Organic Synthesis offers a book on the growing field of copper catalysis, covering cross-coupling reactions, C–H activation, and applications in the total synthesis of natural products. |
| azide alkyne click chemistry: Click Triazoles Janez Košmrlj, 2012-05-30 B. R. Buckley and H. Heaney: Mechanistic Investigations of Copper(I)- Catalyzed Alkyne–Azide Cycloaddition Reactions.- J. D. Crowley and D. A. McMorran: “Click-Triazole” Coordination Chemistry: Exploiting 1,4-Disubstituted-1,2,3-Triazoles as Ligands.- S. Lee and A. H. Flood: Binding Anions in Rigid and Reconfigurable Triazole Receptors.- M. Watkinson: Click Triazoles as Chemosensors.- H.-F. Chow, C.-M. Lo and Y. Chen: Triazole-Based Polymer Gels.- T. Zheng, S. H. Rouhanifard, A. S. Jalloh, P. Wu: Click Triazoles for Bioconjugation.- S. Mignani, Y. Zhou, T. Lecourt and L. Micouin: Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. |
| azide alkyne click chemistry: Green Chemistry Hosam El-Din M. Saleh, Martin Koller, 2018-02-28 To an increasing extent, green chemistry is a new chemical and engineering approach of chemistry and engineering, dedicated to make manufacturing processes and our world as a whole more sustainable world with a growing tendency. Green chemistry approaches are based on ecofriendly technologies, aiming to reduce or eliminate the use of solvents, or render them efficient and safer. Moreover, this scientific field is devoted to reduction or elimination of prevailing environmental and health threats, which typically accompany chemical products and traditional processes. The present book Green Chemistry contains 9 selected chapters, starting with a general introductory chapter on green chemistry, and covers many recent applications and developments based on the principles of green chemistry. This book is considered the appropriate way to communicate the advances in green materials and their applications to the scientific community. Chemists, scientists and researchers from related areas, and undergraduates involved in environmental issues and interested in approaches to improve the quality of life could find an inspiring and effective guide by reading this book. |
| azide alkyne click chemistry: Click Chemistry for Biotechnology and Materials Science Joerg Lahann, 2009-11-23 Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions. |
| azide alkyne click chemistry: Click Polymerization Anjun Qin, Ben Zhong Tang, 2018-08-28 Click Polymerization has been edited by world renowned experts and provides an authoritative guide to this reaction type. |
| azide alkyne click chemistry: DNA Conjugates and Sensors Keith R Fox, Tom Brown, 2012-11-30 Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book is relevant to researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology. |
| azide alkyne click chemistry: Science of Synthesis: Click Chemistry Floris P. J. T. Rutjes, 2021-11-24 This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis. |
| azide alkyne click chemistry: Click Chemistry in Glycoscience Zbigniew J. Witczak, Roman Bielski, 2013-03-18 Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics. The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics. |
| azide alkyne click chemistry: Click Chemistry Ram K. Gupta, 2024-09-06 Click chemistry involves highly efficient, reliable, and stereoselective reactions that can synthesize new materials cost-effectively. The first volume entitled “Click Chemistry: Fundamentals and Synthesis” covers the fundamentals, mechanisms, kinetics, and various approaches to synthesizing new materials making it suitable for synthetic chemists and researchers working in nanoscience and technology. The main objective of this book is to provide information about current, state-of-the-art development in click chemistry as well as challenges. Experts from around the world have contributed towards this book, making this a suitable textbook for students and providing new guidelines to researchers and industries working in these areas. |
| azide alkyne click chemistry: Radiopharmaceutical Chemistry Jason S. Lewis, Albert D. Windhorst, Brian M. Zeglis, 2019-04-02 This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas. |
| azide alkyne click chemistry: Bioactive Surfaces Hans G. Börner, Jean-Francois Lutz, 2013-08-03 Erik Wischerhoff, Nezha Badi, André Laschewsky and Jean-François Lutz Smart Polymer Surfaces: Concepts and Applications in Biosciences; S. Petersen, M. Gattermayer and M. Biesalski Hold on at the Right Spot: Bioactive Surfaces for the Design of Live-Cell Micropatterns; Julien Polleux Interfacing Cell Surface Receptors to Hybrid Nanopatterned Surfaces: A Molecular Approach for Dissecting the Adhesion Machinery; Abigail Pulsipher and Muhammad N. Yousaf Self-Assembled Monolayers as Dynamic Model Substrates for Cell Biology; D. Volodkin, A. Skirtach and H. Möhwald LbL Films as Reservoirs for Bioactive Molecules; R. Gentsch and H. G. Börner Designing Three-Dimensional Materials at the Interface to Biology; Joerg C. Tiller Antimicrobial Surfaces; |
