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| frontier in physiology: Science, the Endless Frontier Vannevar Bush, 2021-02-02 The classic case for why government must support science—with a new essay by physicist and former congressman Rush Holt on what democracy needs from science today Science, the Endless Frontier is recognized as the landmark argument for the essential role of science in society and government’s responsibility to support scientific endeavors. First issued when Vannevar Bush was the director of the US Office of Scientific Research and Development during the Second World War, this classic remains vital in making the case that scientific progress is necessary to a nation’s health, security, and prosperity. Bush’s vision set the course for US science policy for more than half a century, building the world’s most productive scientific enterprise. Today, amid a changing funding landscape and challenges to science’s very credibility, Science, the Endless Frontier resonates as a powerful reminder that scientific progress and public well-being alike depend on the successful symbiosis between science and government. This timely new edition presents this iconic text alongside a new companion essay from scientist and former congressman Rush Holt, who offers a brief introduction and consideration of what society needs most from science now. Reflecting on the report’s legacy and relevance along with its limitations, Holt contends that the public’s ability to cope with today’s issues—such as public health, the changing climate and environment, and challenging technologies in modern society—requires a more capacious understanding of what science can contribute. Holt considers how scientists should think of their obligation to society and what the public should demand from science, and he calls for a renewed understanding of science’s value for democracy and society at large. A touchstone for concerned citizens, scientists, and policymakers, Science, the Endless Frontier endures as a passionate articulation of the power and potential of science. |
| frontier in physiology: Frontiers in Mathematical Biology Simon A. Levin, 2013-03-13 From a mathematical point of view, physiologically structured population models are an underdeveloped branch of the theory of infinite dimensional dynamical systems. We have called attention to four aspects: (i) A choice has to be made about the kind of equations one extracts from the predominantly verbal arguments about the basic assumptions, and subsequently uses as a starting point for a rigorous mathematical analysis. Though differential equations are easy to formulate (different mechanisms don't interact in infinites imal time intervals and so end up as separate terms in the equations) they may be hard to interpret rigorously as infinitesimal generators. Integral equations constitute an attractive alternative. (ii) The ability of physiologically structured population models to increase our un derstanding of the relation between mechanisms at the i-level and phenomena at the p-level will depend strongly on the development of dynamical systems lab facilities which are applicable to this class of models. (iii) Physiologically structured population models are ideally suited for the for mulation of evolutionary questions. Apart from the special case of age (see Charlesworth 1980, Yodzis 1989, Caswell 1989, and the references given there) hardly any theory exists at the moment. This will, hopefully, change rapidly in the coming years. Again the development of appropriate software may turn out to be crucial. |
| frontier in physiology: Crop Physiology Case Histories for Major Crops Victor Sadras, Daniel Calderini, 2020-12-05 Crop Physiology: Case Histories of Major Crops updates the physiology of broad-acre crops with a focus on the genetic, environmental and management drivers of development, capture and efficiency in the use of radiation, water and nutrients, the formation of yield and aspects of quality. These physiological process are presented in a double context of challenges and solutions. The challenges to increase plant-based food, fodder, fiber and energy against the backdrop of population increase, climate change, dietary choices and declining public funding for research and development in agriculture are unprecedented and urgent. The proximal technological solutions to these challenges are genetic improvement and agronomy. Hence, the premise of the book is that crop physiology is most valuable when it engages meaningfully with breeding and agronomy. With contributions from 92 leading scientists from around the world, each chapter deals with a crop: maize, rice, wheat, barley, sorghum and oat; quinoa; soybean, field pea, chickpea, peanut, common bean, lentil, lupin and faba bean; sunflower and canola; potato, cassava, sugar beet and sugarcane; and cotton. - A crop-based approach to crop physiology in a G x E x M context - Captures the perspectives of global experts on 22 crops |
