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| exosome therapy for autism: Mesenchymal Stem Cell Derived Exosomes Yaoliang Tang, Buddhadeb Dawn, 2015-09-02 Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies |
| exosome therapy for autism: Ethics of Modern Stem Cell Research and Therapy Ernst R. von Schwarz, |
| exosome therapy for autism: Handbook of Autism and Pervasive Developmental Disorders, Volume 1 Fred R. Volkmar, Sally J. Rogers, Rhea Paul, Kevin A. Pelphrey, 2014-02-24 The newest edition of the most comprehensive handbook on autism and related disorders Since the original edition was first published more than a quarter of a century ago, The Handbook of Autism and Pervasive Developmental Disorders, Volume 1: Diagnosis, Development, and Brain Mechanisms, has been the most influential reference work in the field of autism and related conditions. The new, updated Fourth Edition takes into account the changes in the disorders' definitions in the DSM-V and ICD-10 that may have profound implications for diagnosis and, by extension, access to services. Along with providing practical clinical advice--including the role of psychopharmacology in treatment—the handbook codifies the ever-expanding current body of research throughout both volumes , offering a wealth of information on the epidemiology of autism and the genetic, environmental, biochemical, social, and neuropathological aspects of the disorder. Volume 1 includes: Information on outcomes in adults with autism spectrum disorders A range of issues and interventions important from infancy, though adolescence and beyond for individuals with autism spectrum disorders Current information about play development, including skills, object play, and interventions Coverage of the state of genetic, biochemical, and neuropathological autism research Chapters on psychopharmacology and medical care in autism and related conditions The new edition includes the relevant updates to help readers stay abreast of the state of this rapidly evolving field and gives them a guide to separate the wheat from the chaff as information about autism proliferates. |
| exosome therapy for autism: Decipher Cellular and Molecular Mechanism of the Development and Degeneration of Functional Spinal Unit with Potential Therapeutic Approaches Bo Gao, Da Jing, Xiao Wang, Lei Ma, 2022-11-09 |
| exosome therapy for autism: Handbook of Stem Cell Therapy Khawaja Husnain Haider, 2022-11-07 The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine. |
| exosome therapy for autism: Cell Type Diversity in the Nervous System: From Genes to Function Miao He, Giordano Lippi, Jiangteng Lu, 2022-02-04 |
| exosome therapy for autism: Exosomes in Brain Health and Disease Konstantin Glebov, Michel Salzet, Oleg Shupliakov, 2022-06-06 |
| exosome therapy for autism: Textbook of Autism Spectrum Disorders, Second Edition Eric Hollander, M.D., Randi Hagerman, M.D., Casara Ferretti, M.S., 2022-03-15 More than 40 years after the official recognition of infantile autism in DSM-III, advances continue to be made in our understanding of the possible causes, assessment and evaluation, and treatment of autism spectrum disorder (ASD). With contributions by dozens of experts in the field, this second edition of the Textbook of Autism Spectrum Disorders has been updated to reflect the latest research in ASD. Unrivaled in its thoroughness, this volume discusses issues of assessment and evaluation; examines the etiology of ASD and its recognized associations with other medical conditions; analyzes standard and experimental treatments; and delves into social policy issues pertinent to individuals with ASD and those who treat them. With summary points in each chapter and copious lists of recommended readings, this is an indispensable resource for psychiatrists, psychologists, neurologists, social workers, speech therapists, educators, and all others in the continuum of care. |
| exosome therapy for autism: Genomics, Proteomics, and Metabolomics Babak Arjmand, 2019-11-14 This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics. |
| exosome therapy for autism: Advances in Cosmetic Surgery, E-Book 2023 Gregory H. Branham, Jeffrey S. Dover, Shilpi Khetarpal, Smita R. Ramanadham, Allan E. Wulc, 2023-04-06 Advances in Cosmetic Surgery reviews the year's most important findings and updates within the field in order to provide surgeons with the current clinical information they need to improve patient outcomes. A distinguished editorial board identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in cosmetic surgery inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. - Contains 25 articles on such topics as non-surgical rhinoplasty; laser and device assisted drug delivery; facial transgender surgery; otoplasty; breast implant illness; special considerations in the treatment of skin of color; and more. - Provides in-depth, clinical reviews in cosmetic surgery, providing actionable insights for clinical practice. - Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. |