| azide alkyne click chemistry: Amide Bond Activation Michal Szostak, 2019-07-12 The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field. |
| azide alkyne click chemistry: Activity-Based Protein Profiling Benjamin F. Cravatt, Ku-Lung Hsu, Eranthie Weerapana, 2019-01-25 This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions. |
| azide alkyne click chemistry: Concepts of Nanochemistry Ludovico Cademartiri, Geoffrey A. Ozin, 2009-10-13 Written by a bestselling author and expert in nanochemistry, this title is ideal for interdisciplinary courses in chemistry, materials science, or physics. |
| azide alkyne click chemistry: Self-Healing Polymers Wolfgang H. Binder, 2013-03-29 Self-healing is a well-known phenomenon in nature: a broken bone merges after some time and if skin is damaged, the wound will stop bleeding and heals again. This concept can be mimicked in order to create polymeric materials with the ability to regenerate after they have suffered degradation or wear. Already realized applications are used in aerospace engineering, and current research in this fascinating field shows how different self-healing mechanisms proven successful by nature can be adapted to produce even more versatile materials. The book combines the knowledge of an international panel of experts in the field and provides the reader with chemical and physical concepts for self-healing polymers, including aspects of biomimetic processes of healing in nature. It shows how to design self-healing polymers and explains the dynamics in these systems. Different self-healing concepts such as encapsulated systems and supramolecular systems are detailed. Chapters on analysis and friction detection in self-healing polymers and on applications round off the book. |
| azide alkyne click chemistry: Modern Applications of Cycloaddition Chemistry Paolo Quadrelli, 2019-03-20 Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. - Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes - Contains the most up-to-date review of the use of pericyclic reactions in drug delivery - Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected - Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area |
| azide alkyne click chemistry: Artificial Nucleases Marina A. Zenkova, 2004-01-07 The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme nucle ases and catalytic RNA structured ribozymes that perform cleavage of the phosphodiester bonds in nucleic acids according to a hydrolytic pathway in the course of different biochemical processes in the cell. A different pathway is used by some antibiotics which cleave DNA via redox-based mechanisms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. A dif ferent approach, in vitro selection, was also used to create artificial RNA and DNA enzymes capable of cleaving RNA. Being less efficient and specific as compared to the natural enzymes, the primitive mimics are smaller and robust and can function in a broad range of conditions. |
| azide alkyne click chemistry: Peptide, Protein and Enzyme Design , 2016-08-27 De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. - Continues the legacy of this premier serial with quality chapters on de novo enzyme design - Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field - Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism |
| azide alkyne click chemistry: Stereoelectronic Effects Igor V. Alabugin, 2016-10-17 Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and reactivity of organic molecules An advanced textbook that provides an up-to-date overview of the field, starting from the fundamental principles Presents a large selection of modern examples of stereoelectronic effects in organic reactivity Shows practical applications of stereoelectronic effects in asymmetric catalysis, photochemical processes, bioorganic chemistry and biochemistry, inorganic and organometallic reactivity, supramolecular chemistry and materials science |
| azide alkyne click chemistry: Organic Polymers Arpit Sand, Elsayed Zaki, 2020-03-11 This book, Organic Polymers, covers aspects that are of immediate concern to a new entrant to the field of polymers. Taken as a whole, these eight chapters aim to help the readers easily assimilate other specialized and exhaustive treatises on the subject. Topics dealing with the chemistry and technology of polymers are presented in a careful and logical manner so as to provide an easy and enjoyable read. Several examples and analogies are included so to make the main concepts easy to follow and tables and figures are included so that the book can serve, to a limited extent, as a hand book dealing with polysaccharides with different parameters. This book is meant for students studying polysaccharides and those working on graft copolymers and other allied polymer industries but without a formal educational background in organic polymers. |
