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| beta cell replacement therapy: Islet Transplantation and Beta Cell Replacement Therapy A. M. James Shapiro, James A. M. Shaw, 2007-07-25 Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and brings together leading multidisciplinary proponents critical to future success in the field. Edited by a surgeon and an endocrinologist at the forefront of the technology, this volume considers challenges associated with this procedure including lack of sufficient donor organs and the side effects of immunosuppressive therapy, as well as the potential benefits for current and future patients. Islet Transplantation and Beta Cell Replacement Therapy, after a brief historical overview, examines: the key role of endocrinologists in holistic assessment and selection of islet transplant recipients the factors underlying attrition of islet function over time and need for enhanced graft monitoring post transplantation future in vivo islet imaging setting up new clinical islet transplant programs by outlining potential models and pitfalls-including cost effectiveness and sustainable integrated approaches clinical outcomes and the future direction for islet transplantation, including alternative sources of beta cells, to meet future clinical needs through xenotransplantation, new insulin-producing cells from adult tissue, and stem cell banks |
| beta cell replacement therapy: Islet Transplantation and Beta Cell Replacement Therapy A. M. James Shapiro, James A. M. Shaw, 2007-07-25 Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and b |
| beta cell replacement therapy: Biobanking and Cryopreservation of Stem Cells Feridoun Karimi-Busheri, Michael Weinfeld, 2016-11-10 Biobanking is considered to be one of the ten ideas changing the world with an estimated value of $45 billion by 2025. Despite the challenges, as the climate for innovation in the biobanking industry continues to flourish around the world, it is certain that amazing discoveries will emerge from this large-scale method of preserving and accessing human samples; biobanking is no longer just a place for collecting and storing samples. This book will cover a wide variety of subjects from across the future biobanking spectrum including scientific strategies, personalized medicine, regenerative medicine and stem cell challenges, disease surveillance, population genetics and innovative methods of biobanking. |
| beta cell replacement therapy: Stem Cells – From Hype to Real Hope Khawaja Husnain Haider, Salim Aziz, MD, 2018-12-17 This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled Stem Cells: from Drug to Drug Discovery which was published in 2017. |
| beta cell replacement therapy: Pancreatic Beta Cell in Health and Disease Susumu Seino, Graeme I. Bell, 2008-04-08 The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes. |
| beta cell replacement therapy: Stem Cell Therapy for Diabetes Shimon Efrat, 2009-12-01 Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes. |
| beta cell replacement therapy: Cell Therapy Dwaine F. Emerich, Gorka Orive, 2017-08-25 This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with contributions from experts in oncology, ophthalmology, stem cells, 3-D printing, and biomaterials where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of transplanted and/or endogeneously mobilized cells. Finally, the book provides insights into the pivotal relationship between academic and industrial partnerships. This volume is designed to touch on the major areas where the field will make its greatest and most immediate clinical impacts. This text will provide a useful resource for physicians and researchers interested in the rapidly changing filed of cell therapy. |
| beta cell replacement therapy: Regenerative Nephrology Michael S. Goligorsky, 2010-11-26 Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. - Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers - Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney |
| beta cell replacement therapy: Pancreas and Islet Transplantation Nadey S. Hakim, Robert Stratta, Derek Gray, 2002 Diabetes Mellitus is the principle cause of kidney failure and blindness in adults and leads to more cases of amputation and impotence than any other disease. It is one of the most common chronic diseases in childhood. The aims of pancreas or islet transplantation are to improve the quality of life of patients with insulin dependent diabetes mellitus and to ameliorate secondary complications. This book provides a comprehensive and international review of the recent advances in pancreas and islet transplantation. It covers surgical techniques, issues surrounding organ preservation, immunosuppression and the control of other complications, all of which contribute to the potential for such transplantations to evolve as the treatment of choice for insulin dependent diabetes. The editors have compiled a strong and international team of contribution authors. This book is essential reading for transplant surgeons and all those involved in researching or treating diabetes mellitus. |
| beta cell replacement therapy: The Pancreatic Beta Cell , 2014-02-20 First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. - Expertise of the contributors - Coverage of a vast array of subjects - In depth current information at the molecular to the clinical levels - Three-dimensional structures in color - Elaborate signaling pathways |