| exosome therapy for autism: Role of Exosomes in Biological Communication Systems Faisal A. Alzahrani, Islam M. Saadeldin, 2020-11-20 This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery. |
| exosome therapy for autism: Neuroimmune Pharmacology Tsuneya Ikezu, Howard E. Gendelman, 2016-12-22 The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond. |
| exosome therapy for autism: Stem Cell Therapy for Diabetes Shimon Efrat, 2009-12-01 Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes. |
| exosome therapy for autism: Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives Neil H. Riordan, 2017-06-20 Stem cells are the repair cells of your body. When there aren't enough of them, or they aren't working properly, chronic diseases can manifest and persist. From industry leaders, sport stars, and Hollywood icons to thousands of everyday, ordinary people, stem cell therapy has helped when standard medicine failed. Many of them had lost hope. These are their stories. Neil H Riordan, author of MSC: Clinical Evidence Leading Medicine's Next Frontier, the definitive textbook on clinical stem cell therapy, brings you an easy-to-read book about how and why stem cells work, and why they're the wave of the future. |
| exosome therapy for autism: Etiology and treatment for children and adolescents with autism spectrum disorder Feiyong Jia, Tingyu Li, Wouter G. Staal, Khaled Saad, 2023-08-02 |
| exosome therapy for autism: Advances in Clinical Chemistry Gregory S. Makowski, 2020-09-20 Advances in Clinical Chemistry, Volume 99, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this release including chapters on Extracellular vesicle associated proteins as potential biomarkers, Molecular and non-molecular approaches to etiologic diagnosis of gastroenteritis, Circular RNAs and cancer: Opportunities and challenges, Mass spectrometry-based metabolomics for an in-depth questioning of human health, Application of microfluidic technology in cancer research and therapy, Advances in aptasensor technology, and much more. - Covers the most up-to-date technologies in clinical chemistry and clinical laboratory science - Authored by world renowned clinical laboratory scientists, physicians and research scientists - Provides the international benchmark for novel analytical approaches in the clinical laboratory |
| exosome therapy for autism: Infantile Autism Stephen M. Edelson, 2014-11-21 In 1964, the release of Dr. Bernard Rimland's book, Infantile Autism, revolutionized the autism field by providing the autism community with much-needed guidance on how to understand and treat individuals on the spectrum. He single-handedly realigned the field from a psychodynamic, parent-blaming perspective to a scientific, physiological course of action. This 50th anniversary edition presents the original book with contributions from leaders in the autism field, including Drs. Martha Herbert and Simon Baron-Cohen, who celebrate Dr. Rimland's exceptional work, and place his findings within the context of autism as we understand it today. Bringing Dr. Rimland's findings up to date for a new generation of readers, this book will be fascinating reading for parents and those on the autism spectrum as well as professionals working with autism and anyone with an interest in autism and/or psychological theory. |
| exosome therapy for autism: Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders Paul C. Guest, 2019-02-12 This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome. |
| exosome therapy for autism: Cellular Transplantation Craig Halberstadt, Dwaine F. Emerich, 2011-10-10 There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation |
| exosome therapy for autism: The Autism Revolution Dr. Martha Herbert, Karen Weintraub, 2013-03-12 “An in-depth, scientific—yet hopeful and positive—look at how the brain and body work together . . . [Dr. Martha Herbert] has developed a new way of seeing autism.”