| frontier in physiology: Bats and Viruses Lin-Fa Wang, Christopher Cowled, 2015-09-08 Approximately 75% of emerging infectious diseases are zoonoses, and the rate of emergence of zoonotic diseases is on the rise. Bats are being increasingly recognised as an important reservoir of zoonotic viruses of different families, including SARS coronavirus, Nipah virus, Hendra virus and Ebola virus. Understanding bats’ role in emerging zoonotic diseases is crucial to this rapidly expanding area of research. Bats and Viruses: A New Frontier of Emerging Infectious Diseases provides an updated overview of research focusing on bat biology and the role bats play as hosts of many major zoonotic viruses. The text covers bat biology, immunology, and genomics. Chapters also delve into the various major bat-borne virus families, including lyssaviruses, paramyxoviruses, coronaviruses, filoviruses and reoviruses, among others. Edited by leaders in the field, Bats and Viruses: A New Frontier of Emerging Infectious Diseases is a timely, invaluable reference for bat researchers studying microbiology, virology and immunology, as well as infectious disease workers and epidemiologists, among others. |
| frontier in physiology: Human Physiology in Extreme Environments Hanns-Christian Gunga, 2014-11-26 Human Physiology in Extreme Environments is the one publication that offers how human biology and physiology is affected by extreme environments while highlighting technological innovations that allow us to adapt and regulate environments. Covering a broad range of extreme environments, including high altitude, underwater, tropical climates, and desert and arctic climates as well as space travel, this book will include case studies for practical application. Graduate students, medical students and researchers will find Human Physiology in Extreme Environments an interesting, informative and useful resource for human physiology, environmental physiology and medical studies. - Presents human physiological challenges in Extreme Environments combined in one single resource - Provides an excellent source of information regarding paleontological and anthropological aspects - Offers practical medical and scientific use of current concepts |
| frontier in physiology: Membrane Physiology Thomas E. Andreoli, Darrell D. Fanestil, Joseph F. Hoffman, Stanley G. Schultz, 2012-12-06 Membrane Physiology (Second Edition) is a soft-cover book containing portions of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections. This text encompasses the first three sections: The Nature of Biological Membranes, Methods for Studying Membranes, and General Problems in Membrane Biology. We hope that this smaller volume will be helpful to individuals interested in general physiology and the methods for studying general physiology. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ vii Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition. Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably. |
| frontier in physiology: Essentials of Glycobiology Ajit Varki, Maarten J. Chrispeels, 1999 Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans. |
| frontier in physiology: Climate Change Impact on Livestock: Adaptation and Mitigation Veerasamy Sejian, John Gaughan, Lance Baumgard, Cadaba Prasad, 2015-03-31 This volume addresses in detail both livestock’s role in climate change and the impacts of climate change on livestock production and reproduction. Apart from these cardinal principles of climate change and livestock production, this volume also examines the various strategies used to mitigate livestock-related GHG emissions, and those which can reduce the impacts of climate change on livestock production and reproduction. Presenting information and case studies collected and analyzed by professionals working in diversified ecological zones, the book explores the influence of climate change on livestock production across the globe. The most significant feature of this book is that it addresses in detail the different adaptation strategies and identifies targets for different stakeholders in connection with climate change and livestock production. Further, it puts forward development plans that will allow the livestock industries to cope with current climate changes and strategies that will mitigate the effects by 2025. Lastly, it provides researchers and policymakers several researchable priorities to help develop economically viable solutions for livestock production with less GHG emissions, promoting a cleaner environment in which human beings and livestock can live in harmony without adverse effects on productivity. Given that livestock production systems are sensitive to climate change and at the same are themselves a contributor to the phenomenon, climate change has the potential to pose an increasingly formidable challenge to the development of the livestock sector. However, there is a dearth of scientific information on adapting livestock production to the changing climate; as such, well-founded reference material on sustaining livestock production systems under the changing climate scenarios in different agro-ecological zones of the world is essential. By methodically and extensively addressing all aspects of climate change and livestock production, this volume offers a valuable tool for understanding the hidden intricacies of climatic stress and its influence on livestock production. |
