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| dual bronchodilator therapy in copd: Pharmacotherapy in Chronic Obstructive Pulmonary Disease Bartolome R. Celli, 2003-12-17 Placing specialists at the cutting-edge of therapeutic and biotechnological research, this reference reviews the extensive array of pharmaceutical options available for the management of patients with COPD. The book considers disease severity, dosing regimens, administration methods, and monitoring procedures, as well as medication-related side-eff |
| dual bronchodilator therapy in copd: Chronic Obstructive Pulmonary Disease Exacerbations Jadwiga A. Wedzicha, Fernando J. Martinez, 2008-09-22 Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat |
| dual bronchodilator therapy in copd: The Statistical Analysis of Failure Time Data John D. Kalbfleisch, Ross L. Prentice, 2011-01-25 Contains additional discussion and examples on left truncationas well as material on more general censoring and truncationpatterns. Introduces the martingale and counting process formulation swillbe in a new chapter. Develops multivariate failure time data in a separate chapterand extends the material on Markov and semi Markovformulations. Presents new examples and applications of data analysis. |
| dual bronchodilator therapy in copd: Clinical Exercise Testing Idelle M. Weisman, R. Jorge Zeballos, 2002-01-01 In the last several years, Clinical Exercise Testing has become an increasingly important tool for patient evaluation in clinical medicine due to a growing awareness of the limitations of traditional resting cardiopulmonary measurements. Emphasizing scientific and technological advances and focusing on clinical applications for patient diagnosis and management, this volume provides a comprehensive interdisciplinary review of clinical exercise testing, concentrating on Cardiopulmonary Exercise Testing (CPET). 25 reader-friendly chapters discuss important topics, including the physiologic responses to exercise in normal subjects, in the aged and in various disease states; the set-up of an exercise lab; the methodology and protocols used for clinical exercise testing; and an integrative approach to the interpretation of CPET results. CPET in heart failure, deconditioning, COPD, ILD, pulmonary vascular disease, neuromuscular disease, and asthma is thoroughly discussed. Clinical applications including pulmonary and cardiac rehabilitation, heart and lung transplantation evaluation, unexplained exertional dyspnea assessment, evaluation for lung resection and lung volume reduction surgery, and impairment-disability evaluation are also covered in detail. Additional chapters on clinical exercise testing in children, during pregnancy and the postpartum, and in other systemic disorders complete this extensive publication. Written by well-respected experts, this volume will be a valuable resource for a wide audience including pulmonologists, cardiologists, pediatricians, exercise physiologists, rehabilitation specialists, nurse clinician specialists, and respiratory therapists. |
| dual bronchodilator therapy in copd: Severe Asthma Kian Fan Chung, Elliot Israel, Peter G. Gibson, 2019-06-01 Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma. |
| dual bronchodilator therapy in copd: Global Surveillance, Prevention and Control of Chronic Respiratory Diseases World Health Organization, 2007 Chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease, kill more than 4 million people every year, and affect hundreds of millions more. These diseases erode the health and well-being of the patients and have a negative impact on families and societies. This report raises awareness of the huge impact of chronic respiratory diseases worldwide, and highlights the risk factors as well as ways to prevent and treat these diseases. |
| dual bronchodilator therapy in copd: Respiratory Health Mieczyslaw Pokorski, 2015-07-29 The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services. Innovative strategies to promote prevention, care coordination and care integration as well as to align disease acceptance and quality of life measures also are tackled. Maintaining respiratory health is of rising research interest as a way of preventing a disease or a non pharmacological therapeutic succor. The book will be of interest to clinicians, family practitioners and medical researchers. |
| dual bronchodilator therapy in copd: Introduction to Basics of Pharmacology and Toxicology Abialbon Paul, Nishanthi Anandabaskar, Jayanthi Mathaiyan, Gerard Marshall Raj, 2021-03-13 This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. |
| dual bronchodilator therapy in copd: ABC of COPD Graeme P. Currie, 2010-11-04 Chronic Obstructive Pulmonary Disease (COPD) is a progressive, largely irreversible lung condition characterised by airflow obstruction. Although cigarette smoking is the single most important risk factor in its development, other associations and risk factors are thought to have increasing relevance throughout the world. COPD is usually managed in primary care, although it is commonly under-diagnosed, and is one of the most common medical conditions necessitating admission to hospital. The second edition of the ABC of COPD provides the entire multidisciplinary team with a reliable, up-to-date and accessible account of COPD. Extensively updated by experienced clinicians - including new chapters on spirometry, inhalers, oxygen, death, dying and end of life issues - this ABC is an authoritative and practical guide for general practitioners, practice nurses, specialist nurses, medical students, paramedical staff, junior doctors, non-specialist doctors and all other health professionals working in both primary and secondary care. |