—Library Journal After years of treating patients and analyzing scientific data, Harvard Medical School researcher and clinician Dr. Martha Herbert offers a revolutionary new view of autism and a transformative strategy for dealing with it. Autism, she concludes, is not a hardwired impairment programmed into a child’s genes and destined to remain fixed forever. Instead, it is the result of a cascade of events, many seemingly minor. And while other doctors may dismiss your child’s physical symptoms—the anxiety, sensory overload, sleeplessness, frequent illnesses or seizures—as coincidental or irrelevant, Dr. Herbert sees them as vital clues to what the underlying problems are, and how to help. Drawing from the newest research, technologies, and insights, as well as inspiring case studies of both children and adults, Dr. Herbert guides you toward restoring health and resiliency in your loved one with autism. Her specific recommendations aim to provide optimal nutrition, reduce toxic exposures, limit stress, and open the door to learning and creativity. As thousands of families who have cobbled together these solutions themselves already know, this program can have dramatic benefits—for your child with autism, and for you, your whole family, and perhaps your next baby as well. “Invaluable . . . a must-read . . . Dr. Martha Herbert gets it. She not only gets it, but she puts it out there in an awesome book so the rest of us can get it, too.”—Autism Watch “[Herbert] goes further than most autism specialists. Her impressive science background merges with common sense and even intuitive sense [making] complex scientific and medical materials seamlessly blend with a holistic viewpoint.”—Relieve Autism “Hope and practical guidance . . . With this easy-to-read book, parents can gain wisdom on how to guide your child to achieve a healthy and thriving life.”—Mom Central |
| exosome therapy for autism: Stem Cell Drugs - A New Generation of Biopharmaceuticals Phuc Van Pham, 2018-10-25 This invaluable resource discusses the current revolution in stem cell-based drugs and their potential use in clinical applications. Each chapter is contributed by a pre-eminent scientist in the field. An introductory section presents current stem cell drugs and stem cell-based products and a discussion of production, quality control, mechanisms, and efficacy. Following sections include discussions on stem cell-derived microvesicles based products, and derived exosomes based products. Stem Cell Drugs - A New Generation of Biopharmaceuticals and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering. This groundbreaking volume is also essential reading for those researching or studying drug development or pharmaceutical science. |
| exosome therapy for autism: Precision Medicine in Neurodegenerative Disorders , 2023-02-16 Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the How in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision medicine–matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more |
| exosome therapy for autism: Human Neural Stem Cells Leonora Buzanska, 2018-09-12 This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs. |
| exosome therapy for autism: Stem Cells – From Hype to Real Hope Khawaja Husnain Haider, Salim Aziz, MD, 2018-12-17 This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled Stem Cells: from Drug to Drug Discovery which was published in 2017. |
| exosome therapy for autism: Adipose-Derived Stem Cells Jeffrey M. Gimble, Bruce A. Bunnell, 2011-08-24 During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular BiologyTM series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs. |
| exosome therapy for autism: Biomarkers in Psychiatry Judith Pratt, Jeremy Hall, 2019-01-05 This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years. |
| exosome therapy for autism: The Neuroscience of Autism Spectrum Disorders Joseph D. Buxbaum, Patrick R. Hof, 2012-10-25 Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available |
| exosome therapy for autism: Stem Cell Banking Dusko Ilic, 2014-05-05 This book exemplifies experience across the globe in banking of cord blood, mesenchymal, embryonic and induced pluripotent stem cells for clinical use from the United States, Canada, the European Union, Switzerland and Japan to Iran, India and Serbia. The concerns are similar regardless of stem cell type or origin. Implementing core values and common standards depend often on specific circumstances of political and economic setting, which makes flexibility as important as systematic planning. Banking of stem cells is not just building a repository and storing samples. The planning, design, construction and maintenance involve multiple skilled professionals. Stem cell banks are points where technology and medicine converge with ethics, laws and regulations. If properly designed and organized, their utilization will have a broad impact not only on the scientific community and medical professionals but also on the general public. |
| exosome therapy for autism: Drug Discovery and Development, Third Edition James J. O'Donnell, John Somberg, Vincent Idemyor, James T. O'Donnell, 2019-12-13 Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business |
| exosome therapy for autism: Nutrition and Immunity Maryam Mahmoudi, Nima Rezaei, 2019-07-30 This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals. |
