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| family history of consanguinity: Consanguinity in Context Alan H. Bittles, 2012-05-24 An essential guide to this major contemporary issue, Consanguinity in Context is a uniquely comprehensive account of intra-familial marriage. Detailed information on past and present religious, social and legal practices and prohibitions is presented as a backdrop to the preferences and beliefs of the 1100+ million people in consanguineous unions. Chapters on population genetics, and the role of consanguinity in reproductive behaviour and genetic variation, set the scene for critical analyses of the influence of consanguinity on health in the early years of life. The discussion on consanguinity and disorders of adulthood is the first review of its kind and is particularly relevant given the ageing of the global population. Incest is treated as a separate issue, with historical and present-day examples examined. The final three chapters deal in detail with practical issues, including genetic testing, education and counselling, national and international legislation and imperatives, and the future of consanguineous marriage worldwide. |
| family history of consanguinity: Cousin Marriages Alison Shaw, Aviad E. Raz, 2015-01-01 Juxtaposing contributions from geneticists and anthropologists, this volume provides a contemporary overview of cousin marriage and what is happening at the interface of public policy, the management of genetic risk and changing cultural practices in the Middle East and in multi-ethnic Europe. It offers a cross-cultural exploration of practices of cousin marriage in the light of new genetic understanding of consanguineous marriage and its possible health risks. Overall, the volume presents a reflective, interdisciplinary analysis of the social and ethical issues raised by both the discourse of risk in cousin marriage, as well as existing and potential interventions to promote “healthy consanguinity” via new genetic technologies. |
| family history of consanguinity: Genetic Disorders Among Arab Populations Ahmad S. Teebi, Talaat I. Farag, 1997 Few regions of the world have a more varied physiography or a richer ethnic, religious, social, and cultural mix than the Arab world. As a consequence, Arabs are genetically diverse despite their linguistic and religious cohesion. High but variable rates of inbreeding prevail in all Arab countries with numerous examples of isolates among them. These include some Bedouin groups, Nubians, Druze, Jews, and others. Arab populations have high frequencies of autosomal recessive disorders, homozygosity of autosomal dominant and X-linked traits, and a wealth of new syndromes and variants, the majority of which are autosomal recessive. Genetic disorders that cause major health problems include hemoglobinopathies, neurogenetic disorders, inherited metabolic diseases, and inborn error of morphogenesis. Because of their characteristically high prevalence, some of these disorders are considered markers for Arab populations. This book presents the unique profile of genetic disorders and variants in Arabs. In addition, it describes their unusual demographic pattern including fertility rates and other population dimensions, family structure, magnitude and effects of consanguineous marriages and indicators of health and disease. Genetic counseling and the distinctive cultural and religious attitudes towards various genetic issues are also presented. Disorders that have increased tribal occurrences or are limited to large kindreds, as well as small geographic or religious isolates, are highlighted to facilitate their recognition, study, and management. |
| family history of consanguinity: Systems of Consanguinity and Affinity of the Human Family Lewis Henry Morgan, 2018-10-14 This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. |
| family history of consanguinity: Practical Genetic Counselling Peter Harper, 2010-08-27 Easy to use, and useful when kept close at hand in the room where you work. The book is a pleasure to read: the style elegant and authoritative.' Lancet'...this book is a wonderful reference to enable primary physicians to be informed about their patients.' Annals of Internal MedicineUniversally used across the world by genetic counsellors, medical |
| family history of consanguinity: Primary Immunodeficiency Disorders Amos Etzioni, Hans D. Ochs, 2014-09-13 Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way. - Facilitates communication among physicians and other investigators concerned with immunological and inflammatory diseases - Summarizes for the first time all the known facts from 60 years of primary immunodeficiency research, and teaches how an important field in medicine was established - Provides stimulating discussions on developing new medical therapiesHighlights the importance of studying humans to understand mechanisms of disease that affect humans |
| family history of consanguinity: Forbidden Relatives Martin Ottenheimer, 1996 CONTENIDO: Laws prohibiting the marriage of relatives -- The reasons for U.S. laws against first cousin marriage -- European laws prohibiting the marriage of relatives -- European views of cousin marriage -- The evolutionary factor -- Biogenetics and first cousin marriage -- Culture and cousin marriage. |