| beta cell replacement therapy: Cost Effectiveness Modelling for Health Technology Assessment Richard Edlin, Christopher McCabe, Claire Hulme, Peter Hall, Judy Wright, 2015-08-11 This book provides an introduction to decision analytic cost-effectiveness modelling, giving the theoretical and practical knowledge required to design and implement analyses that meet the methodological standards of health technology assessment organisations. The book guides you through building a decision tree and Markov model and, importantly, shows how the results of cost-effectiveness analyses are interpreted. Given the complex nature of cost-effectiveness modelling and the often unfamiliar language that runs alongside it, we wanted to make this book as accessible as possible whilst still providing a comprehensive, in-depth, practical guide that reflects the state of the art – that includes the most recent developments in cost-effectiveness modelling. Although the nature of cost effectiveness modelling means that some parts are inevitably quite technical, across the 13 chapters we have broken down explanations of theory and methods into bite-sized pieces that you can work through at your own pace; we have provided explanations of terms and methods as we use them. Importantly, the exercises and online workbooks allow you to test your skills and understanding as you go along. |
| beta cell replacement therapy: Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas Giuseppe Orlando, Lorenzo Piemonti, Camillo Ricordi, Robert J. Stratta, Rainer W.G. Gruessner, 2019-11-09 Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine. - Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation - Includes sections that address donor selection, immunosuppression, complications, allograft pathology, and more - Offers an update on the progress of regenerative medicine research aimed at beta cells replacement in the treatment of diabetes |
| beta cell replacement therapy: Hypoglycemia in Diabetes Philip Cryer, 2016-07-12 Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen. |
| beta cell replacement therapy: Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas Giuseppe Orlando, Lorenzo Piemonti, Camillo Ricordi, Robert J. Stratta, Rainer W.G. Gruessner, 2019-11-10 Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. - Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation - Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more - Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes |
| beta cell replacement therapy: Pancreatic Islet Cell Transplantation Camillo Ricordi, 1992 Intended for researchers and clinicians who work with cell transplantation, this text discusses the latest methods and gives an overall update of the major fields of islet transplantation. Included are reports of recent clinical trials on successful islet transplantation in humans. |
| beta cell replacement therapy: Cardiac Regeneration Masaki Ieda, Wolfram-Hubertus Zimmermann, 2017-10-27 This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration. |
| beta cell replacement therapy: Diabetes Mellitus in Children Mark A. Sperling, 2005 |
| beta cell replacement therapy: Ask a Manager Alison Green, 2018-05-01 From the creator of the popular website Ask a Manager and New York’s work-advice columnist comes a witty, practical guide to 200 difficult professional conversations—featuring all-new advice! There’s a reason Alison Green has been called “the Dear Abby of the work world.” Ten years as a workplace-advice columnist have taught her that people avoid awkward conversations in the office because they simply don’t know what to say. Thankfully, Green does—and in this incredibly helpful book, she tackles the tough discussions you may need to have during your career. You’ll learn what to say when • coworkers push their work on you—then take credit for it • you accidentally trash-talk someone in an email then hit “reply all” • you’re being micromanaged—or not being managed at all • you catch a colleague in a lie • your boss seems unhappy with your work • your cubemate’s loud speakerphone is making you homicidal • you got drunk at the holiday party Praise for Ask a Manager “A must-read for anyone who works . . . [Alison Green’s] advice boils down to the idea that you should be professional (even when others are not) and that communicating in a straightforward manner with candor and kindness will get you far, no matter where you work.”—Booklist (starred review) “The author’s friendly, warm, no-nonsense writing is a pleasure to read, and her advice can be widely applied to relationships in all areas of readers’ lives. Ideal for anyone new to the job market or new to management, or anyone hoping to improve their work experience.”—Library Journal (starred review) “I am a huge fan of Alison Green’s Ask a Manager column. This book is even better. It teaches us how to deal with many of the most vexing big and little problems in our workplaces—and to do so with grace, confidence, and a sense of humor.”—Robert Sutton, Stanford professor and author of The No Asshole Rule and The Asshole Survival Guide “Ask a Manager is the ultimate playbook for navigating the traditional workforce in a diplomatic but firm way.”—Erin Lowry, author of Broke Millennial: Stop Scraping By and Get Your Financial Life Together |
| beta cell replacement therapy: Stem Cells in Reproductive Medicine Carlos Simón, Antonio Pellicer, Renee Reijo Pera, 2013-07-04 Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field. |
| beta cell replacement therapy: Tissue Engineering and Regenerative Medicine Phuc Van Pham, 2019-08-14 This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts. |
