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| flexx integrative muscular therapy: Preclinical Development Handbook Shayne Cox Gad, 2008-03-21 A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin. |
| flexx integrative muscular therapy: International Conference for Innovation in Biomedical Engineering and Life Sciences Fatimah Ibrahim, Juliana Usman, Mas Sahidayana Mohktar, Mohd Yazed Ahmad, 2015-11-26 This volumes presents the proceedings of ICIBEL 2015, organized by the Centre for Innovation in Medical Engineering (CIME) under Innovative Technology Research Cluster, University of Malaya. It was held in Kuala Lumpur, Malaysia, from 6-8 December 2015. The ICIBEL 2015 conference promotes the latest researches and developments related to the integration of the Engineering technology in medical fields and life sciences. This includes the latest innovations, research trends and concerns, challenges and adopted solution in the field of medical engineering and life sciences. |
| flexx integrative muscular therapy: Essentials of Bioinformatics, Volume II Noor Ahmad Shaik, Khalid Rehman Hakeem, Babajan Banaganapalli, Ramu Elango, 2019-10-18 Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies. |
| flexx integrative muscular therapy: In Silico Drug Design Kunal Roy, 2019-02-12 In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. - Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing - Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases - Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing |
| flexx integrative muscular therapy: Musculoskeletal Disorders and the Workplace Institute of Medicine, National Research Council, Commission on Behavioral and Social Sciences and Education, Panel on Musculoskeletal Disorders and the Workplace, 2001-05-24 Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials. |
| flexx integrative muscular therapy: Biological Database Modeling Jake Chen, Amandeep S. Sidhu, 2008 Modern biological research in areas like drug discovery produces a staggering volume of data, and the right modeling tools can help scientists apply it in ways never before imaginable. This collection of next-generation biodata modeling techniques combines innovative concepts, methods, and applications with case studies in genome, microarray, proteomics, and drug discovery projects to help bioinformatics professionals develop ever-more powerful data management systems in any domain. Breaking new ground at the intersection of life sciences and data management, the book introduces practitioners to core biodata modeling techniques, biological database resources, and ontology concepts. It explains the latest envelope-pushing methods and software applications for processing, integrating, and managing biodata. |
| flexx integrative muscular therapy: Human Mark Britnell, 2019 Drawing on the author's experiences ranging from the world's most advanced hospitals to revolutionary new approaches in India and Africa, this book will challenge everything from the role of healthcare in the world economy to the training and leadership of the medical profession and the role of women in the workforce. |
| flexx integrative muscular therapy: Biofeedback John V. Basmajian, 1983 |
| flexx integrative muscular therapy: The Short Fight Lawrence Castanon, 2021-05-08 Have you ever been attacked by a big, assailant? Have you ever been grabbed by a stronger person?Self-defense training in Not a one size fits all approach! Tactics designed for bigger persons do not always work for smaller, weaker individuals. Physiology matters! In this book you will learn: - The most efficient strikes specifically geared for the smaller person. - Crucial blocks and defenses to help you avoid getting hit. - The most effective clinching tactics to stop the assailant from hitting you.- Critical techniques and tactics to use to avoid getting grabbed by a strong assailant.- A complete fitness training program to help you achieve maximum power, speed, and flexibility, to give you the advantage in a fight.Additionally, purchasers of this book get free access to my website's video library. There I demonstrate and teach you all the techniques, tactics, and training methods described in this book, and more!So hurry, purchase the book now so you and your family can stay protected with this essential self-defense training program, because you can never be too safe! |
| flexx integrative muscular therapy: In Search of the Perfect Health System Mark Britnell, 2015-09-14 A practical, succinct guide to the major health systems around the world and what lessons can be drawn from each about improving health worldwide. The essays are designed to give the reader essential knowledge of the history, strengths, weaknesses and lessons of each health system. |
| flexx integrative muscular therapy: Essentials of Bioinformatics, Volume I Noor Ahmad Shaik, Khalid Rehman Hakeem, Babajan Banaganapalli, Ramu Elango, 2019-03-27 Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it mostly focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Unlike other bioinformatics books which are mostly theoretical, this book provides practical examples for the readers on state-of-the-art open source tools to solve biological problems. Flow charts of experiments, graphical illustrations, and mock data are included for quick reference. Volume I is therefore an ideal companion for students and early stage professionals wishing to master this blooming field. |