| frontier in physiology: Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells Carlos Hermano J. Pinheiro, Lucas Guimarães-Ferreira, 2016-05-25 The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef. |
| frontier in physiology: The Life Sciences , 1970-01-01 |
| frontier in physiology: The Metric Tide James Wilsdon, 2016-01-20 ‘Represents the culmination of an 18-month-long project that aims to be the definitive review of this important topic. Accompanied by a scholarly literature review, some new analysis, and a wealth of evidence and insight... the report is a tour de force; a once-in-a-generation opportunity to take stock.’ – Dr Steven Hill, Head of Policy, HEFCE, LSE Impact of Social Sciences Blog ‘A must-read if you are interested in having a deeper understanding of research culture, management issues and the range of information we have on this field. It should be disseminated and discussed within institutions, disciplines and other sites of research collaboration.’ – Dr Meera Sabaratnam, Lecturer in International Relations at the School of Oriental and African Studies, University of London, LSE Impact of Social Sciences Blog Metrics evoke a mixed reaction from the research community. A commitment to using data and evidence to inform decisions makes many of us sympathetic, even enthusiastic, about the prospect of granular, real-time analysis of our own activities. Yet we only have to look around us at the blunt use of metrics to be reminded of the pitfalls. Metrics hold real power: they are constitutive of values, identities and livelihoods. How to exercise that power to positive ends is the focus of this book. Using extensive evidence-gathering, analysis and consultation, the authors take a thorough look at potential uses and limitations of research metrics and indicators. They explore the use of metrics across different disciplines, assess their potential contribution to the development of research excellence and impact and consider the changing ways in which universities are using quantitative indicators in their management systems. Finally, they consider the negative or unintended effects of metrics on various aspects of research culture. Including an updated introduction from James Wilsdon, the book proposes a framework for responsible metrics and makes a series of targeted recommendations to show how responsible metrics can be applied in research management, by funders, and in the next cycle of the Research Excellence Framework. The metric tide is certainly rising. Unlike King Canute, we have the agency and opportunity – and in this book, a serious body of evidence – to influence how it washes through higher education and research. |
| frontier in physiology: Host-Parasite Interactions Gert Flik, Geert Wiegertjes, 2004-07-01 This volume summarizes current research into the physiology and molecular biology of host-parasite interactions. Brought together by leading international experts in the field, the first section outlines fundamental processes, followed by specific examples in the concluding section. Covering a wide range of organisms, Host-Parasite Interactions is essential reading for researchers in the field. |
| frontier in physiology: Improving Diagnosis in Health Care National Academies of Sciences, Engineering, and Medicine, Institute of Medicine, Board on Health Care Services, Committee on Diagnostic Error in Health Care, 2015-12-29 Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety. |
| frontier in physiology: Organellar Ion Channels and Transporters Barbara E. Ehrlich, David E. Clapham, 1996 |
| frontier in physiology: A Clinical Guide to the Treatment of the Human Stress Response George S. Jr. Everly, Jeffrey M. Lating, 2006-02-20 This updated edition covers a range of new topics, including stress and the immune system, post-traumatic stress and crisis intervention, Eye Movement Desensitization and Reprocessing (EMDR), Critical Incident Stress Debriefing (CISD), Crisis Management Briefings in response to mass disasters and terrorism, Critical Incident Stress Management (CISM), spirituality and religion as stress management tools, dietary factors and stress, and updated information on psychopharmacologic intervention in the human stress response. It is a comprehensive and accessible guide for students, practitioners, and researchers in the fields of psychology, psychiatry, medicine, nursing, social work, and public health. |
| frontier in physiology: Molecular and Cellular Approaches to Neural Development W. Maxwell Cowan, Thomas M. Jessell, Stephen Lawrence Zipursky, 1997 This text provides a broad but authoritative view of the cellular and molecular aspects of developmental neurobiology written by leaders in the field. |
| frontier in physiology: Optogenetics Hiromu Yawo, Hideki Kandori, Amane Koizumi, Ryoichiro Kageyama, 2021-01-05 This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics. |
