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| benefits of ketamine-assisted therapy: Ketamine for Treatment-Resistant Depression Sanjay J. Mathew, Carlos A. Zarate, Jr., 2016-11-25 This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research. |
| benefits of ketamine-assisted therapy: The Ketamine Papers Phil Wolfson, Glenn Hartelius, 2016-11 The Ketamine Papers opens the door to a broad understanding of this medicine's growing use in psychiatry and its decades of history providing transformative personal experiences. Now gaining increasing recognition as a promising approach to the treatment of depression, posttraumatic stress disorder (PTSD), and other psychological conditions, ketamine therapies offer new hope for patients and clinicians alike. With multiple routes of administration and practices ranging from anesthesia to psychotherapy, ketamine medicine is a diverse and rapidly growing field. The Ketamine Papers clarifies the issues and is an inspiring introduction to this powerful tool for healing and transformation--from its early use in the 1960s to its emerging role in the treatment of depression, suicidality, and other conditions. This comprehensive volume is the ideal introduction for patients and clinicians alike, and for anyone interested in the therapeutic and transformative healing power of this revolutionary medicine. |
| benefits of ketamine-assisted therapy: Ketamine for Depression Dr. Stephen J. Hyde, 2015-09-04 Given the unacceptably high rates of suffering, disability and premature death experienced by people with treatment-resistant depression and the surprisingly low rates of problems arising from the use of ketamine to treat the disorder, this is a therapy that all patients and their doctors should be discussing. This book summarises the research that has been carried out into ketamine for the treatment of depression over the past 15 years and, most importantly, describes different ways of using ketamine that are both practical and cost–effective. Currently most ketamine therapy is given intravenously in specialised clinics at considerable expense, but the author has successfully treated patients with low-dose sublingual ketamine and his patients have been able to safely take this at home. Profits from the sales of this book will assist further research into the use of ketamine for the treatment of depression. |
| benefits of ketamine-assisted therapy: Ketamine for Treatment-Resistant Depression Gustavo H. Vazquez, Carlos A. Zarate, Elisa Brietzke, 2020-09-16 Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. - Provides efficacy research on ketamine as a treatment for depression - Identifies best practices for clinical use, both long-term and acute - Discusses the molecular mechanisms and neurobiology of action |
| benefits of ketamine-assisted therapy: Identifying, Treating, and Preventing Childhood Trauma in Rural Communities Baker, Marion, Ford, Jacqueline, Canfield, Brittany, Grabb, Traci, 2016-06-09 While there have been great strides made in the treatment options available to trauma victims, there is a noticeable gap in the availability of medical, social, and psychological options in rural communities. As these hurdles gain more recognition, especially in regards to traumatized children, research efforts have been intensified in an effort to increase the overall awareness of and find solutions to the improper treatment being provided. Identifying, Treating, and Preventing Childhood Trauma in Rural Communities depicts the issues and challenges rural areas face when treating victims of trauma, especially children and adolescents. Featuring information on language and cultural barriers, as well as the lack of resources available within these rustic environments, this publication serves as a critical reference for researchers, clinicians, educators, social workers, and medical providers. |
| benefits of ketamine-assisted therapy: Consciousness Medicine Françoise Bourzat, Kristina Hunter, 2019-06-25 A comprehensive guide to the safe and ethical application of expanded states of consciousness for therapists, healing practitioners, and sincere explorers Psychedelic medicines also known as entheogens are entering the mainstream. And it’s no wonder: despite having access to the latest wellness trends and advances in technology, we’re no healthier, happier, or more meaningfully connected. Psilocybin mushrooms, ayahuasca, and LSD—as well as other time-tested techniques with the power to shift consciousness such as drumming, meditation, and vision quests—are now being recognized as potent catalysts for change and healing. But how do we ensure that we’re approaching them effectively? Françoise Bourzat—a counselor and experienced guide with sanctioned training in the Mazatec and other indigenous traditions—and healer Kristina Hunter introduce a holistic model focusing on the threefold process of preparation, journey, and integration. Drawing from more than thirty years of experience, Bourzat’s skillful and heartfelt approach presents the therapeutic application of expanded states, without divorcing them from their traditional contexts. Consciousness Medicine delivers a coherent map for navigating nonordinary states of consciousness, offering an invaluable contribution to the field of healing and transformation. |