| flexx integrative muscular therapy: News of the Weird Chuck Shepherd, John J. Kohut, Roland Sweet, 1989 For news junkies and fans of the bizarre-but-true, here is an outrageous collection of all-real, all-weird news stories culled from the nation's mainstream newspapers. Line art throughout. |
| flexx integrative muscular therapy: The Oil Lamp Ogaga Ifowodo, 2005 |
| flexx integrative muscular therapy: The Integrative Action of the Nervous System Sir Charles Scott Sherrington, 1906 |
| flexx integrative muscular therapy: Proteomic Profiling and Analytical Chemistry Pawel Ciborowski, Jerzy Silberring, 2016-03-02 Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics. - Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measure - Includes practical examples illustrating the importance of problems in quantitation and validation of biomarkers - Helps in designing and executing proteomic experiments with sound analytics |
| flexx integrative muscular therapy: Physiologically Based Pharmacokinetic Modeling Micaela Reddy, R. S. Yang, Melvin E. Andersen, Harvey J. Clewell III, 2005-06-14 A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated Alkenes * Alkene and Aromatic Compounds * Reactive Vapors in the Nasal Cavity * Alkanes, Oxyhydrocarbons, and Related Compounds * Pesticides and Persistent Organic Pollutants * Dioxin and Related Compounds * Metals and Inorganic Compounds * Drugs * Antineoplastic Agents * Perinatal Transfer * Mixtures * Dermal Exposure Models In addition to pinpointing specific information, readers canexplore diverse modeling techniques and applications. Anauthoritative reference for toxicologists, ecotoxicologists, riskassessors, regulators, pharmacologists, pharmacists, and graduatestudents in pharmacokinetics and toxicology, Physiologically-BasedPharmacokinetic Modeling compiles information from leaders in thefield and discusses future directions for PBPK modeling. |
| flexx integrative muscular therapy: Concepts and Experimental Protocols of Modelling and Informatics in Drug Design Om Silakari, Pankaj Kumar Singh, 2020-11-05 Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers. The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling. - Presents exercises with solutions to aid readers in validating their own protocol - Brings a thorough interpretation of results of each exercise to help readers compare them to their own study - Explains each parameter utilized in the algorithms to help readers understand and manipulate various features of molecules and target protein to design their study |
| flexx integrative muscular therapy: Computer-Aided Drug Design Dev Bukhsh Singh, 2020-10-09 This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations. |
| flexx integrative muscular therapy: Microfluidics for Biotechnology Jean Berthier, Pascal Silberzan, 2010 The application of microfluidics to biotechnology is an exciting new area that has already begun to revolutionize how researchers study and manipulate macromolecules like DNA, proteins and cells in vitro and within living organisms. Now in a newly revised and expanded second edition, the Artech House bestseller, Microfluidics for Biotechnology brings you to the cutting edge of this burgeoning field. Among the numerous updates, the second edition features three entirely new chapters on: non-dimensional numbers in microfluidics; interface, capillarity and microdrops; and digital, two-phase and droplet microfluidics.Presenting an enlightening balance of numerical approaches, theory, and experimental examples, this book provides a detailed look at the mechanical behavior of the different types of micro/nano particles and macromolecules that are used in biotechnology. You gain a solid understanding of microfluidics theory and the mechanics of microflows and microdrops. The book examines the diffusion of species and nanoparticles, including continuous flow and discrete Monte-Carlo methods.This unique volume describes the transport and dispersion of biochemical species and particles. You learn how to model biochemical reactions, including DNA hybridization and enzymatic reactions. Moreover, the book helps you master the theory, applications, and modeling of magnetic beads behavior and provides an overview of self-assembly and magnetic composite. Other key topics include the electric manipulation of micro/nanoparticles and macromolecules and the experimental aspects of biological macromolecule manipulation. |
| flexx integrative muscular therapy: Glycobiology and Drug Design Anatole A. Klyosov, 2013-03-14 Will update existing publications on carbohydrate-based drug design and further shape the emerging data and thinking in this new area. |