| beta cell replacement therapy: Hybrid artificial organs C. Baquey, Bernard Dupuy, 1989 |
| beta cell replacement therapy: Stem Cells and the Future of Regenerative Medicine Institute of Medicine, Board on Neuroscience and Behavioral Health, National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on the Biological and Biomedical Applications of Stem Cell Research, 2002-01-25 Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€specifically embryonic stem cell researchâ€into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues. |
| beta cell replacement therapy: Diabetes in Canada , 2011 |
| beta cell replacement therapy: Type 2 Diabetes Barry J. Goldstein, Dirk Mueller-Wieland, 2016-04-19 The incidence and prevalence of type 2 diabetes mellitus have increased dramatically in modernized and developing nations over the past few decades. Thoroughly revised and expanded, this Second Edition responds to the epidemic and supplies a current overview and guide to the management of diabetes in the modern healthcare environment. This Second E |
| beta cell replacement therapy: Feedback Systems Karl Johan Åström, Richard M. Murray, 2021-02-02 The essential introduction to the principles and applications of feedback systems—now fully revised and expanded This textbook covers the mathematics needed to model, analyze, and design feedback systems. Now more user-friendly than ever, this revised and expanded edition of Feedback Systems is a one-volume resource for students and researchers in mathematics and engineering. It has applications across a range of disciplines that utilize feedback in physical, biological, information, and economic systems. Karl Åström and Richard Murray use techniques from physics, computer science, and operations research to introduce control-oriented modeling. They begin with state space tools for analysis and design, including stability of solutions, Lyapunov functions, reachability, state feedback observability, and estimators. The matrix exponential plays a central role in the analysis of linear control systems, allowing a concise development of many of the key concepts for this class of models. Åström and Murray then develop and explain tools in the frequency domain, including transfer functions, Nyquist analysis, PID control, frequency domain design, and robustness. Features a new chapter on design principles and tools, illustrating the types of problems that can be solved using feedback Includes a new chapter on fundamental limits and new material on the Routh-Hurwitz criterion and root locus plots Provides exercises at the end of every chapter Comes with an electronic solutions manual An ideal textbook for undergraduate and graduate students Indispensable for researchers seeking a self-contained resource on control theory |
| beta cell replacement therapy: Biomimetic Medical Materials Insup Noh, 2018-11-23 This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting. |
| beta cell replacement therapy: CDC Yellow Book 2018: Health Information for International Travel Centers for Disease Control and Prevention CDC, 2017-04-17 THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad. |
| beta cell replacement therapy: Cellular Transplantation Craig Halberstadt, Dwaine F. Emerich, 2011-10-10 There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation |
| beta cell replacement therapy: The American Diabetes Association/JDRF Type 1 Diabetes Sourcebook Anne L. Peters, Lori M. Laffel, 2013-03-29 The American Diabetes Association/JDRF Type 1 Diabetes Sourcebook serves as both an evidence-based reference work and consensus report outlining the most critical components of care for individuals with type 1 diabetes throughout their lifespan. The volume serves not only as a comprehensive guide for clinicians, but also reviews the evidence supporting these components of care and provides a perspective on the critical areas of research that are needed to improve our understanding of type 1 diabetes diagnosis and treatment. The volume focuses specifically on the needs of patients with type 1 diabetes and provides clear and detailed guidance on the current standards for the optimal treatment of type 1 diabetes from early childhood to later life. To accomplish the book’s editorial goals, Editors-in-Chief, Drs. Anne Peters and Lori Laffel, assembled an editorial steering committee of prominent research physicians, clinicians, and educators to develop the topical coverage. In addition, a Managing Editor was brought on to help the authors write and focus their chapters. |
| beta cell replacement therapy: The Endocrine Pancreas Ellis Samols, 1991 |
| beta cell replacement therapy: Engineering of Stem Cells Ulrich Martin, 2009-10-15 I am very pleased to present this volume on engineering stem cells in Advances in Biochemical Engineering and Biotechnology. This volume stays abreast of recent developments in stem cell biology and the high expectations concerning the dev- opment of stem cell based regenerative therapies. Regenerative medicine is the focus of current biomedical research, with unique challenges related to scientific, technical and ethical issues of stem cell research, and the potential added value of connecting biomedicine with enabling techno- gies such as materials sciences, mechanical- and nano-engineering. Research activities in regenerative medicine include strategies in endogenous regeneration of injured or degenerated tissues by means of gene therapy or cell transplantation, as well as complex approaches to replace or reconstruct lost or malformed tissue structures, by applying tissue engineering approaches. In most cases, the speci- ized functional cell types of interest cannot be isolated from the diseased organ or expanded to a sufficient degree, and various stem and progenitor cell types rep- sent the only applicable cell source. In almost all cases, stem cells have to be engineered, sometimes for functional improvement, in many cases to produce large numbers of cells, and frequently to achieve efficient and specific differentiation in the cell type(s) of interest. |