| frontier in physiology: Crop Systems Biology Xinyou Yin, Paul C. Struik, 2015-11-11 The sequencing of genomes has been completed for an increasing number of crop species, and researchers have now succeeded in isolating and characterising many important QTLs/genes. High expectations from genomics, however, are waving back toward the recognition that crop physiology is also important for realistic improvement of crop productivity. Complex processes and networks along various hierarchical levels of crop growth and development can be thoroughly understood with the help of their mathematical description – modelling. The further practical application of these understandings also requires quantitative predictions. In order to better support design, engineering and breeding for new crops and cultivars for improving agricultural production under global warming and climate change, there is an increasing call for an interdisciplinary research approach, which combines modern genetics and genomics, traditional physiology and biochemistry, and advanced bioinformatics and modelling. Such an interdisciplinary approach has been practised in various research groups for many years. However, it does not seem to be fully covered in the format of book publications. We want to initiate a book project on crop systems biology - narrowing the gaps between genotypes and phenotypes and the gaps between crop modelling and genetics/genomics, for publication in 2013/2014. The book will be meant for those scientists and graduate students from fundamental plant biology and applied crop science who are interested in bridging the gap between these two fields. We have invited a group of scientists (who have very good track records in publishing excellent papers in this field or in a closely related area) to contribute chapters to this new book, and they have agreed to do so. |
| frontier in physiology: Phenotyping Crop Plants for Physiological and Biochemical Traits P. Sudhakar, P. Latha, PV Reddy, 2016-04-05 Phenotyping Crop Plants for Physiological and Biochemical Traits presents a proven range of methodologies and practices for effective, efficient, and appropriate typing of crop plants. By addressing the basic principles and precautions needed when conducting crop-based experiments, this book guides the reader in selecting the appropriate method based on the growing environment, whether greenhouse, pot, field, or liquid (hydroponic). By addressing the quantification of seed traits related to growth experiments, including their viability and vigor, this book presents methodology options for optimum yield based on potential abiotic stresses. - Discusses various methods that can contribute to phenotyping of crop plants for various physiological and biochemical traits - Presents reliable techniques for phenotyping or quantifying plant characters during varied climatic conditions - Provides insights for selecting appropriate methodologies for specific crop growing situations - Identifies the most appropriate protocols and methods for analyzing crop traits |
| frontier in physiology: Immunophysiology of the Gut W. Allan Walker, Paul R. Harmatz, Barry K. Wershil, 1993 This volume represents Dr. Walker's efforts to integrate intestinal physiology and the mucosal immune system by providing the first comprehensive and systematic survey of information on the immunophysiology of the gut. |
| frontier in physiology: The Neurobiology of Olfaction Anna Menini, 2009-11-24 Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely |
| frontier in physiology: Decision Neuroscience Jean-Claude Dreher, Léon Tremblay, 2016-09-27 Decision Neuroscience addresses fundamental questions about how the brain makes perceptual, value-based, and more complex decisions in non-social and social contexts. This book presents compelling neuroimaging, electrophysiological, lesional, and neurocomputational models in combination with hormonal and genetic approaches, which have led to a clearer understanding of the neural mechanisms behind how the brain makes decisions. The five parts of the book address distinct but inter-related topics and are designed to serve both as classroom introductions to major subareas in decision neuroscience and as advanced syntheses of all that has been accomplished in the last decade. Part I is devoted to anatomical, neurophysiological, pharmacological, and optogenetics animal studies on reinforcement-guided decision making, such as the representation of instructions, expectations, and outcomes; the updating of action values; and the evaluation process guiding choices between prospective rewards. Part II covers the topic of the neural representations of motivation, perceptual decision making, and value-based decision making in humans, combining neurcomputational models and brain imaging studies. Part III focuses on the rapidly developing field of social decision neuroscience, integrating recent mechanistic understanding of social decisions in both non-human primates and humans. Part IV covers clinical aspects involving disorders of decision making that link together basic research areas including systems, cognitive, and clinical neuroscience; this part examines dysfunctions of decision making in neurological and psychiatric disorders, such as Parkinson's