| benefits of ketamine-assisted therapy: Rapid Acting Antidepressants , 2020-06-29 The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series |
| benefits of ketamine-assisted therapy: IV Ketamine Infusion Therapy for Depression Frank M Ligons, 2021-05-26 Ketamine infusions for depression relieve TWO-THIRDS of treatment-resistant cases. Is it addictive? What is a k hole? Cost and dosage? |
| benefits of ketamine-assisted therapy: Ketamine Karl Jansen, 2001-01-01 |
| benefits of ketamine-assisted therapy: Pain Management and the Opioid Epidemic National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse, 2017-09-28 Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring. |
| benefits of ketamine-assisted therapy: Human Caring Science Jean Watson, 2012 Rev. ed. of: Nursing: human science and human care / Jean Watson. c1999. |
| benefits of ketamine-assisted therapy: Hello I Want to Die Please Fix Me Anna Mehler Paperny, 2020-03-31 An engrossing memoir-meets-investigative report that takes a fresh, frank look at how we treat depression. Depression is a havoc-wreaking illness that masquerades as personal failing and hijacks your life. After a major suicide attempt in her early twenties, Anna Mehler Paperny resolved to put her reporter’s skills to use to get to know her enemy, setting off on a journey to understand her condition, the dizzying array of medical treatments on offer, and a medical profession in search of answers. Charting the way depression wrecks so many lives, she maps competing schools of therapy, pharmacology, cutting-edge medicine, the pill-popping pitfalls of long-term treatment, the glaring unknowns and the institutional shortcomings that both patients and practitioners are up against. She interviews leading medical experts across the US and Canada, from psychiatrists to neurologists, brain-mapping pioneers to family practitioners, and others dabbling in strange hypotheses—and shares compassionate conversations with fellow sufferers. Hello I Want to Die Please Fix Me tracks Anna’s quest for knowledge and her desire to get well. Impeccably reported, it is a profoundly compelling story about the human spirit and the myriad ways we treat (and fail to treat) the disease that accounts for more years swallowed up by disability than any other in the world. If you or someone you know is struggling with suicidal thoughts, help is available. Contact the National Suicide Prevention Lifeline at 800-273-8255. |
| benefits of ketamine-assisted therapy: The Joy Plan Kaia Roman, 2017-07-11 As a mother, a wife, and a businesswoman, Kaia Roman always had a plan. But when her biggest plan, the business she cofounded, collapsed, Kaia found herself crushed by depression. And what felt even worse was that, with a husband and two kids relying on her to get out of bed, she didn't have a plan to move forward. Determined to turn her life around and put her ingrained habits of stress and anxiety behind her, Kaia decided to put everything else on hold and dedicate thirty days to the singular pursuit of joy. The results were astonishing—and lasted much longer than the initial monthlong project. In this uplifting and eye-opening memoir, Kaia uses her business savvy to create a concrete Joy Plan to get back on her feet fast. Using scientific research on hormones, neurotransmitters, and mindfulness, along with the daily dedication to creating a more joyful existence, Kaia teaches readers how to move past temporary happiness and succeed in creating joy that lasts. Complete with advice, exercises, and key takeaways, The Joy Plan is Kaia's step-by-step guide to how she, and everyone else, can ditch the negative and plan for the joy in their lives. |
| benefits of ketamine-assisted therapy: Manufacturing Depression Gary Greenberg, 2010-02-02 Am I depressed or just unhappy? In the last two decades, antidepressants have become staples of our medicine cabinets—doctors now write 120 million prescriptions annually, at a cost of more than 10 billion dollars. At the same time, depression rates have skyrocketed; twenty percent of Americans are now expected to suffer from it during their lives. Doctors, and drug companies, claim that this convergence is a public health triumph: the recognition and treatment of an under-diagnosed illness. Gary Greenberg, a practicing therapist and longtime depressive, raises a more disturbing possibility: that the disease has been manufactured to suit (and sell) the cure. Greenberg draws on sources ranging from the Bible to current medical journals to show how the idea that unhappiness is an illness has been packaged and sold by brilliant scientists and shrewd marketing experts—and why it has been so successful. Part memoir, part intellectual history, part exposé—including a vivid chronicle of his participation in a clinical antidepressant trial—Manufacturing Depression is an incisive look at an epidemic that has changed the way we have come to think of ourselves. |