| exosome therapy for autism: Dairy Chemistry and Biochemistry P. F. Fox, T. Uniacke-Lowe, P. L. H. McSweeney, J. A. O'Mahony, 2015-06-19 This book is the most comprehensive introductory text on the chemistry and biochemistry of milk. It provides a comprehensive description of the principal constituents of milk (water, lipids, proteins, lactose, salts, vitamins, indigenous enzymes) and of the chemical aspects of cheese and fermented milks and of various dairy processing operations. It also covers heat-induced changes in milk, the use of exogenous enzymes in dairy processing, principal physical properties of milk, bioactive compounds in milk and comparison of milk of different species. This book is designed to meet the needs of senior students and dairy scientists in general. |
| exosome therapy for autism: Rab GTPases Guangpu Li (Molecular biologist), Nava Segev, 2021 This second edition volume expands on the previous edition with a discussion of new research and discoveries in the Rab field. Chapters in this book cover topics such as new information on Rab regulation and localization; interaction; function; and diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Rab GTPases: Methods and Protocols, Second Edition is a valuable resource for scientists working in the fields of Rab and other small GTPases, and beyond. |
| exosome therapy for autism: Novel Biomaterials for Regenerative Medicine Heung Jae Chun, Kwideok Park, Chun-Ho Kim, Gilson Khang, 2018-10-24 This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine. |
| exosome therapy for autism: Advances and Challenges in Nanomedicine Susan Hua, Sherry Y. Wu, 2019-02-28 Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. Nanomedicines have demonstrated significant therapeutic advantages for a multitude of biomedical applications, however the clinical translation of these nanotechnology platforms has not progressed as quickly as the plethora of positive results would have suggested. Understanding the advances in nanomedicine to date and the challenges that still need to be overcome, will allow future research to improve on existing platforms and to address the current translational and regulatory limitations. This eBook “Advances and Challenges in Nanomedicine” has brought together experts in the fields of nanomedicine, nanotechnology, nanotoxicology, pharmaceutics, manufacturing, and translation to discuss the application of nanotechnology to drug delivery. This information is presented as original research, opinion, perspective, and review articles. The goal of this eBook is to generate collaborative discussion on the current status, general trends, challenges, strategies, and future direction of pharmaceutical nanotechnology, as well as highlight current and emerging nanoparticulate platforms with potential medical applications. |
| exosome therapy for autism: Emergency Medicine Amal Mattu, Deepi G. Goyal, 2008-04-15 Emergency Medicine is a brand new book focusing on the common pitfalls and mistakes that can occur when dealing with high-risk conditions during standard medical practice. Concise chapters focus on clinical relevance, addressing the mistakes, the consequences and the knowledge necessary to avoid high-risk mistakes. An essential book for all staff dealing with emergencies. |
| exosome therapy for autism: A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics Xiao-Dong Chen, 2018-08-31 A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent. - Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy - Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials - Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward - Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies |
| exosome therapy for autism: Loving Bravely Alexandra H. Solomon, 2017-02-02 As seen on The TODAY Show! “A godsend to anyone searching for, but struggling to find, true love in their lives.” —Kristin Neff, PhD, author of Self-Compassion Empowering and compassionate, and its lessons are universal. —Publishers Weekly Real love starts with you. In order to attract a life partner and build a healthy intimate relationship, you must first become a good partner to yourself. This book offers twenty invaluable lessons that will help you explore and commit to your own emotional and psychological well-being so you can be ready, resilient, and confident in love. Many of us enter into romantic relationships full of expectation and hope, only to be sorely disappointed by the realization that the partner we’ve selected is a flawed human being with their own neuroses, history, and desires. Most relationships end because one or both people haven’t done the internal work necessary to develop self-awareness and take responsibility for their own experiences. We’ve all heard “You can’t love anyone unless you love yourself,” but