| beta cell replacement therapy: Quick Guide to Kidney Transplantation Phuong-Chi T Pham, Phuong-Thu T Pham, 2019-02-11 Concise, easy to read, and designed for quick reference,Quick Guide to Kidney Transplantationis a compact resource for general nephrologists, residents, fellows, nurse practitioners, and others involved in the care of post-transplant patients. Focusing on must-know clinical information needed to provide optimal patient care, this expertly written guide helps you gain the knowledge and expertise you need in this complex area. |
| beta cell replacement therapy: Transplantation of the Pancreas Rainer W.G. Gruessner, David E.R. Sutherland, 2004-04-27 Although pancreas transplants have been performed for more than 30 years, the last few years have witnessed significant growth in the options available for pancreas transplantation. Transplantation of the Pancreas, edited by Drs. Gruessner and Sutherland provides a state-of-the-art, definitive reference work on pancreas transplantation for transplant surgeons and physicians as well as for endocrinologists, diabetologists, nephrologists, and neurologists. The editors, from the renowned University of Minnesota Transplant Division and the Diabetes Institute, have assembled a group of renowned experts to provide an all-inclusive overview of pancreas transplantation. The text features insights on the pathophysiology of diabetes mellitus and the limitations of nontransplant treatments, highlights experimental research and clinical history of pancreas transplantation, and compares and contrasts different surgical procedures. The discussions detail the broad spectrum of post-transplant complications and their treatments, which frequently require skills in general, vascular, and laparoscopic surgery; interventional radiology; critical care; and infectious disease. Chapters on pretransplant evaluation, immunosuppression, immunology, pathology, long-term outcome, quality of life, and cost-effectiveness focus on issues unique to pancreas recipients. Evolving areas, such as pretransplant evaluation of pancreas transplant candidates, living donation, and the current status of islet transplantation are discussed. Augmented by more than 280 illustrations, including full color line drawings created exclusively for the text, this book is the standard reference for all transplant professionals as well as for all physicians caring for the transplant patient. |
| beta cell replacement therapy: Human Embryonic Stem Cells Arlene Chiu, Mahendra S. Rao, 2003-08 A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property. |
| beta cell replacement therapy: Canadian Immunization Guide Canada. Comité consultatif national de l'immunisation, Canada. National Advisory Committee on Immunization, 2006 The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization. |
| beta cell replacement therapy: Insulin Action Ashok K. Srivastava, Barry I. Posner, 1998-05-31 In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action. |
| beta cell replacement therapy: Pluripotent Stem Cells Minoru Tomizawa, 2016-07-20 Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors. |
| beta cell replacement therapy: Stem Cell Drugs - A New Generation of Biopharmaceuticals Phuc Van Pham, 2018-10-25 This invaluable resource discusses the current revolution in stem cell-based drugs and their potential use in clinical applications. Each chapter is contributed by a pre-eminent scientist in the field. An introductory section presents current stem cell drugs and stem cell-based products and a discussion of production, quality control, mechanisms, and efficacy. Following sections include discussions on stem cell-derived microvesicles based products, and derived exosomes based products. Stem Cell Drugs - A New Generation of Biopharmaceuticals and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering. This groundbreaking volume is also essential reading for those researching or studying drug development or pharmaceutical science. |
| beta cell replacement therapy: Jasper's Basic Mechanisms of the Epilepsies Jeffrey Noebels, 2012-06-29 Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for a better understanding of the epilepsies and rational methods of prevention and treatment., the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies. |
| beta cell replacement therapy: Mesenchymal Stem Cell Therapy Lucas G. Chase, Mohan C Vemuri, 2012-12-12 Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field. |
Beta - Wikipedia
Beta (UK: / ˈ b iː t ə /, US: / ˈ b eɪ t ə / ⓘ; uppercase Β, lowercase β, or cursive ϐ; Ancient Greek: βῆτα, romanized: bē̂ta or Greek: βήτα, romanized: víta) is the second letter of the Greek …
Beta Symbol (β)
The Greek letter beta (β). In mathematics and science, it is often used to denote a variable or a parameter, such as an angle or the beta coefficient in regression analysis.