| flexx integrative muscular therapy: Matching Pursuit and Unification in EEG Analysis Piotr Durka, 2007 Bridging the gap from visual analysis of EEGs to signal processing techniques, this guide provides engineers, researchers, and clinicians with an innovative, clear methodology for biomedical signal analysis. It covers various applications in sleep, ERD/ERS, pharmaco-EEG, and epilepsy research and includes a Web link with downloadable free software. |
| flexx integrative muscular therapy: Life Science Automation Fundamentals and Applications Mingjun Zhang, Bradley J. Nelson, Robin Felder, 2007 This comprehensive resource provides a solid grounding in life science and automation engineering essentials and describes state-of-the-art techniques for the design and development of sensors and actuators, lab-on-a-chip and bio-MEMs platforms, and more. |
| flexx integrative muscular therapy: Intelligent Systems Modeling and Decision Support in Bioengineering Mahdi Mahfouf, 2006 Intelligent systems try to achieve, through the use of computers, flexible learning and adaptive activity like that found in the human brain. For the first time, this groundbreaking resource provides a detailed understanding of the analysis, design, and application of new intelligent systems in the biomedical industry. |
| flexx integrative muscular therapy: Modeling and Informatics in Drug Design Prasad V. Bharatam, 2007-10 This book serves as an introduction to advanced research topics related to molecular modeling, chemoinformatics, bioinformatics, and pharmacoinformatics. It functions as a text for post-graduate level students as well as a reference for researchers. Both fundamentals and recent research applications are included in the book. Topics related to molecular modeling (QSAR, molecular docking, pharmacophore mapping, etc.), chemoinformatics, bioinformatics, and pharmacoinformatics are treated as new technologies; meaning there is an introduction and description of the advantages and disadvantages of these methodologies. |
| flexx integrative muscular therapy: Multi-Scale Approaches in Drug Discovery Alejandro Speck-Planche, 2017-03-07 Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents. After an introduction to multi-scale approaches outlining the need for and benefits of their use, the book goes on to explore a range of useful techniques and research areas, and their potential applications to this process. Profiling drug binding by thermodynamics, machine learning for predicting enzyme sub-classes, and multitasking models for computer-aided design and virtual compound screening are discussed, before the book goes on to review Alkaloid Menispermaceae leads, natural chemotherapeutic agents and methods for speeding up the design and virtual screening of therapeutic peptides. Flavonoids as multi-target compounds are then explored, before the book concludes with a review of Quasi-SMILES as a novel tool. Collecting together reviews and original research contributions written by leading experts in the field, Multi-Scale Approaches to Drug Discovery highlights cutting-edge approaches and practical examples of their implementation for those involved in the drug discovery process at many different levels. Using the combined knowledge of medicinal, computational, pharmaceutical and bio- chemists, it aims to support growth in the multi-scale approach to promote greater success in the development of new drugs. |
| flexx integrative muscular therapy: Biomolecular Computation for Bionanotechnology Jian-Qin Liu, Katsunori Shimohara, 2007 The drive toward non-silicon computing is underway, and this first-of-its-kind guide to molecular computation gives researchers a firm grasp of the technologies, biochemical details, and theoretical models at the cutting edge. It explores advances in molecular biology and nanotechnology and illuminates how the convergence of various technologies is propelling computational capacity beyond the limitations of traditional hardware technology and into the realm of moleware. |
| flexx integrative muscular therapy: Systems Bioinformatics Gil Alterovitz, Marco F. Ramoni, 2007-01-01 This trailblazing guide gives biological and biomedical research engineers a quantitative systems approach to bioinformatics research using computational tools drawn from technical disciplines. A major milestone in systems biology, this groundbreaking work points engineers to new frontiers in the convergence of engineering and biological research. |
| flexx integrative muscular therapy: Text Mining for Biology and Biomedicine Sophia Ananiadou, 2006 Here's the first focused book that puts the full range of cutting-edge biological text mining techniques and tools at your command. This comprehensive volume describes the methods of natural language processing (NLP) and their applications in the biological domain, and spells out in detail the various lexical, terminological, and ontological resources now at your disposal - and how best to utilize them. |