amid life’s distractions and the myth of perfect, romantic love, how exactly do you do that? In Loving Bravely, psychologist, professor and relationship expert Alexandra H. Solomon introduces the idea of relational self-awareness, encouraging you to explore your personal history to gain an understanding of your own relational patterns, as well as your strengths and weaknesses in relationships. By doing so, you’ll learn what relationships actually require, beyond the fairytale notions of romance. And by maintaining a steady but gentle focus on yourself, you’ll build the best possible foundation for making a loving connection. By understanding your past relationship experiences, cultivating a strong sense of self-awareness, and determining what it is you really want in a romantic partner—you’ll be ready to find the healthy, lasting love your heart desires. |
| exosome therapy for autism: Neuromodulation , 2009-05-05 Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices. All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come.Key Features - The first comprehensive reference on the emerging field of Neuromodulation - Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society - Over 90 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise - Over 1200 pages in splendid full color, richly illustrated - Important areas of application include: control of chronic pain delivery of drugs to the nervous system via implanted devices control of epilepsy, Parkinson, etc. functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs) overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces |
| exosome therapy for autism: Regenerative Medicine I Ioannis V. Yannas, 2005-02-10 With contributions by numerous experts |
| exosome therapy for autism: Neurobiology of Bipolar Disorder Joao L. de Quevedo, Andre Ferrer Carvalho, Eduard Vieta, 2020-11-25 The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. - Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations - Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics - Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder |
Exosome (vesicle) - Wikipedia
Exosomes, ranging in size from 30 to 150 nanometers, [1] are membrane-bound extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic …
Q&A: What are exosomes, exactly? | BMC Biology | Full …
Jun 13, 2016 · Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell–cell communication and the transmission of disease states, and …
The biology, function, and biomedical applications of ex…
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They are mediators of near and long-distance intercellular …
Exosomes: a review of biologic function, diagnostic and targe…
Jul 11, 2024 · In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies …
Exosomes - PubMed
Jun 20, 2019 · Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, …
Exosome (vesicle) - Wikipedia
Exosomes, ranging in size from 30 to 150 nanometers, [1] are membrane-bound extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic cells. …
Q&A: What are exosomes, exactly? | BMC Biology | Full Text
Jun 13, 2016 · Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell–cell communication and the transmission of disease states, and explored as …
The biology, function, and biomedical applications of exosomes
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They are mediators of near and long-distance intercellular …
Exosomes: a review of biologic function, diagnostic and targeted ...
Jul 11, 2024 · In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as …
Exosomes - PubMed
Jun 20, 2019 · Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, …
Exosome | Definition, Size, & Function | Britannica
Exosome, nano-sized vesicle secreted from cells that contains any of various biomolecules, such as proteins or nucleic acids. Intercellular communication by exosomes plays a critical role in …
Exosomes: Biogenesis, Composition, and Roles in Health and Disease
Apr 29, 2025 · Understanding exosome biogenesis, composition, and functions could unlock new therapeutic avenues. This article delves into the intricate processes behind exosome …
Exosomes: Biological function, Clinical Potential & Utility (2025)
Apr 9, 2025 · Exosomes are small, membrane-bound vesicles produced by cells, typically between 30 and 100 nanometers in diameter. They originate from the endosomal …
Exosomes: composition, biogenesis and function - Nature
Aug 1, 2002 · Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells in culture. Interest in exosomes has intensified after their recent description in …
An Introduction of Exosomes
Jun 9, 2025 · The process of exosome generation takes several hours to days and is closely dependent on the cell types, the physiological state of the cells, and the influences of external …