| benefits of ketamine-assisted therapy: Psychedelic Neuroscience Tanya Calvey, 2018-11-21 We are in the midst of what is being called the 'psychedelic renaissance' with growing interest into how psychedelics alter consciousness, brain function and brain connectivity. The acute, often profound, effects of the psychedelic experience can induce lasting improvements in mental health demonstrating that chemistry forms the basis of mystical experience, consciousness and mental wellbeing. - This volume is a collection of chapters by world leaders in fields of neurobiology, neuropsychiatry, psychology, ethnography and pharmacology, addressing the neurobiological mechanisms of action of various classic and atypical psychedelics, their therapeutic potential as well as the possible risks associated with their use |
| benefits of ketamine-assisted therapy: A Dose of Hope Dan Engle, Alex Young, 2021-07-20 MDMA-assisted therapy for PTSD is in the final stages of FDA testing. Clinical trials are reporting a 70 percent cure rate for a condition that claims thousands of lives globally every day-hundreds in the US alone. But until it's fully legalized, MDMA is still a Schedule I drug, saddled with years of misunderstanding, misinformation, and misuse. In this groundbreaking, informative, and easy-to-read book, Dr. Dan Engle shows you the treatment through the eyes of a fictional patient so you can see how it works without ever setting foot in a doctor's office. Follow in-depth conversations between doctor and patient, learn about the history of MDMA-assisted therapy, understand how and why it helps, and experience the process for yourself-without ever having to take anything. The treatment presented here is a synthesis of the real experiences and stunning results happening today in trials around the world. Whether you or a loved one suffer from PTSD, or you just want to heal something that's keeping you from living your best life, don't miss A Dose of Hope. |
| benefits of ketamine-assisted therapy: Chronic Pain and Addiction Michael R. Clark, Glenn J. Treisman, 2011-01-01 The relationship between chronic pain and addiction Patients with chronic pain understandably seek relief from their distress and discomfort, but many medications that alleviate pain are potentially addictive, and most chronic pain conditions only have a temporary response to opiate analgesic drugs. This volume reviews the fundamental topics that underlie the complex relationships of this controversial domain. The authors review behavioral models and practical methods for understanding and treating chronic pain and addiction including methods to formulate patients with complex comorbidity and screen patients with chronic pain for addictive liability. Finally, the authors describe the current findings from clinical and basic science that illuminate the role of opiates, cannabinoids and ketamine in the treatment of chronic pain. Up to date and comprehensive, this book is relevant to all professionals engaged in the care of patients with chronic pain or addiction and all others interested in these contemporary issues, particularly non-clinicians seeking clarity in the controversy over the best approach to patients with chronic pain. |
| benefits of ketamine-assisted therapy: Reflections on Motivation Gary Chambers, 2001 The first of an annual series, Reflections on Motivation draws on the work and experience of colleagues in universities, schools and local authorities to provide a blend of theory and practical classroom application. The reader is provided not only with an insight into activities which have succeeded in motivating foreign language learners but also the rationale behind them, with the aim of providing a template for others to follow to enhance motivation in their working contexts. |
| benefits of ketamine-assisted therapy: Cancer Pain Relief World Health Organization, 1996 The second edition of a guide, which introduced a simple, yet highly effective method for the relief of cancer pain. Thoroughly revised and updated, the new edition further refines the WHO method, which advocates the use of a small number of relatively inexpensive drugs, including morphine. Revisions draw on experiences with millions of patients around the world as well as new knowledge about the specific pain syndromes unique to cancer. Completely new are chapters describing the international system by which morphine and other opioids are made available for medical purposes. The book has two parts. Part one provides a practical guide to the relief of cancer pain, concentrating on drug treatment as the mainstay of pain management. The most extensive section sets out detailed guidelines for the selection and prescribing of non-opioid analgesics, opioid analgesics, drugs for neuropathic pain, and adjuvant drugs for the treatment of adverse effects, the enhancement of pain relief and the management of concomitant psychological disturbances. Information ranges from explanations of how specific drugs work, through the precautions to take in the presence of certain disorders, to a list of factors that influence the effectiveness of opioids. Concerning the use of opioids, readers are reminded that psychological dependence does not occur in cancer patients and that the only correct dose of morphine is the one that relieves the pain. Part two provides a guide to opioid availability. A discussion of the reasons why opioids continue to be underprescribed or difficult to obtain is followed by an explanation of the Single Convention on Narcotic Drugs. |