disease, schizophrenia, behavioral addictions, and focal brain lesions. Part V focuses on the roles of various hormones (cortisol, oxytocin, ghrelin/leptine) and genes that underlie inter-individual differences observed with stress, food choices, and social decision-making processes. The volume is essential reading for anyone interested in decision making neuroscience. With contributions that are forward-looking assessments of the current and future issues faced by researchers, Decision Neuroscience is essential reading for anyone interested in decision-making neuroscience. - Provides comprehensive coverage of approaches to studying individual and social decision neuroscience, including primate neurophysiology, brain imaging in healthy humans and in various disorders, and genetic and hormonal influences on decision making - Covers multiple levels of analysis, from molecular mechanisms to neural-systems dynamics and computational models of how we make choices - Discusses clinical implications of process dysfunctions, including schizophrenia, Parkinson's disease, eating disorders, drug addiction, and pathological gambling - Features chapters from top international researchers in the field and full-color presentation throughout with numerous illustrations to highlight key concepts |
| frontier in physiology: The New Frontier of Network Physiology: From Temporal Dynamics to the Synchronization and Principles of Integration in Networks of Physiological Systems Plamen Ch. Ivanov, Andras Eke, Olga Sosnovtseva, 2022-02-17 |
| frontier in physiology: From Neurons to Neighborhoods National Research Council, Institute of Medicine, Board on Children, Youth, and Families, Committee on Integrating the Science of Early Childhood Development, 2000-11-13 How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of expertise. The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about brain wiring and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows. |
| frontier in physiology: Life at the Edge of Sight Scott Chimileski, Roberto Kolter, 2017-09-25 This stunning photographic essay opens a new frontier for readers to explore through words and images. Microbial studies have clarified life’s origins on Earth, explained the functioning of ecosystems, and improved both crop yields and human health. Scott Chimileski and Roberto Kolter are expert guides to an invisible world waiting in plain sight. |
| frontier in physiology: Fundamentals of Soil Ecology David C. Coleman, D. A. Crossley, Paul F. Hendrix, 2004-07-19 Publisher Description |
| frontier in physiology: Rice Improvement Jauhar Ali, Shabir Hussain Wani, 2021-05-05 This book is open access under a CC BY 4.0 license. By 2050, human population is expected to reach 9.7 billion. The demand for increased food production needs to be met from ever reducing resources of land, water and other environmental constraints. Rice remains the staple food source for a majority of the global populations, but especially in Asia where ninety percent of rice is grown and consumed. Climate change continues to impose abiotic and biotic stresses that curtail rice quality and yields. Researchers have been challenged to provide innovative solutions to maintain, or even increase, rice production. Amongst them, the ‘green super rice’ breeding strategy has been successful for leading the development and release of multiple abiotic and biotic stress tolerant rice varieties. Recent advances in plant molecular biology and biotechnologies have led to the identification of stress responsive genes and signaling pathways, which open up new paradigms to augment rice productivity. Accordingly, transcription factors, protein kinases and enzymes for generating protective metabolites and proteins all contribute to an intricate network of events that guard and maintain cellular integrity. In addition, various quantitative trait loci associated with elevated stress tolerance have been cloned, resulting in the detection of novel genes for biotic and abiotic stress resistance. Mechanistic understanding of the genetic basis of traits, such as N and P use, is allowing rice researchers to engineer nutrient-efficient rice varieties, which would result in higher yields with lower inputs. Likewise, the research in micronutrients biosynthesis opens doors to genetic engineering of metabolic pathways to enhance micronutrients production. With third generation sequencing techniques on the horizon, exciting progress can be expected to vastly improve molecular markers for gene-trait associations forecast with increasing accuracy. This book emphasizes on the areas of rice science that attempt to overcome the foremost limitations in rice production. Our intention is to highlight research advances in the fields of physiology, molecular breeding and genetics, with a special focus on increasing productivity, improving biotic and abiotic stress tolerance and nutritional quality of rice. |
| frontier in physiology: Experiments and Observations on the Gastric Juice, and the Physiology of Digestion William Beaumont, 1833 Concerns the case of Alexis St. Martin, whose relations with Beaumont are summarized in the introduction. |