Beta tools: professional and work's tools production
Beta Tools. Beta tools leads the way in the production of professional working tools and instruments. Our catalogue comprises over 16,000 coded items for use in a wide variety of working …
What Beta Means for Investors
May 30, 2025 · Beta equal to 1: A stock with a beta of 1.0 means its price activity correlates with the market. Adding a stock to a portfolio with a beta of 1.0 doesn’t add any risk to the …
Beta - What is Beta (β) in Finance? Guide and Examples
Levered beta, also known as equity beta or stock beta, is the volatility of returns for a stock, taking into account the impact of the company’s leverage from its capital structure. It compares the …
Editorial: Diabetes, transplantation and regenerative medicine
diabetes mellitus, transplantation, post-transplant diabetes mellitus (PTDM), beta-cell replacement therapy, pancreas transplantation, islet transplantation, stem cell-based therapy, type 1 …
Gene therapy targeting key beta cell regulators as a potential ...
Jun 6, 2024 · glycemia as beta cell function progressively declines. While immunotherapies for type 1 diabetes (T1D) have been unsuccessful, emerging evidence suggests that therapies to …
Endogenous Reprogramming of Alpha Cells into Beta Cells
treatment is to preserve and restore a functional beta cell mass, perhaps through beta cell replacement therapy. However, beta cell replacement may fall short in autoimmune type 1 …
EVOTEC REGAINS GLOBAL RIGHTS TO BETA CELL …
beta cell mass and, thereby, reduce or eliminate the need for insulin injections. Furthermore, beta cell replacement therapy also has the potential to prevent or reverse the decline in beta cell …
Imaging in Type 1 Diabetes, Current Perspectives and …
technologies to quantify beta cell mass and function throughout T1D progression and beta cell replacement therapy. Molecular imaging techniques oer a possible solution through both …
Human pluripotent stem cell-derived insulin-producing cells: …
betes cell replacement therapy and fueled many scientists worldwide to further develop fine-tuned stepwise protocols to ... itive beta-like cell marker CD49a (Veres et al., 2019); and nega …
HHS Public Access Sang Mo Kang - ResearchGate
HIV-positive patients with diabetes were initially excluded from beta cell replacement therapy. Early reports of pancreas transplant in patients with HIV described high rates of early graft loss ...
Multifunctional PLGA nanocomposites to improve beta cell …
Figure S1 - Relaxivity measurements at 1.5 T (a,b) and at 3.0 T (c,d). Multifunctional PLGA nanocomposites to improve beta cell replacement therapy in Type 1 Diabetes Cátia Vieira …
MIT Open Access Articles Economics of Beta-Cell …
Economics of Beta-cell Replacement Therapy, Current Diabetes Reports, doi: 10.1007/s11892-019-1203-9 This Author Accepted Manuscript is a PDF file of a an unedited peer-reviewed …
Can Calcineurin Inhibitor-Free Immunosuppression Become a …
Co-Stimulation Blockade for Beta Cell Replacement Therapy Nicole Wojcik, Nathan Appelbaum, Braden Juengel, Lindsay Basto, Minelly Escobedo, Alexandra Juszczyk, Irena Kovacevic, Ling …
Protecting Stem Cell Derived Pancreatic Beta-Like Cells From ...