| benefits of ketamine-assisted therapy: Loveseed Kathleen Hanagan, 2018-10-22 The Most Powerful Thing You Can Do is Be Fully Yourself. Indigenous societies believe that we each possess original medicine, a kind of personal power, that is ours and ours alone. The greatest challenge of our lives is to find the seed of that power and let it bloom. Combining dramatic real- life experiences with mythic tales, Kathleen Hanagan draws on her 30 years as a psychotherapist, modern mystic, and spiritual adventurer to weave the threads of ancient wisdom with today's intelligence. As you read, you will learn how to discover and grow your Loveseed, and then, shine its brilliant light by living with loving kindness, generosity, and truth. |
| benefits of ketamine-assisted therapy: Eating Disorders National Collaborating Centre for Mental Health (Great Britain), 2004 This guideline has been developed to advise on the identification, treatment and management of the eating disorders anorexia nervosa, bulimia nervosa, and related conditions. The guideline recommendations have been developed by a multidisciplinary group of health care professionals, patients and their representatives, and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to clinicians and service commissioners in providing and planning high quality care for those with eating disorders while also emphasising the importance of the experience of care for patients and carers. |
| benefits of ketamine-assisted therapy: Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) Mary C. Zanarini, Director Laboratory for the Study of Adult Development McLean Hospital Belmont Massachusetts Associate Professor of Psychology Harvard Medical School Boston Massachusetts Mary C Zanarini, Ed.D, 2007-03 The Zanarini Rating Scale for BPD is a nine-item, validated, clinician-based diagnostic interview. It assesses the severity of DSM-IV-based Borderline Personality Disorder symptoms. This scale also measures meaningful changes in symptoms over time. The 0-4 points rating ranges from No Symptoms (0) to Severe Symptoms (4) for the following categories: Affective: Inappropriate anger / frequent angry acts; chronic feelings of emptiness; mood instability Cognitive: Stress-related paranoia / dissociation; severe identity disturbance based on false personal beliefs Impulsive: Self-mutilation and/or suicidal efforts; two other forms of impulsivity Interpersonal: Unstable interpersonal relationships; frantic efforts to avoid abandonment |
| benefits of ketamine-assisted therapy: Clinical Manual of Electroconvulsive Therapy Mehul V. Mankad, John L. Beyer, Richard D. Weiner, Andrew Krystal, 2010-04-13 Increasingly, electroconvulsive therapy (ECT) is recognized as a proven, effective, and even life-saving intervention in certain mood and thought disorders when other treatments have had little or no effect. Despite the proven efficacy and safety of this standard treatment in psychiatry, its availability is variable. Part of this disparity in access is related to misunderstanding by laypersons regarding the treatment and its potential adverse effects. Adequate education and training of psychiatrists and their support staff are essential to ensuring patients' access to this vital treatment tool. The authors of Clinical Manual of Electroconvulsive Therapy offer this expansive yet reader-friendly volume to help psychiatrists successfully incorporate ECT into their clinical practices. It is also a valuable resource for medical students and psychiatric residents, as well as experienced clinicians and researchers. The book updates the 1985 original and 1998 second edition of Electroconvulsive Therapy: A Programmed Text, and provides readers with a scheduled approach to understanding the fundamental concepts of ECT while offering practical guidance for establishing and maintaining an ECT program. Topics include the history of ECT, indications for use, patient referral and evaluation, the basics of ECT, clinical applications, anesthetics and other medications, seizure monitoring and management, ictal motor and cardiovascular response, adverse effects, and maintenance ECT. Included are detailed descriptions of recent advances including ultra-brief pulse ECT, oxygenation, muscle relaxation, and other modifications that have made this very effective treatment much safer and more acceptable to patients. Currently, it is estimated that more than 100,000 people receive ECT treatments each year in the U.S. Indications for use of ECT are for mood disorders such as major depressive disorder and mania, and thought disorders including schizophrenia and schizoaffective disorder. Indications for use in other psychiatric disorders and general medical disorders such as Parkinson's disease, which appears to respond especially well to ECT, are reviewed as well. This highly-readable manual is a must-have for the library of any clinician interested in or currently practicing ECT: Provides background information on the origins of psychiatric treatments preceding ECT, including efforts using hydrotherapy and insulin comas Includes an algorithm for the management of ECT seizure adequacy Discusses contraindications as well as the potential adverse effects of ECT, including cognitive changes and cardiovascular complications Provides specific information about ECT device manufacturers, reprintable patient information sheets, and a written informed consent form This clinical manual comprehensively explores and explains the available knowledge regarding ECT -- based on extensive research over the past 70 years -- in order to help potential ECT clinicians make informed choices about the development and management of their ECT program. |