| azide alkyne click chemistry: Click Chemistry Chen Yu, Tong Zong Rui, 2017 Click chemistry, which is also referred to as linkage chemistry, dynamic, combinatorial chemistry or quick linking combinatorial chemistry describes the reaction that joins molecular fragments as simply, efficient and versatile as clicking a mouse. The two units with specific click structures can be linked by a click reaction no matter what is attached to the structure, and only the specific click structures can be joined. It emphasises the development of new combinatorial chemistries on the basis of the synthesis of efficient and highly selective carbon-heteroatom bonds (C-X-C), and effectively prepares molecules with high diversity via these simple reactions. It significantly simplified and promoted the development of synthesis chemistry. Click chemistry has become one of the most useful and attractive synthetic strategies in many fields. In this book, the definition of click chemistry is explained, the characteristics and types of click chemistry are introduced, and some specific reaction types are focused on. The progress for using click chemistry for the synthesis and functionalisation of hydrogels, elastomers, surface modifications, membrane preparations, assemble polyaromatic structures, biomedical fields and optical sensing in biological analyses are described in detail. The problems and challenges for using click chemistry in different fields are analysed. |
| azide alkyne click chemistry: Bioconjugate Techniques Greg T. Hermanson, 2010-07-26 Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions |
| azide alkyne click chemistry: Superbases for Organic Synthesis Tsutomu Ishikawa, 2009-01-26 Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources. Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects: an introduction to organosuperbases physicochemical properties of organic superbases amidines and guanidines in organic synthesis phosphazene: preparation, reaction and catalytic role polymer-supported organosuperbases application of organosuperbases to total synthesis related organocatalysts: proton sponges and urea derivatives amidines and guanidines in natural products and medicines Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products. |
| azide alkyne click chemistry: Organic Azides Stefan Bräse, Klaus Banert, 2011-09-23 Most current state-of-the-art overview of this important class of compounds, encompassing many new and emerging applications The number of articles on organic azides continues to increase tremendously; on average, there are more than 1000 new publications a year Covers basic chemistry as well as state-of-the-art applications in life science and materials science World-ranked authors describe their own research in the wider context of azide chemistry Includes a chapter on safe synthesis and handling (azides can decompose explosively) |
| azide alkyne click chemistry: Synthetic Methods in Step-Growth Polymers Martin E. Rogers, Timothy E. Long, 2003-08-08 Alles über die Stufenwachstums-Polymerisation - von Syntheseverfahren und Reinigungsmethoden bis zur Charakterisierung der Produkte - finden Sie in diesem Buch. - bietet einen Ausblick auf zukünftige Trends - mit historischen Informationen - erläutert die Klassifikation von Stufenwachstumspolymeren |
| azide alkyne click chemistry: Modified Nucleic Acids Kazuhiko Nakatani, Yitzhak Tor, 2016-04-04 This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes. |
| azide alkyne click chemistry: Advances in Organic Crystal Chemistry Masami Sakamoto, Hidehiro Uekusa, 2020-07-10 This book summarizes and records the recent notable advances in diverse topics in organic crystal chemistry, which has made substantial progress along with the rapid development of a variety of analysis and measurement techniques for solid organic materials. This review book is one of the volumes that are published periodically on this theme. The previous volume, published in 2015, systematically summarized the remarkable progress in assorted topics of organic crystal chemistry using organic solids and organic–inorganic hybrid materials during the previous 5 years, and it has been widely read. The present volume also shows the progress of organic solid chemistry in the last 5 years, with contributions mainly by invited members of the Division of Organic Crystal Chemistry of the Chemical Society of Japan (CSJ), together with prominent invited authors from countries other than Japan. |