| dual bronchodilator therapy in copd: Bayesian Approaches to Clinical Trials and Health-Care Evaluation David J. Spiegelhalter, Keith R. Abrams, Jonathan P. Myles, 2004-01-16 READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton, Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society. Originating from the Medical Research Council’s biostatistics unit, David has played a leading role in the Bristol heart surgery and Harold Shipman inquiries. Order a copy of this author’s comprehensive text TODAY! The Bayesian approach involves synthesising data and judgement in order to reach conclusions about unknown quantities and make predictions. Bayesian methods have become increasingly popular in recent years, notably in medical research, and although there are a number of books on Bayesian analysis, few cover clinical trials and biostatistical applications in any detail. Bayesian Approaches to Clinical Trials and Health-Care Evaluation provides a valuable overview of this rapidly evolving field, including basic Bayesian ideas, prior distributions, clinical trials, observational studies, evidence synthesis and cost-effectiveness analysis. Covers a broad array of essential topics, building from the basics to more advanced techniques. Illustrated throughout by detailed case studies and worked examples Includes exercises in all chapters Accessible to anyone with a basic knowledge of statistics Authors are at the forefront of research into Bayesian methods in medical research Accompanied by a Web site featuring data sets and worked examples using Excel and WinBUGS - the most widely used Bayesian modelling package Bayesian Approaches to Clinical Trials and Health-Care Evaluation is suitable for students and researchers in medical statistics, statisticians in the pharmaceutical industry, and anyone involved in conducting clinical trials and assessment of health-care technology. |
| dual bronchodilator therapy in copd: Dyspnea Donald A. Mahler, Denis E. O'Donnell, 2014-01-20 With the high prevalence of chronic pulmonary diseases, including asthma, COPD, and interstitial lung disease, physicians need to recognize the cause of dyspnea and know how to treat it so that patients can cope effectively with this distressing symptom. Detailing recent developments and treatment methods, this revised and updated third edition of |
| dual bronchodilator therapy in copd: Middleton's Allergy Essentials E-Book Robyn E O'Hehir, Stephen T Holgate, Aziz Sheikh, 2015-12-09 For decades, health care practitioners have relied on Middleton’s Allergy as their go-to reference for comprehensive information on allergic disorders. Now Middleton’s Allergy Essentials, by Drs. Robyn E. O'Hehir, Stephen T. Holgate, and Aziz Sheikh, offers a concise resource that’s both easily accessible and highly authoritative. Perfect for clinicians in primary and secondary care settings, this practical volume covers what is most useful in your daily practice, with a strong emphasis on disease diagnosis and management. A practical approach to evaluation, differential diagnosis, and treatment of allergic disorders, focused specifically on what the non-specialist needs to know for everyday practice. Each chapter begins with a handy summary of key concepts to help you quickly identify important information. Coverage of today’s hot topics includes asthma, drug allergies, food allergies and gastrointestinal disorders, anaphylaxis, atopic dermatitis, and allergic contact dermatitis. Concise sections on mechanisms are included where relevant, keeping you up to date with this rapidly evolving field. Authored by the same internationally recognized experts that produce Middleton’s Allergy, the definitive text in the field. Ideal for physicians, residents, general and family practitioners, nurse practitioners, primary care doctors, hospitalists, general internists – anyone who is called upon to make effective diagnostic and treatment decisions regarding allergic disorders. |
| dual bronchodilator therapy in copd: Controversies in COPD Antonio Anzueto, Yvonne Heijdra, John R. Hurst, 2015-09-01 COPD is one of the most common diseases worldwide and is projected to be the third leading cause of death by 2020. But that does not mean it is easy to understand or manage. In everyday practice, pulmonologists face areas of controversy in COPD, for which evidence-based medicine is often unavailable. This ERS Monograph considers where the current controversies in COPD lie, discussing areas such as screening, premature birth, asthma–COPD overlap syndrome, treatment, rehabilitation and palliative care. This book will be of great interest to both clinicians and scientists, and aims to stimulate further discussion about this diverse and fascinating disease. ...contains a vast amount of information on the disease, its prevalence, signs and symptoms, diagnositc tests and treatment options. The book's format makes it quick and simple to find out what you need to know, and its size would make it easy to take to work for use in practice [...] invaluable for anyone working with patients with the disease. Emma Vincent, Nursing Standard |
