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| dendritic cell vaccine therapy: Vaccines for Cancer Immunotherapy Nima Rezaei, Mahsa Keshavarz-Fathi, 2018-10-17 Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. - Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer - Presents the status of past and current vaccines for cancer treatment - Considers advantages and disadvantages of different therapeutic cancer vaccines - Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods - Analyzes obstacles to development of therapeutic cancer vaccines - Gives a view on future perspectives in the application of therapeutic cancer vaccines |
| dendritic cell vaccine therapy: Translational Immunotherapy of Brain Tumors John H. Sampson, 2017-02-06 Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. 2018 BMA Medical Book Awards Highly Commended in Oncology - Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas - Edited by a prominent neurosurgeon with contributions by leading researchers in the field - Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors |
| dendritic cell vaccine therapy: Cancer Vaccines and Immunotherapy Peter L. Stern, Peter C. L. Beverley, Miles Carroll, 2000-08-17 Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments. |
| dendritic cell vaccine therapy: A Historical Perspective on Evidence-Based Immunology Edward J. Moticka, 2015-11-25 A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells |
| dendritic cell vaccine therapy: Toll-Like Receptors (TLRs) and Innate Immunity Stefan Bauer, Gunther Hartmann, 2007-12-11 Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention. |
| dendritic cell vaccine therapy: Immunopharmacogenomics Yusuke Nakamura, 2015-09-18 This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. |
| dendritic cell vaccine therapy: Blood and Marrow Transplant Handbook Richard T. Maziarz, Susan Schubach Slater, 2015-04-20 This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. Concise, comprehensive, and easy-to-use, Blood and Marrow Transplant Handbook, 2nd Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees. |
| dendritic cell vaccine therapy: Tumor Immunology and Immunotherapy Robert C. Rees, 2014 Tumor immunology and immunotherapy provides a comprehensive account of cancer immunity and immunotherapy. Examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines, this book provides insight into how these problems may be overcome as viewed by leaders in the field. |
| dendritic cell vaccine therapy: Anticancer Drug Development Bruce C. Baguley, David J. Kerr, 2001-11-17 Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. - One work that can be consulted for all aspects of anticancer drug development - Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts - A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death - Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products - Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques - Hundreds of references that allow the reader to access relevant scientific and medical literature - Clear illustrations, some in color, that provide both understanding of the field and material for teaching |
| dendritic cell vaccine therapy: Advances in Cancer Research , 2018-01-24 Advances in Cancer Research, Volume 137, the latest release in this ongoing, well-regarded serial provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, with this volume covering unconventional approaches to modulating the immunogenicity of tumor cells, tumor dormancy and immunoediting, the emerging role of anti-apoptotic Bcl-2 family proteins in chemoresistance, Beclin-1 and autophagy, MDA-7/IL-24, and nanotechnology and medicine. |
| dendritic cell vaccine therapy: Ovarian Cancer Immunotherapy Samir A. Farghaly, 2018-08-31 Ovarian Cancer Immunotherapy provides a broad overview of several aspects of basic sciences, and clinical and therapeutic aspects of immunotherapy for ovarian cancer, as well as state-of-the-art information on molecular genetics and biology. Chapters are written by a team of expert contributors from around the world and explore topics such as antibody therapeutics for ovarian carcinoma, emerging serum biomarkers, ovarian cancer immunity, adoptive cell immunotherapy, the biology of dendritic cells, the role of growth factors, and more. Readers will also gain a better understanding of the molecular and cellular events that underlie ovarian cancer immunology. This book is an ideal resource for clinicians, basic medical scientists, graduate basic medical science students, and medical students caring for patients with ovarian cancer, including attending surgeons and physicians, and clinical fellows and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology. |
| dendritic cell vaccine therapy: Mucosal Vaccines Hiroshi Kiyono, 1996-10-23 This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization |
| dendritic cell vaccine therapy: Oncoimmunology Laurence Zitvogel, Guido Kroemer, 2017-12-13 In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field. |