| azide alkyne click chemistry: Peptide-Based Materials Timothy Deming, 2012-01-10 Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.- |
| azide alkyne click chemistry: Peptide Conjugation Waleed M. Hussein, Rachel J. Stephenson, Istvan Toth, 2021-08-14 This volume explores diverse protocols for peptide conjugation, and provides thoroughly tested and scientifically valid techniques that allow researchers and scientists to prepare, purify, characterize, and use peptide conjugation methods for chemical, biochemical, and biological studies. Some of the topics discussed in this book are gold nanoparticles, proteins, pegylated lipids, and vitamins. Chapters also cover enzymatic ligation using sortase A, construction of a phage-displayed cyclic-peptide library, quantum dot-peptide conjugates, and preparation of lipopeptides by CLipPA chemistry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Conjugation: Methods and Protocols is a valuable resource for experienced researches and undergraduate students alike who are interested in learning more about this exciting and developing field. |
| azide alkyne click chemistry: Current Topics in Chirality Takashiro Akitsu, 2021-09-01 Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions. |
| azide alkyne click chemistry: Green Chemistry Applications Murat Eyvaz, Ebubekir Yüksel, 2019-09-18 Green chemistry is defined as the use of a dozen principles that reduce or eliminate hazardous materials in the design, manufacture, and use of chemical products. Today, it is understood that focusing on precautions to reduce or eliminate existing pollution sources is more effective than looking for a cleaning path after exiting. This book presents the principles of green chemistry for clean production in light of the latest technological developments and increasing environmental awareness. Chapters cover such topics as synthesis and applications of nanomaterials for energy and environmental applications, climate process, alternative green energy sources, and removal of emerging pollutants from water. |
| azide alkyne click chemistry: Nano Hydrogels Jiya Jose, Sabu Thomas, Vijay Kumar Thakur, 2022-01-06 This book introduces the reader to important aspects of the nano-hydrogels. It covers the development of hydrogels and their biology, chemistry and properties. Focus is also given to innovative characterization techniques and advances in structural design, with special emphasis on molecular structure, dynamic behavior and structural modifications of hydrogels. This book serves as a consolidated reference work for the diverse aspects of hydrogels, creating a valuable resource for students and researchers in academia and industry. |
| azide alkyne click chemistry: Macromolecular Syntheses Charles Gilbert Overberger, 2002 This book is an up-to-date collection of presentations and posters given at a tutorial and workshop sponsored by the Polymer Division of the American Chemical Society. The material included encompasses recent research results, overviews of critical areas and short presentations in the form of posters and preprints. The book is targeted at established workers in the field of fluoropolymers as well as those wishing to develop a quick understanding of current knowledge and trends in this important field. |
| azide alkyne click chemistry: Interventional Nuclear Medicine Richard Paul Spencer, 1984 |
| azide alkyne click chemistry: Peptide and Protein Engineering Olga Iranzo, Ana Cecília Roque, 2021-07-23 This thorough book aims to present the methods that have enabled the success of peptides and proteins in a wide variety of applications. It opens with a section on chemical tools applied to the production or engineering of peptides and proteins, and concludes with a collection of chapters on biological approaches used to engineer structure and function in peptides and proteins. As a book in the Springer Protocols Handbooks series, chapters include the kind of detailed descriptions and tips necessary for successful results in practice. Authoritative and practical, Peptide and Protein Engineering: From Concepts to Biotechnological Applications will be of great use to scientists in academia and industry seeking a better understanding of the emerging principles and methodologies in peptide and protein engineering. |