| frontier in physiology: The Metabolic Ghetto Jonathan C. K. Wells, 2016-07-21 A multidisciplinary analysis of the role of nutrition in generating hierarchical societies and cultivating a global epidemic of chronic diseases. |
| frontier in physiology: On the Frontier of Adulthood Richard A. Settersten Jr., Frank F. Furstenberg, Rubén G. Rumbaut, 2008-09-15 On the Frontier of Adulthood reveals a startling new fact: adulthood no longer begins when adolescence ends. A lengthy period before adulthood, often spanning the twenties and even extending into the thirties, is now devoted to further education, job exploration, experimentation in romantic relationships, and personal development. Pathways into and through adulthood have become much less linear and predictable, and these changes carry tremendous social and cultural significance, especially as institutions and policies aimed at supporting young adults have not kept pace with these changes. This volume considers the nature and consequences of changes in early adulthood by drawing upon a wide variety of historical and contemporary data from the United States, Canada, and Western Europe. Especially dramatic shifts have occurred in the conventional markers of adulthood—leaving home, finishing school, getting a job, getting married, and having children—and in how these experiences are configured as a set. These accounts reveal how the process of becoming an adult has changed over the past century, the challenges faced by young people today, and what societies can do to smooth the transition to adulthood. This book is the most thorough, wide-reaching, and insightful analysis of the new life stage of early adulthood.—Andrew Cherlin, Johns Hopkins University From West to East, young people today enter adulthood in widely diverse ways that affect their life chances. This book provides a rich portrait of this journey-an essential font of knowledge for all who care about the younger generation.—Glen H. Elder Jr., University of North Carolina at Chapel Hill On the Frontier of Adulthood adds considerably to our knowledge about the transition from adolescence to adulthood. . . . It will indeed be the definitive resource for researchers for years to come. Anyone working in the area—whether in demography, sociology, economics, or developmental psychology—will wish to make use of what is gathered here.—John Modell, Brown University This is a must-read for scholars and policymakers who are concerned with the future of today's youth and will become a touchpoint for an emerging field of inquiry focused on adult transitions.—Jeanne Brooks-Gunn, Columbia University |
| frontier in physiology: Anna Across the Arctic Liz O'Connell, Arin Underwood, 2020-01-28 |
| frontier in physiology: Plant RNA Biology Dóra Szakonyi, Ana Confraria, Concetta Valerio, Paula Duque, Dorothee Staiger, 2019-11-18 Discoveries from the past decades revealed that RNA molecules are much more than inert intermediates between the coding DNA sequences and their functional products, proteins. Today, RNAs are recognized as active regulatory molecules influencing gene expression, chromatin organization and genome stability, thus impacting all aspects of plant life including development, growth, reproduction and stress tolerance. Innovations in methodologies, the expanding application of next-generation sequencing technologies, and the creation of public datasets and databases have exposed a new universe of RNA-based mechanisms and led to the discovery of new families of non-coding RNAs, uncovered the large extent of alternative splicing events, and highlighted the potential roles of RNA modifications and RNA secondary structures. Furthermore, considerable advances have been made in identifying RNA-binding and processing factors involved in the synthesis and maturation of different forms of RNA molecules as well as in RNA processing, biochemical modifications or degradation. This Research Topic showcases the broad biological significance of RNAs in plant systems and contains eight original research articles, one review and four mini-reviews, covering various RNA-based mechanisms in higher plants. Emerging new technologies and novel multidisciplinary approaches are empowering the scientific community and will expectedly bring novel insights into our understanding of the mechanisms through which RNA is regulated and regulates biological processes in plant cells. |
| frontier in physiology: On Combat Dave Grossman, Loren W. Christensen, 2007 Looks at the effect of deadly battle on the body and mind and offers new research findings to help prevent lasting adverse effects. |