| dendritic cell vaccine therapy: Biology of Myelomonocytic Cells Anirban Ghosh, 2017-05-10 Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research. |
| dendritic cell vaccine therapy: Tumor Immunology and Immunotherapy - Cellular Methods Part B , 2020-01-28 Tumor Immunology and Immunotherapy - Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered include Quantitation of calreticulin exposure associated with immunogenic cell death, Side-by-side comparisons of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death, Quantitative determination of phagocytosis by bone marrow-derived dendritic cells via imaging flow cytometry, Cytofluorometric assessment of dendritic cell-mediated uptake of cancer cell apoptotic bodies, Methods to assess DC-dependent priming of T cell responses by dying cells, and more. |
| dendritic cell vaccine therapy: Peptide and Protein Vaccines Rossen Donev, 2015-06-08 Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. - Describes advances in application of powerful techniques in a wide bioscience area - Chapters are written by authorities in their field - Targeted to a wide audience of researchers, specialists, and students - The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables |
| dendritic cell vaccine therapy: Immunology for Pharmacy - E-Book Dennis Flaherty, 2011-09-02 With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. - Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. - 165 full-color illustrations help to illuminate difficult concepts. - Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. - Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. - A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. - Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. - A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. - Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. - Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. - Over 60 tables summarize and provide quick reference to important material. - A companion Evolve website includes animations and pharmacy terminology flashcards. |
| dendritic cell vaccine therapy: The Duke Glioma Handbook Allan H. Friedman, 2016-03-31 Provides a summary of glioma biology, genetics and management, based on the world-leading Duke University Preston Robert Tisch Brain Tumor Center program. |
| dendritic cell vaccine therapy: Cancer Vaccines Michael J.P. Lawman, Patricia D. Lawman, 2014-03-12 Cancer Vaccines: Methods and Protocols explores the manipulation and modification of immune cells, the manipulation and modification of tumor cells as well as the manipulation of immune/tumor interactions and various delivery mechanisms, with the overall end goal of evoking a tumor-specific response and overcoming the immuno-evasive mechanisms employed by the tumor cells. This detailed volume also covers the subject of cancer vaccines in a more global sense with its section on the advances, challenges, and future of cancer vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Cancer Vaccines: Methods and Protocols aims to help guide researchers toward developing further generations of cancer vaccines that are both safe and efficacious, with the hope that cancer vaccines will be the standard of care in the very near future. |
| dendritic cell vaccine therapy: Encyclopedia of Cancer , 2018-10-12 Encyclopedia of Cancer, Third Edition, Three Volume Set provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health |
| dendritic cell vaccine therapy: Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy Herbert B. Newton, 2018-03-28 Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. - Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors - Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors - Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods - Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors |
| dendritic cell vaccine therapy: Vaccine Design Sunil Thomas, 2016 |
| dendritic cell vaccine therapy: Current Trends in Cancer Management Liliana Streba, Dan Ionut Gheonea, Michael Schenker, 2019-09-25 The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques. |
| dendritic cell vaccine therapy: Immunopotentiators in Modern Vaccines Virgil Schijns, Derek O'Hagan, 2005-12-19 Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. - Contributions from leading international authorities in the field - Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system - Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator |
| dendritic cell vaccine therapy: Vaccines for the Prevention of Cervical Cancer Peter L. Stern, Henry C. Kitchener, 2008 Cervical cancer is the second most common form of cancer found in women, and it is responsible for more than a quarter of a million deaths worldwide each year. With approximately 70% of cervical cancers now known to be caused by two types of the human pailloma virus (HPV), there is great interest surrounding the approval of the first preventative vaccines for clinical use. Despite this excitement, many questions remain about how the new vaccines should best be implemented and how cervical cnancer screening will change following vaccination. Part of the Oxford Oncology Library series, this practical handbook provides an overview of the role of HPV in the pathology of cervical cancer and its current screening and management, the principles of immune control of HPV infection in cervical cancer, and the challenges of implementing HPV vaccines and future developments. |
| dendritic cell vaccine therapy: Immunotherapy of Hepatocellular Carcinoma Tim F. Greten, 2018-08-22 In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. |
| dendritic cell vaccine therapy: Brain Tumor Immunotherapy Linda M. Liau, Donald P. Becker, Timothy F. Cloughesy, Darell D. Bigner, 2000-11-10 An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics. |
| dendritic cell vaccine therapy: Encyclopedia of Cell Biology , 2015-08-07 The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences |
| dendritic cell vaccine therapy: Lipid A in Cancer Therapy Jean-Francois Jeannin, 2010-07-28 Cancer remains a major challenge for modern society. Not only does cancer rank among the first three causes of mortality in most population groups but also the therapeutic options available for most tumor types are limited. The existing ones have limited efficacy, lack specificity and their administration carry major side effects. Hence the urgent need for novel cancer therapies. One of the most promising avenues in research is the use of specific immunotherapy. The notion that the immune system may have important anti-tumor effects has been around for more than a century now. Every major progress in microbiology and immunology has been immediately followed by attempts to apply the new knowledge to the treatment of cancer. Progress has reached a point where it is well established that most cancer patients mount specific T cell responses against their tumors. The molecular identity of the antigens recognized by anti-tumor T cells has been elucidated and several hundreds of tumor-derived antigenic peptides have been discovered. Upon recognition of such peptides presented by self MHC molecules, both CD8 and CD4 T cells are activated, expand to high numbers and differentiate into effective anti-tumor agents. CD8 T cells directly destroy tumor cells and can cause even large tumors to completely regress in experimental mouse models. These observations have spurred intense research activity aimed at designing and testing cancer vaccines. Over 100 years ago Coley successfully used intratumoral injection of killed bacteria to treat sarcomas. The important anti-tumor effects observed in a fraction of these patients fueled major research efforts. These led to major discoveries in the 80s and the 90s. It turns out that bacterial lipopolysaccharides stimulate the production of massive amounts of a cytokine still known today as tumor necrosis factor (TNF-a). They do so by engagement of a rather complex set of interactions culminating in the ligation of a Toll-like receptor, TLR -4. Ensuing signaling through this receptor initiates potent innate immune responses. Unfortunately the clinical use of both TNF-a and LPS can not be generalized due to their very narrow therapeutic margin. Importantly, synthetic Lipid A analogs have been identified that retain useful bioactivity and yet possess only mild toxicity. The relatively large body of information accumulated thus far on the molecular and cellular interactions set in motion by administration of LPS as well as by the synthetic lipid A analogs allow to place this family of bacterially-derived molecules at the crossroads between innate and adaptive immunity. By virtue of this key position, the therapeutic applications being pursued aim at using these compounds either as direct anti-tumor agents or as vaccine adjuvants. The clinical experience acquired so far on these two avenues is asymmetric. Few clinical trials using Lipid A analogs as single anti-cancer agents involving less than 100 patients with advanced cancer have been reported. In contrast, lipid A has been tested in over 300,000 individuals in various vaccines trials, including therapeutic cancer vaccines. Clearly most of the work needed to develop lipid A as effective anti-cancer agents and/or as vaccine adjuvant lies ahead in the near future. This book is a timely contribution and provides a much needed up-to-date overview of the chemical, biological and physiological aspects of lipid A. It should be a beacon to all those involved in this field of research. |