| benefits of ketamine-assisted therapy: How to Change Your Mind Michael Pollan, 2019-05-14 Now on Netflix as a 4-part documentary series! “Pollan keeps you turning the pages . . . cleareyed and assured.” —New York Times A #1 New York Times Bestseller, New York Times Book Review 10 Best Books of 2018, and New York Times Notable Book A brilliant and brave investigation into the medical and scientific revolution taking place around psychedelic drugs--and the spellbinding story of his own life-changing psychedelic experiences When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third. Thus began a singular adventure into various altered states of consciousness, along with a dive deep into both the latest brain science and the thriving underground community of psychedelic therapists. Pollan sifts the historical record to separate the truth about these mysterious drugs from the myths that have surrounded them since the 1960s, when a handful of psychedelic evangelists inadvertently catalyzed a powerful backlash against what was then a promising field of research. A unique and elegant blend of science, memoir, travel writing, history, and medicine, How to Change Your Mind is a triumph of participatory journalism. By turns dazzling and edifying, it is the gripping account of a journey to an exciting and unexpected new frontier in our understanding of the mind, the self, and our place in the world. The true subject of Pollan's mental travelogue is not just psychedelic drugs but also the eternal puzzle of human consciousness and how, in a world that offers us both suffering and joy, we can do our best to be fully present and find meaning in our lives. |
| benefits of ketamine-assisted therapy: Managing Treatment-Resistant Depression Joao Luciano de Quevedo, Patricio Riva-Posse, William V. Bobo, 2022-04-04 Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD. Defines Treatment-Resistant Depression and Staging Treatment Intensity Includes Treatment-Resistant Depression options for children, adolescents, geriatrics, during pregnancy, and during post-partum and menopause transitions Discusses the use of Ketamine and Esketamine for treatment-resistant depression |
| benefits of ketamine-assisted therapy: Spontaneous Happiness Andrew Weil, 2011-11-08 Everyone wants to be happy. But what does that really mean? Increasingly, scientific evidence shows us that true satisfaction and well-being come only from within. Dr. Andrew Weil has proven that the best way to maintain optimum physical health is to draw on both conventional and alternative medicine. Now, in Spontaneous Happiness, he gives us the foundation for attaining and sustaining optimum emotional health. Rooted in Dr. Weil's pioneering work in integrative medicine, the book suggests a reinterpretation of the notion of happiness, discusses the limitations of the biomedical model in treating depression, and elaborates on the inseparability of body and mind. Dr. Weil offers an array of scientifically proven strategies from Eastern and Western psychology to counteract low mood and enhance contentment, comfort, resilience, serenity, and emotional balance. Drawn from psychotherapy, mindfulness training, Buddhist psychology, nutritional science, and more, these strategies include body-oriented therapies to support emotional wellness, techniques for managing stress and anxiety and changing mental habits that keep us stuck in negative patterns, and advice on developing a spiritual dimension in our lives. Lastly, Dr. Weil presents an eight-week program that can be customized according to specific needs, with short- and long-term advice on nutrition, exercise, supplements, environment, lifestyle, and much more. Whether you are struggling with depression or simply want to feel happier, Dr. Weil's revolutionary approach will shift the paradigm of emotional health and help you achieve greater contentment in your life. |
| benefits of ketamine-assisted therapy: Global Status Report on Alcohol and Health 2018 World Health Organization, 2018 The report provides an overview of alcohol consumption and harms in relation to the UN Sustainable Development Goals (Chapter 1) presents global strategies action plans and monitoring frameworks (Chapter 2) gives detailed information on: the consumption of alcohol in populations (Chapter 3); the health consequences of alcohol consumption (Chapter 4); and policy responses at national level (Chapter 5). In its final chapter 6 the imperative for reducing harmful use of alcohol in a public health perspective is presented. In addition the report contains country profiles for WHO Member States and appendices with statistical annexes a description of the data sources and methods used to produce the estimates and references. |