| frontier in physiology: Conservation Physiology Christine L. Madliger, Craig E. Franklin, Oliver P. Love, Steven J. Cooke, 2020 Conservation physiology is a rapidly expanding, multidisciplinary field that utilizes physiological knowledge and tools to understand and solve conservation challenges. This novel text provides the first consolidated overview of its scope, purpose, and applications, with a focus on wildlife. It outlines the major avenues and advances by which conservation physiology is contributing to the monitoring, management, and restoration of wild animal populations. This book also defines opportunities for further growth in the field and identifies critical areas for future investigation. By using a series of global case studies, contributors illustrate how approaches from the conservation physiology toolbox can tackle a diverse range of conservation issues including the monitoring of environmental stress, predicting the impact of climate change, understanding disease dynamics, improving captive breeding, and reducing human-wildlife conflict. Moreover, by acting as practical road maps across a diversity of sub-disciplines, these case studies serve to increase the accessibility of this discipline to new researchers. The diversity of taxa, biological scales, and ecosystems highlighted illustrate the far-reaching nature of the discipline and allow readers to gain an appreciation for the purpose, value, applicability, and status of the field of conservation physiology. Conservation Physiology is an accessible supplementary textbook suitable for graduate students, researchers, and practitioners in the fields of conservation science, eco-physiology, evolutionary and comparative physiology, natural resources management, ecosystem health, veterinary medicine, animal physiology, and ecology. |
| frontier in physiology: Users' Guides to the Medical Literature Gordon Guyatt, Drummond Rennie, Maureen O. Meade, Deborah J. Cook, 2008-03-01 The “essential” companion to the landmark Users' Guides to the Medical Literature - completely revised and updated! 5 STAR DOODY'S REVIEW! This second edition is even better than the original. Information is easier to find and the additional resources that will be available at www.JAMAevidence.com will provide readers with a one-stop source for evidence-based medicine.--Doody's Review Service Evidence-based medicine involves the careful interpretation of medical studies and its clinical application. And no resource helps you do it better-and faster-than Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. This streamlined reference distills the most clinically-relevant coverage from the parent Users' Guide Manual into one highly-focused, portable resource. Praised for its clear explanations of detailed statistical and mathematical principles, The Essentials concisely covers all the basic concepts of evidence-based medicine--everything you need to deliver optimal patient care. It's a perfect at-a-glance source for busy clinicians and students, helping you distinguish between solid medical evidence and poor medical evidence, tailor evidence-based medicine for each patient, and much more. Now in its second edition, this carry-along quick reference is more clinically relevant--and more essential--than ever! FEATURES Completely revised and updated with all new coverage of the basic issues in evidence-based medicine in patient care Abundant real-world examples drawn from the medical literature are woven throughout, and include important related principles and pitfalls in using clinical research in patient care decisions Edited by over 60 internationally recognized editors and contributors from around the globe Also look for JAMAevidence.com, a new interactive database for the best practice of evidence based medicine. |
| frontier in physiology: Understanding Evidence-Based Rheumatology Hasan Yazici, Yusuf Yazici, Emmanuel Lesaffre, 2014-10-29 It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined and the book closes with a summary of future directions for scientific and clinical studies in rheumatology. Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, clinicians and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology. |
| frontier in physiology: 2019-20 MATRIX Annals Jan de Gier, Cheryl E. Praeger, Terence Tao, 2021-02-10 MATRIX is Australia’s international and residential mathematical research institute. It facilitates new collaborations and mathematical advances through intensive residential research programs, each 1-4 weeks in duration. This book is a scientific record of the ten programs held at MATRIX in 2019 and the two programs held in January 2020: · Topology of Manifolds: Interactions Between High and Low Dimensions · Australian-German Workshop on Differential Geometry in the Large · Aperiodic Order meets Number Theory · Ergodic Theory, Diophantine Approximation and Related Topics · Influencing Public Health Policy with Data-informed Mathematical Models of Infectious Diseases · International Workshop on Spatial Statistics · Mathematics of Physiological Rhythms · Conservation Laws, Interfaces and Mixing · Structural Graph Theory Downunder · Tropical Geometry and Mirror Symmetry · Early Career Researchers Workshop on Geometric Analysis and PDEs · Harmonic Analysis and Dispersive PDEs: Problems and Progress The articles are grouped into peer-reviewed contributions and other contributions. The peer-reviewed articles present original results or reviews on a topic related to the MATRIX program; the remaining contributions are predominantly lecture notes or short articles based on talks or activities at MATRIX. |