| dendritic cell vaccine therapy: AIDS Vaccine Research Flossie Wong-Staal, Robert C. Gallo, 2002-02-22 This reference describes the latest advances in the development and design of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV infection for the construction of molecular and therapeutic strategies to reduce the progression and transmission of AIDS. With contributions by universally recognized authorities in the field, AIDS Vaccine Research discusses major obstacles in the identification of a preventive vaccine the role of innate immunity in management of HIV infection the impact of highly active antiretroviral therapy (HAART) on AIDS research the creation of an effective mucosal DNA vaccine the effect of the AIDS epidemic on developing countries Offering nearly 2000 contemporary references to facilitate further study, AIDS Vaccine Research is a timely manual suitable for immunologists, virologists, pathologists, epidemiologists, pharmacologists, microbiologists, hematologists, hepatologists, AIDS researchers, and upper-level undergraduate and graduate students in these disciplines. |
| dendritic cell vaccine therapy: Advances in Precision Medicine Oncology Hilal Arnouk, Bassam Abdul Rasool Hassan, 2021 Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin's drug resistance and critical side effects. |
| dendritic cell vaccine therapy: Nanovaccines Sergio Rosales-Mendoza, Omar González-Ortega, 2019-11-07 This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient ́s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed. Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines; Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines; Transmits the state of the art for the development of mucosal nanovaccines; Provides routes for the design and evaluation of mucosal nanovaccines; Presents key perspectives for the field of mucosal vaccine development. |
| dendritic cell vaccine therapy: Gene Therapy of Cancer Stanton L. Gerson, Edmund C. Lattime, 2002-04-04 The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. - Provides in-depth description of targeted systems and treatment strategies - Explains the underlying cancer biology necessary for understanding a given therapeutic approach - Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses - Presents translational focus with emphasis on requirements for clinical implementation - Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference |
| dendritic cell vaccine therapy: The Future of Pharmaceuticals Sarfaraz K. Niazi, 2022-03-01 Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development. |
| dendritic cell vaccine therapy: Targeted Antigen Delivery: Bridging Innate and Adaptive Immunity Bénédicte Manoury, Piergiuseppe De Berardinis, 2019 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| dendritic cell vaccine therapy: Adoptive Immunotherapy Burkhard Ludewig, Matthias W. Hoffmann, 2008-02-02 An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy. |
| dendritic cell vaccine therapy: Crossroads Between Innate and Adaptive Immunity V Stephen P. Schoenberger, Peter D. Katsikis, Bali Pulendran, 2015-08-31 This volume presents a collection of reviews derived from work presented at the Aegean Conference: “5th Crossroads Between Innate and Adaptive Immunity”. This meeting was the fifth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference “Crossroads between Innate and Adaptive Immunity” brought together leading international scientists and experts to address critical areas of Innate and Adaptive Immunity, a necessary step in the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive Immunity, and maximized scientific interchange through lecture presentations, poster sessions and informal discussions. |
| dendritic cell vaccine therapy: Dendritic Cells in Clinics Morikazu Onji, Sk. Md. Fazle Akbar, 2013-06-29 Great advances have taken place in basic research and the clinical usefulness of dendritic cells (DCs). It has now been clearly established, for instance, that these cells play a crucial role in immune responses against infectious diseases and cancers. Antigen-presenting DCs are widely distributed in the body and regulate both immunity and immune tolerance. Experimental studies have provided important insights into DCs and how they can be used for treating animal models of various diseases that occur in humans. The role of these cells in pathogenesis and the treatment of human diseases is elaborately set forth in this valuable book. Researchers in the field are optimistic that DCs, already in use for treating patients with cancers, soon can be used therapeutically for patients with chronic infections, autoimmune diseases, and allergic manifestations. This volume provides a working definition of DCs and also explains the phenotypes and functions of DCs so that these can be readily understood not only by clinicians but by immunologists, researchers, and students as well. |