| azide alkyne click chemistry: Polysaccharides in Medicinal Applications Severian Dumitriu, 1996-06-14 Integrates the latest advances in polysaccharide chemistry and structure analysis, with the practical applications of polysaccharides in medicine and pharmacy, highlighting the role of glycoconjugates in basic biological processes and immunology. It also presents recent developments in glycobiology and glycopathology. The work covers bacterial, fungal and cell-wall polysaccharides, microbial and bacterial exopolysaccharides, industrial gums, the biosynthesis of bacterial polysaccharides, and the production of microbial polysaccharides. |
| azide alkyne click chemistry: Click Chemistry for Biotechnology and Materials Science Joerg Lahann, 2009-12-15 Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These ‘spring loaded’ reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on drug discovery, the concept has been successfully applied to materials science, polymer chemistry and biotechnology. The first book to consider this topic, Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application to the precise design and synthesis of macromolecules, and its numerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trends and future applications, and provides an important nucleation point for research. Edited by one of the top 100 young innovators with the greatest potential to have an impact on technology in the 21st century according to Technology Review and with contributions from pioneers in the field, Click Chemistry for Biotechnology and Materials Science provides an ideal reference for anyone wanting to learn more about click reactions. |
| azide alkyne click chemistry: Modification of Polymers Charles E. Carraher, James A. Moore, 2012-12-06 The sheer volume of topics which could have been included under our general title prompted us to make some rather arbitrary decisions about content. Modification by irradiation is not included because the activity in this area is being treated elsewhere. We have chosen to emphasize chemical routes to modification and have striven to pre sent as balanced a representation of current activity as time and page count permit. Industrial applications, both real and potential, are included. Where appropriate, we have encouraged the contributors to include review material to help provide the reader with adequate context. The initial chapter is a review from a historical perspective of polymer modification and contains an extensive bibliography. The remainder of the book is divided into four general areas: Reactions and Preparation of Copolymers Reactions and Preparation of Block and Graft Copolymers Modification Through Condensation Reactions Applications The chemical modification of homopolymers such as polyvinylchlo ride, polyethylene, poly(chloroalkylene sulfides), polysulfones, poly chloromethylstyrene, polyisobutylene, polysodium acrylate, polyvinyl alcohol, polyvinyl chloroformate, sulfonated polystyrene; block and graft copolymers such as poly(styrene-block-ethylene-co-butylene block-styrene), poly(I,4-polybutadiene-block ethylene oxide), star chlorine-telechelic polyisobutylene, poly(isobutylene-co-2,3-dimethyl- 1,3-butadiene), poly(styrene-co-N-butylmethacrylate); cellulose, dex tran and inulin, is described. |
| azide alkyne click chemistry: Modeling of Molecular Properties Peter Comba, 2011-10-17 Molecular modeling encompasses applied theoretical approaches and computational techniques to model structures and properties of molecular compounds and materials in order to predict and / or interpret their properties. The modeling covered in this book ranges from methods for small chemical to large biological molecules and materials. With its comprehensive coverage of important research fields in molecular and materials science, this is a must-have for all organic, inorganic and biochemists as well as materials scientists interested in applied theoretical and computational chemistry. The 28 chapters, written by an international group of experienced theoretically oriented chemists, are grouped into four parts: Theory and Concepts; Applications in Homogeneous Catalysis; Applications in Pharmaceutical and Biological Chemistry; and Applications in Main Group, Organic and Organometallic Chemistry. The various chapters include concept papers, tutorials, and research reports. |
Azide - Wikipedia
In chemistry, azide (/ ˈ eɪ z aɪ d /, AY-zyd) is a linear, polyatomic anion with the formula N − 3 and structure − N=N + =N −. It is the conjugate base of hydrazoic acid HN 3. Organic azides are …
Azide | Synthesis, Reactions, Explosive | Britannica
azide, any of a class of chemical compounds containing three nitrogen atoms as a group, represented as (-N 3). Azides are considered as derived from hydrazoic acid (HN 3 ), an …
Some Reactions of Azides - Master Organic Chemistry
Jun 29, 2018 · The Lewis structure of N3- , the azide ion, looks very weird. But it's a useful nucleophile, and organic azides undergo several useful reactions. Let's see.