| family history of consanguinity: Brenner's Encyclopedia of Genetics Stanley Maloy, Kelly Hughes, 2013-03-03 The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics |
| family history of consanguinity: Consanguineous Marriages in the American Population George Byron Louis Arner, 1969 |
| family history of consanguinity: Genomics of Rare Diseases Claudia Gonzaga-Jauregui, James R. Lupski, 2021-06-12 Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. - Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes - Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions - Explores opportunities for novel therapeutics - Features chapter contributions from leading researchers and clinicians |
| family history of consanguinity: Model Rules of Professional Conduct American Bar Association. House of Delegates, Center for Professional Responsibility (American Bar Association), 2007 The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts. |
| family history of consanguinity: The Genetics of African Populations in Health and Disease Muntaser E. Ibrahim, Charles N. Rotimi, 2019-12-19 A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches. |
| family history of consanguinity: Principles and Practice of Clinical Research John I. Gallin, Frederick P Ognibene, 2011-04-28 The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.*Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research*Delves into data management and addresses how to collect data and use it for discovery*Contains valuable, up-to-date information on how to obtain funding from the federal government |
| family history of consanguinity: Vogel and Motulsky's Human Genetics Friedrich Vogel, Arno G. Motulsky, 1997 Provides information on the molecular basis of human genetics and outlines the principles of other epigenetic processes which together create the phenotype of a human being. This work also discusses the molecular basis for the concepts, methods and results in fields such as population genetics. |
| family history of consanguinity: Essential Concepts in Molecular Pathology William B. Coleman, Gregory J. Tsongalis, 2019-11-23 Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the molecular aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of molecular medicine and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology |
| family history of consanguinity: Mackenzie's Mission Rachael Casella, 2020-06-02 A story of triumph over adversity, the strength that can be found in love and kindness, and the power of one couple to effect positive change in the world. 'A true love story' - Mia Freedman, founder of Mamamia Rachael and Jonathan were thrilled to welcome their baby Mackenzie into the world and to start their new lives as parents. Little did they know that in a few months they would be tested to endurance and beyond. Like many other couples starting a family, Rachael and Jonathan had no idea they were both carriers for a genetic disease, and that 1 in 20 babies are affected by genetic birth defects. Their daughter was one of those babies, and Mackenzie's Mission is Rachael's beautiful and heartwarming account of Mackenzie's life, child loss, and a journey through IVF. Determined that other couples should not go through the same heartbreak, Rachael and Jonathan are now champions for genetic testing. This is a story of triumph over adversity, the strength that can be found in kindness and the power of one couple to effect positive change in the world. 'Heartbreaking and inspiring. A must read for anyone who's lost a child, loved a child, or is desperately trying to for a child. You will cry but you will also find comfort in this incredible story.' - Erin Molan, sports presenter, Nine Network 'A book about grief and finding purpose through unimaginable loss and heartbreak. Beautiful Mackenzie will continue to have a powerful impact on this world through the work of her remarkable parents.' - Libby Trickett, Olympic swimming gold medallist and author of Beneath the Surface 'The most extraordinary story of a mother's love and her daughter's legacy.' - Marcia Leone, creator of Not So Mumsy |
| family history of consanguinity: Advances in the Study of Genetic Disorders Kenji Ikehara, 2011-11-21 The studies on genetic disorders have been rapidly advancing in recent years as to be able to understand the reasons why genetic disorders are caused. The first Section of this volume provides readers with background and several methodologies for understanding genetic disorders. Genetic defects, diagnoses and treatments of the respective unifactorial and multifactorial genetic disorders are reviewed in the second and third Sections. Certainly, it is quite difficult or almost impossible to cure a genetic disorder fundamentally at the present time. However, our knowledge of genetic functions has rapidly accumulated since the double-stranded structure of DNA was discovered by Watson and Crick in 1956. Therefore, nowadays it is possible to understand the reasons why genetic disorders are caused. It is probable that the knowledge of genetic disorders described in this book will lead to the discovery of an epoch of new medical treatment and relieve human beings from the genetic disorders of the future. |