| flexx integrative muscular therapy: Electrotherapeutic Devices George D. O'Clock, 2007 This scientifically rigorous guide gives healthcare professionals and engineers essential technical, biological, and clinical background together with hands-on guidelines to design the most effective electrotherapeutic devices and treatment protocols for today's expanding list of clinical applications. This definitive one-stop resource introduces electrotherapeutic fundamentals and discusses how the body's cells, tissues, and organs respond to electrotherapy. |
| flexx integrative muscular therapy: Literature-based Discovery Peter Bruza, Marc Weeber, 2008-08-17 This is the first coherent book on literature-based discovery (LBD). LBD is an inherently multi-disciplinary enterprise. The aim of this volume is to plant a flag in the ground and inspire new researchers to the LBD challenge. |
| flexx integrative muscular therapy: Process Intensification Fernando Israel Gómez-Castro, Juan Gabriel Segovia-Hernández, 2019-10-21 Intensified processes have found widespread application in the chemical and petrochemical industries. The use of intensified systems allows for a reduction of operating costs and supports the “greening” of chemical processes. However, the design of intensified equipment requires special methodologies. This book describes the fundamentals and applications of these design methods, making it a valuable resource for use in both industry and academia. |
| flexx integrative muscular therapy: Modelling Methodologies in Analogue Integrated Circuit Design Günhan Dündar, Mustafa Berke Yelten, 2020-02-07 Modelling Methodologies in Analogue Integrated Circuit Design provides a holistic view of modelling for analogue, high frequency, mixed signal, and heterogeneous systems for designers working towards improving efficiency, reducing design times, and addressing the challenges of representing aging, variability, and other technical challenges at the nanometre scale. |
| flexx integrative muscular therapy: Practical SGML Eric van Herwijnen, 2012-12-06 Since the initial publication of Practical SGML the computer industry has seen a dramatic increase in the use and acceptance of SGML and many of the concepts derived from it. The existence of Practical SGML has helped to foster this growth as it provides a practical and vital introduction to the many facets of SGML and how its fits into an organization, whether it be business or government. Practical SGML, Second Edition is an extensive revision and update that puts greater emphasis and focus on helping the novice work his or her way through the vast amounts of information required to become proficient in SGML. Practical SGML, Second Edition provides the reader with an understanding of: the tools currently on the market that enable the easy creation of SGML data and the use and distribution of that data in a variety of forms; the minimum amount of information needed by people who wish to understand and use ISO 8879; aids and information on how to stay current with the volumes of material written on SGML in publications throughout the world; practical examples of the many SGML constructs and guidelines on their appropriate uses; other helpful hints and insights based on years of working with the standard and integrating it into a complex and challenging computer environment. Exercises throughout the text allow the readers to test their understanding. Answers are given in Appendix A. Practical SGML, Second Edition is an invaluable reference manual for anyone interested in understanding and using SGML. |
| flexx integrative muscular therapy: Polypharmacology in Drug Discovery Jens-Uwe Peters, 2012-03-13 An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the one drug, one target philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects. |
| flexx integrative muscular therapy: Molecular Docking for Computer-Aided Drug Design Mohane S. Coumar, 2021-02-17 Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. - Covers the latest information and state-of-the-art trends in structure-based drug design methodologies - Includes case studies that complement learning - Consolidates fundamental concepts and current practice of molecular docking into one convenient resource |
| flexx integrative muscular therapy: Drug Repurposing in Cancer Therapy Kenneth K.W. To, William C.S. Cho, 2020-07-29 Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types |
| flexx integrative muscular therapy: Transporters and Drug-Metabolizing Enzymes in Drug Toxicity Albert P. Li, 2021-07-27 TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries. |
| flexx integrative muscular therapy: Human Pharmaceuticals in the Environment Bryan W. Brooks, Duane B. Huggett, 2012-06-08 Human interaction with the environment remains one of the most pervasive facets of modern society. In a world characterized by rapid population growth, unprecedented global trade and digital communications, energy security, natural resource scarcities, climatic changes and environmental quality, emerging diseases and public health, biodiversity and habitat modifications are routinely touted by the popular press as they canvas global political agendas and scholarly endeavors. |
The Flexx USA
Welcome to our comfortable way of life with over two centuries of Italian craftsmanship. The Flexx shoes are made for today's modern and active women.