| dual bronchodilator therapy in copd: Nocturnal Asthma Peter J. Barnes, Jonathan Levy, 1984 |
| dual bronchodilator therapy in copd: Drugs for the Treatment of Respiratory Diseases Domenico Spina, 2003-01-30 Respiratory diseases affect millions of people each year and represent a major health burden around the world. This timely reference surveys and evaluates the drug treatments available for the main categories of lung diseases including asthma, tuberculosis, chronic obstructive pulmonary disease, lung cancer, and respiratory infections. The recent re-emergence of tuberculosis and the increase in asthma in certain populations underlines the importance of finding effective new treatments for these diseases. This publication, a comprehensive reference, is one of the first to survey current and novel drug treatments for this group of diseases. It is certain to establish itself as an essential source of reference for respiratory physicians, clinicians and clinical pharmacologists. |
| dual bronchodilator therapy in copd: Cyclic Nucleotide Phosphodiesterases in Health and Disease Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay, 2006-12-05 Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph |
| dual bronchodilator therapy in copd: McMaster Textbook of Internal Medicine 2019/20 Roman Jaeschke, Piotr Gajewski, Paul M. O'Byrne, 2019-10-30 A convenient compact textbook that fits snugly into your scrubs pocket. Developed at McMaster University, the birthplace of evidence-based medicine (EBM) and one of the world's top universities, in cooperation with over 300 highly renowned scientists from North America and Poland. |
| dual bronchodilator therapy in copd: Pediatric Emergency Medicine Jill M. Baren, 2008-01-01 This authoritative reference equips you with the essential knowledge to provide comprehensive and effective care to children in an emergency setting. From age-specific diagnoses and chief complaints through developmental considerations and psychosocial issues, this text guides you through the full range of medical and surgical conditions commonly encountered when treating pediatric emergencies. The use of full color throughout, diagnostic algorithms, text boxes, charts, clinical pearls and pitfalls, and other visual features ensure the book will make crucial clinical information easy to find and apply. Tap into expert guidance on all aspects of pediatric emergency medicine, from the physical exam and usual and unusual presentations through to disposition criteria and transfer issues. Access step-by-step guidance on administering critical life support interventions and providing effective diagnostic and therapeutic ambulatory care. Quickly review specific treatment protocols for various emergency settings, including general emergency departments, community hospitals, tertiary care centers, EMS and transport, and triage. Find information fast with or without a known diagnosis, with content organized both by chief complaints and by specific diagnoses. Better understand how problems present differently in infants, children, and adolescents with age-specific diagnoses. Identify and manage the psychosocial issues surrounding pediatric patients, including major depression and suicidality, sexual and physical abuse, child neglect, and violence. Easily absorb key information with the aid of text boxes, algorithms, clinical pearls, and pitfalls. Retrieve information easily with a consistent templated format. |
| dual bronchodilator therapy in copd: Pulmonary/respiratory Therapy Secrets Polly E. Parsons, John E. Heffner, 2002 The new edition of this popular pulmonary/respiratory therapy text in question-and-answer format is completely updated and expanded. The new edition contains expanded coverage of endoscopy. Great as a concise clinical text or as a review for rounds and exams. The book contains 83 chapters organized in 18 sections, covering all aspects of pulmonary evaluation, disease, and therapy. All chapters are thoroughly revised and updated. The new edition features a new chapter on Interventional Bronchoscopy. Thorough, highly detailed index. |
| dual bronchodilator therapy in copd: Glucocorticoids Xiaoxiao Qian, 2012-11-28 As one class of the most important steroid hormones, glucocorticoids have long been recognised and their therapeutic benefits have been widely used in clinical treatment, especially in anti-inflammation cases. Glucocorticoids regulate various processes in the body including the mobilization of energy stores, immune functions, gene expression, and maintenance of the homeostasis as well as the stress response, this is not surprising that the concept of glucocorticoids is mentioned in almost all medical text books that focus on specific organs or systems such as the cardiovascular system, the immune system, and the neuroendocrine system. The book of Glucocorticoids - New Recognition of Our Familiar Friend aims to introduce the latest findings relating to glucocorticoids, either freshly from the laboratory or from clinical case studies, and to open up a new angle of looking at the issue of balancing the therapeutic benefits and side effects brought up by glucocorticoids. |
| dual bronchodilator therapy in copd: Report of the Medical Research Council Medical Research Council (Great Britain), 1951 |