| family history of consanguinity: Conferencia Mundial de Las Encuestas de Demografia Y Salud , 1991 |
| family history of consanguinity: Stiehm's Immune Deficiencies Kathleen E. Sullivan, E. Richard Stiehm, 2020-05-23 Stiehm's Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. - Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians - Fills an increasingly deep gap in the information available to clinicians - Presents both clinical management and scientific advances for immune deficiencies - Provides a primary resource for physicians in the field of immunodeficiencies - Includes website access to a range of videos relevant to the topics discussed |
| family history of consanguinity: Genomics and Society Dhavendra Kumar, Ruth Chadwick, 2015-10-29 Genomics and Society; Ethical, Legal-Cultural, and Socioeconomic Implications is the first book to address the vast and thorny web of ELSI topics identified as core priorities of the NHGRI in 2011. The work addresses fundamental issues of biosociety and bioeconomy as the revolution in biology moves from research lab to healthcare system. Of particular interest to healthcare practitioners, bioethicists, and health economists, and of tangential interest to the gamut of applied social scientists investigating the societal impact of new medical paradigms, the work describes a myriad of issues around consent, confidentiality, rights, patenting, regulation, and legality in the new era of genomic medicine. - Addresses the vast and thorny web of ELSI topics identified as core priorities of the NHGRI in 2011 - Presents the core fundamental issues of biosociety and bioeconomy as the revolution in biology moves from research lab to healthcare system - Describes a myriad of issues around consent, including confidentiality, rights, patenting, regulation, and more |
| family history of consanguinity: Family Communication about Genetics Clara L. Gaff, Carma L. Bylund, 2010 Genetics is in all senses a family affair. The diagnosis of a genetic condition affects not only the patient and biological family members who may themselves be at risk, but also family more generally as support may be sought from those considered kin and who may or may not be at risk themselves. It is considered best practice in genetic consultations to explore who will be informed within the family when a genetic condition or risk is diagnosed, particularly when the health of other family members is at risk. There is little guidance or consensus on how to achieve the implicit goal of informed family members while respecting patient confidentiality, however. There is a need for practitioners to be aware of the dynamics of family communication and to have guidance about how they may sensitively facilitate communication about genetics within families. This handbook facilitates the development of clinical practices relating to family communication about genetics. Relevant theories of family communication are summarized and related to a clinical genetics milieu and, from this, frameworks for practitioners are presented. A book of this nature is particularly timely as the completion of the Human Genome Project will result in an unprecedented amount of information about genetic constitution and health risks becoming available to individuals and their families. The presence of a potentially genetic condition in a family is not a new phenomenon. However, the growth in testing for genetic conditions, common complex conditions and variants that may influence health as well as drug metabolism means that a greater number of individuals will face decisions about communicating this information to their relatives. Many health professionals in all levels of health care will be confronted with issues of responsibility and practice in family communication about genetic information as they become providers of this testing. |
| family history of consanguinity: Essentials of Palliative Care Nalini Vadivelu, Alan David Kaye, Jack M. Berger, 2012-11-28 Essentials of Palliative Care is a to-the-point, clinically oriented resource for all members of the multidisciplinary palliative care team and trainees. It covers practical clinical topics, including assessment of the patient and pain and symptom management, and practical non-medical topics central to providing effective palliative care, including psychological management, guidance on how to help patients and their families through the many healthcare decision points they face, and sensitivity to the goals and culture of the patient. Review questions, with detailed answers, provide a convenient way for readers to test their knowledge. Features: · Concise, comprehensive, clinically focused · Multiple choice review questions, with detailed answers · Expert contributors from leading institutions · Coordination of care by palliative care team a major focus |