| benefits of ketamine-assisted therapy: Psychedelic Psychiatry Erika Dyck, 2008-09-15 LSD's short but colorful history in North America carries with it the distinct cachet of counterculture and government experimentation. The truth about this mind-altering chemical cocktail is far more complex—and less controversial—than generally believed. Psychedelic Psychiatry is the tale of medical researchers working to understand LSD’s therapeutic properties just as escalating anxieties about drug abuse in modern society laid the groundwork for the end of experimentation at the edge of psychopharmacology. Historian Erika Dyck deftly recasts our understanding of LSD to show it as an experimental substance, a medical treatment, and a tool for exploring psychotic perspectives—as well as a recreational drug. She recounts the inside story of the early days of LSD research in small-town, prairie Canada, when Humphry Osmond and Abram Hoffer claimed incredible advances in treating alcoholism, understanding schizophrenia and other psychoses, and achieving empathy with their patients. In relating the drug’s short, strange trip, Dyck explains how concerns about countercultural trends led to the criminalization of LSD and other so-called psychedelic drugs—concordantly opening the way for an explosion in legal prescription pharmaceuticals—and points to the recent re-emergence of sanctioned psychotropic research among psychiatric practitioners. This challenge to the prevailing wisdom behind drug regulation and addiction therapy provides a historical corrective to our perception of LSD’s medical efficacy. |
| benefits of ketamine-assisted therapy: Inflammation-Associated Depression: Evidence, Mechanisms and Implications Robert Dantzer, Lucile Capuron, 2016-12-28 Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level. |
| benefits of ketamine-assisted therapy: Integrative Geriatric Medicine Mikhail Kogan, 2017-12-05 Integrative Geriatric Medicine summarizes a patient-centered, wholistic approaches to medical care of the elderly. Deeply rooted in life style interventions such as nutrition, movement therapies, and mind-body and spirituality approaches integrative geriatrics allows patients to have different path to their healthcare, one that utilizes pharmaceuticals and invasive procedures only when safer integrative approaches are not available or not effective. |
| benefits of ketamine-assisted therapy: Kainic Acid as a Tool in Neurobiology Edith G. McGeer, John W. Olney, Patrick L. McGeer, 1978 |
| benefits of ketamine-assisted therapy: Psychedelic Justice Beatriz Caiuby Labate, Clancy Cavnar, 2021-09-14 CULTIVATING A PSYCHEDELIC RENAISSANCE THAT INCLUDES EVERYONE Radical, cultural transformation is the guiding force behind this socially visionary anthology. Its unifying value is social justice. It guides us in cultivating a psychedelic renaissance that represents everyone, honors voices that have been suppressed for too long, and envisions a more beautiful tomorrow through a psychedelic lens. Psychedelic culture is at an inflection point. Within the last decade, psychedelics have assimilated into the mainstream, even becoming a multimillion-dollar industry. As they integrate into the dominant culture, a lot of longtime participants in psychedelic communities are wondering: will psychedelics help us revolutionize society, or will they merely reinforce old narratives? As psychedelic medicine integrates into mainstream, capitalist culture, the question of what forces will gain control and shape the direction of the psychedelic renaissance is front and center. In this pivotal time, with so many new players emerging, those of us who believe that psychedelics can help us transform society are being challenged to define, and embody, the values that will shape this growing movement. To do this, we must first acknowledge the shadow side of the psychedelic movement and challenge its longstanding injustices. If the psychedelic renaissance is going to expand and revolutionize society, it must include and serve everybody. The anthology highlights Chacruna's ongoing work promoting diversity and inclusion by prominently featuring voices that have been long marginalized in Western psychedelic culture: women, queer people, people of color, and indigenous people. The essays examine both historical and current issues within psychedelics that many may not know about, and orient around policy, reciprocity, diversity and inclusion, sex and power, colonialism, and indigenous concerns. |
| benefits of ketamine-assisted therapy: Pocket Pain Medicine Richard D. Urman, 2012-03-29 Pocket Pain Medicine is an invaluable tool for every resident and practicing physician who needs to understand the essentials of acute and chronic pain management, including all current guidelines and standards of care. This concise, up-to-date, evidence-based reference guide is written in the popular Pocket Notebook Series format that is ideal for today's fast-paced health care environment. Information is presented in a schematic, outline format, with diagrams and tables for quick, easy reference. The book contains all the practical information the resident or practitioner needs to quickly diagnose the pain disorder, safely prescribe the required medications, and arrange for advanced pain care if needed. Pocket Pain Medicine will appeal to physicians in every specialty in both academic and private practice throughout the world. |