| dual bronchodilator therapy in copd: Intuitive Biostatistics Harvey Motulsky, 2017-11-15 Intuitive Biostatistics takes a non-technical, non-quantitative approach to statistics and emphasizes interpretation of statistical results rather than the computational strategies for generating statistical data. This makes the text especially useful for those in health-science fields who have not taken a biostatistics course before. The text is also an excellent resource for professionals in labs, acting as a conceptually oriented and accessible biostatistics guide. With an engaging and conversational tone, Intuitive Biostatistics provides a clear introduction to statistics for undergraduate and graduate students and also serves as a statistics refresher for working scientists. -- |
| dual bronchodilator therapy in copd: Therapy in Sleep Medicine E-Book Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, Karl Doghramji, 2011-10-31 Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance. |
| dual bronchodilator therapy in copd: Pocket Guide to COPD Diagnosis, Management and Prevention Global Initiative for Chronic Obstructive Lung Disease, 2017-11-15 Chronic Obstructive Pulmonary Disease (COPD) represents an important public health challenge and is a major cause of chronic morbidity and mortality throughout the world. COPD is currently the fourth leading cause of death in the world1 but is projected to be the 3rd leading cause of death by 2020. More than 3 million people died of COPD in 2012 accounting for 6% of all deaths globally. Globally, the COPD burden is projected to increase in coming decades because of continued exposure to COPD risk factors and aging of the population.2 This Pocket Guide has been developed from the Global Strategy for the Diagnosis, Management, and Prevention of COPD (2018 Report), which aims to provide a non-biased review of the current evidence for the assessment, diagnosis and treatment of patients with COPD that can aid the clinician. Discussions of COPD and COPD management, evidence levels, and specific citations from the scientific literature are included in that source document, which is available from www.goldcopd.org. The tables and figures in this Pocket Guide follow the numbering of the 2018 Global Strategy Report for reference consistency. |
| dual bronchodilator therapy in copd: COPD Donald A. Mahler, 2022-01-25 Providing up-to-date, evidence-based content that covers more than just medications, COPD gives you the tools you need to keep active—and thrive. |
| dual bronchodilator therapy in copd: Acute Exacerbations in COPD. Mario Cazzola, A. Anzueto, F. Blasi, S. Prakash Sethi, 2009 Annotation The pronounced variability in the incidence and severity of chronic respiratory diseases such as asthma and COPD, makes effective treatment more difficult, and the social and economic costs of these diseases all the greater. Acute exacerbations are multi-factorial in origin, and are known to be linked with a number of agents including allergens, atmospheric pollution and infectious agents. Effective treatment requires a similarly complex approach that addresses each of the component causes. This text brings together current knowledge of the epidemiology and pathophysiology of these episodes, and the latest experimental models by which researchers are seeking to improve our understanding of their incidence and progression. The book concludes with a review of the latest ideas on therapy for exacerbations. The authors evaluate the individual efficacy of current treatments in the light of this knowledge and present new recommendations for formulating effective therapeutic regimes. |
| dual bronchodilator therapy in copd: Respiratory Muscles in Chronic Obstructive Pulmonary Disease A. Grassino, C. Fracchia, C. Rampulla, 2014-01-15 |
| dual bronchodilator therapy in copd: Oxygen Administration National Safety Council, 1995 Providing supplemental oxygen is an essential element of emergency care. Anyone expected to use a medical oxygen device can benefit from this program. The text effectively outlines the importance and |
| dual bronchodilator therapy in copd: European Lung White Book European Respiratory Society (United Kingdom), Robert Loddenkemper, European Lung Foundation, G. J. Gibson, Y. Sibille, 2003-01-01 |
| dual bronchodilator therapy in copd: Pharmacotherapy of Asthma James Li, 2005-09-23 Standing as the only text focused on the pharmaceutical treatment of asthma, this reference details the pharmacology, mechanisms of action, efficacy, and safety of every drug currently used in the management and care of asthma patients. Internationally renowned authorities cover published practice guidelines, treatment plans, pharmacologic agents, and clinical studies to provide the most authoritative and up-to-date information on the use of medications to control and prevent this common condition. Reviewing the role of pharmacotherapy in the overall management of asthma, this guide: * reviews the pharmacology and clinical use of inhaled corticosteroids, beta adrenergic agonists, leukotriene modifiers, combination products, and many other asthma drugs * provides a practical framework for the optimal pharmacotherapy of asthma, focusing on outpatient therapy * examines international guidelines for the drug treatment of asthma. |