| dendritic cell vaccine therapy: Youmans and Winn Neurological Surgery H. Richard Winn, 2017 Dramatically updated to reflect recent advances in the basic and clinical neurosciences, Youmans and Winn Neurological Surgery, 7th Edition remains your reference of choice for authoritative guidance on surgery of the nervous system. Four comprehensive volumes thoroughly cover all you need to know about functional and restorative neurosurgery, (FRN)/deep brain stimulation (DBS), stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally-invasive surgeries in spine and peripheral nerve surgery, endoscopic and other approaches for cranial procedures and cerebrovascular diseases. Seventy new chapters, an expanded video library, and revised content throughout help you master new procedures, new technologies, and essential anatomic knowledge. This unparalleled multimedia resource covers the entire specialty with the unquestioned guidance you've come to expect from the Bible of neurological surgery. |
| dendritic cell vaccine therapy: Immunobiology of Dendritic Cells Part B , 2019-11-22 Immunobiology of Dendritic Cells Part B, Volume 349 in the International Review of Cell and Molecular Biology series highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Cell and Molecular Biology series - Includes the latest information on the Immunobiology of Dendritic Cells |
Dendritic cell - Wikipedia
Dendritic cells are present in tissues that are in contact with the body's external environment, such as the …
DENDRITIC Definition & Meaning - Merriam-Webster
The meaning of DENDRITIC is resembling or having dendrites : branching like a tree. How to use …
Dendritic Cells - The Definitive Guide | Biology Dictionary
Jul 17, 2020 · Dendritic cells are named after their shape and are not neurons with dendrites, as was thought when …
Review of Dendritic Cells, Their Role in Clinical Immunology, …
Dendritic cells (DCs) are cells derived from the hematopoietic stem cells (HSCs) of the bone marrow and form …
Dendritic Cells- Definition, Structure, Immunity, Types, F…
Apr 30, 2022 · Dendritic cells represent a distinct type of white blood cells capable of alerting the immune …
A Pilot Trial of the Combination of Transgenic NY-ESO-1 …
Background: Transgenic adoptive cell therapy (ACT) targeting the tumor antigen NY-ESO-1 can be effective for the treatment of sarcoma and melanoma. Preclinical models have shown that …
Autologous Dendritic Vaccine Therapy in Metastatic Kidney …
Clinical Studies Update Autologous Dendritic Vaccine Therapy in Metastatic Kidney Cancer: The ADAPT Trial and Beyond Viraj A. Mastera,*, Robert G. Uzzob, Gennady Bratlavskyc, Jose A. …
Dendritic Cell Vaccine Therapy Copy - staging …
Dendritic Cell Vaccine Therapy: Dendritic Cell Vaccine Therapy for Breast Cancer Micro-Metastases ,1995 This project is studying the development of dendritic cell vaccines for …
FEASIBILITY, SAFETY, AND EFFICACY EVALUATION OF ALPHA …
DENDRITIC CELL (DC)-BASED VACCINES LOADED WITH ALLOGENEIC PROSTATE CELL LINE IN COMBINATION WITH ANDROGEN ABLATION IN PATIENTS WITH PSA …
A Review of Dendritic Cell Therapy for Cancer: Progress and …
‘‘dendritic cell vaccine’’ and ‘‘cancer’’ limited to the last 10 years, clinical trials, and the English language was performed and resulted in 259 matches. A search of ClinicalTrials.gov on 1 …
Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic …
importance of dendritic cell vaccine therapy, including the antigen sources or route of administration of these cells, it has been extensively studied. For the DCs administration …
Metabolic glycan labeling immobilizes dendritic cell …
antitumor efficacy of dendritic cell vaccine Joonsu Han 1, ... (CAR) T cell therapy 1,2.However,thelow patient response rate towards checkpoint blockades, limited ef ficacy
Combinational adenovirus-mediated gene therapy and …
Keywords: gene therapy, adenovirus, dendritic cells, vaccine, cytotoxic T lymphocytes, antitumor immunity Correspondence: Jim Xiang ... [11]; (iii) they can modulate dendritic cell maturation by
An iPSC-derived exosome-pulsed dendritic cell vaccine …
An iPSC-derived exosome-pulsed dendritic cell vaccine boosts antitumor immunity in melanoma Ronghao Wang, 1,2 4Tianchuan Zhu, Bingzong Hou,2 and Xi Huang 3 ... cell-free products …
Dendritic cell vaccine as a potential strategy to end the …
viral infection. Dendritic cell-based vaccine is a novel vaccina-tion approach. Studies of dendritic cell vaccines in cancer patients that have been conducted to date show promising results …
Nonrandomised controlled trial in recurrent glioblastoma …
The lysate-loaded dendritic cell (DCVax-L) vaccine is a cell-based vaccine able to stimulate a ... therapy provides additional benefits in comparison to the standard of care, the results …
Personalized dendritic cell vaccine in multimodal …
2.3 | Manufacturing of dendritic cell vaccine and immunomonitoring of the patients The autologous tumor lysate-pulsed dendritic cell vaccines were pro-duced in accordance with the Good …
Report Anti-Obesity Dendritic Cell Vaccine Therapy …
Anti-Obesity Dendritic Cell Vaccine Therapy Targeting Neovascular Vessels in High-Fat-Diet-Fed Mice Yoshikazu Sawaguchi,a Keiichi Hirata,b Ryo Suzuki,b,c Kazuo Maruyama,c,d and Naoki …
Editorial:Harnessingthe ParticipationofDendriticCellsin ...