| frontier in physiology: Law in the Laboratory Robert P. Charrow, 2010-07-15 The National Institutes of Health and the National Science Foundation together fund more than $40 billon of research annually in the United States and around the globe. These large public expenditures come with strings, including a complex set of laws and guidelines that regulate how scientists may use NIH and NSF funds, how federally funded research may be conducted, and who may have access to or own the product of the research. Until now, researchers have had little instruction on the nature of these laws and how they work. But now, with Robert P. Charrow’s Law in the Laboratory, they have a readable and entertaining introduction to the major ethical and legal considerations pertaining to research under the aegis of federal science funding. For any academic whose position is grant funded, or for any faculty involved in securing grants, this book will be an essential reference manual. And for those who want to learn how federal legislation and regulations affect laboratory research, Charrow’s primer will shed light on the often obscured intersection of government and science. |
| frontier in physiology: Trading in the Zone Mark Douglas, 2001-01-01 Douglas uncovers the underlying reasons for lack of consistency and helps traders overcome the ingrained mental habits that cost them money. He takes on the myths of the market and exposes them one by one teaching traders to look beyond random outcomes, to understand the true realities of risk, and to be comfortable with the probabilities of market movement that governs all market speculation. |
| frontier in physiology: Biophysics of the Failing Heart R. John Solaro, Jil C. Tardiff, 2013-08-13 Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies. |
Re: Clawsons in SW PA, frontie - Genealogy.com
Aug 28, 1999 · In reply to: Re: Clawsons in SW PA, frontier Ohio & Ind. 8/28/99 Your Lewis Clawson is from the line of Peter Clawson Jr., who moved to Indiana ca 1824 and to …
COTTLE's in Early Texas Histor - Genealogy.com
Oct 26, 2007 · Frontier Times, Mar., 1939 Stephen Cottle, of a family so numerous in St. Charles county, Missouri, a town was called "Cottleville" for them * Adam Turner * Ben …
Colonel Peter Bellinger - Genealogy.com
Mar 10, 2003 · Colonel Peter Bellinger By David Bellinger March 10, 2003 at 06:04:32. Peter P. Bellinger (1726-1813) made his imprint on history through his service as …
Pennsylvania Revolutionary War - Genealogy.com
Pennsylvania Revolutionary War service Records By David Agricola December 20, 2003 at 04:01:34. As I mentioned in a recent message, I plan to post various record …
Revolutionary War Bounty Land Grants - Genealogy.com
The extension of settlements on the frontier would, in time, also increase the tax rolls and contribute to the reduction of their Revolutionary War debts. In the aftermath …
Re: Clawsons in SW PA, frontie - Genealogy.com
Aug 28, 1999 · In reply to: Re: Clawsons in SW PA, frontier Ohio & Ind. 8/28/99 Your Lewis Clawson is from the line of Peter Clawson Jr., who moved to Indiana ca 1824 and to Carroll Co …
COTTLE's in Early Texas Histor - Genealogy.com
Oct 26, 2007 · Frontier Times, Mar., 1939 Stephen Cottle, of a family so numerous in St. Charles county, Missouri, a town was called "Cottleville" for them * Adam Turner * Ben Highsmith * …
Colonel Peter Bellinger - Genealogy.com
Mar 10, 2003 · Colonel Peter Bellinger By David Bellinger March 10, 2003 at 06:04:32. Peter P. Bellinger (1726-1813) made his imprint on history through his service as Commander of the …
Pennsylvania Revolutionary War - Genealogy.com
Pennsylvania Revolutionary War service Records By David Agricola December 20, 2003 at 04:01:34. As I mentioned in a recent message, I plan to post various record series on this …
Revolutionary War Bounty Land Grants - Genealogy.com
The extension of settlements on the frontier would, in time, also increase the tax rolls and contribute to the reduction of their Revolutionary War debts. In the aftermath of the war, the …
Fort Breckenridge aka Fort Man - Genealogy.com
Aug 19, 2002 · "Fort Breckenridge, also called Fort Mann, stood three miles west at the mouth of Falling Spring Creek, It was built by 1756 during the French and Indian War (1754-1763) as …
Early Warwick family informati - Genealogy.com
May 16, 2009 · With the outbreak of the Revolution, Indian hostilities encouraged by the British broke out on the Virginia frontier. On December 7th 1777, during an unexpected snowstorm, …
Daniel Boone & The Melungeons - Genealogy.com
Jul 14, 2007 · Instead he was with Capt Looney, Lieut. Daniel Boone and Lieut. John Cox guarding the Clinch frontier. In 1772 -73 Both Micajah Bunch and a number of Collins were …
Deaton History Volumes on CD - Genealogy.com
Dec 13, 2003 · Deaton History Volumes on CD By Lawson Deaton December 13, 2003 at 06:27:09. In case you haven't heard, the Deaton History Volumes, including "Sons and …
Francis Lyman Worden-Biography - Genealogy.com
May 8, 1999 · The construction of the Northern Pacific railroad across Montana in the early eighties ended Missoula's frontier isolation and brought a new era of expansion. Worden …