| dual bronchodilator therapy in copd: Chronic Obstructive Pulmonary Disease, An Issue of Clinics in Chest Medicine Gerard Criner, Bartolome R. Celli, 2020-09-01 This issue of Clinics in Chest Medicine, guest-edited by Dr. Gerard Criner and Dr. Bartolome Celli, is focused on Chronic Obstructive Pulmonary Disease. Topics discussed in this issue include but are not limited to: COPD Pathogenesis; Epidemiology of COPD; Host, Gender, and Early Life Factors as Risks for COPD; Alpha One Antitrypsin Deficiency; Lung Function Testing; Assessing Symptom Burden; Chest Imaging in the Diagnosis and Assessment of the Patient with COPD; Biomarkers in the Diagnosis and Assessment of COPD; Asthma/COPD Overlap; Multimorbidity in the Patient with COPD; Definition Causes, Pathogenesis, and Consequences of Exacerbations; Treatment of Acute Exacerbations; Prevention of Exacerbations; Bronchodilators; Benefits and Risks of Inhaled Corticosteroids in COPD; Systemic Medications; Smoking Cessation/Vaccinations; Pulmonary Rehabilitation; Oxygen Therapy/Noninvasive Ventilation; and Interventional and Surgical Therapies for COPD. |
| dual bronchodilator therapy in copd: A COPD Primer Ralph Panos, William Eschenbacher, 2015-01-01 In 2012 we received a grant from the Veterans Health Administration Office of Specialty Care entitled, “Patient-Centered Model for the Management of Chronic Obstructive Pulmonary Disease.” The grant’s goals were to enhance the recognition and diagnosis of COPD and implement a Patient-Centered Model for the Management of COPD. As the work on that proposal progressed, we realized that providers did not have an up-to-date, comprehensive, easily read, “how to” manual for the management of COPD despite all the advances in COPD care that have occurred over the past 5 years. Consensus documents such as the VA-DOD Guidelines were abbreviated summaries that were rarely used. From those discussions, the concept for this volume, a COPD Primer, developed. The goal was to develop a practical book that concisely presented COPD to providers with sufficient background and explanation of the physiologic and scientific rationale for various management strategies without becoming an esoteric academic work. We hope that this COPD Primer has achieved that goal and will be a useful, practical text for practitioners and medical trainees alike. The COPD Primer begins with an examination of what COPD is; it is really a syndrome, a constellation of historical features and clinical, physiologic, and radiographic findings. However, those elements come together in many different ways to create multiple different COPD phenotypes that are only now being recognized and used to define specific management strategies. COPD research has progressed beyond the simple classification of “blue bloaters” and “pink puffers.” Next, the epidemiology and economic consequences of COPD are reviewed. Bill Eschenbacher presents an approach to the patient with respiratory symptoms with detailed discussions of pulmonary function testing and how airflow limitation/obstruction is identified by spirometry and the use of lung imaging to identify individuals with COPD. Michael Borchers and Gregory Motz summarize current evidence implicating genetics, proteolytic imbalance, oxidative stress, inflammation, occupational and environmental exposures, and innate and adaptive immune function in the pathogenesis of COPD and the implication of these findings to future treatments. The single most important intervention in the prevention and treatment of COPD is smoking cessation. Shari Altum, Katherine Butler, and Rachel Juran present a practical approach to smoking cessation utilizing motivational interviewing in combination with pharmacologic interventions. Then, they expand upon these concepts to provide practitioners with convenient, realistic suggestions to encourage patient self-management in all aspects of COPD care and overall health. Ahsan Zafar reviews the natural history, recently described COPD phenotypes, and gender differences that clearly illustrate the broad spectrum of disease that comprises the term, COPD. The cover illustration highlights Dr. Zafar’s creative and artistic talents. The extensive nonpulmonary aspects of COPD are reviewed by Ralph Panos in an examination of COPD’s multi-organ manifestations. Next, the effect of COPD on sleep and the overlap syndrome, the concurrence of COPD and obstructive sleep apnea, and its consequences are presented. Jean Elwing examines the effect of COPD on the pulmonary vasculature with a detailed discussion of the evaluation and management of pulmonary hypertension associated with COPD. COPD’s effects on psychosocial functioning and familial interactions are presented by Mary Panos and Ralph Panos. The focus of the Primer then shifts from manifestations to treatment with a discussion of stable COPD management. With the current plethora of devices for delivering respiratory medications, it is difficult for both patients and providers to sustain knowledge of their proper use. Aaron Mulhall presents a practical guide to correct inhaler use that reviews all the current devices. Folarin Sogbetun then reviews the management of outpatient COPD exacerbations and Nishant Gupta discusses the approach to the patient hospitalized with COPD. Because patients with COPD often see multiple subspecialty physicians in addition to their primary care providers, interdisciplinary communication and coordination of care is essential for their management; Sara Krzywkowski-Mohn reviews the interactions between primary and specialty care for the patient with COPD with suggestions for improved communication and care coordination. Finally, advance care planning including palliative care and hospice is reviewed with a discussion of how end stage COPD affects not only the patient but also their family and social network. This COPD Primer incorporates the knowledge that we have learned over the past several years during the development and implementation of a patient-centered model for the management of COPD. It was written with the explicit goal of assisting both the practicing provider and medical trainee in the care of patients with COPD. |