by these cells, but also by other cell types. Recent data indicate that several other cell types play a prominent role in the production of type I IFN, depending on the pathogen causing infection. …
Agent-based Modeling of Tumor and Immune System …
in Combinational Therapy with Low-dose 5-fluorouracil and Dendritic Cell Vaccine in Melanoma B16F10 Sarah Rahbar1, Sajad Shafiekhani1, Armin Allahverdy2, Arezoo Jamali3,4, Nasim …
Predictors of Response to Autologous Dendritic Cell Therapy …
Jan 9, 2025 · Autologous Dendritic Cell Therapy in Glioblastoma Multiforme. Front. Immunol. 9:727. doi: 10.3389/fimmu.2018.00727 Predictors of response to autologous Dendritic cell …
First step results from a phase II study of a dendritic cell …
Aug 13, 2024 · glioblastoma, vaccine, immunotherapy, dendritic cell, adoptive cell therapy, radiochemotherapy Introduction Glioblastoma (GBM) is a poor prognosis malignant WHO …
Therapeutic cancer vaccines: advancements, challenges and
autologous dendritic cell vaccine, sipuleucel-T, which prolonged ... adjuvant therapy was conducted, however, the vaccine didn’t improve the clinical benefits of the patients with …
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Cell Infusion and Vaccine Administration (Day 0, 14, 28, and 42) You will receive the dendritic cell vaccine every 2 weeks for 8 weeks. The vaccine will be administered as both an intravenous …
Vaccine-boostedCARTcrosstalkwithhostimmunity to reject …
boosted CAR T promoted dendritic cell (DC) recruitment to tumors, increased tumor antigen uptake by DCs, and elicited thepriming ofendogenous anti-tumorT cells. This process …
HMGB1/GPC3 dual targeting vaccine induces dendritic cells …
plasmid into the nucleus of the target cell to express it stably.31 In this study, our result also demonstrated that PLGA/PEI-HMGB1/GPC3 vaccine could be efficiently expressedin vitroand …
Prognostic survival biomarkers of tumor-fused dendritic cell …
Prognostic survival biomarkers of tumor‑fused dendritic cell vaccine therapy in patients with newly diagnosed glioblastoma ... Dendritic cell (DC)-based immunotherapy has been applied to …
mRNA Therapies in Oncology: Key Pipeline Developments and …
engineered cell-based therapies. Dendritic cell therapies and mRNA modified T cell receptor therapies are also progressing, with pr omising results in early trials. mRNA therapies offer …
Combination Therapy with Tumor Cell-pulsed Dendritic Cells …
safety and immune response of tumor cell-pulsed dendritic cell (DC) vaccine therapy against cancer patients with multiple metastases. DCs, generated from adherent cells of peripheral …
Contribution of pre-existing neoantigen-specific T cells to a …
Tumor antigen-pulsed dendritic cell (DC) vaccine therapy activates tumor-specific cytotoxic T lymphocytes, making it an important immunotherapeutic strategy. Salivary duc-tal carcinoma …
Autologous tumor lysate-loaded dendritic cell vaccination in ...
One such treatment is the dendritic cell (DC) vaccine. This cell-based vaccination works by stimulating the patient's own dendritic cells' antigenic repertoire, therefore inducing a polyclonal …
The MDCTL Facilities Lung Center of the Philippines
What is a Dendritic Cell Vaccine? It is a form of active immunotherapy using dendritic cells to trigger the immune response against diseases including cancer. Antigens derived from …
Targeting cancer stem cells by TPA leads to inhibition of …
(IFO), standard systemic therapy for soft tissue sarcomas, is an obstacle to successful treatment because of clinical relapse, local recurrence, and metastatic spread, despite its initial strong …
The MDCTL Facilities Lung Center of the Philippines
What is a Dendritic Cell Vaccine? It is a form of active immunotherapy using dendritic cells to trigger the immune response against diseases including cancer. Antigens derived from …
A novel allogeneic off-the-shelf dendritic cell vaccine for …
rates and poor survival. Dendritic cell (DC)-based immunotherapy is a promising alternative treatment strategy. A novel allogeneic DC vaccine, DCP-001, was developed from an AML …
Application of Engineered Dendritic Cell Vaccines in Cancer ...