| benefits of ketamine-assisted therapy: Integrating Psychotherapy and Psychopharmacology Irismar Reis de Oliveira, Thomas Schwartz, Stephen M. Stahl, 2013-12-04 Integrating Psychotherapy and Psychopharmacology: A Handbook for Clinicians is a practical guide for the growing number of mental-health practitioners searching for information on treatments that combine psychopharmacology, psychotherapy, and psychosocial rehabilitation. Research shows that combined approaches are among the most effective ways to treat an increasing number of psychiatric disorders. However, though these combined treatments are becoming the everyday practice of psychiatrists, psychologists, and other mental-health professionals, identifying the right treatment plan can be notoriously difficult, and clinicians are often left scrambling to answer questions about how to design and customize their treatment strategies. In Integrating Psychotherapy and Psychopharmacology, readers will find these questions fully addressed and the answers explained, and they’ll come away from the book with a toolbox full of strategies for helping their patients improve symptoms, achieve remission, and stay well using a combination of drug and psychological treatments. |
| benefits of ketamine-assisted therapy: A Guide to Functional Analytic Psychotherapy Mavis Tsai, Robert J. Kohlenberg, Jonathan W. Kanter, Barbara Kohlenberg, William C. Follette, Glenn M. Callaghan, 2008-10-25 For more than two decades, Functional Analytic Psychotherapy has brought new meaning – and new meaningfulness – to client/therapist relationships. And clients with disorders as varied as depression, PTSD, and fibromyalgia have benefited from its nuanced, curative power. In A Guide to Functional Analytic Psychotherapy, originators Robert Kohlenberg and Mavis Tsai join with other FAP practitioners to present a clinical framework, addressing points of convergence and divergence with other behavior therapies. Tracing FAP’s emerging evidence base, it takes readers through the deep complexities and possibilities of the therapeutic bond. And the attention to mindfulness and the self makes maximum clinical use of the uniqueness of every client – and every therapist. |
| benefits of ketamine-assisted therapy: Modern Anesthetics Jürgen Schüttler, Helmut Schwilden, 2008-01-08 Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”. |
| benefits of ketamine-assisted therapy: Advances in Psychedelic Medicine Michael J. Winkelman, Ben Sessa MD, 2019-03-22 Researchers, program administrators, and practicing clinicians explain the most recent developments in using psychedelic substances to treat psychological, physiological, and social problems. More than a decade ago, the U.S. government lifted its ban on all testing of psychedelic substances. Winkelman and Sessa now provide updated scientific research and applications of these substances, now moving into approved categories of medicine. The text is an up-to-date assessment of the latest advances in the field of psychedelic medicine, covering the use of LSD, psilocybin, MDMA, ayahuasca, and other substances to augment psychotherapies for a range of disorders. It discusses medical and psychiatric concerns, clinical efficacy and safety, ethical considerations, and neuroscience findings regarding the psychedelic compounds. Topics covered include an overview of psychiatric applications of psychedelics; treatments for addictions and depressive disorders; effects of psychedelics on inflammation and neuroplasticity; evidence for clinical applications of DMT, ayahuasca, and cannabidiol; psychedelic treatment of sociopathic disorders; microdosing psychedelics; training psychedelic therapists; and community-based harm reduction approaches to managing psychedelic crises. |
| benefits of ketamine-assisted therapy: The Pharmacology of LSD Annelie Hintzen, Torsten Passie, 2010-06-10 LSD has a controversial and extraordinary reputation, due to the special effects it can induce on human consciousness.This book is the first ever comprehensive review of the psychological and pharmacological effects of LSD. It draws on data from more than 3000 experimental and clinical studies. |
| benefits of ketamine-assisted therapy: The Therapeutic Use of Ayahuasca Beatriz Caiuby Labate, Clancy Cavnar, 2013-11-22 This book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies. |
| benefits of ketamine-assisted therapy: Psychedelic Drugs Reconsidered Lester Grinspoon, James B. Bakalar, 1997 First published in 1979, Psychedelic Drugs Reconsidered is regarded by many as the most comprehensive, accurate, and accessible analysis of psychedelic drugs for the general reader. It records the extensive history of scientific research on, and societal experience with, psychedelic drugs. The Lindesmith Center reprint edition features a new introduction by the authors on recent developments in psychedelic research, as well as a preface by Dr. Ethan Nadelmann, director of the Lindesmith center. |
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