| dual bronchodilator therapy in copd: COPD - Pathology, Diagnosis, Treatment, and Future Directions Steven Jones, 2024-06-05 Chronic obstructive pulmonary disease is a (currently) incurable and irreversible lung condition with worldwide mortality rates similar to stroke, diabetes, and Alzheimer’s disease. Treatments are limited to the removal of the underlying causes (e.g., exposure to smoke), easing some of the symptoms, and slowing the rate at which the disease worsens. As a consequence of smoking, it is less well known than lung cancer even though it has an equal or higher mortality rate. It is a combination of diseases that affects bronchioles and alveoli to different extents from patient to patient. An accurate diagnosis of each patient’s physiology is potentially useful in tailoring treatment to the underlying physiology. This book provides an overview of the underlying pathology of the disease. It then discusses some of the clinical tools available to obtain pathology-specific diagnosis for a given patient. A section then discusses the consequences of the disease. While some of these consequences are readily expected from a cursory understanding of the disease (anemia and shortness of breath), others are less obvious (muscle atrophy, impaired balance, and cardiac problems). In the final sections, disease treatment is addressed. The book is intended to convey two important points. The first is that hope exists for more effective treatments in the future, while the second is that these treatments will require strong collaborations among researchers in a variety of disciplines. |
| dual bronchodilator therapy in copd: New Drugs and Targets for Asthma and COPD T.T. Hansel, P.J. Barnes, 2010-08-31 Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists. |
| dual bronchodilator therapy in copd: COPD in the 21st Century Jadwiga A. Wedzicha, James P. Allinson, Peter M.A. Calverley, 2024-03-01 COPD remains a major cause of ill health, disability, healthcare costs and premature mortality. Scientists and clinicians across many countries have made great efforts to understand this important disease, and these have yielded positive results. This Monograph provides an up-to-date overview of what is happening in this exciting field, both at a basic and a clinical level. Beginning, crucially, with the patient’s perspective, the chapters that follow consider the best way to define COPD, changes in the disease’s incidence and prevalence, and offer new insights into the role of the microbiome in COPD, advances in imaging and treatment options, both pharmacological and non-pharmacological. Taken together, these chapters are an important contribution to the Monograph series and the COPD field in general. |
| dual bronchodilator therapy in copd: Managing chronic obstruction pulmonary disease: From translational research to public health practice Shu-Chuan Ho, Chia-Li Han, Kin-fai Ho, Hsiao-Chi Chuang, Ting-Yu Lin, 2023-02-08 |
| dual bronchodilator therapy in copd: Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders Gabriele De Rubis, Ronan MacLoughlin, Hélder A. Santos, Saritha Shetty, Divya Suares, Kamal Dua, 2024-10-21 Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders focuses on 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling. The book, written by a team of leading experts in the field, is an essential resource for anyone interested in the future of CRD treatment. Chapters discuss the emerging therapeutic approaches for CRDs, including biologicals and phytoceuticals. Core chapters of the book then cover the application of 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling to different CRDs. The book concludes with a discussion of the current clinical trials and future prospects for the management of CRDs.This is a valuable resource for researchers, clinicians, and other healthcare professionals who are interested in the latest technological advances in the field of CRDs. It will also be of interest to students and scientists working in the fields of pharmaceutical sciences, microfluidics, bioinformatics, drug design, drug delivery, and 3D printing. - Provides the most recent and updated perspectives and challenges in the management of chronic respiratory disorders - Covers exciting new technologies such as 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modelling - Includes the most recent information on the development of advanced drug delivery systems for the treatment of chronic respiratory disorders |