immune cell interface, PD-L1 and HLA class I, beta cell replacement therapy, genome engineering, human pluripotent stem cells, direct differentiation INTRODUCTION Type 1 …
File Islet Transplantation And Beta Cell Replacement Therapy
The Flexibility of Islet Transplantation And Beta Cell Replacement Therapy Islet Transplantation And Beta Cell Replacement Therapy is not just a static document; it is a adaptable resource …
Data S1: The clinical study protocol, related to STAR Methods
diabetes-related complications. Beta cell replacement therapy, by pancreas or islet transplantation, is an ideal therapeutic option for T1DM, but limitations such as donor …
Insulin Therapy for Type 2 Diabetes: Rescue, Augmentation, …
therapy with basal insulin is useful if some beta-cell function remains. Replace-ment therapy with basal-bolus insulin is required for beta-cell exhaustion. Rescue therapy using replacement ...
Human Bone Marrow Mesenchymal Stem Cells Transfected …
Beta-cell replacement therapy by pancreatic islet transplantation has become a promising treatment for type 1 diabetes. However, the limited supply of human islet tissue prevents this …
Stem cells and beta cell replacement therapy: a prospective …
In 2011 Weir et al. mention, due to the need for beta cell replacement therapy, much work has been done in the past decade to generate beta cells from a variety of cell sources [13 ]. …
Breakthrough T1D Request for Applications: Supportive …
implementation and expansion of next-generation beta cell replacement therapies. This initiative will award grants to academic investigators and industry partners of up to $600,000.00 over 2 …
ATM-24-129-Peer Review File - cdn.amegroups.cn
An autologous source for a beta cell replacement therapy has certainly an interesting perspective since it avoids immune suppressive therapy. Extending the target population to type 2 …
EVOTEC ACHIEVES THIRD MILESTONE IN CELL THERAPY …
In August 2015, Evotec and Sanofi announced a research alliance to develop a beta cell replacement therapy based on functional human beta cells derived from human stem cells for …
Stem cell approaches for diabetes: towards beta cell …
reversed using beta cell replacement therapy. For type 1 diabetes this concept is supported by the success of pancreas and islet transplantation [1,2]. For type 2 diabetes, the potential of beta …
Information on kidney failure treatment in Norway Norwegian …
beta-cell replacement therapy (insulin producing cells for patients with diabetes) are also included in the registry as most of these are also kidney transplanted. The registry is operated at Oslo …
An unmet need: Pancreatic beta cell replacement
termination of exogenous glucose-lowering therapy use. The only definitive restoration of glucose control is through the replacement of a functioning endocrine pancreas or islet cells.[11] …
Large Mammalian Model for Extrahepatic Langerhans …
Beta-cell replacement therapy, by transplantation of insulin-producing tissue (either as whole pancreas or isolated islets of Langerhans) offers a physiologic alternative to subcutaneous …
An unmet need: Pancreatic beta cell replacement
termination of exogenous glucose-lowering therapy use. The only definitive restoration of glucose control is through the replacement of a functioning endocrine pancreas or islet cells.[11] …
Beta cell replacement therapy - viamedica.pl
Beta cell replacement therapy may be offered to patients with both good kidney function and renal failure. In pro-gressive renal failure, beta cell transplantation may be performed simultaneously …
Economics of Beta-Cell Replacement Therapy - Springer
Economics of Beta-Cell Replacement Therapy Cátia Bandeiras1,2,3 & Albert J. Hwa4 & Joaquim M. S. Cabral1,2 & Frederico Castelo Ferreira1,2 & Stan N. Finkelstein3,5 & Robert A. …
BETA CELL REPLACEMENT THERAPIES IN T1D JDRF-NIH …
- Gene editing strategies may be combined with stem cell approaches to create beta cells that are protected from immune destruction after transplantation. Gene editing is being explored as a …
Stem cells and beta cell replacement therapy: a prospective …
The form of beta cell replacement therapy was as a series of retrievable subcutaneous implant devices which protect the enclosed pancreatic progenitors cells from the immune system. This …