Information on Azide Compounds – Stanford Environmental Health …
Azides are energy-rich molecules with many applications. Sodium azide, for example, is used as a preservative, mutagen, biocide, and assay reagent. Organic azides are capable of a great …
Azide | N3- | CID 33558 - PubChem
Azide | N3- | CID 33558 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, …
Azide Compounds - Florida State University
Azide Compounds . Azides are energy -rich molecules with many applications. Sodium azide, for example, is used as a preservative, mutagen, biocide, and assay reagent. Organic azides are …
Azide - an overview | ScienceDirect Topics
Azide refers to a linear anion that is isoelectronic with CO2 and N2O, and can be represented by several resonance structures. It is characterized by its explosive nature and can form …
Azides - Chemistry LibreTexts
Jan 23, 2023 · Azide is the anion with the formula \(N_3^−\). It is the conjugate base of hydrazoic acid (\(HN_3\)). \(N_3^−\) is a linear anion that is isoelectronic with \(CO_2\) and \(N_2O\).
Azides - MilliporeSigma
Sodium azide (NaN3) is an inorganic compound known for its potent inhibitory properties. It exists in the form of a water-soluble crystalline powder with no discernible odor. This ionic substance …
Organic azide - Wikipedia
An organic azide is an organic compound that contains an azide (– N 3) functional group. [1] Because of the hazards associated with their use, few azides are used commercially although …
Azide - Wikipedia
In chemistry, azide (/ ˈ eɪ z aɪ d /, AY-zyd) is a linear, polyatomic anion with the formula N − 3 and structure − N=N + =N −. It is the conjugate base of hydrazoic acid HN 3. Organic azides are …
Azide | Synthesis, Reactions, Explosive | Britannica
azide, any of a class of chemical compounds containing three nitrogen atoms as a group, represented as (-N 3). Azides are considered as derived from hydrazoic acid (HN 3 ), an …
Some Reactions of Azides - Master Organic Chemistry
Jun 29, 2018 · The Lewis structure of N3- , the azide ion, looks very weird. But it's a useful nucleophile, and organic azides undergo several useful reactions. Let's see.
Information on Azide Compounds – Stanford Environmental …
Azides are energy-rich molecules with many applications. Sodium azide, for example, is used as a preservative, mutagen, biocide, and assay reagent. Organic azides are capable of a great …
Azide | N3- | CID 33558 - PubChem
Azide | N3- | CID 33558 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, …
Azide Compounds - Florida State University
Azide Compounds . Azides are energy -rich molecules with many applications. Sodium azide, for example, is used as a preservative, mutagen, biocide, and assay reagent. Organic azides are …
Azide - an overview | ScienceDirect Topics
Azide refers to a linear anion that is isoelectronic with CO2 and N2O, and can be represented by several resonance structures. It is characterized by its explosive nature and can form …
Azides - Chemistry LibreTexts
Jan 23, 2023 · Azide is the anion with the formula \(N_3^−\). It is the conjugate base of hydrazoic acid (\(HN_3\)). \(N_3^−\) is a linear anion that is isoelectronic with \(CO_2\) and \(N_2O\).
Azides - MilliporeSigma
Sodium azide (NaN3) is an inorganic compound known for its potent inhibitory properties. It exists in the form of a water-soluble crystalline powder with no discernible odor. This ionic substance …
Organic azide - Wikipedia
An organic azide is an organic compound that contains an azide (– N 3) functional group. [1] Because of the hazards associated with their use, few azides are used commercially although …