| family history of consanguinity: Black Families Harriette Pipes McAdoo, 2007 Publisher Description |
| family history of consanguinity: Vogel and Motulsky's Human Genetics Michael Speicher, Stylianos E. Antonarakis, Arno G. Motulsky, 2009-11-26 The fourth edition of this classical reference book can once again be relied upon to present a cohesive and up-to-date exposition of all aspects of human and medical genetics. Human genetics has become one of the main basic sciences in medicine, and molecular genetics is increasingly becoming a major part of this field. This new edition integrates a wealth of new information - mainly describing the influence of the molecular revolution - including the principles of epigenetic processes which together create the phenotype of a human being. Other revisions are an improved layout, sub-division into a larger number of chapters, as well as two-colour print throughout for ease of reference, and many of the figures are now in full colour. For graduates and those already working in medical genetics. |
| family history of consanguinity: Marriage and the Family in the Middle Ages Frances Gies, Joseph Gies, 2019-07-22 From bestselling historians Frances and Joseph Gies, authors of the classic Medieval Life series, comes this compelling, lucid, and highly readable account of the family unit as it evolved throughout the Medieval period--reissued for the first time in decades. Some particular books that I found useful for Game of Thrones and its sequels deserve mention. Life in a Medieval Castle and Life in a Medieval City, both by Joseph and Frances Gies. --George R. R. Martin, author of Game of Thrones Throughout history, the significance of the family--the basic social unit--has been vital. In Marriage and the Family in the Middle Ages, acclaimed historians Frances and Joseph Gies trace the development of marriage and the family from the medieval era to early modern times. It describes how the Roman and barbarian cultural streams merged under the influence of the Christian church to forge new concepts, customs, laws, and practices. Century by century, the Gies follow the development--sometimes gradual, at other times revolutionary--of significant components in the history of the family including: The basic functions of the family as a production unit, as well as its religious, social, judicial, and educational roles. The shift of marriage from private arrangement between families to public ceremony between individuals, and the adjustments in dowry, bride-price, and counter-dowry. The development of consanguinity rules and incest taboos in church law and lay custom. The peasant family in its varying condition of being free or unfree, poor, middling, or rich. The aristocratic estate, the problem of the younger son, and the disinheritance of daughters. The Black Death and its long-term effects on the family. Sex attitudes and customs: the effects of variations in age of men and women at marriage. The changing physical environment of noble, peasant, and urban families. Arrangements by families for old age and retirement. Expertly researched, master historians Frances and Joseph Gies--whose books were used by George R.R. Martin in his research for Game of Thrones--paint a compelling, detailed portrait of family life and social customs in one of the most riveting eras in history. |
| family history of consanguinity: Ancient Society Lewis Henry Morgan, 1909 |
| family history of consanguinity: Ties of Kinship Christian Raffensperger, 2016 Describes and analyzes the dynastic marriages of the descendants of Volodimer, the first ruler of Kyivan Rus', across medieval Europe from the tenth through the twelfth centuries and presents more than twenty-two genealogical charts with accompanying bibliographic information-- |
| family history of consanguinity: Incestuous and Close-kin Marriage in Ancient Egypt and Persia Paul John Frandsen, 2009 For both ancient Egypt and Iran, as a cultural feature, incestuous relationships are usually dismissed on the grounds that they are only found as the exception, being allowed for royalty as representatives for the divine on earth, or that the evidence for such relationships are unreliable. Neither view, from the perspective of this study, is tenable. This work examines the evidence for marriage and sexual relations between siblings, and between a parent and child, in ancient Egypt and pre-Islamic Iran. The book restricts its examination to incestuous relationships between members of non-royal nuclear families and puts forth arguments against the generally held axiom that the prohibition of incest is a universal phenomenon. |
| family history of consanguinity: Blood and Kinship Christopher H. Johnson, Bernhard Jussen, David Warren Sabean, Simon Teuscher, 2013-01-01 The word “blood” awakens ancient ideas, but we know little about its historical representation in Western cultures. Anthropologists have customarily studied how societies think about the bodily substances that unite them, and the contributors to this volume develop those questions in new directions. Taking a radically historical perspective that complements traditional cultural analyses, they demonstrate how blood and kinship have constantly been reconfigured in European culture. This volume challenges the idea that blood can be understood as a stable entity, and shows how concepts of blood and kinship moved in both parallel and divergent directions over the course of European history. |