Human Beta Cell Regenerative Drug Therapy for Diabetes: …
Human Beta Cell Regenerative Drug Therapy for Diabetes: Past Achievements and Future Challenges Peng Wang1, Esra Karakose1, Lauryn Choleva2, Kunal Kumar3, Robert J. …
BETA-C REPLACEMENT FOR T IDIABETES - eScholarship
Key Words pancreas, islet, transplantation, tolerance, stem cell Abstract The ability to achieve insulin independence with either solid-organ pancreas or islet transplantation has increased …
The Last Mile in Beta-Cell Replacement Therapy for Type 1 …
The field of beta cell replacement therapy for type 1 diabetes (T1D) is currently undergoing a remarkable transformation [3]. Over the past two decades, the well-established islet …
The BETA-2 score web app calculator: …
beta-cell replacement therapy in the treatment of diabetes: a con-sensus report on the Igls criteria from the IPITA/EPITA Opinion Leaders Workshop. Transplantation 1420: 1190. 78) 29; -( …
50 years forward: beta cells - rd.springer.com
therapy. This is one of a series of commentaries under the banner‘50years forward’, giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of …
Beta cell replacement therapy - journals.viamedica.pl
corresponding to the current body requirements. Beta cell replacement options available for highly selected patients with brittle type 1 diabetes include solid--organ pancreas and islet …
Stem Cell Approaches for Diabetes: Beta Cell Replacement
beta cell replacement therapy for diabetes patients. In type 1 diabetes, the beta cells are mostly destroyed. In type 2 diabetes beta cell numbers are reduced by 40% to 60%. The proof-of …
Stem cells and beta cell replacement therapy: a prospective …
The form of beta cell replacement therapy was as a series of retrievable subcutaneous implant devices which protect the enclosed pancreatic progenitors cells from the immune system. This …
Engineering human stellate cells for beta cell replacement …
Engineering human stellate cells for beta cell replacement therapy promotes in vivo recruitment of regulatory T cells D.C. Orana, T. Lokumcua, Y. Inceoglud, M.B ...
Coverage Report - investorvillage.com
Evotec and Sernova collaborate into beta cell replacement therapy for diabetes 5/17 16 Seeking Alpha 7,994,502 Evotec teams up with Sernova to develop diabetes therapy, commits €20M …
The Potential of Cell Sheet Technology for Beta Cell …
The Potential of Cell Sheet Technology for Beta Cell Replacement Therapy Carolin Hermanns1 · Omar Paulino da Silva Filho1 · Vijayganapathy Vaithilingam 1 · Aart van Apeldoorn ... and …
Protecting Stem Cell Derived Pancreatic Beta-Like Cells From ...
immune cell interface, PD-L1 and HLA class I, beta cell replacement therapy, genome engineering, human pluripotent stem cells, direct differentiation INTRODUCTION Type 1 …
Immunological Monitoring in Beta Cell Replacement: …
Beta cell replacement (through pancreas or islet transplantation), is the only available treatment that allows restoring endogenous insulin production, thereby providing an optimized glucose …
Stem Cell Transplantation in the Treatment of Type 1 …
to Beta-Cell Replacement Xin-Xing Wan1, Dan-Yi Zhang 2, Md. Asaduzzaman Khan3, Sheng-Yuan Zheng , Xi-Min Hu4,QiZhang4, Rong-Hua Yang5* and Kun Xiong4,6,7* ... stem cell …
FULL PROGRAM DETAILS! - Taking Control Of Your Diabetes®
Jul 24, 2024 · 2. The Latest Research on Beta Cell Replacement Therapy – REPEATS BAY VIEW ROOM Manasi Jaiman, MD, MPH 3. Top 10 Blood Sugar Controlling Tips from Two …
SPONSORSHIP OPPORTUNITIES - esot.org
related to current and future beta cell replacement therapy in light of current best practises using insulin therapy. esot.org About EPITA Symposium Event’s description This is the largest …
Defining outcomes for beta cell replacement therapy: a
entitled ‘Defining outcomes for beta cell replacement therapy in the treatment of diabetes’ in January 2017 in Igls, Austria. The main objective was to develop consensus on the defini-
An analysis of the UK national pancreas allocation scheme
Aug 15, 2024 · complex and effective glucose sensing and insulin pump therapy techniques (2, 3). Beta cell replacement therapy (solid organ pancreas and islet cell transplantation) however …