| dual bronchodilator therapy in copd: Severe Pulmonary Emphysema: Luis Carlos Losso, Pallav L. Shah, Gerald J. Criner, Walter Weder, José R Jardim, 2024-10-24 Chronic obstructive pulmonary disease is, of 2024, one of the three main causes of death in the world, affecting around 12% of the world's population. Its incidence is estimated to increase in the coming decades due to continuous exposure to risk factors and to an aging population. Pulmonary emphysema is one of its most serious phenotypes, with chronic and inexorable progression and, in the most severe stages, it is highly disabling and lethal. This book reviews knowledge about the pathophysiology of severe pulmonary emphysema and the current innovative interventional and minimally invasive therapeutic concepts for the management of these advanced stages of emphysema, based on the best scientific evidence. This guide provides to multidisciplinary pulmonary boards of experts in advanced lung diseases, current criteria for the choice of precision therapeutic options and beyond to maintaining optimized medical treatment to controlling lung hyperinflation, and alleviating patients' symptoms. This book is a valuable resource for clinicians dealing with critically ill patients with COPD. |
| dual bronchodilator therapy in copd: Targeting Cellular Signalling Pathways in Lung Diseases Kamal Dua, Raimar Löbenberg, Ângela Cristina Malheiros Luzo, Shakti Shukla, Saurabh Satija, 2021-07-02 The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine. |
| dual bronchodilator therapy in copd: Murray & Nadel's Textbook of Respiratory Medicine E-Book V. Courtney Broaddus, Joel D. Ernst, Talmadge E. King Jr, Stephen C. Lazarus, Kathleen F. Sarmiento, Lynn M. Schnapp, Renee D. Stapleton, Michael B. Gotway, 2021-05-28 Known for its clear readability, thorough coverage, and expert authorship, Murray & Nadel's Textbook of Respiratory Medicine has long been the gold standard text in the fast-changing field of pulmonary medicine. The new 7th Edition brings you fully up to date with newly expanded content, numerous new chapters, a new editorial team, and extensive updates throughout. It covers the entire spectrum of pulmonology in one authoritative point-of-care reference, making it an ideal resource for pulmonary physicians, fellows, and other pulmonary practitioners. - Offers definitive, full-color coverage of basic science, diagnosis, evaluation, and treatment of the full range of respiratory diseases. - Provides detailed explanations of each disease entity and differential diagnoses with state-of-the-art, evidence-based content by global leaders in the field. - Contains a newly expanded section on common presentations of respiratory disease, plus new chapters on COVID-19, asthma and obesity, airplane travel, lung cancer screening, noninvasive support of oxygenation, lung microbiome, thoracic surgery, inhaled substances, treatment of lung cancer, and more. - Covers hot topics such as vaping; advanced ultrasound applications and procedures; interventional pulmonology; immunotherapy; lung cancer targeted therapy; outbreaks, pandemics and bioterrorism; point-of-care ultrasound; use of high-flow oxygen, and more. - Includes extensively reorganized sections on basic science, pleural disease, and sleep, with new chapters and approaches to the topics. - Features more than 1,450 anatomic, algorithmic, and radiologic images (400 are new!) including CT, PET, MR, and HRCT, plus extensive online-only content: 200 procedural and conceptual videos plus audio clips of lung sounds. - Brings you up to date with the latest respiratory drugs, mechanisms of action, indications, precautions, adverse effects, and recommendations, with increased emphasis on algorithms to illustrate decision making. - Enhanced eBook version included with purchase. Your enhanced eBook allows you access to all of the text, figures, reporting templates, and references from the book on a variety of devices. |
Marvel Rivals Console/Controller Settings Guide 2025
Dec 27, 2024 · Aim Response Curve Type: Determines how your controller responds when you tilt your right analog stick. You have a choice between Dual-Zone (the new default Overwatch …
Best armour and augments for Dual Guns + Longsword build
Apr 18, 2025 · Tc did specifically mention blossom dance. And resistances aren't important when using ghost walker/factory, which I assume he is given the dual guns. Yup I want to abuse …
Conditions for Dual Ultimates? - Dragon Ball: Xenoverse 2
As long as the custom partner has the Dual Ultimate equipped, they will use it every so often and then you can do the input for the second part of the attack no matter what you have equipped. …
Can I dual wield? - The Elder Scrolls IV: Oblivion - GameFAQs
Sep 10, 2007 · At stage 25 of The Path of Dawn quest, it is scripted for no apparent reason for Martin Septim to have a Lesser Staff of Lightning removed from his inventory, even though, …
Character Creation - Icewind Dale: Enhanced Edition ... - GameFAQs
Apr 30, 2021 · For two-class combinations, dual-classing from Fighter is slightly better than multiclassing because dual-classing gives Grand Mastery, more HP and faster level gain. …
Resident Evil: Director's Cut Walkthrough & Guide - GameFAQs
Mar 24, 2024 · The Director's Cut is the first version of the original Resident Evil that I had played and the one I like best. While the Dual Shock edition that followed adds functionality to the …
Differences between original and Dual Shock versions?