Keywords Cancer · Dendritic cell · Vaccines · Immunotherapy Opinion statement The primary objective of this study is to evaluate the effectiveness of cancer vaccines containing genetically …
Dendritic cell therapy with CD137L-DC-EBV-VAX in locally
Dendritic cell therapy with CD137L‑DC‑EBV‑VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benet ... Results Of the 12 patients …
A novel CTLA-4 blocking strategy based on nanobody …
complex was constructed and utilized as a blocker of the CTLA-4/B7 signal pathway in a combination with dendritic cell (DC)/tumor fusion vaccine to enhance the CD8+ T cell cytokine …
Clinical use of dendritic cells for cancer therapy - The Lancet
potency of dendritic cell-based vaccination. We review the clinical eff ectiveness of dendritic cell-based vaccine therapy in melanoma, prostate cancer, malignant glioma, and renal cell …
Immunoradiation Therapy for End-Stage Undifferentiated
critical for enhancing anti-cancer immunity [7]. The combination of irradiation and dendritic cell therapy is an excellent way to reactivate the weakened anti-cancer immune system in …
Dendritic cells pulsed with multifunctional Wilms tumor 1 …
T cells and programmed cell death protein-1+ cells within the pancreatic tumor microenvironment (TME). All patients with long-term WT1-DTH positivity were alive for at least 4.5 years after …
A double-blind randomized comparative clinical trial to …
This trial focuses on a dendritic cell vaccine therapy in which tumor antigen-specific cytotoxic T lymphocytes (CTLs) are induced. We generated the dendritic cell vac-
Dendritic cell vaccine strategy may improve breast cancer …
Dendritic cell vaccine strategy may improve ... HER2-directed dendritic cells into neoadjuvant therapy of early stage HER2+ER- breast cancer, npj Breast Cancer (2025). DOI: 2/3.
Dendritic Cell Vaccines in Ovarian Cancer - Frontiers
Dendritic Cell Vaccines in ... therapy are the basis for the treatment of ovarian cancer patients, but the outcome is ... dendritic cells (DCs), ovarian cancer (OC), immunotherapy, tumor …
CAR T cells and dendritic cells: vaccinomics perspectives
May 5, 2023 · A. Integrating CAR T cells and dendritic cell-based vaccines Cancer immunotherapy has gained momentum in recent years, with the development of novel …
WT1-pulsed Dendritic Cell Vaccine Combined with …
pancreatic cancer, a WT1-peptide vaccine and WT1-peptide pulsed-dendritic cell (WT1-DC) vaccine have already been used in combination with chemotherapy agents, such as …
Preclinical Considerations for Products Regulated in OCTGT
Examples of Cancer/Therapeutic Vaccines • Conventional antigen-based vaccines – Synthetic peptides, protein antigens, tumor lysates, conjugated vaccines, etc…) • Cell-based vaccines ...
Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic …
peptide-pulsed DC vaccine administration therapy has clinical and immunological efficacy and safety. Cancer vaccine therapy induces its effects by amplifying the antitumor activity of cancer …
Enhancing the T-cell Stimulatory Capacity of Human …
A critical factor that determines whether a DC vaccine will be able to reverse established T-cell tolerance to tumor antigens and to induce potent antitumor T cells, is the DC’s activation or …
Effect of dendritic cell vaccine therapy on lymphocyte …
DC vaccine has the potential for inducing an immune cytotoxic effect directed toward tumor cells. Key Words: Dendritic cell vaccine, immunotherapy, primary brain tumor Introduction It is …
Radioimmunotherapy With WT1 Dendritic Cell Vaccine for …
WT1 dendritic cell vaccine therapy. As a result, the massive lung cancer shrank significantly and blood tests showed an improved immune profile. The growth of the lung cancer was …
Individualized cancer therapy with specific activation of the
Interactions with other forms of therapy Triggering immunogenic cell death Hyperthermia – an ideal additional treatment tool ... have been in contact with dead tumour cell material. Firstly, it …
Targeting WEE1 in tumor-associated dendritic cells …
Ar ticle Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway Ian-Ian Ng,1 Zhihua Zhang,1,4 Kaimin Xiao,1,2 Minjie Ye,1 Tingzhong …