Welcome to Flexx’s documentation! — Flexx 1.0 documentation
Flexx is a pure Python toolkit for creating graphical user interfaces (GUI’s), that uses web technology for its rendering. Apps are written purely in Python; The PScript transpiler generates …
flexxui/flexx: Write desktop and web apps in pure Python - GitHub
Flexx is a pure Python toolkit for creating graphical user interfaces (GUI's), that uses web technology for its rendering. Apps are written purely in Python; The PScript transpiler generates …
Women's The FLEXX Shoes - Nordstrom
Find the latest selection of Women's The FLEXX Shoes in-store or online at Nordstrom. Shipping is always free and returns are accepted at any location. In-store pickup and alterations services …
Flexibilty without compromise - Flexx
Flexx automates the responsibilities of performance management with customizable notifications and reporting. Proactively engage with your employees and hold them accountable when they …
Amazon.com: The FLEXX - Women's Shoes / Women's Fashion: …
Online shopping for Clothing, Shoes & Jewelry from a great selection of Sandals, Boots, Fashion Sneakers, Pumps, Athletic, Slippers & more at everyday low prices.
Sandals - The Flexx USA
THE FLEXX Sandals: Perfect for, work, the beach, anything! It's easy to fit these versatile styles into your wardrobe. Italian style and comfort with THE FLEXX.
Flexx Nutrition - Healthy indy meal prep
We are Flexx Nutrition We're Indy's premiere meal prep service, we focus on delivering the highest quality products, high protein, low carb, low fat, low calorie meals to help you reach your fitness …
Flexx shoes + FREE SHIPPING | Zappos
Free shipping BOTH ways on flexx shoes from our vast selection of styles. Fast delivery, and 24/7/365 real-person service with a smile. Click or call 800-927-7671.
Shop The FLEXX Online - Nordstrom
Find the latest selection of The FLEXX in-store or online at Nordstrom. Shipping is always free and returns are accepted at any location. In-store pickup and alterations services available.
The Flexx USA
Welcome to our comfortable way of life with over two centuries of Italian craftsmanship. The Flexx shoes are made for today's modern and active women.
Welcome to Flexx’s documentation! — Flexx 1.0 documentation
Flexx is a pure Python toolkit for creating graphical user interfaces (GUI’s), that uses web technology for its rendering. Apps are written purely in Python; The PScript transpiler …
flexxui/flexx: Write desktop and web apps in pure Python - GitHub
Flexx is a pure Python toolkit for creating graphical user interfaces (GUI's), that uses web technology for its rendering. Apps are written purely in Python; The PScript transpiler …
Women's The FLEXX Shoes - Nordstrom
Find the latest selection of Women's The FLEXX Shoes in-store or online at Nordstrom. Shipping is always free and returns are accepted at any location. In-store pickup and alterations …
Flexibilty without compromise - Flexx
Flexx automates the responsibilities of performance management with customizable notifications and reporting. Proactively engage with your employees and hold them accountable when they …
Amazon.com: The FLEXX - Women's Shoes / Women's Fashion: …
Online shopping for Clothing, Shoes & Jewelry from a great selection of Sandals, Boots, Fashion Sneakers, Pumps, Athletic, Slippers & more at everyday low prices.
Sandals - The Flexx USA
THE FLEXX Sandals: Perfect for, work, the beach, anything! It's easy to fit these versatile styles into your wardrobe. Italian style and comfort with THE FLEXX.
Flexx Nutrition - Healthy indy meal prep
We are Flexx Nutrition We're Indy's premiere meal prep service, we focus on delivering the highest quality products, high protein, low carb, low fat, low calorie meals to help you reach …
Flexx shoes + FREE SHIPPING | Zappos
Free shipping BOTH ways on flexx shoes from our vast selection of styles. Fast delivery, and 24/7/365 real-person service with a smile. Click or call 800-927-7671.
Shop The FLEXX Online - Nordstrom
Find the latest selection of The FLEXX in-store or online at Nordstrom. Shipping is always free and returns are accepted at any location. In-store pickup and alterations services available.