| family history of consanguinity: Adoption Medicine Council on Foster Care, Adoption, and Kinship Care, American Academy of Pediatrics. Council on Foster Care, Adoption and Kinship Care, 2014 In Adoption Medicine: A Manual for Those Caring for Children and Families, leading experts provide data and guidance for health professionals on a wide variety of adoption medicine topics. The first part of the book covers the process of adoption, including historical perspectives and legal issues. Then, individual chapters focus in on common health concerns for adopted children, such as behavior, speech, and maltreatment issues. Additional chapters tackle long-term support for adopted children and their families, including school issues and search for identity. |
| family history of consanguinity: The Genealogical Sublime Julia Creet, 2020 Since the early 2000s, genealogy has become a lucrative business, an accelerating online industry, a massive data mining project, and fodder for reality television. But the fact remains that our contemporary fascination with family history cannot be understood independently of the powerful technological tools that aid and abet in the search for traces of blood, belonging, and difference. In The Genealogical Sublime, Julia Creet traces the histories of the largest, longest-running, most lucrative, and most rapidly growing genealogical databases to delineate a broader history of the industry. As each unique case study reveals, new database and DNA technologies enable an obsessive completeness -- the desire to gather all of the world's genealogical records in the interests of life beyond death. Archival research and firsthand interviews with Church of Jesus Christ of Latter-day Saints officials, key industry players (including Ancestry.com founders and Family Search executives), and professional and amateur family historians round out this timely and essential study. |
| family history of consanguinity: Worldwide Variation in Human Growth Phyllis B. Eveleth, James Mourilyan Tanner, 1976-12-30 |
| family history of consanguinity: Thompson & Thompson Genetics in Medicine Robert L. Nussbaum, Roderick R. McInnes, Huntington F. Willard, 2015-08-16 Updated to reflect the newest changes in genetics, Thompson & Thompson's Genetics in Medicine returns as one of the most favored texts in this fascinating and rapidly evolving field. By integrating the classic principles of human genetics with modern molecular genetics, this medical reference book utilizes a variety of learning tools to help you understand a wide range of genetic disorders. Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics. Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies. Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos. |
| family history of consanguinity: Uniparental Disomy (UPD) in Clinical Genetics Thomas Liehr, 2014-06-26 This book focus on genetic diagnostics for Uniparental Disomy (UPD), a chromosomal disorder defined by the exceptional presence of a chromosome pair derived from only one parent, which leads to a group of rare diseases in humans. First the molecular and cytogenetic background of UPD is described in detail; subsequently, all available information of the various chromosomal origins and the latest findings on genotype-phenotype correlations and clinical consequences are discussed. Numerous personal reports from families with a child suffering from a UPD-induced syndrome serve to complement the scientific and clinical aspects. Their experiences with genetic counseling and living with a family member affected by this chromosomal aberration present a vivid picture of what UPD means for its victims. |
| family history of consanguinity: The Book of Genes & Genomes Huntington Willard, Susanne Haga, 2017-01-08 The Book of Genes & Genomes presents a concise overview of the advances in genetics and genomics and provide the unfamiliar reader with a succinct description of many of the applications and implications of this field. Given the substantial investment in genetics and genomics over the past several decades and the many recent discoveries and developments, this book will help the reader begin to understand the importance of genetics and genomics to us all. This exciting new title includes information on how genetics and genomics has advanced our understanding of health and medicine, evolution, and biology, as well as how they are pushing the boundaries of ethics and social values. |
| family history of consanguinity: Human Mating Patterns C. G. N. Mascie-Taylor, Anthony J. Boyce, 1988-12-15 This book examines the causes and consequences of different mating patterns in man with particular reference to historical, biological, medical and demographic factors. Each of these reference points are covered in carefully edited and integrated papers for advanced students and research workers in human biology and genetics. |