My bad, in regards to the Ink Ribbons... to be really specific, in both modes of the original Director's Cut and in Arrange Mode in the Dual Shock version, you get 3 ribbons each pickup. …
Character Creation - Baldur's Gate: Enhanced Edition ... - GameFAQs
Apr 21, 2024 · Multiclass vs. Dual Class There is a subtle distinction between multiclass characters and dual-class characters. The idea of playing an A / B multiclass character (for …
Ideal build for Rush for the first playthrough
For me I'm just going for a dual-wield build. Probably a ninja if I can get the requirements for it down. I was BR25 at The Fallen on PC and I got Rush to Ninja about halfway through. Now …
Some suggestions after 20+ hours for those still struggling
Oct 26, 2024 · Dual Gunner (Tech): fire-infused attack; Quadrastrike (Tech): high-BP damage (perfect for United Attack) Heeled Sandals (Legs): allows you to use a special kick attack …
Marvel Rivals Console/Controller Settings Guide 2025
Dec 27, 2024 · Aim Response Curve Type: Determines how your controller responds when you tilt your right analog stick. You have a choice between Dual-Zone (the new default Overwatch curve …
Best armour and augments for Dual Guns + Longsword build
Apr 18, 2025 · Tc did specifically mention blossom dance. And resistances aren't important when using ghost walker/factory, which I assume he is given the dual guns. Yup I want to abuse Ghost …
Conditions for Dual Ultimates? - Dragon Ball: Xenoverse 2
As long as the custom partner has the Dual Ultimate equipped, they will use it every so often and then you can do the input for the second part of the attack no matter what you have equipped. …
Can I dual wield? - The Elder Scrolls IV: Oblivion - GameFAQs
Sep 10, 2007 · At stage 25 of The Path of Dawn quest, it is scripted for no apparent reason for Martin Septim to have a Lesser Staff of Lightning removed from his inventory, even though, …
Character Creation - Icewind Dale: Enhanced Edition ... - GameFAQs
Apr 30, 2021 · For two-class combinations, dual-classing from Fighter is slightly better than multiclassing because dual-classing gives Grand Mastery, more HP and faster level gain. …
Resident Evil: Director's Cut Walkthrough & Guide - GameFAQs
Mar 24, 2024 · The Director's Cut is the first version of the original Resident Evil that I had played and the one I like best. While the Dual Shock edition that followed adds functionality to the …
Differences between original and Dual Shock versions?
My bad, in regards to the Ink Ribbons... to be really specific, in both modes of the original Director's Cut and in Arrange Mode in the Dual Shock version, you get 3 ribbons each pickup. It's only in …
Character Creation - Baldur's Gate: Enhanced Edition ... - GameFAQs
Apr 21, 2024 · Multiclass vs. Dual Class There is a subtle distinction between multiclass characters and dual-class characters. The idea of playing an A / B multiclass character (for example, a …
Ideal build for Rush for the first playthrough
For me I'm just going for a dual-wield build. Probably a ninja if I can get the requirements for it down. I was BR25 at The Fallen on PC and I got Rush to Ninja about halfway through. Now that …
Some suggestions after 20+ hours for those still struggling
Oct 26, 2024 · Dual Gunner (Tech): fire-infused attack; Quadrastrike (Tech): high-BP damage (perfect for United Attack) Heeled Sandals (Legs): allows you to use a special kick attack …