| family history of consanguinity: Negotiating Risk Alison Shaw, 2009 Drawing on fieldwork with British Pakistani clients of a UK genetics service, this book explores the personal and social implications of a 'genetic diagnosis'. Through case material and comparative discussion, the book identifies practical ethical dilemmas raised by new genetic knowledge and shows how, while being shaped by culture, these issues also cross-cut differences of culture, religion and ethnicity. The book also demonstrates how identifying a population-level elevated 'risk' of genetic disorders in an ethnic minority population can reinforce existing social divisions and cultural stereotypes. The book addresses questions about the relationship between genetic risk and clinical practice that will be relevant to health workers and policy makers. |
| family history of consanguinity: Those of My Blood Constance Brittain Bouchard, 2010-11-24 For those who ruled medieval society, the family was the crucial social unit, made up of those from whom property and authority were inherited and those to whom it passed. One's kin could be one's closest political and military allies or one's fiercest enemies. While the general term used to describe family members was consanguinei mei, those of my blood, not all of those relations-parents, siblings, children, distant cousins, maternal relatives, paternal ancestors, and so on-counted as true family in any given time, place, or circumstance. In the early and high Middle Ages, the family was a very different group than it is in modern society, and the ways in which medieval men and women conceptualized and structured the family unit changed markedly over time. Focusing on the Frankish realm between the eighth and twelfth centuries, Constance Brittain Bouchard outlines the operative definitions of family in this period when there existed various and flexible ways by which individuals were or were not incorporated into the family group. Even in medieval patriarchal society, women of the aristocracy, who were considered outsiders by their husbands and their husbands' siblings and elders, were never completely marginalized and paradoxically represented the very essence of family to their male children. Bouchard also engages in the ongoing scholarly debate about the nobility around the year 1000, arguing that there was no clear point of transition from amorphous family units to agnatically structured kindred. Instead, she points out that great noble families always privileged the male line of descent, even if most did not establish father-son inheritance until the eleventh or twelfth century. Those of My Blood clarifies the complex meanings of medieval family structure and family consciousness and shows the many ways in which negotiations of power within the noble family can help explain early medieval politics. |
| family history of consanguinity: Human Genetics in Nursing Suresh K Sharma, 2010-01-02 |
| family history of consanguinity: Community Control of Genetic and Congenital Disorders Alaʻdin A. S. Alwan, B. Modell, 1997 A comprehensive guide to recommended strategies for controlling genetic and congenital disorders in Eastern Mediterranean countries. Addressed to policy-makers and service providers, the book aims to heighten awareness of these disorders while also increasing understanding of the interventions available for prevention and control. Although all major hereditary disorders are covered, particular attention is given to haemoglobin disorders, including thalassaemia and sickle cell disease, which are extremely common in these countries. The book has fourteen chapters presented in four parts. Part one introduces the growing problem of genetic disorders, outlines options for treatment and prevention, and explains the principals of diagnosis. Current and future applications of genetic technology are also briefly discussed. Chapters in part two assess the epidemiological situation in Eastern Mediterranean countries for congenital malformation and chromosomal disorders, single gene disorders, and several common diseases, such as hypertension, diabetes, coronary heart disease, and some cancers that are now know to have a hereditary component. The genetic implications of consanguineous marriage, which remains common in some of these countries, are considered in particular detail. Available approaches for prevention are described in part three. Separate chapters cover primary health care approaches, the use of family history and population screening to identify couples or families at risk, and the roles of counseling, prenatal diagnosis, and neonatal screening. Part four offers practical advice on policies and services for prevention. |
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Records Images Family Tree Genealogies Catalog Books Wiki United States, Census, 1890 Fragments of the US census population schedule exist only for the states of Alabama, District …
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